{"id":"https://openalex.org/W3115546439","doi":null,"title":"Intricate Relationship Between Adaptive and Innate Immune System in Allergic Contact Dermatitis.","display_name":"Intricate Relationship Between Adaptive and Innate Immune System in Allergic Contact Dermatitis.","publication_year":2020,"publication_date":"2020-12-01","ids":{"openalex":"https://openalex.org/W3115546439","mag":"3115546439","pmid":"https://pubmed.ncbi.nlm.nih.gov/33380932","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7757059"},"language":"en","primary_location":{"id":"pmid:33380932","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33380932","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Yale journal of biology and medicine","raw_type":"Journal Article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7757059/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068831197","display_name":"Muhammad Azeem","orcid":"https://orcid.org/0000-0002-4440-1039","observed_orcids":["https://orcid.org/0000-0002-4440-1039"]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Muhammad Azeem","raw_affiliation_strings":["Department of Molecular Pathology, Institute of Pathology, University of W\u00fcrzburg, W\u00fcrzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pathology, Institute of Pathology, University of W\u00fcrzburg, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081946076","display_name":"Hidaya Abdul Kader","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201726411","display_name":"United Arab Emirates University","ror":"https://ror.org/01km6p862","country_code":"AE","type":"education","lineage":["https://openalex.org/I201726411"]}],"countries":["AE"],"is_corresponding":false,"raw_author_name":"Hidaya Kader","raw_affiliation_strings":["Department of Biology, College of Science, United Arab Emirates University, Al Ain, United Arab Emirates"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, College of Science, United Arab Emirates University, Al Ain, United Arab Emirates","institution_ids":["https://openalex.org/I201726411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019937386","display_name":"Andreas Kerstan","orcid":"https://orcid.org/0000-0001-6483-0191","observed_orcids":["https://orcid.org/0000-0001-6483-0191"]},"institutions":[{"id":"https://openalex.org/I4210126310","display_name":"Universit\u00e4tsklinikum W\u00fcrzburg","ror":"https://ror.org/03pvr2g57","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210126310"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andreas Kerstan","raw_affiliation_strings":["Department of Dermatology, Venereology and Allergology, University Hospital W\u00fcrzburg, W\u00fcrzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Venereology and Allergology, University Hospital W\u00fcrzburg, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I4210126310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066619473","display_name":"Helal F. Hetta","orcid":"https://orcid.org/0000-0001-8541-7304","observed_orcids":["https://orcid.org/0000-0001-8541-7304"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]},{"id":"https://openalex.org/I91041137","display_name":"Assiut University","ror":"https://ror.org/01jaj8n65","country_code":"EG","type":"education","lineage":["https://openalex.org/I91041137"]}],"countries":["EG","US"],"is_corresponding":false,"raw_author_name":"Helal F Hetta","raw_affiliation_strings":["Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, Egypt","Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, Egypt","institution_ids":["https://openalex.org/I91041137"]},{"raw_affiliation_string":"Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089027869","display_name":"Edgar Serfling","orcid":"https://orcid.org/0000-0002-1458-3767","observed_orcids":["https://orcid.org/0000-0002-1458-3767"]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Edgar Serfling","raw_affiliation_strings":["Department of Molecular Pathology, Institute of Pathology, University of W\u00fcrzburg, W\u00fcrzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pathology, Institute of Pathology, University of W\u00fcrzburg, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076078511","display_name":"Matthias Goebeler","orcid":"https://orcid.org/0000-0001-7095-9848","observed_orcids":["https://orcid.org/0000-0001-7095-9848"]},"institutions":[{"id":"https://openalex.org/I4210126310","display_name":"Universit\u00e4tsklinikum W\u00fcrzburg","ror":"https://ror.org/03pvr2g57","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210126310"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Matthias Goebeler","raw_affiliation_strings":["Department of Dermatology, Venereology and Allergology, University