{"id":"https://openalex.org/W3112201611","doi":"https://doi.org/10.21037/apm-20-449","title":"Comparison between the first-line and second-line immunotherapy drugs in the progression-free survival and overall survival in advanced non-small cell lung cancer: a systematic review and meta-analysis of randomized controlled trials","display_name":"Comparison between the first-line and second-line immunotherapy drugs in the progression-free survival and overall survival in advanced non-small cell lung cancer: a systematic review and meta-analysis of randomized controlled trials","publication_year":2020,"publication_date":"2020-12-11","ids":{"openalex":"https://openalex.org/W3112201611","doi":"https://doi.org/10.21037/apm-20-449","mag":"3112201611","pmid":"https://pubmed.ncbi.nlm.nih.gov/33302640"},"language":"en","primary_location":{"id":"doi:10.21037/apm-20-449","doi":"https://doi.org/10.21037/apm-20-449","is_oa":true,"landing_page_url":"https://doi.org/10.21037/apm-20-449","pdf_url":"https://apm.amegroups.com/article/viewFile/57835/pdf","source":{"id":"https://openalex.org/S2764761676","display_name":"Annals of Palliative Medicine","issn_l":"2224-5820","issn":["2224-5820","2224-5839"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","medline","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Palliative Medicine","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://apm.amegroups.com/article/viewFile/57835/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071627317","display_name":"Shengyu Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210127126","display_name":"Shanghai Pulmonary Hospital","ror":"https://ror.org/033nbnf69","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127126"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shengyu Wu","raw_affiliation_strings":["Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai, China; Tongji University, Shanghai, China","Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai, China","Tongji University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai, China; Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210127126"]},{"raw_affiliation_string":"Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210127126"]},{"raw_affiliation_string":"Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I116953780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100435747","display_name":"Lei Wang","orcid":"https://orcid.org/0000-0001-6604-3175","observed_orcids":["https://orcid.org/0000-0001-6604-3175"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210127126","display_name":"Shanghai Pulmonary Hospital","ror":"https://ror.org/033nbnf69","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127126"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Wang","raw_affiliation_strings":["Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai, China; Tongji University, Shanghai, China","Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai, China","Tongji University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai, China; Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210127126"]},{"raw_affiliation_string":"Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210127126"]},{"raw_affiliation_string":"Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I116953780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115604755","display_name":"Wei Li","orcid":"https://orcid.org/0000-0003-3980-1318","observed_orcids":["https://orcid.org/0000-0003-3980-1318"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210127126","display_name":"Shanghai Pulmonary Hospital","ror":"https://ror.org/033nbnf69","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127126"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Li","raw_affiliation_strings":["Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai, China; Tongji University, Shanghai, China","Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai, China","Tongji University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai, China; Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210127126"]},{"raw_affiliation_string":"Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210127126"]},{"raw_affiliation_string":"Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I116953780"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Bin Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210127126","display_name":"Shanghai Pulmonary Hospital","ror":"https://ror.org/033nbnf69","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127126"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bin Chen","raw_affiliation_strings":["Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai, China; Tongji University, Shanghai, China","Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai, China","Tongji University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai, China; Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210127126"]},{"raw_affiliation_string":"Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210127126"]},{"raw_affiliation_string":"Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I116953780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100345653","display_name":"Yu Liu","orcid":"https://orcid.org/0009-0005-5475-2632","observed_orcids":["https://orcid.org/0009-0005-5475-2632"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210127126","display_name":"Shanghai Pulmonary Hospital","ror":"https://ror.org/033nbnf69","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127126"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Liu","raw_affiliation_strings":["Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai, China; Tongji University, Shanghai, China","Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai, China","Tongji University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai, China; Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210127126"]},{"raw_affiliation_string":"Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210127126"]},{"raw_affiliation_string":"Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I116953780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100446031","display_name":"Hao