{"id":"https://openalex.org/W3113042016","doi":"https://doi.org/10.1093/humupd/dmaa049","title":"Nanoparticles in pregnancy: the next frontier in reproductive therapeutics","display_name":"Nanoparticles in pregnancy: the next frontier in reproductive therapeutics","publication_year":2020,"publication_date":"2020-10-17","ids":{"openalex":"https://openalex.org/W3113042016","doi":"https://doi.org/10.1093/humupd/dmaa049","mag":"3113042016","pmid":"https://pubmed.ncbi.nlm.nih.gov/33279994","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9034208"},"language":"en","primary_location":{"id":"doi:10.1093/humupd/dmaa049","doi":"https://doi.org/10.1093/humupd/dmaa049","is_oa":false,"landing_page_url":"https://doi.org/10.1093/humupd/dmaa049","pdf_url":null,"source":{"id":"https://openalex.org/S19450991","display_name":"Human Reproduction Update","issn_l":"1355-4786","issn":["1355-4786","1362-4946","1460-2369"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Reproduction Update","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9034208","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019836429","display_name":"Natasha Pritchard","orcid":"https://orcid.org/0000-0002-7388-2193","observed_orcids":["https://orcid.org/0000-0002-7388-2193"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I2800974353","display_name":"Mercy Hospital for Women","ror":"https://ror.org/01ch4qb51","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800974353"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Natasha Pritchard","raw_affiliation_strings":["Mercy Perinatal, Mercy Hospital for Women, Heidelberg, Victoria, Australia","Translational Obstetrics Group, Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne, Heidelberg, Victoria, Australia"],"raw_orcid":"https://orcid.org/0000-0002-7388-2193","affiliations":[{"raw_affiliation_string":"Mercy Perinatal, Mercy Hospital for Women, Heidelberg, Victoria, Australia","institution_ids":["https://openalex.org/I2800974353"]},{"raw_affiliation_string":"Translational Obstetrics Group, Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne, Heidelberg, Victoria, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I2800974353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081990591","display_name":"Tu\u2019uhevaha J. Kaitu\u2019u\u2010Lino","orcid":"https://orcid.org/0000-0001-6233-9737","observed_orcids":["https://orcid.org/0000-0001-6233-9737"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I2800974353","display_name":"Mercy Hospital for Women","ror":"https://ror.org/01ch4qb51","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800974353"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Tu\u2019uhevaha Kaitu\u2019u-Lino","raw_affiliation_strings":["Department of Obstetrics and Gynaecology, Diagnostics Discovery and Reverse Translation, University of Melbourne, Heidelberg, Victoria, Australia","Mercy Perinatal, Mercy Hospital for Women, Heidelberg, Victoria, Australia","Translational Obstetrics Group, Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne, Heidelberg, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, Diagnostics Discovery and Reverse Translation, University of Melbourne, Heidelberg, Victoria, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Mercy Perinatal, Mercy Hospital for Women, Heidelberg, Victoria, Australia","institution_ids":["https://openalex.org/I2800974353"]},{"raw_affiliation_string":"Translational Obstetrics Group, Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne, Heidelberg, Victoria, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I2800974353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021918263","display_name":"Lynda K. Harris","orcid":"https://orcid.org/0000-0001-7709-5202","observed_orcids":["https://orcid.org/0000-0001-7709-5202"]},"institutions":[{"id":"https://openalex.org/I2799725268","display_name":"Manchester Academic Health Science Centre","ror":"https://ror.org/04rrkhs81","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799725268"]},{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]},{"id":"https://openalex.org/I4210087748","display_name":"St Mary's