{"id":"https://openalex.org/W3112005437","doi":"https://doi.org/10.1093/neuonc/noaa215.535","title":"NCMP-24. PRE-INFUSION NEUROFILAMENT LIGHT CHAIN (NFL) LEVELS PREDICT THE DEVELOPMENT OF IMMUNE EFFECTOR CELL-ASSOCIATED NEUROTOXICITY SYNDROME (ICANS)","display_name":"NCMP-24. PRE-INFUSION NEUROFILAMENT LIGHT CHAIN (NFL) LEVELS PREDICT THE DEVELOPMENT OF IMMUNE EFFECTOR CELL-ASSOCIATED NEUROTOXICITY SYNDROME (ICANS)","publication_year":2020,"publication_date":"2020-11-01","ids":{"openalex":"https://openalex.org/W3112005437","doi":"https://doi.org/10.1093/neuonc/noaa215.535","mag":"3112005437"},"language":"en","primary_location":{"id":"doi:10.1093/neuonc/noaa215.535","doi":"https://doi.org/10.1093/neuonc/noaa215.535","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noaa215.535","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/22/Supplement_2/ii127/34690456/noaa215.535.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/neuro-oncology/article-pdf/22/Supplement_2/ii127/34690456/noaa215.535.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001703836","display_name":"Omar Hameed Butt","orcid":"https://orcid.org/0000-0003-2252-3673","observed_orcids":["https://orcid.org/0000-0003-2252-3673"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Omar Butt","raw_affiliation_strings":["Washington University in Saint Louis, St. Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University in Saint Louis, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089816080","display_name":"Alice Yao Zhou","orcid":"https://orcid.org/0000-0002-3916-8666","observed_orcids":["https://orcid.org/0000-0002-3916-8666"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alice Zhou","raw_affiliation_strings":["Washington University in Saint Louis, St. Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University in Saint Louis, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077789520","display_name":"Suzanne E. Schindler","orcid":"https://orcid.org/0000-0002-1680-1465","observed_orcids":["https://orcid.org/0000-0002-1680-1465"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suzanne Schindler","raw_affiliation_strings":["Washington University in Saint Louis, St. Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University in Saint Louis, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025837253","display_name":"Anne M. Fagan","orcid":"https://orcid.org/0000-0002-5383-0214","observed_orcids":["https://orcid.org/0000-0002-5383-0214"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anne Fagan","raw_affiliation_strings":["Washington University in Saint Louis, St. Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University in Saint Louis, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065066309","display_name":"John F. DiPersio","orcid":"https://orcid.org/0000-0002-0429-3133","observed_orcids":["https://orcid.org/0000-0002-0429-3133"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Dipersio","raw_affiliation_strings":["Washington University in Saint Louis, St. Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University in Saint Louis, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085514831","display_name":"Armin Ghobadi","orcid":"https://orcid.org/0000-0001-8848-8474","observed_orcids":["https://orcid.org/0000-0001-8848-8474"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Armin Ghobadi","raw_affiliation_strings":["Washington University in Saint Louis, St. Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University in Saint Louis, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076073942","display_name":"Beau M. Ances","orcid":"https://orcid.org/0000-0003-3862-7397","observed_orcids":["https://orcid.org/0000-0003-3862-7397"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Beau Ances","raw_affiliation_strings":["Washington University in Saint Louis, St. Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University in Saint Louis, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I204465549"],"apc_list":{"value":5132,"currency":"USD","value_usd":5132},"apc_paid":null,"fwci":0.0883,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.43716629,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"22","issue":"Supplement_2","first_page":"ii127","last_page":"ii128"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9442999958992004,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9442999958992004,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11627","display_name":"Autoimmune Neurological Disorders and Treatments","score":0.009200000204145908,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.008100000210106373,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immune-effector-cell-associated-neurotoxicity-syndrome","display_name":"immune effector cell-associated neurotoxicity syndrome","score":0.9750000238418579},{"id":"https://openalex.org/keywords/neurofilament-light-chain","display_name":"neurofilament light chain","score":0.9369999766349792},{"id":"https://openalex.org/keywords/car-t-cell-therapy","display_name":"CAR T-cell therapy","score":0.9459999799728394},{"id":"https://openalex.org/keywords/tisagenlecleucel","display_name":"tisagenlecleucel","score":0.9110000133514404},{"id":"https://openalex.org/keywords/axicabtagene-ciloleucel","display_name":"axicabtagene ciloleucel","score":1.0},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.7770000100135803},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.6480000019073486},{"id":"https://openalex.org/keywords/neurological-adverse-events","display_name":"neurological adverse