Wang","orcid":"https://orcid.org/0000-0001-6489-6940","observed_orcids":["https://orcid.org/0000-0001-6489-6940"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210127126","display_name":"Shanghai Pulmonary Hospital","ror":"https://ror.org/033nbnf69","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127126"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hao Wang","raw_affiliation_strings":["Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai, China; Tongji University, Shanghai, China","Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai, China","Tongji University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai, China; Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210127126"]},{"raw_affiliation_string":"Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210127126"]},{"raw_affiliation_string":"Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I116953780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029378981","display_name":"Sha Zhao","orcid":"https://orcid.org/0000-0002-4298-228X","observed_orcids":["https://orcid.org/0000-0002-4298-228X"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210127126","display_name":"Shanghai Pulmonary Hospital","ror":"https://ror.org/033nbnf69","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127126"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sha Zhao","raw_affiliation_strings":["Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai, China; Tongji University, Shanghai, China","Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai, China","Tongji University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai, China; Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210127126"]},{"raw_affiliation_string":"Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210127126"]},{"raw_affiliation_string":"Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I116953780"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Lingyun Ye","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210127126","display_name":"Shanghai Pulmonary Hospital","ror":"https://ror.org/033nbnf69","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127126"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lingyun Ye","raw_affiliation_strings":["Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai, China; Tongji University, Shanghai, China","Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai, China","Tongji University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai, China; Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210127126"]},{"raw_affiliation_string":"Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210127126"]},{"raw_affiliation_string":"Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I116953780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028743678","display_name":"Hui Sun","orcid":"https://orcid.org/0000-0002-7145-6991","observed_orcids":["https://orcid.org/0000-0002-7145-6991"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210127126","display_name":"Shanghai Pulmonary Hospital","ror":"https://ror.org/033nbnf69","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127126"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hui Sun","raw_affiliation_strings":["Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai, China; Tongji University, Shanghai, China. sunhui2018@163.com","Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai, China","Tongji University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai, China; Tongji University, Shanghai, China. sunhui2018@163.com","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210127126"]},{"raw_affiliation_string":"Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210127126"]},{"raw_affiliation_string":"Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I116953780"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100321791","display_name":"Yayi He","orcid":"https://orcid.org/0000-0002-2820-9119","observed_orcids":["https://orcid.org/0000-0002-2820-9119"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210127126","display_name":"Shanghai Pulmonary Hospital","ror":"https://ror.org/033nbnf69","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127126"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yayi He","raw_affiliation_strings":["Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai, China. 2250601@qq.com","Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai, China. 2250601@qq.com","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210127126"]},{"raw_affiliation_string":"Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210127126"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5028743678","https://openalex.org/A5100321791"],"corresponding_institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210127126"],"apc_list":null,"apc_paid":null,"fwci":0.2893,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.35518672,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"10","issue":"2","first_page":"1717","last_page":"1726"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.5365999937057495,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.5365999937057495,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.38960000872612,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.03240000084042549,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9940000176429749},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.8209999799728394},{"id":"https://openalex.org/keywords/first-line-treatment","display_name":"first-line therapy","score":0.8230000138282776},{"id":"https://openalex.org/keywords/second-line-treatment","display_name":"second-line therapy","score":1.0},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.8830000162124634},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9959999918937683},{"id":"https://openalex.org/keywords/single-agent-immunotherapy","display_name":"single-agent