Hospital","ror":"https://ror.org/001x4vz59","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800602287","https://openalex.org/I4210087748","https://openalex.org/I4210092852"]},{"id":"https://openalex.org/I4210092852","display_name":"Manchester University NHS Foundation Trust","ror":"https://ror.org/00he80998","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210092852"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Lynda Harris","raw_affiliation_strings":["Division of Pharmacy and Optometry, University of Manchester, Manchester, UK","Maternal and Fetal Health Research Centre, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK","Maternal and Fetal Health Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Sciences Centre, St Mary\u2019s Hospital, Manchester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pharmacy and Optometry, University of Manchester, Manchester, UK","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"Maternal and Fetal Health Research Centre, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"Maternal and Fetal Health Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Sciences Centre, St Mary\u2019s Hospital, Manchester, UK","institution_ids":["https://openalex.org/I2799725268","https://openalex.org/I4210087748","https://openalex.org/I4210092852"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044161059","display_name":"Stephen Y. C. Tong","orcid":"https://orcid.org/0000-0002-2319-0586","observed_orcids":["https://orcid.org/0000-0002-2319-0586"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I2800974353","display_name":"Mercy Hospital for Women","ror":"https://ror.org/01ch4qb51","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800974353"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Stephen Tong","raw_affiliation_strings":["Mercy Perinatal, Mercy Hospital for Women, Heidelberg, Victoria, Australia","Translational Obstetrics Group, Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne, Heidelberg, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mercy Perinatal, Mercy Hospital for Women, Heidelberg, Victoria, Australia","institution_ids":["https://openalex.org/I2800974353"]},{"raw_affiliation_string":"Translational Obstetrics Group, Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne, Heidelberg, Victoria, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I2800974353"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062361099","display_name":"Natalie J. Hannan","orcid":"https://orcid.org/0000-0001-8446-2250","observed_orcids":["https://orcid.org/0000-0001-8446-2250"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I2800974353","display_name":"Mercy Hospital for Women","ror":"https://ror.org/01ch4qb51","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800974353"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Natalie Hannan","raw_affiliation_strings":["Mercy Perinatal, Mercy Hospital for Women, Heidelberg, Victoria, Australia","Therapeutics Discovery and Vascular Function Group, Department of Obstetrics and Gynaecology, University of Melbourne, Heidelberg, Victoria, Australia","Translational Obstetrics Group, Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne, Heidelberg, Victoria, Australia"],"raw_orcid":"https://orcid.org/0000-0001-8446-2250","affiliations":[{"raw_affiliation_string":"Mercy Perinatal, Mercy Hospital for Women, Heidelberg, Victoria, Australia","institution_ids":["https://openalex.org/I2800974353"]},{"raw_affiliation_string":"Therapeutics Discovery and Vascular Function Group, Department of Obstetrics and Gynaecology, University of Melbourne, Heidelberg, Victoria, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Translational Obstetrics Group, Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne, Heidelberg, Victoria, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I2800974353"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3973,"currency":"EUR","value_usd":4490},"apc_paid":null,"fwci":0.7934,"has_fulltext":false,"cited_by_count":101,"citation_normalized_percentile":{"value":0.60390879,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"27","issue":"2","first_page":"280","last_page":"304"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.7583000063896179,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.7583000063896179,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14089","display_name":"Nanotechnology