events","score":0.5170000195503235},{"id":"https://openalex.org/keywords/host-factors","display_name":"host factors","score":0.41100001335144043}],"concepts":[{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.7139984369277954},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5688836574554443},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5448349714279175},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.4941413700580597},{"id":"https://openalex.org/C2778621155","wikidata":"https://www.wikidata.org/wiki/Q576349","display_name":"Encephalopathy","level":2,"score":0.4843907952308655},{"id":"https://openalex.org/C76318530","wikidata":"https://www.wikidata.org/wiki/Q16833590","display_name":"Area under the curve","level":2,"score":0.43383318185806274},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.32685744762420654}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1093/neuonc/noaa215.535","doi":"https://doi.org/10.1093/neuonc/noaa215.535","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noaa215.535","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/22/Supplement_2/ii127/34690456/noaa215.535.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:7461204","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC7651371","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:7651371","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7651371","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro Oncol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/neuonc/noaa215.535","doi":"https://doi.org/10.1093/neuonc/noaa215.535","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noaa215.535","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/22/Supplement_2/ii127/34690456/noaa215.535.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3112005437.pdf","grobid_xml":"https://content.openalex.org/works/W3112005437.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4402802425","https://openalex.org/W3215392495","https://openalex.org/W4205496583","https://openalex.org/W3212146590","https://openalex.org/W4409227473","https://openalex.org/W4413002578","https://openalex.org/W4294001823","https://openalex.org/W4391615027","https://openalex.org/W4293105087","https://openalex.org/W7124682169"],"abstract_inverted_index":{"Abstract":[0],"Neurological":[1],"side":[2],"effects":[3],"after":[4],"chimeric":[5],"antigen":[6],"receptor-modified":[7],"(CAR)":[8],"T":[9,72],"cell":[10,73],"therapy":[11,74],"are":[12,253],"common":[13],"and":[14,82,137,159,175,181,232],"potentially":[15],"devastating.":[16],"Termed":[17],"immune":[18],"effector":[19],"cell-associated":[20],"neurotoxicity":[21],"syndrome":[22],"(ICANS),":[23],"symptoms":[24],"range":[25],"from":[26,96],"mild":[27],"encephalopathy":[28],"to":[29,37,58],"diffuse":[30],"cerebral":[31],"edema.":[32],"No":[33,225],"predictive":[34],"biomarkers":[35],"exist":[36],"identify":[38],"individuals":[39,69,98,119,153],"at":[40,124,166],"risk":[41,267],"for":[42,258],"developing":[43,269],"ICANS.":[44,262],"Serum":[45,140],"neurofilament":[46],"light":[47],"chain":[48],"(NfL)":[49],"is":[50],"a":[51,90,121,145,220,254],"well-established":[52],"marker":[53,257],"of":[54,93,207,217,222,237,242,261,268,280],"neural":[55],"injury":[56],"known":[57],"dynamically":[59],"change":[60],"in":[61,85,162,278],"neuro-inflammatory":[62],"disorders":[63],"(e.g.":[64],"multiple":[65,191],"sclerosis).":[66],"We":[67,88,150],"hypothesized":[68],"undergoing":[70],"CAR":[71],"who":[75,154],"ultimately":[76],"developed":[77,155],"ICANS":[78,156,270],"would":[79],"have":[80],"early":[81,158,256],"sustained":[83,160],"elevations":[84,161],"serum":[86,94,163,208,250],"NfL.":[87],"performed":[89],"retrospective":[91],"analysis":[92],"samples":[95],"11":[97],"treated":[99],"with":[100,113,219],"tisagenlecleucel":[101],"or":[102,235],"axicabtagene":[103],"ciloleucel":[104],"(mean":[105],"age":[106],"61.3,":[107],"18%":[108],"female,":[109],"27%":[110],"ICANS,":[111],"all":[112],"peak":[114],"severity":[115],"score":[116],"3).":[117],"Most":[118],"had":[120,157],"longitudinal":[122],"sampling":[123],"baseline,":[125],"pre-infusion,":[126],"post-transfusion":[127],"day":[128],"(PTD)":[129],"1,":[130],"PTD":[131,133,135,138,176,182],"3,":[132],"7,":[134],"14,":[136],"30.":[139],"NfL":[141,164,209,230,251],"were":[142],"assayed":[143],"using":[144,194],"Simoa":[146],"HD-1/HD-X":[147],"kit":[148],"(QuanterixTM).":[149],"found":[151,249],"that":[152],"levels":[165,231,252],"baseline":[167],"(p":[168,172,178,184],"=":[169,173,179,185],"0.0075),":[170],"pre-infusion":[171],"0.0172),":[174],"3":[177],"0.0026)":[180],"30":[183],"0.0066).":[186],"All":[187],"group":[188],"comparisons":[189],"survived":[190],"comparison":[192],"testing":[193],"false-discovery":[195],"rate":[196],"(FDR).":[197],"Receiver":[198],"operating":[199],"characteristic":[200],"(ROC)":[201],"curve":[202,215],"classification":[203],"by":[204],"logistic":[205],"regression":[206],"revealed":[210],"an":[211],"area":[212],"under":[213],"the":[214,243,259,266,275],"(AUC)":[216],"1.0":[218],"cut-off":[221],"44":[223],"pg/mL.":[224],"correlation":[226],"was":[227],"observed":[228],"between":[229],"age,":[233],"sex,":[234],"history":[236],"central":[238],"nervous":[239],"system":[240],"involvement":[241],"underlying":[244],"malignancy.":[245],"In":[246],"summary,":[247],"we":[248],"robust,":[255],"development":[260],"Our":[263],"findings":[264],"suggest":[265],"reflects":[271],"pre-transfusion":[272],"host-factors,":[273],"permitting":[274],"screening":[276],"well":[277],"advance":[279],"drug":[281],"administration.":[282]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-12-21T00:00:00"}
