{"id":"https://openalex.org/W3114658317","doi":"https://doi.org/10.1186/s12902-021-00687-9","title":"Relationship between insulin sensitivity and gene expression in human skeletal muscle","display_name":"Relationship between insulin sensitivity and gene expression in human skeletal muscle","publication_year":2021,"publication_date":"2021-02-27","ids":{"openalex":"https://openalex.org/W3114658317","doi":"https://doi.org/10.1186/s12902-021-00687-9","mag":"3114658317","pmid":"https://pubmed.ncbi.nlm.nih.gov/33639916"},"language":"en","primary_location":{"id":"doi:10.1186/s12902-021-00687-9","doi":"https://doi.org/10.1186/s12902-021-00687-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12902-021-00687-9","pdf_url":"https://bmcendocrdisord.biomedcentral.com/counter/pdf/10.1186/s12902-021-00687-9","source":{"id":"https://openalex.org/S61153829","display_name":"BMC Endocrine Disorders","issn_l":"1472-6823","issn":["1472-6823"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Endocrine Disorders","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcendocrdisord.biomedcentral.com/counter/pdf/10.1186/s12902-021-00687-9","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048875579","display_name":"Hemang M. Parikh","orcid":"https://orcid.org/0000-0002-9076-6709","observed_orcids":["https://orcid.org/0000-0002-9076-6709"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]},{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]},{"id":"https://openalex.org/I4210137844","display_name":"Sk\u00e5ne University Hospital","ror":"https://ror.org/02z31g829","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210137844"]}],"countries":["SE","US"],"is_corresponding":true,"raw_author_name":"Hemang M. Parikh","raw_affiliation_strings":["Department of Clinical Sciences, Diabetes & Endocrinology, Lund University, University Hospital Malm\u00f6, SE-20502, Malm\u00f6, Sweden. parikhhemangm@gmail.com","Health Informatics Institute, Morsani College of Medicine, University of South Florida, 3650 Spectrum Blvd, Tampa, FL, 33612, USA. parikhhemangm@gmail.com","Department of Clinical Sciences, Diabetes & Endocrinology, Lund University, University Hospital Malm\u00f6, Malm\u00f6, Sweden","Health Informatics Institute, Morsani College of Medicine, University of South Florida, Tampa, USA"],"raw_orcid":"https://orcid.org/0000-0002-9076-6709","affiliations":[{"raw_affiliation_string":"Department of Clinical Sciences, Diabetes & Endocrinology, Lund University, University Hospital Malm\u00f6, SE-20502, Malm\u00f6, Sweden. parikhhemangm@gmail.com","institution_ids":["https://openalex.org/I187531555","https://openalex.org/I4210137844"]},{"raw_affiliation_string":"Health Informatics Institute, Morsani College of Medicine, University of South Florida, 3650 Spectrum Blvd, Tampa, FL, 33612, USA. parikhhemangm@gmail.com","institution_ids":["https://openalex.org/I2613432"]},{"raw_affiliation_string":"Department of Clinical Sciences, Diabetes & Endocrinology, Lund University, University Hospital Malm\u00f6, Malm\u00f6, Sweden","institution_ids":["https://openalex.org/I187531555"]},{"raw_affiliation_string":"Health Informatics Institute, Morsani College of Medicine, University of South Florida, Tampa, USA","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087998655","display_name":"Targ Elgzyri","orcid":"https://orcid.org/0000-0002-2376-3743","observed_orcids":["https://orcid.org/0000-0002-2376-3743"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]},{"id":"https://openalex.org/I4210137844","display_name":"Sk\u00e5ne University Hospital","ror":"https://ror.org/02z31g829","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210137844"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Targ Elgzyri","raw_affiliation_strings":["Department of Clinical Sciences, Diabetes & Endocrinology, Lund University, University Hospital Malm\u00f6, SE-20502, Malm\u00f6, Sweden","Department of Clinical Sciences, Diabetes & Endocrinology, Lund University, University Hospital Malm\u00f6, Malm\u00f6, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Sciences, Diabetes & Endocrinology, Lund University, University Hospital