Hospital W\u00fcrzburg, W\u00fcrzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Venereology and Allergology, University Hospital W\u00fcrzburg, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I4210126310"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078830156","display_name":"Khalid Muhammad","orcid":"https://orcid.org/0000-0001-6488-1722","observed_orcids":["https://orcid.org/0000-0001-6488-1722"]},"institutions":[{"id":"https://openalex.org/I201726411","display_name":"United Arab Emirates University","ror":"https://ror.org/01km6p862","country_code":"AE","type":"education","lineage":["https://openalex.org/I201726411"]}],"countries":["AE"],"is_corresponding":false,"raw_author_name":"Khalid Muhammad","raw_affiliation_strings":["Department of Biology, College of Science, United Arab Emirates University, Al Ain, United Arab Emirates"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, College of Science, United Arab Emirates University, Al Ain, United Arab Emirates","institution_ids":["https://openalex.org/I201726411"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5887,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.49634551,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":98},"biblio":{"volume":"93","issue":"5","first_page":"699","last_page":"709"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11033","display_name":"Contact Dermatitis and Allergies","score":0.9458000063896179,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11033","display_name":"Contact Dermatitis and Allergies","score":0.9458000063896179,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.038100000470876694,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/allergic-contact-dermatitis","display_name":"allergic contact dermatitis","score":1.0},{"id":"https://openalex.org/keywords/adaptive-immunity","display_name":"adaptive immunity","score":0.8669999837875366},{"id":"https://openalex.org/keywords/innate-immune-system","display_name":"innate immune system","score":0.9940000176429749},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.8009999990463257},{"id":"https://openalex.org/keywords/b-cells","display_name":"B cells","score":1.0},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":1.0},{"id":"https://openalex.org/keywords/innate-lymphoid-cells","display_name":"innate lymphoid cells","score":0.9390000104904175},{"id":"https://openalex.org/keywords/immune-regulation","display_name":"immune regulation","score":0.3070000112056732}],"concepts":[{"id":"https://openalex.org/C47742525","wikidata":"https://www.wikidata.org/wiki/Q13418826","display_name":"Innate lymphoid cell","level":4,"score":0.7789844274520874},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.7626255750656128},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7327194213867188},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6739957332611084},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.6458721160888672},{"id":"https://openalex.org/C2776056826","wikidata":"https://www.wikidata.org/wiki/Q16242752","display_name":"Allergic contact dermatitis","level":3,"score":0.5971037149429321},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5781720876693726},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4216381013393402},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30657529830932617},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.27811336517333984},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007107","descriptor_name":"Immune System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017449","descriptor_name":"Dermatitis, Allergic Contact","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056704","descriptor_name":"Adaptive Immunity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:33380932","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33380932","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Yale journal of biology and medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7757059","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7757059/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Yale J Biol Med","raw_type":"Text"},{"id":"mag:3115546439","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33380932","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7757059","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7757059/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Yale J Biol