{"id":"https://openalex.org/W3112188317","doi":"https://doi.org/10.2147/ijgm.s310844","title":"Hematopoietic Stem-Cell Transplantation versus Immunosuppressive Therapy in Patients with Adult Acquired Severe Aplastic Anemia: A Cost-Effectiveness Analysis","display_name":"Hematopoietic Stem-Cell Transplantation versus Immunosuppressive Therapy in Patients with Adult Acquired Severe Aplastic Anemia: A Cost-Effectiveness Analysis","publication_year":2021,"publication_date":"2021-07-01","ids":{"openalex":"https://openalex.org/W3112188317","doi":"https://doi.org/10.2147/ijgm.s310844","mag":"3112188317","pmid":"https://pubmed.ncbi.nlm.nih.gov/34290524"},"language":"en","primary_location":{"id":"doi:10.2147/ijgm.s310844","doi":"https://doi.org/10.2147/ijgm.s310844","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijgm.s310844","pdf_url":"https://www.dovepress.com/getfile.php?fileID=71732","source":{"id":"https://openalex.org/S123199335","display_name":"International Journal of General Medicine","issn_l":"1178-7074","issn":["1178-7074"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of General Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.dovepress.com/getfile.php?fileID=71732","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060643324","display_name":"Mengxue Zhang","orcid":"https://orcid.org/0000-0002-5682-6544","observed_orcids":["https://orcid.org/0000-0002-5682-6544"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210159575","display_name":"Huashan Hospital","ror":"https://ror.org/05201qm87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159575"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meng-Xue Zhang","raw_affiliation_strings":["Department of Hematology, Huashan Hospital, Fudan University, Shanghai, 200040, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Huashan Hospital, Fudan University, Shanghai, 200040, People's Republic of China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210159575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035590933","display_name":"Qian Wang","orcid":"https://orcid.org/0000-0002-8378-2196","observed_orcids":["https://orcid.org/0000-0002-8378-2196"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210159575","display_name":"Huashan Hospital","ror":"https://ror.org/05201qm87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159575"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qian Wang","raw_affiliation_strings":["Department of Hematology, Huashan Hospital, Fudan University, Shanghai, 200040, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Huashan Hospital, Fudan University, Shanghai, 200040, People's Republic of China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210159575"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100403889","display_name":"Xiaoqin Wang","orcid":"https://orcid.org/0000-0001-9779-5089","observed_orcids":["https://orcid.org/0000-0001-9779-5089"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210159575","display_name":"Huashan Hospital","ror":"https://ror.org/05201qm87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159575"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiao-Qin Wang","raw_affiliation_strings":["Department of Hematology, Huashan Hospital, Fudan University, Shanghai, 200040, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Huashan Hospital, Fudan University, Shanghai, 200040, People's Republic of China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210159575"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100403889"],"corresponding_institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210159575"],"apc_list":{"value":2836,"currency":"USD","value_usd":2836},"apc_paid":{"value":2836,"currency":"USD","value_usd":2836},"fwci":2.083,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.89189893,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"Volume 14","issue":null,"first_page":"3529","last_page":"3537"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10804","display_name":"Health Systems, Economic Evaluations, Quality of Life","score":0.6919000148773193,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10804","display_name":"Health Systems, Economic Evaluations, Quality of Life","score":0.6919000148773193,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.28029999136924744,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13374","display_name":"Hematological disorders and diagnostics","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/severe-aplastic-anemia","display_name":"severe aplastic anemia","score":0.9800000190734863},{"id":"https://openalex.org/keywords/hematopoietic-stem-cell-transplantation","display_name":"hematopoietic stem cell transplantation","score":0.9789999723434448},{"id":"https://openalex.org/keywords/immunosuppressive-therapy","display_name":"immunosuppressive therapy","score":1.0},{"id":"https://openalex.org/keywords/cost-effectiveness","display_name":"cost-effectiveness","score":0.9649999737739563},{"id":"https://openalex.org/keywords/adult-patients","display_name":"adult patients","score":0.6169999837875366},{"id":"https://openalex.org/keywords/quality-adjusted-life-years","display_name":"quality-adjusted life years","score":0.8790000081062317},{"id":"https://openalex.org/keywords/markov-model","display_name":"Markov model","score":0.7540000081062317},{"id":"https://openalex.org/keywords/induction-therapy","display_name":"induction therapy","score":0.4740000069141388}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9416985511779785},{"id":"https://openalex.org/C2777408962","wikidata":"https://www.wikidata.org/wiki/Q1128050","display_name":"Hematopoietic stem cell transplantation","level":3,"score":0.7079294919967651},{"id":"https://openalex.org/C2781440808","wikidata":"https://www.wikidata.org/wiki/Q846316","display_name":"Aplastic anemia","level":3,"score":0.560527503490448},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.4911012649536133},{"id":"https://openalex.org/C64332521","wikidata":"https://www.wikidata.org/wiki/Q614165","display_name":"Quality-adjusted life year","level":3,"score":0.48006686568260193},{"id":"https://openalex.org/C3019080777","wikidata":"https://www.wikidata.org/wiki/Q1754768","display_name":"Cost