Malm\u00f6, SE-20502, Malm\u00f6, Sweden","institution_ids":["https://openalex.org/I187531555","https://openalex.org/I4210137844"]},{"raw_affiliation_string":"Department of Clinical Sciences, Diabetes & Endocrinology, Lund University, University Hospital Malm\u00f6, Malm\u00f6, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029409177","display_name":"Amra Ciric Alibegovic","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amra Alibegovic","raw_affiliation_strings":["Steno Diabetes Center, DK-2820, Gentofte, Denmark","Steno Diabetes Center, Gentofte, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Steno Diabetes Center, DK-2820, Gentofte, Denmark","institution_ids":[]},{"raw_affiliation_string":"Steno Diabetes Center, Gentofte, Denmark","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078725491","display_name":"Natalie J. Hiscock","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1342131907","display_name":"Unilever (United Kingdom)","ror":"https://ror.org/05n8ah907","country_code":"GB","type":"company","lineage":["https://openalex.org/I1342131907"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Natalie Hiscock","raw_affiliation_strings":["Unilever Discover R & D, Colworth Science Park, Sharnbrook, Bedfordshire, MK44 1LQ, UK","Unilever Discover R & D, Bedfordshire, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unilever Discover R & D, Colworth Science Park, Sharnbrook, Bedfordshire, MK44 1LQ, UK","institution_ids":["https://openalex.org/I1342131907"]},{"raw_affiliation_string":"Unilever Discover R & D, Bedfordshire, UK","institution_ids":["https://openalex.org/I1342131907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037004122","display_name":"Ola Ekstr\u00f6m","orcid":"https://orcid.org/0000-0002-4857-0892","observed_orcids":["https://orcid.org/0000-0002-4857-0892"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]},{"id":"https://openalex.org/I4210137844","display_name":"Sk\u00e5ne University Hospital","ror":"https://ror.org/02z31g829","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210137844"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Ola Ekstr\u00f6m","raw_affiliation_strings":["Department of Clinical Sciences, Diabetes & Endocrinology, Lund University, University Hospital Malm\u00f6, SE-20502, Malm\u00f6, Sweden","Department of Clinical Sciences, Diabetes & Endocrinology, Lund University, University Hospital Malm\u00f6, Malm\u00f6, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Sciences, Diabetes & Endocrinology, Lund University, University Hospital Malm\u00f6, SE-20502, Malm\u00f6, Sweden","institution_ids":["https://openalex.org/I187531555","https://openalex.org/I4210137844"]},{"raw_affiliation_string":"Department of Clinical Sciences, Diabetes & Endocrinology, Lund University, University Hospital Malm\u00f6, Malm\u00f6, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109877132","display_name":"Karl\u2010Fredrik Eriksson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]},{"id":"https://openalex.org/I4210137844","display_name":"Sk\u00e5ne University Hospital","ror":"https://ror.org/02z31g829","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210137844"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Karl-Fredrik Eriksson","raw_affiliation_strings":["Department of Clinical Sciences, Diabetes & Endocrinology, Lund University, University Hospital Malm\u00f6, SE-20502, Malm\u00f6, Sweden","Department of Clinical Sciences, Diabetes & Endocrinology, Lund University, University Hospital Malm\u00f6, Malm\u00f6, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Sciences, Diabetes & Endocrinology, Lund University, University Hospital Malm\u00f6, SE-20502, Malm\u00f6, Sweden","institution_ids":["https://openalex.org/I187531555","https://openalex.org/I4210137844"]},{"raw_affiliation_string":"Department of Clinical Sciences, Diabetes & Endocrinology, Lund University, University Hospital Malm\u00f6, Malm\u00f6, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069291545","display_name":"Allan Arthur Vaag","orcid":"https://orcid.org/0000-0002-3690-2191","observed_orcids":["https://orcid.org/0000-0002-3690-2191"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Allan Vaag","raw_affiliation_strings":["Steno