research and applications","score":0.05999999865889549,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.03739999979734421,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nanoparticles","display_name":"nanoparticles","score":0.9200000166893005},{"id":"https://openalex.org/keywords/nanomedicine","display_name":"nanomedicine","score":0.9950000047683716},{"id":"https://openalex.org/keywords/targeted-drug-delivery","display_name":"targeted drug delivery","score":0.7139999866485596},{"id":"https://openalex.org/keywords/reproductive-medicine","display_name":"reproductive medicine","score":0.6690000295639038},{"id":"https://openalex.org/keywords/obstetrics","display_name":"obstetrics","score":0.921999990940094},{"id":"https://openalex.org/keywords/fertility-preservation","display_name":"fertility preservation","score":0.6299999952316284},{"id":"https://openalex.org/keywords/endometriosis","display_name":"endometriosis","score":0.8420000076293945},{"id":"https://openalex.org/keywords/uterine-fibroids","display_name":"uterine fibroids","score":0.9309999942779541},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.6480000019073486},{"id":"https://openalex.org/keywords/ectopic-pregnancy","display_name":"ectopic pregnancy","score":0.8569999933242798},{"id":"https://openalex.org/keywords/gestational-trophoblastic-disease","display_name":"gestational trophoblastic disease","score":0.9980000257492065},{"id":"https://openalex.org/keywords/preeclampsia","display_name":"preeclampsia","score":0.996999979019165},{"id":"https://openalex.org/keywords/intrauterine-growth-restriction","display_name":"fetal growth restriction","score":0.9670000076293945},{"id":"https://openalex.org/keywords/preterm-birth","display_name":"preterm birth","score":0.9900000095367432},{"id":"https://openalex.org/keywords/gestational-diabetes-mellitus","display_name":"gestational diabetes mellitus","score":0.9980000257492065},{"id":"https://openalex.org/keywords/warfarin","display_name":"warfarin","score":0.7039999961853027}],"concepts":[{"id":"https://openalex.org/C15083742","wikidata":"https://www.wikidata.org/wiki/Q261659","display_name":"Nanomedicine","level":3,"score":0.8440424203872681},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5327684283256531},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.504104495048523},{"id":"https://openalex.org/C2780665704","wikidata":"https://www.wikidata.org/wiki/Q959298","display_name":"Intervention (counseling)","level":2,"score":0.4749301075935364},{"id":"https://openalex.org/C2776210078","wikidata":"https://www.wikidata.org/wiki/Q351870","display_name":"Reproductive medicine","level":3,"score":0.4300451874732971},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3245031237602234},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.2875511050224304},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25606006383895874},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.10690417885780334},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.07634598016738892},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005298","descriptor_name":"Fertility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011271","descriptor_name":"Pregnancy, Ectopic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012098","descriptor_name":"Reproduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047928","descriptor_name":"Premature Birth","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1093/humupd/dmaa049","doi":"https://doi.org/10.1093/humupd/dmaa049","is_oa":false,"landing_page_url":"https://doi.org/10.1093/humupd/dmaa049","pdf_url":null,"source":{"id":"https://openalex.org/S19450991","display_name":"Human Reproduction Update","issn_l":"1355-4786","issn":["1355-4786","1362-4946","1460-2369"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Reproduction Update","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9034208","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9034208","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hum