effectiveness","level":2,"score":0.4790314733982086},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46491652727127075},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.4588310420513153},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.41660264134407043},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.0},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.2147/ijgm.s310844","doi":"https://doi.org/10.2147/ijgm.s310844","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijgm.s310844","pdf_url":"https://www.dovepress.com/getfile.php?fileID=71732","source":{"id":"https://openalex.org/S123199335","display_name":"International Journal of General Medicine","issn_l":"1178-7074","issn":["1178-7074"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of General Medicine","raw_type":"journal-article"},{"id":"pmid:34290524","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34290524","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of general medicine","raw_type":"Journal Article"},{"id":"pmh:oai:dovepress.com/67006","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/hematopoietic-stem-cell-transplantation-versus-immunosuppressive-thera-peer-reviewed-fulltext-article-IJGM","pdf_url":"https://www.dovepress.com/hematopoietic-stem-cell-transplantation-versus-immunosuppressive-thera-peer-reviewed-fulltext-article-IJGM","source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8289465","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8289465","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Int J Gen Med","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.2147/ijgm.s310844","doi":"https://doi.org/10.2147/ijgm.s310844","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijgm.s310844","pdf_url":"https://www.dovepress.com/getfile.php?fileID=71732","source":{"id":"https://openalex.org/S123199335","display_name":"International Journal of General Medicine","issn_l":"1178-7074","issn":["1178-7074"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of General Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321885","display_name":"Science and Technology Commission of Shanghai Municipality","ror":"https://ror.org/03kt66j61"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3112188317.pdf","grobid_xml":"https://content.openalex.org/works/W3112188317.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1764263346","https://openalex.org/W1983523617","https://openalex.org/W1983705969","https://openalex.org/W1997774904","https://openalex.org/W2002499169","https://openalex.org/W2018493712","https://openalex.org/W2027724440","https://openalex.org/W2062443484","https://openalex.org/W2067526714","https://openalex.org/W2089278876","https://openalex.org/W2111099034","https://openalex.org/W2131799119","https://openalex.org/W2170693279","https://openalex.org/W2180801403","https://openalex.org/W2270804113","https://openalex.org/W2318702586","https://openalex.org/W2339432217","https://openalex.org/W2412237844","https://openalex.org/W2418980574","https://openalex.org/W2437532536","https://openalex.org/W2505284615","https://openalex.org/W2577173078","https://openalex.org/W2765147629","https://openalex.org/W2791937447","https://openalex.org/W2802220623","https://openalex.org/W2802531307","https://openalex.org/W2804330928","https://openalex.org/W2886591166","https://openalex.org/W2889683568","https://openalex.org/W2894159083","https://openalex.org/W2896077020","https://openalex.org/W2897454756","https://openalex.org/W3134477994","https://openalex.org/W4251540792","https://openalex.org/W4290227755"],"related_works":["https://openalex.org/W2005049219","https://openalex.org/W2159627298","https://openalex.org/W4293872311","https://openalex.org/W2187740012","https://openalex.org/W2041145027","https://openalex.org/W2043028331","https://openalex.org/W2153547577","https://openalex.org/W3007581650","https://openalex.org/W3173598066","https://openalex.org/W1991263975"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Controversy":[1],"remains":[2],"regarding":[3],"which":[4,112,196],"therapy":[5,29],"to":[6,21,26,106,183],"initially":[7],"select":[8],"for":[9,176,190],"severe":[10],"aplastic":[11],"anemia":[12],"(SAA)":[13],"patients":[14,38,55,89,126,177,191],"aged":[15,90,127,178,192],"35-50.":[16],"This":[17],"cost-effectiveness":[18,43,80],"analysis":[19,44],"aimed":[20],"use":[22],"the":[23,102,116,149,153,158,187],"Markov":[24,47],"model":[25,48,145],"compare":[27],"immunosuppressive":[28],"(IST)":[30],"with":[31,39,51,56,180],"hematopoietic":[32],"stem-cell":[33],"transplantation":[34],"(HSCT)":[35],"in":[36,53,88,125,148],"age-stratified":[37,54],"SAA.":[40,57],"METHODS:":[41],"A":[42],"using":[45],"a":[46,63],"compared":[49],"IST":[50,107,122],"HSCT":[52,85,105,136],"Baseline":[58],"data":[59],"were":[60,162],"derived":[61],"from":[62,69,164],"systematic":[64],"literature":[65],"review":[66],"and":[67,101,137,167,186],"collected":[68],"Huashan":[70],"Hospital,":[71],"Fudan":[72],"University.":[73],"The":[74,84,121,144,172],"primary":[75],"outcome":[76],"was":[77,95,108,113,131,146],"an":[78],"incremental":[79],"ratio":[81],"(ICER).":[82],"RESULTS:":[83],"strategy":[86,123,175,189],"dominated":[87,124],"18-35":[91,179],"even":[92],"though":[93],"it":[94,130],"$146,970":[96],"more":[97,141],"expensive":[98,134],"than":[99,115,135,142],"IST,":[100,195],"ICER":[103],"of":[104,119,152],"$14,054.19/quality-adjusted":[109],"life-year":[110],"(QALY),":[111],"less":[114,133],"willingness-to-pay":[117],"value":[118],"$25,397.57/QALY.":[120],"35-50,":[128],"because":[129],"$72,009":[132],"yielded":[138],"3.24":[139],"QALYs":[140],"HSCT.":[143],"vigorous":[147],"sensitivity":[150],"analyses":[151],"key":[154],"variables":[155],"tested":[156],"through":[157],"plausible":[159],"ranges":[160],"that":[161],"acquired":[163],"costing":[165],"sources":[166],"previously":[168],"published":[169],"literature.":[170],"CONCLUSION:":[171],"preferred":[173,188],"induction":[174],"SAA":[181],"appears":[182],"be":[184],"HSCT,":[185],"35-50":[193],"is":[194],"minimizes":[197],"costs":[198],"while":[199],"maximizing":[200],"QALYs.":[201]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}
