{"id":"https://openalex.org/W3111343568","doi":"https://doi.org/10.1002/alz.045981","title":"Deep phenotyping of the 5XFAD model: IU/JAX/PITT MODEL\u2010AD center","display_name":"Deep phenotyping of the 5XFAD model: IU/JAX/PITT MODEL\u2010AD center","publication_year":2020,"publication_date":"2020-12-01","ids":{"openalex":"https://openalex.org/W3111343568","doi":"https://doi.org/10.1002/alz.045981","mag":"3111343568"},"language":"en","primary_location":{"id":"doi:10.1002/alz.045981","doi":"https://doi.org/10.1002/alz.045981","is_oa":true,"landing_page_url":"https://doi.org/10.1002/alz.045981","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.045981","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.045981","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045057254","display_name":"Adrian L. Oblak","orcid":"https://orcid.org/0000-0003-1210-8791","observed_orcids":["https://orcid.org/0000-0003-1210-8791"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Adrian L. Oblak","raw_affiliation_strings":["Indiana University School of Medicine, Indianapolis, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028687972","display_name":"Gregory W. Carter","orcid":"https://orcid.org/0000-0002-2834-8186","observed_orcids":["https://orcid.org/0000-0002-2834-8186"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory W. Carter","raw_affiliation_strings":["The Jackson Laboratory, Bar Harbor, ME, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, ME, USA","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018525513","display_name":"Gareth R. Howell","orcid":"https://orcid.org/0000-0003-0565-6474","observed_orcids":["https://orcid.org/0000-0003-0565-6474"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gareth Howell","raw_affiliation_strings":["The Jackson Laboratory, Bar Harbor, ME, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, ME, USA","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054219325","display_name":"Stacey J. Sukoff Rizzo","orcid":"https://orcid.org/0000-0002-1460-8127","observed_orcids":["https://orcid.org/0000-0002-1460-8127"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stacey J. Sukoff Rizzo","raw_affiliation_strings":["University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063586680","display_name":"Michael Sasner","orcid":"https://orcid.org/0000-0002-6612-6111","observed_orcids":["https://orcid.org/0000-0002-6612-6111"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Sasner","raw_affiliation_strings":["The Jackson Laboratory, Bar Harbor, ME, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, ME, USA","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071706141","display_name":"Paul R. Territo","orcid":"https://orcid.org/0000-0003-0460-332X","observed_orcids":["https://orcid.org/0000-0003-0460-332X"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul R. Territo","raw_affiliation_strings":["Indiana University School of Medicine, Indianapolis, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013468402","display_name":"Carl T. Ash","orcid":"https://orcid.org/0000-0002-0767-9605","observed_orcids":["https://orcid.org/0000-0002-0767-9605"]},"institutions":[{"id":"https://openalex.org/I12113309","display_name":"DePauw University","ror":"https://ror.org/02mks6v46","country_code":"US","type":"education","lineage":["https://openalex.org/I12113309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carl T. Ash","raw_affiliation_strings":["DePauw University, Greencastle, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DePauw University, Greencastle, IN, USA","institution_ids":["https://openalex.org/I12113309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042167588","display_name":"Cynthia M. Ingraham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cynthia Ingraham","raw_affiliation_strings":["Indiana University, Stark Neurosciences Research Institute, Indianapolis, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University, Stark Neurosciences Research Institute, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I592451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008245134","display_name":"Kevin P. Kotredes","orcid":"https://orcid.org/0000-0001-7874-4139","observed_orcids":["https://orcid.org/0000-0001-7874-4139"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin P. Kotredes","raw_affiliation_strings":["The Jackson Laboratory, Bar Harbor, ME, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, ME, USA","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045599761","display_name":"Adam Bleckert","orcid":"https://orcid.org/0000-0002-8141-2474","observed_orcids":["https://orcid.org/0000-0002-8141-2474"]},"institutions":[{"id":"https://openalex.org/I4210103654","display_name":"TissueVision (United States)","ror":"https://ror.org/01anxpp02","country_code":"US","type":"company","lineage":["https://openalex.org/I4210103654"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam Bleckert","raw_affiliation_strings":["TissueVision, Somerville, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TissueVision, Somerville, MA, USA","institution_ids":["https://openalex.org/I4210103654"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024871170","display_name":"Marissa Masek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103654","display_name":"TissueVision (United States)","ror":"https://ror.org/01anxpp02","country_code":"US","type":"company","lineage":["https://openalex.org/I4210103654"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marissa