{"id":"https://openalex.org/W3114864035","doi":"https://doi.org/10.1182/blood.v130.suppl_1.3065.3065","title":"Aplidin (Plitidepsin) Regulates Viability and Function of Myeloma Cells and Bone Cells in Combination with Other Anti-MM Drugs","display_name":"Aplidin (Plitidepsin) Regulates Viability and Function of Myeloma Cells and Bone Cells in Combination with Other Anti-MM Drugs","publication_year":2017,"publication_date":"2017-12-07","ids":{"openalex":"https://openalex.org/W3114864035","doi":"https://doi.org/10.1182/blood.v130.suppl_1.3065.3065","mag":"3114864035"},"language":"en","primary_location":{"id":"mag:3114864035","doi":"https://doi.org/10.1182/blood.v130.suppl_1.3065.3065","is_oa":false,"landing_page_url":"https://ashpublications.org/blood/article/130/Supplement%201/3065/80450/Aplidin-Plitidepsin-Regulates-Viability-and","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Blood","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083902061","display_name":"Jes\u00fas Delgado\u2010Calle","orcid":"https://orcid.org/0000-0002-2083-2774","observed_orcids":["https://orcid.org/0000-0002-2083-2774"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jes\u00fas Delgado\u2010Calle","raw_affiliation_strings":["Medicine, Division of Hematology/Oncology, Indiana Univeristy School of Medicine, Indianapolis, IN"],"raw_orcid":"https://orcid.org/0000-0002-2083-2774","affiliations":[{"raw_affiliation_string":"Medicine, Division of Hematology/Oncology, Indiana Univeristy School of Medicine, Indianapolis, IN","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101701765","display_name":"Emily G. Atkinson","orcid":"https://orcid.org/0000-0003-2511-4605","observed_orcids":["https://orcid.org/0000-0003-2511-4605"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily G. Atkinson","raw_affiliation_strings":["Indiana University School of Medicine; Indianapolis"],"raw_orcid":"https://orcid.org/0000-0003-2511-4605","affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine; Indianapolis","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066196519","display_name":"Jessica H. Nelson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica Nelson","raw_affiliation_strings":["Indiana University School of Medicine; Indianapolis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine; Indianapolis","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062332683","display_name":"Noriyoshi Kurihara","orcid":"https://orcid.org/0000-0002-2836-9972","observed_orcids":["https://orcid.org/0000-0002-2836-9972"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Noriyoshi Kurihara","raw_affiliation_strings":["Indiana University School of Medicine; Indianapolis"],"raw_orcid":"https://orcid.org/0000-0002-2836-9972","affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine; Indianapolis","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067025614","display_name":"Carlos Mar\u00eda Galmarini","orcid":"https://orcid.org/0000-0001-5494-6617","observed_orcids":["https://orcid.org/0000-0001-5494-6617","https://orcid.org/0000-0003-3361-217X"]},"institutions":[{"id":"https://openalex.org/I4210116403","display_name":"PharmaMar (Spain)","ror":"https://ror.org/02h694m69","country_code":"ES","type":"company","lineage":["https://openalex.org/I4210116403"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Carlos M. Galmarini","raw_affiliation_strings":["PharmaMar, Madrid, Spain"],"raw_orcid":"https://orcid.org/0000-0001-5494-6617","affiliations":[{"raw_affiliation_string":"PharmaMar, Madrid, Spain","institution_ids":["https://openalex.org/I4210116403"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007296257","display_name":"David Roodman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Roodman","raw_affiliation_strings":["Medicine/Hematology and Oncology, Indiana University School of Medicine, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine/Hematology and Oncology, Indiana University School of Medicine, Indianapolis, IN","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053404897","display_name":"Teresita Bellido","orcid":"https://orcid.org/0000-0002-8203-7004","observed_orcids":["https://orcid.org/0000-0002-8203-7004"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Teresita Bellido","raw_affiliation_strings":["Indiana University School of Medicine; Indianapolis"],"raw_orcid":"https://orcid.org/0000-0002-8203-7004","affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine; Indianapolis","institution_ids":["https://openalex.org/I4394709130"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.39835579,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"130","issue":null,"first_page":"3065","last_page":"3065"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plitidepsin","display_name":"plitidepsin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9879999756813049},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.5659999847412109},{"id":"https://openalex.org/keywords/bortezomib","display_name":"bortezomib","score":0.902999997138977},{"id":"https://openalex.org/keywords/glucocorticoids","display_name":"glucocorticoids","score":0.996999979019165},{"id":"https://openalex.org/keywords/osteoclasts","display_name":"osteoclasts","score":0.800000011920929},{"id":"https://openalex.org/keywords/osteoblasts","display_name":"osteoblasts","score":0.9570000171661377},{"id":"https://openalex.org/keywords/osteocytes","display_name":"osteocytes","score":0.9670000076293945},{"id":"https://openalex.org/keywords/bone-resorption","display_name":"bone