Reprod Update","raw_type":"Text"},{"id":"pmid:33279994","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33279994","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human reproduction update","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/b1dc0fdb-22f1-4b62-875e-9edbcedadb79","doi":null,"is_oa":false,"landing_page_url":"https://research.manchester.ac.uk/en/publications/b1dc0fdb-22f1-4b62-875e-9edbcedadb79","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pritchard, N, Kaitu'u-Lino, T, Harris, L K, Tong, S & Hannan, N 2020, 'Nanoparticles in pregnancy: The next frontier in reproductive therapeutics', Human Reproduction Update.","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9034208","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9034208","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hum Reprod Update","raw_type":"Text"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2325196506","display_name":"Translating new therapeutics and diagnostics for major pregnancy complications","funder_award_id":"1136418","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G2348937833","display_name":"New diagnostics to predict preelampsia and fetal growth restriction","funder_award_id":"1159261","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G2591845871","display_name":"Development of novel therapeutics to prevent or treat preeclampsia","funder_award_id":"1146128","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G4492622922","display_name":"Development of vascular homing peptides as a drug delivery system in pregnancy","funder_award_id":"BB/H022627/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G5832671507","display_name":"Developing personalized nanotherapies to target placental abnormalities causing fetal growth restriction","funder_award_id":"MR/P023401/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":272,"referenced_works":["https://openalex.org/W21436401","https://openalex.org/W1513717411","https://openalex.org/W1516954147","https://openalex.org/W1517029702","https://openalex.org/W1518898595","https://openalex.org/W1543814382","https://openalex.org/W1599431022","https://openalex.org/W1721689174","https://openalex.org/W1749110650","https://openalex.org/W1793124009","https://openalex.org/W1812840031","https://openalex.org/W1852891668","https://openalex.org/W1854963518","https://openalex.org/W1868158647","https://openalex.org/W1896852452","https://openalex.org/W1929513149","https://openalex.org/W1954757690","https://openalex.org/W1964748278","https://openalex.org/W1965313332","https://openalex.org/W1966042314","https://openalex.org/W1966318343","https://openalex.org/W1968160707","https://openalex.org/W1969018878","https://openalex.org/W1970122977","https://openalex.org/W1970366126","https://openalex.org/W1971470501","https://openalex.org/W1972203768","https://openalex.org/W1974090429","https://openalex.org/W1975058211","https://openalex.org/W1975131013","https://openalex.org/W1975160431","https://openalex.org/W1975588119","https://openalex.org/W1975755498","https://openalex.org/W1975776673","https://openalex.org/W1975875236","https://openalex.org/W1976650998","https://openalex.org/W1978602215","https://openalex.org/W1980584878","https://openalex.org/W1982106711","https://openalex.org/W1982462999","https://openalex.org/W1983743860","https://openalex.org/W1985962805","https://openalex.org/W1989230986","https://openalex.org/W1989428356","https://openalex.org/W1989658253","https://openalex.org/W1992220874","https://openalex.org/W1992768781","https://openalex.org/W1993020708","https://openalex.org/W1993162436","https://openalex.org/W1994057593","https://openalex.org/W1995864089","https://openalex.org/W2001018320","https://openalex.org/W2001338687","https://openalex.org/W2003774981","https://openalex.org/W2004704880","https://openalex.org/W2006587369","https://openalex.org/W2006682004","https://openalex.org/W2011370547","https://openalex.org/W2012891879","https://openalex.org/W2016618798","https://openalex.org/W2016670146","https://openalex.org/W2017904618","https