Diabetes Center, DK-2820, Gentofte, Denmark","Steno Diabetes Center, Gentofte, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Steno Diabetes Center, DK-2820, Gentofte, Denmark","institution_ids":[]},{"raw_affiliation_string":"Steno Diabetes Center, Gentofte, Denmark","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074771810","display_name":"Leif Groop","orcid":"https://orcid.org/0000-0002-0187-3263","observed_orcids":["https://orcid.org/0000-0002-0187-3263"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"id":"https://openalex.org/I4210137844","display_name":"Sk\u00e5ne University Hospital","ror":"https://ror.org/02z31g829","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210137844"]}],"countries":["FI","SE"],"is_corresponding":false,"raw_author_name":"Leif C. Groop","raw_affiliation_strings":["Department of Clinical Sciences, Diabetes & Endocrinology, Lund University, University Hospital Malm\u00f6, SE-20502, Malm\u00f6, Sweden","Finnish Institute of Molecular Medicine, FI-00014, University of Helsinki, Helsinki, Finland","Department of Clinical Sciences, Diabetes & Endocrinology, Lund University, University Hospital Malm\u00f6, Malm\u00f6, Sweden","Finnish Institute of Molecular Medicine, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Sciences, Diabetes & Endocrinology, Lund University, University Hospital Malm\u00f6, SE-20502, Malm\u00f6, Sweden","institution_ids":["https://openalex.org/I187531555","https://openalex.org/I4210137844"]},{"raw_affiliation_string":"Finnish Institute of Molecular Medicine, FI-00014, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"raw_affiliation_string":"Department of Clinical Sciences, Diabetes & Endocrinology, Lund University, University Hospital Malm\u00f6, Malm\u00f6, Sweden","institution_ids":["https://openalex.org/I187531555"]},{"raw_affiliation_string":"Finnish Institute of Molecular Medicine, Helsinki, Finland","institution_ids":["https://openalex.org/I4210133586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030916585","display_name":"Kristoffer Str\u00f6m","orcid":"https://orcid.org/0000-0003-4483-435X","observed_orcids":["https://orcid.org/0000-0003-4483-435X"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]},{"id":"https://openalex.org/I4210137844","display_name":"Sk\u00e5ne University Hospital","ror":"https://ror.org/02z31g829","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210137844"]},{"id":"https://openalex.org/I56475706","display_name":"Mid Sweden University","ror":"https://ror.org/019k1pd13","country_code":"SE","type":"education","lineage":["https://openalex.org/I56475706"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Kristoffer Str\u00f6m","raw_affiliation_strings":["Department of Clinical Sciences, Diabetes & Endocrinology, Lund University, University Hospital Malm\u00f6, SE-20502, Malm\u00f6, Sweden","Swedish Winter Sports Research Centre, Mid Sweden University, SE-83125, \u00d6stersund, Sweden","Department of Clinical Sciences, Diabetes & Endocrinology, Lund University, University Hospital Malm\u00f6, Malm\u00f6, Sweden","Swedish Winter Sports Research Centre, Mid Sweden University, \u00d6stersund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Sciences, Diabetes & Endocrinology, Lund University, University Hospital Malm\u00f6, SE-20502, Malm\u00f6, Sweden","institution_ids":["https://openalex.org/I187531555","https://openalex.org/I4210137844"]},{"raw_affiliation_string":"Swedish Winter Sports Research Centre, Mid Sweden University, SE-83125, \u00d6stersund, Sweden","institution_ids":["https://openalex.org/I56475706"]},{"raw_affiliation_string":"Department of Clinical Sciences, Diabetes & Endocrinology, Lund University, University Hospital Malm\u00f6, Malm\u00f6, Sweden","institution_ids":["https://openalex.org/I187531555"]},{"raw_affiliation_string":"Swedish Winter Sports Research Centre, Mid Sweden University, \u00d6stersund, Sweden","institution_ids":["https://openalex.org/I56475706"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033111679","display_name":"Ola Hansson","orcid":"https://orcid.org/0000-0002-7394-7639","observed_orcids":["https://orcid.org/0000-0002-7394-7639"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"id":"https://openalex.org/I4210137844","display_name":"Sk\u00e5ne