immunotherapy","score":0.7770000100135803},{"id":"https://openalex.org/keywords/treatment-timing","display_name":"treatment timing","score":0.6060000061988831}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9121567010879517},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.7804508209228516},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.681014895439148},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.6693727970123291},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6504113078117371},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6466101408004761},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.6423454880714417},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.5470602512359619},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4285150468349457},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.42166274785995483},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3679957389831543}],"mesh":[{"descriptor_ui":"D000077982","descriptor_name":"Progression-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.21037/apm-20-449","doi":"https://doi.org/10.21037/apm-20-449","is_oa":true,"landing_page_url":"https://doi.org/10.21037/apm-20-449","pdf_url":"https://apm.amegroups.com/article/viewFile/57835/pdf","source":{"id":"https://openalex.org/S2764761676","display_name":"Annals of Palliative Medicine","issn_l":"2224-5820","issn":["2224-5820","2224-5839"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","medline","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Palliative Medicine","raw_type":"journal-article"},{"id":"pmid:33302640","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33302640","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of palliative medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.21037/apm-20-449","doi":"https://doi.org/10.21037/apm-20-449","is_oa":true,"landing_page_url":"https://doi.org/10.21037/apm-20-449","pdf_url":"https://apm.amegroups.com/article/viewFile/57835/pdf","source":{"id":"https://openalex.org/S2764761676","display_name":"Annals of Palliative Medicine","issn_l":"2224-5820","issn":["2224-5820","2224-5839"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","medline","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Palliative Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"},{"display_name":"Meta-Analysis","id":"https://openalex.org/study-designs/meta-analysis"}],"awards":[{"id":"https://openalex.org/G1147737000","display_name":null,"funder_award_id":"fkyq1901","funder_id":"https://openalex.org/F4320322449","funder_display_name":"Tongji University"},{"id":"https://openalex.org/G1312756230","display_name":null,"funder_award_id":"19411950300","funder_id":"https://openalex.org/F4320322449","funder_display_name":"Tongji University"},{"id":"https://openalex.org/G1792620616","display_name":null,"funder_award_id":"fk18005","funder_id":"https://openalex.org/F4320321885","funder_display_name":"Science and Technology Commission of Shanghai Municipality"},{"id":"https://openalex.org/G1857778124","display_name":null,"funder_award_id":"81802255","funder_id":"https://openalex.org/F4320329745","funder_display_name":"Shanghai Pulmonary Hospital"},{"id":"https://openalex.org/G212289638","display_name":null,"funder_award_id":"2019 QNBJ","funder_id":"https://openalex.org/F4320322449","funder_display_name":"Tongji University"},{"id":"https://openalex.org/G3535862999","display_name":null,"funder_award_id":"fkyq1901","funder_id":"https://openalex.org/F4320329745","funder_display_name":"Shanghai Pulmonary Hospital"},{"id":"https://openalex.org/G3624751900","display_name":null,"funder_award_id":"81802255","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4069794247","display_name":null,"funder_award_id":"2019 QNBJ","funder_id":"https://openalex.org/F4320321885","funder_display_name":"Science and Technology Commission of Shanghai Municipality"},{"id":"https://openalex.org/G4163078952","display_name":null,"funder_award_id":"19411950300","funder_id":"https://openalex.org/F4320329745","funder_display_name":"Shanghai Pulmonary Hospital"},{"id":"https://openalex.org/G4301721887","display_name":null,"funder_award_id":"2019 QNBJ","funder_id":"https://openalex.org/F4320329745","funder_display_name":"Shanghai Pulmonary Hospital"},{"id":"https://openalex.org/G4307042601","display_name":null,"funder_award_id":"19411950300","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4854234644","display_name":null,"funder_award_id":"fk18005","funder_id":"https://openalex.org/F4320322449","funder_display_name":"Tongji University"},{"id":"https://openalex.org/G497077928","display_name":null,"funder_award_id":"81802255","funder_id":"https://openalex.org/F4320321885","funder_display_name":"Science and Technology Commission of Shanghai Municipality"},{"id":"https://openalex.org/G5444704385","display_name":null,"funder_award_id":"19411950300","funder_id":"https://openalex.org/F4320321885","funder_display_name":"Science and Technology Commission of Shanghai Municipality"},{"id":"https://openalex.org/G5639236966","display_name":null,"funder_award_id":"fkyq1901","funder_id":"https://openalex.org/F4320321885","funder_display_name":"Science and Technology Commission of Shanghai Municipality"},{"id":"https://openalex.org/G5747545179","display_name":null,"funder_award_id":"2017YQ050","funder_id":"https://openalex.org/F4320321885","funder_display_name":"Science and Technology Commission of Shanghai Municipality"},{"id":"https://openalex.org/G5896251305","display_name":null,"funder_award_id":"2017YQ050","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6109391545","display_name":null,"funder_award_id":"81802255","funder_id":"https://openalex.org/F4320322449","funder_display_name":"Tongji University"},{"id":"https://openalex.org/G7177688801","display_name":null,"funder_award_id":"2017YQ050","funder_id":"https://openalex.org/F4320322449","funder_display_name":"Tongji