://openalex.org/W2018457027","https://openalex.org/W2019704184","https://openalex.org/W2020667221","https://openalex.org/W2022480295","https://openalex.org/W2022786065","https://openalex.org/W2023425646","https://openalex.org/W2024710619","https://openalex.org/W2024787650","https://openalex.org/W2028063483","https://openalex.org/W2029942805","https://openalex.org/W2030184956","https://openalex.org/W2032760352","https://openalex.org/W2033125684","https://openalex.org/W2033278320","https://openalex.org/W2033468145","https://openalex.org/W2033598179","https://openalex.org/W2033612573","https://openalex.org/W2034052150","https://openalex.org/W2035133075","https://openalex.org/W2036243374","https://openalex.org/W2036254354","https://openalex.org/W2036453518","https://openalex.org/W2037225002","https://openalex.org/W2037800265","https://openalex.org/W2037958826","https://openalex.org/W2038218071","https://openalex.org/W2038552054","https://openalex.org/W2040041663","https://openalex.org/W2041296249","https://openalex.org/W2041577840","https://openalex.org/W2043082218","https://openalex.org/W2044038984","https://openalex.org/W2045282097","https://openalex.org/W2045381262","https://openalex.org/W2045663983","https://openalex.org/W2048018575","https://openalex.org/W2049265088","https://openalex.org/W2050017273","https://openalex.org/W2050179350","https://openalex.org/W2051720243","https://openalex.org/W2052829618","https://openalex.org/W2054726204","https://openalex.org/W2054964677","https://openalex.org/W2055095957","https://openalex.org/W2056012391","https://openalex.org/W2056194261","https://openalex.org/W2057341990","https://openalex.org/W2058999017","https://openalex.org/W2061510929","https://openalex.org/W2061896947","https://openalex.org/W2063138798","https://openalex.org/W2064286496","https://openalex.org/W2064663956","https://openalex.org/W2066234893","https://openalex.org/W2067173404","https://openalex.org/W2067796149","https://openalex.org/W2068465762","https://openalex.org/W2069218640","https://openalex.org/W2073156616","https://openalex.org/W2073175172","https://openalex.org/W2073974662","https://openalex.org/W2075757089","https://openalex.org/W2080418767","https://openalex.org/W2082992860","https://openalex.org/W2084068159","https://openalex.org/W2086407668","https://openalex.org/W2087337895","https://openalex.org/W2087904101","https://openalex.org/W2090108558","https://openalex.org/W2090503386","https://openalex.org/W2092111633","https://openalex.org/W2092637942","https://openalex.org/W2094988566","https://openalex.org/W2098393170","https://openalex.org/W2099412187","https://openalex.org/W2099655932","https://openalex.org/W2100786900","https://openalex.org/W2100963977","https://openalex.org/W2102592169","https://openalex.org/W2103665144","https://openalex.org/W2103880807","https://openalex.org/W2108836062","https://openalex.org/W2110902330","https://openalex.org/W2112927272","https://openalex.org/W2114245999","https://openalex.org/W2116672721","https://openalex.org/W2117254142","https://openalex.org/W2120212949","https://openalex.org/W2124038911","https://openalex.org/W2124072430","https://openalex.org/W2124304994","https://openalex.org/W2125920557","https://openalex.org/W2127126241","https://openalex.org/W2127311828","https://openalex.org/W2127458175","https://openalex.org/W2127942631","https://openalex.org/W2128802900","https://openalex.org/W2135103684","https://openalex.org/W2135126633","https://openalex.org/W2135890357","https://openalex.org/W2136556043","https://openalex.org/W2136558504","https://openalex.org/W2136656707","https://openalex.org/W2138444098","https://openalex.org/W2139462280","https://openalex.org/W2139683943","https://openalex.org/W2140535499","https://openalex.org/W2141297439","https://openalex.org/W2141948830","https://openalex.org/W2142337801","https://openalex.org/W2143180984","https://openalex.org/W2146670754","https://openalex.org/W2148362802","https://openalex.org/W2148942574","https://openalex.org/W2149131980","https://openalex.org/W2150482113","https://openalex.org/W2152179330","https://openalex.org/W2152678860","https://openalex.org/W2152692460","https://