University Hospital","ror":"https://ror.org/02z31g829","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210137844"]}],"countries":["FI","SE"],"is_corresponding":false,"raw_author_name":"Ola Hansson","raw_affiliation_strings":["Department of Clinical Sciences, Diabetes & Endocrinology, Lund University, University Hospital Malm\u00f6, SE-20502, Malm\u00f6, Sweden","Finnish Institute of Molecular Medicine, FI-00014, University of Helsinki, Helsinki, Finland","Department of Clinical Sciences, Diabetes & Endocrinology, Lund University, University Hospital Malm\u00f6, Malm\u00f6, Sweden","Finnish Institute of Molecular Medicine, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Sciences, Diabetes & Endocrinology, Lund University, University Hospital Malm\u00f6, SE-20502, Malm\u00f6, Sweden","institution_ids":["https://openalex.org/I187531555","https://openalex.org/I4210137844"]},{"raw_affiliation_string":"Finnish Institute of Molecular Medicine, FI-00014, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"raw_affiliation_string":"Department of Clinical Sciences, Diabetes & Endocrinology, Lund University, University Hospital Malm\u00f6, Malm\u00f6, Sweden","institution_ids":["https://openalex.org/I187531555"]},{"raw_affiliation_string":"Finnish Institute of Molecular Medicine, Helsinki, Finland","institution_ids":["https://openalex.org/I4210133586"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5048875579"],"corresponding_institution_ids":["https://openalex.org/I187531555","https://openalex.org/I2613432","https://openalex.org/I4210137844"],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":{"value":2490,"currency":"USD","value_usd":2490},"fwci":0.8044,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.66621621,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"21","issue":"1","first_page":"32","last_page":"32"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.8159000277519226,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.8159000277519226,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.055799998342990875,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.041600000113248825,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.9879999756813049},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.7229999899864197},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.7799999713897705},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9229999780654907},{"id":"https://openalex.org/keywords/homa-ir","display_name":"HOMA-IR","score":0.9599999785423279},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9210000038146973},{"id":"https://openalex.org/keywords/mtor-signaling","display_name":"mTOR signaling","score":0.949999988079071},{"id":"https://openalex.org/keywords/sirt2","display_name":"SIRT2","score":0.9860000014305115},{"id":"https://openalex.org/keywords/pgc-1alpha","display_name":"PGC-1\u03b1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nutrient-sensing","display_name":"nutrient sensing","score":0.8450000286102295},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.968999981880188}],"concepts":[{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.8466975688934326},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.7720088958740234},{"id":"https://openalex.org/C112446052","wikidata":"https://www.wikidata.org/wiki/Q422579","display_name":"Insulin receptor","level":4,"score":0.6293655633926392},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.60946124792099},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6000723242759705},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5242995619773865},{"id":"https://openalex.org/C199848840","wikidata":"https://www.wikidata.org/wiki/Q18036605","display_name":"SIRT2","level":5,"score":0.496237576007843},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.4547138214111328},{"id":"https://openalex.org/C12304452","wikidata":"https://www.wikidata.org/wiki/Q21118081","display_name":"PPARGC1A","level":5,"score":0.438118577003479},{"id":"https://openalex.org/C2778096610","wikidata":"https://www.wikidata.org/wiki/Q1476525","display_name":"Dyslipidemia","level":3,"score":0.43455785512924194},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43406254053115845},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.427263468503952},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4144907593727112},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4139097332954407},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4106217324733734},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.25896841287612915},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.19462212920188904},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19391945004463196},{"id":"https://openalex.org/C2780561631","wikidata":"https://www.wikidata.org/wiki/Q421331","display_name":"Sirtuin","level":4,"score":0.13023972511291504},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.0},{"id":"https://openalex.org/C119157956","wikidata":"https://www.wikidata.org/wiki/Q796604","display_name":"Acetylation","level":3,"score":0.0},{"id":"https://openalex.org/C77445288","wikidata":"https://www.wikidata.org/wiki/Q637488","display_name":"Coactivator","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057185","descriptor_name":"Sedentary Behavior","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057185","descriptor_name":"Sedentary Behavior","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057185","descriptor_name":"Sedentary Behavior","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1186/s12902-021-00687-9","doi":"https://doi.org/10.1186/s12902-021-00687-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12902-021-00687-9","pdf_url":"https://bmcendocrdisord.biomedcentral.com/counter/pdf/10.1186/s12902-021-00687-9","source":{"id":"https://openalex.org/S61153829","display_name":"BMC Endocrine Disorders","issn_l":"1472-6823","issn":["1472-6823"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Endocrine Disorders","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-42125/v1","doi":"https://doi.org/10.21203/rs.3.rs-42125/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-42125/v1","pdf_url":"https://www.researchsquare.com/article/rs-42125/v1.pdf?c=1597083269000","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"doi:10.21203/rs.3.rs-42125/v2","doi":"https://doi.org/10.21203/rs.3.rs-42125/v2","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-42125/v2","pdf_url":"https://www.researchsquare.com/article/rs-42125/v2.pdf?c=1605829419000","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmid:33639916","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33639916","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC endocrine disorders","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7912896","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7912896","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Endocr Disord","raw_type":"Text"},{"id":"pmh:oai:DiVA.org:miun-41649","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-41649","pdf_url":null,"source":{"id":"https://openalex.org/S4306400653","display_name":"Diva portal (Dalarna University Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:a6ed4a5771f74190b226281bc86d4bb0","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a6ed4a5771f74190b226281bc86d4bb0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Endocrine Disorders, Vol 21, Iss 1, Pp 1-12 (2021)","raw_type":"article"},{"id":"pmh:oai:helda.helsinki.fi:10138/329437","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/329437","pdf_url":null,"source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:lup.lub.lu.se:78bb3f0f-2039-40e5-9d41-33c38284d699","doi":null,"is_oa":false,"landing_page_url":"https://lup.lub.lu.se/record/78bb3f0f-2039-40e5-9d41-33c38284d699","pdf_url":null,"source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1472-6823","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1186/s12902-021-00687-9","doi":"https://doi.org/10.1186/s12902-021-00687-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12902-021-00687-9","pdf_url":"https://bmcendocrdisord.biomedcentral.com/counter/pdf/10.1186/s12902-021-00687-9","source":{"id":"https://openalex.org/S61153829","display_name":"BMC Endocrine