resorption","score":0.6460000276565552},{"id":"https://openalex.org/keywords/osteolytic-lesions","display_name":"osteolytic lesions","score":0.8190000057220459},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.5270000100135803}],"concepts":[{"id":"https://openalex.org/C2777478702","wikidata":"https://www.wikidata.org/wiki/Q419319","display_name":"Bortezomib","level":3,"score":0.7291632294654846},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.6487093567848206},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.6335437893867493},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.5474298000335693},{"id":"https://openalex.org/C2776033226","wikidata":"https://www.wikidata.org/wiki/Q828410","display_name":"Osteoclast","level":3,"score":0.5268836617469788},{"id":"https://openalex.org/C673006","wikidata":"https://www.wikidata.org/wiki/Q4941581","display_name":"Bone resorption","level":2,"score":0.5008273124694824},{"id":"https://openalex.org/C2780070996","wikidata":"https://www.wikidata.org/wiki/Q61482373","display_name":"Trypan blue","level":3,"score":0.4578827917575836},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4534091055393219},{"id":"https://openalex.org/C133605539","wikidata":"https://www.wikidata.org/wiki/Q913236","display_name":"Bone cell","level":2,"score":0.44947901368141174},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4337219297885895},{"id":"https://openalex.org/C2776169692","wikidata":"https://www.wikidata.org/wiki/Q4941552","display_name":"Bone disease","level":3,"score":0.4253194332122803},{"id":"https://openalex.org/C2780973866","wikidata":"https://www.wikidata.org/wiki/Q913236","display_name":"Osteocyte","level":4,"score":0.42462795972824097},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4225318729877472},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39746394753456116},{"id":"https://openalex.org/C2778260815","wikidata":"https://www.wikidata.org/wiki/Q917177","display_name":"Osteoblast","level":3,"score":0.3513725996017456},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.35028940439224243},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3305910527706146},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.30464842915534973},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.29020509123802185},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.16180327534675598},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1288255751132965}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:3114864035","doi":"https://doi.org/10.1182/blood.v130.suppl_1.3065.3065","is_oa":false,"landing_page_url":"https://ashpublications.org/blood/article/130/Supplement%201/3065/80450/Aplidin-Plitidepsin-Regulates-Viability-and","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Blood","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2953751231","https://openalex.org/W2053957621","https://openalex.org/W2560533902","https://openalex.org/W2980161076","https://openalex.org/W3023140457","https://openalex.org/W2558133464","https://openalex.org/W2140038388","https://openalex.org/W2024311349","https://openalex.org/W1995517837","https://openalex.org/W2887207938"],"abstract_inverted_index":{"Abstract":[0],"In":[3,215,386,496,514],"multiple":[4],"myeloma":[5,138],"(MM)":[6],"the":[7,15,20,41,63,76,103,119,125,154,205,247,298,327,368,375,392,403,411,444,455,480,490,618],"clonal":[8],"expansion":[9],"of":[10,22,52,105,118,127,156,208,292,297,329,370,377,394,405,434,446,457,482,492,613,617],"malignant":[11],"plasma":[12],"cells":[13,87,109,139,142,163,310,616],"within":[14],"bone":[16,24,29,43,64,108,112,141,345,602,606],"marrow":[17],"results":[18],"in":[19,34,85,95,100,131,148,185,228,236,249,306,340,374,402,415,454],"development":[21],"lytic":[23],"lesions":[25],"due":[26,171],"to":[27,89,123,172,225,233,265,304,308,442,470,597],"exacerbated":[28,528],"resorption.":[30],"Despite":[31],"recent":[32],"progress":[33],"its":[35,511],"treatment,":[36],"MM":[37,58,86,162,186,201,309,503,596],"remains":[38],"incurable":[39],"and":[40,61,92,110,140,145,159,203,212,227,244,267,314,360,407,409,468,474,487,500,506,518,524,539,545,550,565,571,573,608],"associated":[42],"disease":[44,113],"persists":[45],"even":[46,84],"after":[47,189,399],"complete":[48],"remission.":[49],"Thus,":[50],"identification":[51],"new":[53],"therapeutic":[54],"approaches":[55],"that":[56,429,584],"suppress":[57],"cell":