University"},{"id":"https://openalex.org/G7480834049","display_name":null,"funder_award_id":"fkyq1901","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7637035824","display_name":null,"funder_award_id":"2017YQ050","funder_id":"https://openalex.org/F4320329745","funder_display_name":"Shanghai Pulmonary Hospital"},{"id":"https://openalex.org/G8083701073","display_name":null,"funder_award_id":"fk18005","funder_id":"https://openalex.org/F4320329745","funder_display_name":"Shanghai Pulmonary Hospital"},{"id":"https://openalex.org/G8127793893","display_name":null,"funder_award_id":"fkcx1903","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8429470263","display_name":null,"funder_award_id":"fkcx1903","funder_id":"https://openalex.org/F4320329745","funder_display_name":"Shanghai Pulmonary Hospital"},{"id":"https://openalex.org/G8508903879","display_name":null,"funder_award_id":"2019 QNBJ","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8755174377","display_name":null,"funder_award_id":"fkcx1903","funder_id":"https://openalex.org/F4320321885","funder_display_name":"Science and Technology Commission of Shanghai Municipality"},{"id":"https://openalex.org/G8774271182","display_name":null,"funder_award_id":"fk18005","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G888050874","display_name":null,"funder_award_id":"fkcx1903","funder_id":"https://openalex.org/F4320322449","funder_display_name":"Tongji University"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321885","display_name":"Science and Technology Commission of Shanghai Municipality","ror":"https://ror.org/03kt66j61"},{"id":"https://openalex.org/F4320322449","display_name":"Tongji University","ror":"https://ror.org/03rc6as71"},{"id":"https://openalex.org/F4320329745","display_name":"Shanghai Pulmonary Hospital","ror":"https://ror.org/033nbnf69"},{"id":"https://openalex.org/F4320336355","display_name":"Shanghai Institute of Technical Physics, Chinese Academy of Sciences","ror":"https://ror.org/02txedb84"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3112201611.pdf","grobid_xml":"https://content.openalex.org/works/W3112201611.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1953677527","https://openalex.org/W2104347254","https://openalex.org/W2156353875","https://openalex.org/W2198093519","https://openalex.org/W2293531514","https://openalex.org/W2342642001","https://openalex.org/W2418354692","https://openalex.org/W2508020951","https://openalex.org/W2527905628","https://openalex.org/W2567564314","https://openalex.org/W2587327379","https://openalex.org/W2594592303","https://openalex.org/W2601854298","https://openalex.org/W2623388110","https://openalex.org/W2625684877","https://openalex.org/W2635951006","https://openalex.org/W2762777471","https://openalex.org/W2769635882","https://openalex.org/W2790743957","https://openalex.org/W2797675588","https://openalex.org/W2883463731","https://openalex.org/W2893824814","https://openalex.org/W2920304776","https://openalex.org/W2923986778","https://openalex.org/W2925446385","https://openalex.org/W2930852633","https://openalex.org/W2945823283","https://openalex.org/W2969408442","https://openalex.org/W2969539132","https://openalex.org/W2970742722","https://openalex.org/W2977084368","https://openalex.org/W2991165944","https://openalex.org/W4255483444","https://openalex.org/W6759431858"],"related_works":["https://openalex.org/W7124420421","https://openalex.org/W3105209713","https://openalex.org/W6920876789","https://openalex.org/W2948610106","https://openalex.org/W4286298037","https://openalex.org/W6982349446","https://openalex.org/W2982362823","https://openalex.org/W3004989554","https://openalex.org/W3167422493","https://openalex.org/W2618078827"],"abstract_inverted_index":{"BACKGROUND:":[0],"Non-small":[1],"cell":[2],"lung":[3,11,25],"cancer":[4,12],"(NSCLC)":[5],"accounts":[6],"for":[7,67],"the":[8,32,62,79,89,95,169,200],"majority":[9],"of":[10,46,65,86],"but":[13,184],"with":[14,125],"a":[15,120],"low":[16],"early":[17],"diagnosis":[18],"rate.":[19],"With":[20],"immunotherapy":[21,28,66,114,138,152,161,174,198,205],"becomes":[22],"popular":[23],"in":[24,123,135,149,185,208],"cancer,":[26],"single":[27,113,137,151,173,196,204],"drug":[29,115,139,153,162,175,197],"treatment":[30,116,140,163],"as":[31,98],"first-line":[33,110,136,160,172],"or":[34],"second-line":[35,112,150,209],"plays":[36],"an":[37],"important":[38,59],"role.":[39],"The":[40,105],"meta-analysis":[41],"compares":[42],"different":[43],"clinical":[44],"effects":[45,167],"them":[47],"by":[48,77],"overall":[49],"survival":[50,54],"(OS)":[51],"and":[52,84,93,111,141],"progression-free":[53],"(PFS)":[55],"because":[56],"it":[57,156],"is":[58],"to":[60,118,158],"detect":[61],"best":[63],"time":[64],"NSCLC":[68],"patients.":[69],"METHODS:":[70],"Randomized":[71],"controlled":[72],"trials":[73],"(RCTs)":[74],"were":[75,103],"selected":[76],"using":[78],"Cochrane":[80],"Library,":[81],"Embase,":[82],"PubMed":[83],"Web":[85],"science.":[87],"Pool":[88],"hazard":[90],"ratio":[91],"(HR)":[92],"use":[94],"PFS,":[96,124],"OS":[97],"outcomes.":[99],"RESULTS:":[100],"Ten":[101],"RCTs":[102],"included.":[104],"pooled":[106],"results":[107],"indicated":[108],"that":[109],"seems":[117],"have":[119],"tiny":[121],"difference":[122],"HR":[126,142,177,187],"0.79,":[127],"95%":[128,144,179,189],"confidence":[129],"interval":[130],"(CI):":[131],"0.51-1.21,":[132],"I2":[133,147,182,192],"=89%":[134],"0.74,":[143],"CI:":[145,180,190],"0.62-0.89,":[146],"=84%":[148],"treatment.":[154,210],"When":[155],"comes":[157],"OS,":[159],"still":[164],"has":[165],"better":[166,202],"than":[168,203],"second-line.":[170],"In":[171],"treatment,":[176],"0.78,":[178],"0.55-1.11,":[181],"=83%,":[183],"second-line,":[186],"0.70,":[188],"0.64-0.76,":[191],"=53%.":[193],"CONCLUSIONS:":[194],"First-line":[195],"had":[199],"tendency":[201],"drugs":[206],"used":[207]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2020-12-21T00:00:00"}