Med","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":120,"referenced_works":["https://openalex.org/W131338218","https://openalex.org/W1485272564","https://openalex.org/W1507781793","https://openalex.org/W1512887313","https://openalex.org/W1515043948","https://openalex.org/W1523296592","https://openalex.org/W1538172952","https://openalex.org/W1605861898","https://openalex.org/W1608909099","https://openalex.org/W1646237332","https://openalex.org/W1695995011","https://openalex.org/W1697370658","https://openalex.org/W1840746127","https://openalex.org/W1850074881","https://openalex.org/W1882900263","https://openalex.org/W1912634928","https://openalex.org/W1926521347","https://openalex.org/W1932984089","https://openalex.org/W1938177405","https://openalex.org/W1948284414","https://openalex.org/W1972452655","https://openalex.org/W1975848200","https://openalex.org/W1982590004","https://openalex.org/W1983601075","https://openalex.org/W1989552966","https://openalex.org/W1990268036","https://openalex.org/W1993026721","https://openalex.org/W1993565885","https://openalex.org/W1996713852","https://openalex.org/W1996812526","https://openalex.org/W1998440908","https://openalex.org/W2000088222","https://openalex.org/W2006538571","https://openalex.org/W2011319298","https://openalex.org/W2011644825","https://openalex.org/W2015347941","https://openalex.org/W2017046428","https://openalex.org/W2020548971","https://openalex.org/W2028621964","https://openalex.org/W2033289727","https://openalex.org/W2039047166","https://openalex.org/W2041564493","https://openalex.org/W2043762074","https://openalex.org/W2043774001","https://openalex.org/W2043862206","https://openalex.org/W2044825971","https://openalex.org/W2046860633","https://openalex.org/W2046864860","https://openalex.org/W2047344004","https://openalex.org/W2047416556","https://openalex.org/W2048185003","https://openalex.org/W2050492409","https://openalex.org/W2052275203","https://openalex.org/W2053031631","https://openalex.org/W2070550392","https://openalex.org/W2070915602","https://openalex.org/W2074205207","https://openalex.org/W2074883153","https://openalex.org/W2075221279","https://openalex.org/W2076870975","https://openalex.org/W2077297620","https://openalex.org/W2082355065","https://openalex.org/W2091128689","https://openalex.org/W2092894443","https://openalex.org/W2093395242","https://openalex.org/W2099763862","https://openalex.org/W2107455390","https://openalex.org/W2114269157","https://openalex.org/W2116767253","https://openalex.org/W2117942222","https://openalex.org/W2119381274","https://openalex.org/W2120382367","https://openalex.org/W2120672352","https://openalex.org/W2122206763","https://openalex.org/W2125334139","https://openalex.org/W2125739592","https://openalex.org/W2132900457","https://openalex.org/W2147491616","https://openalex.org/W2150107812","https://openalex.org/W2151566115","https://openalex.org/W2157508907","https://openalex.org/W2160258620","https://openalex.org/W2162287533","https://openalex.org/W2162970323","https://openalex.org/W2168405751","https://openalex.org/W2169751144","https://openalex.org/W2171749585","https://openalex.org/W2338495285","https://openalex.org/W2347018476","https://openalex.org/W2360722042","https://openalex.org/W2402906839","https://openalex.org/W2463034533","https://openalex.org/W2471802697","https://openalex.org/W2507810843","https://openalex.org/W2515914179","https://openalex.org/W2518374784","https://openalex.org/W2518502109","https://openalex.org/W2527891547","https://openalex.org/W2535214781","https://openalex.org/W2574820137","https://openalex.org/W2600219441","https://openalex.org/W2614033339","https://openalex.org/W2726683946","https://openalex.org/W2767294203","https://openalex.org/W2771806116","https://openalex.org/W2781752850","https://openalex.org/W2793796255","https://openalex.org/W2900397481","https://openalex.org/W2900475552","https://openalex.org/W2900975251","https://openalex.org/W2903715882","https://openalex.org/W2909551877","https://openalex.org/W2960592492","https://openalex.org/W2981600318","https://openalex.org/W3006897160","https://openalex.org/W3013426388","https://openalex.org/W4247958036","https://openalex.org/W4248336599","https://openalex.org/W4256379901","https://openalex.org/W4313331748"],"related_works":["https://openalex.org/W2946014937","https://openalex.org/W2402344397","https://openalex.org/W2885618627","https://openalex.org/W2264465757","https://openalex.org/W2284504913","https://openalex.org/W107712519","https://openalex.org/W4231371814","https://openalex.org/W3031801412","https://openalex.org/W2921361565","https://openalex.org/W2403684457"],"abstract_inverted_index":{"T":[0],"cells,":[1,3],"B":[2],"neutrophils,":[4],"and":[5],"innate":[6],"lymphoid":[7],"cells":[8],"(ILCs).":[9],"Such":[10],"insights":[11],"can":[12],"be":[13],"useful":[14],"for":[15,20],"devising":[16],"future":[17],"therapeutic":[18],"interventions":[19],"ACD.":[21]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-01-05T00:00:00"}