Disorders","issn_l":"1472-6823","issn":["1472-6823"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Endocrine Disorders","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.6600000262260437,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G2004031785","display_name":null,"funder_award_id":"2009-1039","funder_id":"https://openalex.org/F4320320940","funder_display_name":"Stiftelsen f\u00f6r\u00a0Strategisk Forskning"},{"id":"https://openalex.org/G263730981","display_name":null,"funder_award_id":"2009-1039","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G3032835362","display_name":null,"funder_award_id":"Dnr 2009-1039","funder_id":"https://openalex.org/F4320320940","funder_display_name":"Stiftelsen f\u00f6r\u00a0Strategisk Forskning"},{"id":"https://openalex.org/G3918735012","display_name":null,"funder_award_id":"IRC15-0067","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G492660439","display_name":null,"funder_award_id":"Dnr IRC15\u20100067","funder_id":"https://openalex.org/F4320320940","funder_display_name":"Stiftelsen f\u00f6r\u00a0Strategisk Forskning"},{"id":"https://openalex.org/G55242246","display_name":null,"funder_award_id":"2009-1039","funder_id":"https://openalex.org/F4320322327","funder_display_name":"Knut och Alice Wallenbergs Stiftelse"},{"id":"https://openalex.org/G5790206077","display_name":null,"funder_award_id":"NNF18OC0033572","funder_id":"https://openalex.org/F4320325957","funder_display_name":"Novo Nordisk Fonden"},{"id":"https://openalex.org/G6373074959","display_name":null,"funder_award_id":"2009-1039","funder_id":"https://openalex.org/F4320321806","funder_display_name":"Lunds Universitet"},{"id":"https://openalex.org/G67379338","display_name":null,"funder_award_id":"Dnr2009\u20101039","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G7629580587","display_name":"LUDC-IRC f\u00f6r individanpassad medicin i diabetes","funder_award_id":"IRC15-0067","funder_id":"https://openalex.org/F4320320940","funder_display_name":"Stiftelsen f\u00f6r\u00a0Strategisk Forskning"},{"id":"https://openalex.org/G804694337","display_name":null,"funder_award_id":"IRC15-0067","funder_id":"https://openalex.org/F4320321806","funder_display_name":"Lunds Universitet"},{"id":"https://openalex.org/G8817567552","display_name":null,"funder_award_id":"Dnr IRC15-0067","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"}],"funders":[{"id":"https://openalex.org/F4320320940","display_name":"Stiftelsen f\u00f6r\u00a0Strategisk Forskning","ror":"https://ror.org/044wr7g58"},{"id":"https://openalex.org/F4320321761","display_name":"Crafoordska Stiftelsen","ror":"https://ror.org/02hwwbr17"},{"id":"https://openalex.org/F4320321806","display_name":"Lunds Universitet","ror":"https://ror.org/012a77v79"},{"id":"https://openalex.org/F4320322315","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691"},{"id":"https://openalex.org/F4320322327","display_name":"Knut och Alice Wallenbergs Stiftelse","ror":"https://ror.org/004hzzk67"},{"id":"https://openalex.org/F4320322436","display_name":"Novo Nordisk","ror":"https://ror.org/0435rc536"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"},{"id":"https://openalex.org/F4320323741","display_name":"Magnus Bergvalls Stiftelse","ror":"https://ror.org/040ya8k73"},{"id":"https://openalex.org/F4320325957","display_name":"Novo Nordisk Fonden","ror":"https://ror.org/04txyc737"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3114658317.pdf","grobid_xml":"https://content.openalex.org/works/W3114658317.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W1577577364","https://openalex.org/W1584781794","https://openalex.org/W1636974729","https://openalex.org/W1754742998","https://openalex.org/W1823374409","https://openalex.org/W1836005048","https://openalex.org/W1884484468","https://openalex.org/W1972033020","https://openalex.org/W1975924645","https://openalex.org/W1976588209","https://openalex.org/W1982488301","https://openalex.org/W1990838637","https://openalex.org/W2002890991","https://openalex.org/W2005838165","https://openalex.org/W2013444425","https://openalex.org/W2020553313","https://openalex.org/W2023568495","https://openalex.org/W2026017489","https://openalex.org/W2028497702","https://openalex.org/W2032