openalex.org/W2155085262","https://openalex.org/W2159491179","https://openalex.org/W2159980541","https://openalex.org/W2160282642","https://openalex.org/W2162317615","https://openalex.org/W2165570288","https://openalex.org/W2166710455","https://openalex.org/W2167232017","https://openalex.org/W2169101968","https://openalex.org/W2169282855","https://openalex.org/W2171914753","https://openalex.org/W2176374714","https://openalex.org/W2189897946","https://openalex.org/W2233974801","https://openalex.org/W2252538240","https://openalex.org/W2264069562","https://openalex.org/W2267639294","https://openalex.org/W2281317375","https://openalex.org/W2293304001","https://openalex.org/W2301631169","https://openalex.org/W2303408513","https://openalex.org/W2317933941","https://openalex.org/W2344644350","https://openalex.org/W2345399665","https://openalex.org/W2346489100","https://openalex.org/W2373764771","https://openalex.org/W2388009875","https://openalex.org/W2405805057","https://openalex.org/W2410227866","https://openalex.org/W2441368245","https://openalex.org/W2468363339","https://openalex.org/W2469253990","https://openalex.org/W2487202013","https://openalex.org/W2487308214","https://openalex.org/W2503127780","https://openalex.org/W2509751626","https://openalex.org/W2517663779","https://openalex.org/W2519028278","https://openalex.org/W2521600319","https://openalex.org/W2524116126","https://openalex.org/W2530378947","https://openalex.org/W2548146385","https://openalex.org/W2555066822","https://openalex.org/W2585392067","https://openalex.org/W2586274172","https://openalex.org/W2593833768","https://openalex.org/W2617060383","https://openalex.org/W2617638935","https://openalex.org/W2727442359","https://openalex.org/W2728557398","https://openalex.org/W2735578100","https://openalex.org/W2739739164","https://openalex.org/W2741412812","https://openalex.org/W2747135489","https://openalex.org/W2751143162","https://openalex.org/W2751185666","https://openalex.org/W2766239875","https://openalex.org/W2766250687","https://openalex.org/W2767025889","https://openalex.org/W2768568484","https://openalex.org/W2770132733","https://openalex.org/W2771670745","https://openalex.org/W2777846841","https://openalex.org/W2787513289","https://openalex.org/W2789163159","https://openalex.org/W2790011625","https://openalex.org/W2792114554","https://openalex.org/W2793855157","https://openalex.org/W2794622040","https://openalex.org/W2794851038","https://openalex.org/W2796863918","https://openalex.org/W2799524602","https://openalex.org/W2799862683","https://openalex.org/W2800316002","https://openalex.org/W2884616676","https://openalex.org/W2884912041","https://openalex.org/W2889675966","https://openalex.org/W2890167612","https://openalex.org/W2897851471","https://openalex.org/W2901511860","https://openalex.org/W2921036713","https://openalex.org/W2922242776","https://openalex.org/W2953232159","https://openalex.org/W3020667157","https://openalex.org/W3021299116","https://openalex.org/W3041102054","https://openalex.org/W4211236108","https://openalex.org/W4235266600","https://openalex.org/W4244638239","https://openalex.org/W6714480985","https://openalex.org/W7018408063"],"related_works":["https://openalex.org/W4396513266","https://openalex.org/W1929513149","https://openalex.org/W4412392503","https://openalex.org/W4406552081","https://openalex.org/W4307263599","https://openalex.org/W4238349560","https://openalex.org/W4387515923","https://openalex.org/W3025953323","https://openalex.org/W4292253290","https://openalex.org/W7095756952"],"abstract_inverted_index":{"BACKGROUND:":[0],"Nanotechnology":[1],"involves":[2],"the":[3,39,60,85,88,95,106,124,197,206,218,294,318,328,336,350,380,389],"engineering":[4],"of":[5,38,57,67,87,109,135,139,163,196,202,220,230,246,314,333,359,385,391],"structures":[6],"on":[7],"a":[8,23,29,70,365],"molecular":[9],"level.":[10],"Nanomedicine":[11],"and":[12,47,90,115,123,137,168,176,180,189,192,209,238,255,275,290,308,374,382,387,393],"nano-delivery":[13],"systems":[14,77],"have":[15],"been":[16],"designed":[17],"to":[18,22,59,144,158,205,263,271,285,293,296,302,317,327,335,341,370],"deliver":[19,287],"therapeutic":[20,40