[59,174,187,251,262,504,522,543],"growth":[60],"protect":[62],"is":[65,93,527],"an":[66,165],"unmet":[67],"need.":[68],"Aplidin,":[69,128,348],"a":[70,182,592],"novel":[71,593],"anti-cancer":[72],"compound":[73],"isolated":[74],"from":[75,343],"marine":[77],"tunicate":[78],"Aplidium":[79],"albicans,":[80],"exhibits":[81],"anti-MM":[82,135,206,512],"activity":[83,207],"resistant":[88],"conventional":[90],"chemotherapy":[91],"currently":[94],"phase":[96],"III":[97],"clinical":[98],"trials":[99],"Europe.":[101],"However,":[102],"effects":[104,278,445,552,612],"Aplidin":[106,152,209,217,258,282,293,305,325,388,430,447,471,478,498,516,537,563,586,614],"on":[107,137,448,464,615],"MM-induced":[111],"are":[114,553],"unknown.":[115],"The":[116],"goal":[117],"current":[120],"study":[121],"was":[122,283,317],"examine":[124],"effect":[126,526],"alone":[129],"or":[130,196,311,383,508],"combination":[132,229,291],"with":[133,164,192,230,285,294,382,587],"other":[134],"drugs,":[136],"(osteocytes,":[143],"osteoblasts,":[144],"osteoclasts)":[146],"using":[147],"vitro":[149],"approaches.":[150],"decreased":[153,173,200,268,326,389,489],"number":[155,328,369,393,481,491],"human":[157],"JJN3":[158],"murine":[160,344],"5TGM1":[161],"EC50~10nM,":[166],"determined":[167],"by":[168,177,210,254,274,290,332,336,362,366,390,419,437,461,485,529,534,555,560,604],"MTT":[169],"assay,":[170],"viability,":[175],"assessed":[176],"Trypan":[178],"blue":[179],"exclusion,":[180],"reaching":[181],"20%":[183,266],"increase":[184,248],"death":[188,252,263,544],"48h.":[190],"Treatment":[191],"glucocorticoids":[193],"(GC)":[194],"(10-5M)":[195],"Bortezomib":[197,238],"(3nM)":[198],"also":[199],"viability":[202,243,505,523],"enhanced":[204,280],"1.6-fold":[211],"2.5-fold,":[213],"respectively.":[214],"addition,":[216,387,515],"at":[218,319,349],">10nM":[219],"induced":[220,253,418],"MLO-A5":[221,250],"osteocytic":[222,521],"dead":[223],"up":[224,232,264],"15%":[226],"GC":[231,507,530],"50%;":[234],"whereas,":[235],"contrast,":[237],"did":[239,422],"not":[240,423],"affect":[241,424],"osteocyte":[242],"partially":[245,288,532,558],"prevented":[246,289,533,559],"Aplidin.":[255,385],"Further,":[256],"1nM":[257],"increased":[259,414,554],"OB-6":[260],"osteoblastic":[261,312,542,619],"their":[269,547],"matrix":[270],"mineralization":[271],"capacity,":[272],"quantified":[273,335,365],"Alizarin":[275],"red.":[276],"These":[277],"were":[279,459],"when":[281],"combined":[284],"GC,":[286,556],"but":[287,421,531,557],"Bortezomib.":[295,535,561],"Cells":[296],"osteoclastic":[299],"lineage":[300],"exhibited":[301],"higher":[302],"sensitivity":[303],"comparison":[307],"cells,":[313],"thus":[315],"it":[316],"tested":[318],"lower":[320],"concentrations.":[321],"Specifically,":[322],"50":[323],"pM":[324],"hematopoietic":[330],"precursors":[331,372,436],"15-20%,":[333],"as":[334,351,353,364],"enumerating":[337,367],"GM-CSF":[338],"colonies":[339],"cultures":[341],"established":[342],"marrow.":[346],"Moreover,":[347,536],"concentrations":[350],"low":[352],"0.01":[354],"pM,":[355],"reduced":[356,479],"osteoclast":[357,371,435,568,576],"precursor":[358,569],"commitment":[359,570],"differentiation":[361,433],"10%,":[363],"maintained":[373],"presence":[376,404,456],"M-CSF":[378,406],"for":[379,472,595],"3":[380,473],"days":[381,401],"without":[384],"40%":[391],"TRAP":[395],"positive":[396],"osteoclasts":[397,449,452,484],"generated":[398,453],"4":[400],"sRANKL;":[408],"blunted":[410],"rapid":[412],"(5-15min)":[413],"ERK":[416,439],"phosphorylation":[417],"Rankl,":[420],"RANKL-induced":[425,432],"p38":[426],"phosphorylation,":[427],"suggesting":[428],"inhibited":[431],"preventing":[438],"activation.":[440],"Lastly,":[441],"test":[443],"function,":[450],"mature":[451,483,575],"M-CSF/sRANKL":[458],"detached":[460],"trypsinization,":[462],"replated":[463],"bovine":[465],"dentin":[466],"slides":[467],"exposed":[469],"7":[475],"days.":[476],"10pM":[477],"60%":[486],"markedly":[488],"resorption":[493,577],"pits.":[494],"summary,":[497],"(1nM":[499,538],"up)":[501,519,540,566],"decreases":[502,520,546],"Borteozmib":[509],"enhances":[510],"activity.":[513,578],"(10nM":[517],"this":[525],"induces":[541],"mineral":[548],"production,":[549],"these":[551,581],"Furthermore,":[562],"(0.01pM":[564],"reduces":[567],"differentiation,":[572],"inhibits":[574],"Taken":[579],"together":[580],"findings":[582],"suggest":[583],"combining":[585],"proteosomal":[588],"inhibitors":[589],"may":[590],"be":[591],"therapy":[594],"enhance":[598],"anti-tumor":[599],"responses,":[600],"decrease":[601],"destruction":[603],"inhibiting":[605],"resorption,":[607],"prevent":[609],"potential":[610],"side":[611],"lineage.":[620],"Disclosures":[624],"Delgado-Calle:":[626],"PharmaMar:":[627,631,634,638],"Research":[628,635,639],"Funding.":[629,636,640],"Galmarini:":[630],"Employment.":[632],"Roodman:":[633],"Bellido:":[637]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2021-01-05T00:00:00"}