707929","https://openalex.org/W2038259293","https://openalex.org/W2041427362","https://openalex.org/W2049481764","https://openalex.org/W2051313176","https://openalex.org/W2068876411","https://openalex.org/W2082476985","https://openalex.org/W2092441434","https://openalex.org/W2103659405","https://openalex.org/W2106561187","https://openalex.org/W2109972881","https://openalex.org/W2110121134","https://openalex.org/W2110839026","https://openalex.org/W2111972845","https://openalex.org/W2112186681","https://openalex.org/W2120547043","https://openalex.org/W2121505622","https://openalex.org/W2123106337","https://openalex.org/W2130682212","https://openalex.org/W2131492087","https://openalex.org/W2134293572","https://openalex.org/W2135667395","https://openalex.org/W2148482472","https://openalex.org/W2148562280","https://openalex.org/W2148713009","https://openalex.org/W2150090192","https://openalex.org/W2152148024","https://openalex.org/W2152386173","https://openalex.org/W2157037423","https://openalex.org/W2158951820","https://openalex.org/W2160234571","https://openalex.org/W2160391830","https://openalex.org/W2164277931","https://openalex.org/W2164418602","https://openalex.org/W2170075604","https://openalex.org/W2170989872","https://openalex.org/W2171699473","https://openalex.org/W2334309509","https://openalex.org/W2474014923","https://openalex.org/W2591955138","https://openalex.org/W2604445208","https://openalex.org/W2780974917","https://openalex.org/W2787696532","https://openalex.org/W2946173685","https://openalex.org/W4300367614"],"related_works":["https://openalex.org/W3150996080","https://openalex.org/W3084314445","https://openalex.org/W2971498403","https://openalex.org/W2498134948","https://openalex.org/W2047203015","https://openalex.org/W4386878711","https://openalex.org/W2227804297","https://openalex.org/W3151903987","https://openalex.org/W4387413093","https://openalex.org/W3217467817"],"abstract_inverted_index":{"BACKGROUND:":[0],"Insulin":[1],"resistance":[2,64],"(IR)":[3],"in":[4,80,94,103,116,174,194],"skeletal":[5,42,82,196],"muscle":[6,43,156],"is":[7],"a":[8,52,199],"key":[9,142],"feature":[10],"of":[11,47,55,62,98,130,141,147,158,171],"the":[12,26,139,145],"pre-diabetic":[13],"state,":[14],"hypertension,":[15],"dyslipidemia,":[16],"cardiovascular":[17],"diseases":[18],"and":[19,72,119,126,132,179,183],"also":[20,135],"predicts":[21],"type":[22],"2":[23],"diabetes.":[24],"However,":[25],"underlying":[27],"molecular":[28],"mechanisms":[29],"are":[30,188],"still":[31],"poorly":[32],"understood.":[33],"METHODS:":[34],"To":[35],"explore":[36],"these":[37],"mechanisms,":[38],"we":[39],"related":[40],"global":[41],"gene":[44],"expression":[45,140,157],"profiling":[46],"38":[48],"non-diabetic":[49,100],"men":[50,101],"to":[51],"surrogate":[53],"measure":[54],"insulin":[56,63,78,91,111,149,164,192],"sensitivity,":[57,112],"i.e.":[58],"homeostatic":[59],"model":[60],"assessment":[61],"(HOMA-IR).":[65],"RESULTS:":[66],"We":[67],"identified":[68],"70":[69],"genes":[70,74,86,106,143,160,172,180],"positively":[71,88,136],"110":[73],"inversely":[75],"correlated":[76,89,109,137,162],"with":[77,90,110,138,163,190],"sensitivity":[79,193],"human":[81,195],"muscle,":[83,197],"identifying":[84],"autophagy-related":[85],"as":[87],"sensitivity.":[92,165],"Replication":[93],"an":[95,148],"independent":[96],"study":[97],"9":[99],"resulted":[102],"10":[104],"overlapping":[105],"that":[107,121,169],"strongly":[108],"including":[113],"SIRT2,":[114,178],"involved":[115,173],"lipid":[117,175],"metabolism,":[118,176],"FBXW5":[120,133],"regulates":[122],"mammalian":[123],"target-of-rapamycin":[124],"(mTOR)":[125],"autophagy.":[127],"The":[128,155],"expressions":[129],"SIRT2":[131],"were":[134,161],"promoting":[144],"phenotype":[146],"sensitive":[150],"myocyte":[151],"e.g.":[152,177,186],"PPARGC1A.":[153],"CONCLUSIONS:":[154],"180":[159],"These":[166],"data":[167],"suggest":[168],"activation":[170],"regulating":[181],"autophagy":[182],"mTOR":[184],"signaling,":[185],"FBXW5,":[187],"associated":[189],"increased":[191],"reflecting":[198],"highly":[200],"flexible":[201],"nutrient":[202],"sensing.":[203]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}