,222],"agents":[21],"target":[24],"site":[25],"or":[26,63,66,199],"organ":[27],"in":[28,112,148,166,217,227,257,364],"controlled":[30],"manner,":[31],"maximizing":[32],"efficacy":[33],"while":[34],"minimizing":[35,91],"off-target":[36],"effects":[37,348],"agent":[41],"administered.":[42],"In":[43,279],"both":[44],"reproductive":[45,72,113,231,366,383],"medicine":[46,114],"obstetrics,":[48,116],"developing":[49,64],"innovative":[50],"therapeutics":[51],"is":[52,224],"often":[53],"tempered":[54],"by":[55],"fears":[56],"damage":[58],"gamete,":[61,207],"embryo":[62,208],"foetus":[65,210,337],"negatively":[68],"impacting":[69,379],"woman's":[71],"potential.":[73],"Thus,":[74],"nanomedicine":[75,110],"delivery":[76,223,256,282,313,332],"may":[78,240,324,345],"provide":[79,241],"alternative":[80,269],"targeted":[81,331,360],"intervention":[82],"strategies,":[83],"treating":[84],"source":[86],"disease":[89],"long-term":[92],"consequences":[93],"for":[94,126,193,236,252,306,349,377,388],"mother":[96,198],"and/or":[97],"her":[98],"foetus.":[99,200,329],"OBJECTIVE":[100],"AND":[101],"RATIONALE:":[102],"This":[103],"review":[104],"summarizes":[105],"current":[107],"state":[108],"technology":[111,165],"including":[117],"safety,":[118],"potential":[119],"applications,":[120],"future":[121],"directions":[122],"hurdles":[125],"translation.":[127],"SEARCH":[128],"METHODS:":[129],"A":[130],"comprehensive":[131],"electronic":[132],"literature":[133],"search":[134],"PubMed":[136],"Web":[138],"Science":[140],"databases":[141],"was":[142,211],"performed":[143],"identify":[145],"studies":[146],"published":[147],"English":[149],"up":[150],"until":[151],"February":[152],"2020.":[153],"Relevant":[154],"keywords":[155],"were":[156],"used":[157],"obtain":[159],"information":[160],"regarding":[161],"use":[162],"nanoparticle":[164,221,234],"fertility":[167],"gene":[169,253,298],"therapy,":[170],"early":[171,264],"pregnancy":[172,175,265,392,395],"complications":[173,182],"(ectopic":[174],"gestational":[177,190,276],"trophoblastic":[178,277],"disease)":[179],"obstetric":[181],"(preeclampsia,":[183],"foetal":[184,309,343],"growth":[185,310],"restriction,":[186],"preterm":[187],"birth":[188],"diabetes)":[191],"selective":[194],"treatment":[195],"Safety":[201],"specific":[203],"nanoparticles":[204,363],"also":[212],"investigated.":[213],"OUTCOMES:":[214],"Pre-clinical":[215],"research":[216],"development":[219,358],"being":[225],"undertaken":[226],"many":[228],"fields":[229],"medicine.":[232],"Non-hormonal-targeted":[233],"therapy":[235],"fibroids":[237],"endometriosis":[239],"fertility-sparing":[242],"medical":[243],"management.":[244],"Delivery":[245],"interventions":[247],"via":[248],"nanotechnology":[249],"provides":[250,267],"opportunities":[251],"manipulation":[254],"mammalian":[258],"gametes.":[259],"Targeting":[260],"cytotoxic":[261],"treatments":[262,305,376],"tissue":[266],"an":[268],"approach":[270],"manage":[272],"ectopic":[273],"pregnancies":[274],"disease.":[278],"pregnancy,":[280],"nanotherapeutic":[281],"offers":[283],"options":[284],"stably":[286],"silencing":[288],"RNA":[289],"microRNA":[291],"inhibitors":[292],"placenta":[295],"regulate":[297],"expression,":[299],"opening":[300],"doors":[301],"novel":[303],"genetic":[304],"preeclampsia":[307],"restriction.":[311],"Restricting":[312],"teratogenic":[315],"drugs":[316,334],"maternal":[319],"compartment":[320],"(such":[321,338],"as":[322,339],"warfarin)":[323],"reduce":[325],"risks":[326],"Alternatively,":[330],"those":[340],"treat":[342],"arrythmias)":[344],"minimize":[346],"side":[347],"mother.":[351],"WIDER":[352],"IMPLICATIONS:":[353],"We":[354],"expect":[355],"that":[356],"further":[357],"therapies":[361],"using":[362],"setting":[367],"has":[368],"promise":[369],"eventually":[371],"allow":[372],"safe":[373],"directed":[375],"conditions":[378],"health":[381],"capacity":[384],"women":[386],"management":[390],"serious":[394],"complications.":[396]},"counts_by_year":[{"year":2026,"cited_by_count":21},{"year":2025,"cited_by_count":19},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":24},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-12-21T00:00:00"}