Masek","raw_affiliation_strings":["TissueVision, Somerville, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TissueVision, Somerville, MA, USA","institution_ids":["https://openalex.org/I4210103654"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101151915","display_name":"Neil Patel","orcid":"https://orcid.org/0000-0002-3602-1415","observed_orcids":["https://orcid.org/0000-0002-3602-1415"]},"institutions":[{"id":"https://openalex.org/I4210103654","display_name":"TissueVision (United States)","ror":"https://ror.org/01anxpp02","country_code":"US","type":"company","lineage":["https://openalex.org/I4210103654"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neil Patel","raw_affiliation_strings":["TissueVision, Somerville, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TissueVision, Somerville, MA, USA","institution_ids":["https://openalex.org/I4210103654"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007275439","display_name":"Ritesh Chidambaram","orcid":"https://orcid.org/0009-0001-1797-1191","observed_orcids":["https://orcid.org/0009-0001-1797-1191"]},"institutions":[{"id":"https://openalex.org/I4210103654","display_name":"TissueVision (United States)","ror":"https://ror.org/01anxpp02","country_code":"US","type":"company","lineage":["https://openalex.org/I4210103654"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ritesh Chidambaram","raw_affiliation_strings":["TissueVision, Somerville, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TissueVision, Somerville, MA, USA","institution_ids":["https://openalex.org/I4210103654"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108793425","display_name":"Tim Ragan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103654","display_name":"TissueVision (United States)","ror":"https://ror.org/01anxpp02","country_code":"US","type":"company","lineage":["https://openalex.org/I4210103654"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tim Ragan","raw_affiliation_strings":["TissueVision, Somerville, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TissueVision, Somerville, MA, USA","institution_ids":["https://openalex.org/I4210103654"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032343032","display_name":"Bruce T. Lamb","orcid":"https://orcid.org/0000-0001-8507-2561","observed_orcids":["https://orcid.org/0000-0001-8507-2561"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruce T. Lamb","raw_affiliation_strings":["Indiana University, Stark Neurosciences Research Institute, Indianapolis, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University, Stark Neurosciences Research Institute, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I592451"]}]},{"author_position":"last","author":{"id":null,"display_name":"MODEL\u2010AD","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"MODEL\u2010AD","raw_affiliation_strings":["Indiana University School of Medicine , Indianapolis , IN , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine , Indianapolis , IN , USA","institution_ids":["https://openalex.org/I4394709130"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5045057254"],"corresponding_institution_ids":["https://openalex.org/I4394709130"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.13421914,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"S2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8489999771118164},{"id":"https://openalex.org/keywords/5xfad-mice","display_name":"5xFAD mice","score":0.9520000219345093}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6961163282394409},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6008376479148865},{"id":"https://openalex.org/C29331040","wikidata":"https://www.wikidata.org/wiki/Q7239554","display_name":"Preclinical imaging","level":3,"score":0.521778404712677},{"id":"https://openalex.org/C57742111","wikidata":"https://www.wikidata.org/wiki/Q7168","display_name":"Histology","level":2,"score":0.5181492567062378},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.47076892852783203},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.44498351216316223},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4411343038082123},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4399193525314331},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.35661381483078003},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35532015562057495},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17026671767234802},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/alz.045981","doi":"https://doi.org/10.1002/alz.045981","is_oa":true,"landing_page_url":"https://doi.org/10.1002/alz.045981","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.045981","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1002/alz.045981","doi":"https://doi.org/10.1002/alz.045981","is_oa":true,"landing_page_url":"https://doi.org/10.1002/alz.045981","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.045981","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3111343568.pdf","grobid_xml":"https://content.openalex.org/works/W3111343568.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2895829196","https://openalex.org/W3184377705","https://openalex.org/W3113218562","https://openalex.org/W3207056385","https://openalex.org/W3112577575","https://openalex.org/W4211205244","https://openalex.org/W4312086440","https://openalex.org/W3112318758","https://openalex.org/W1492700209","https://openalex.org/W4312088307"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Alzheimer\u2019s":[2],"disease":[3,252],"(AD)":[4],"is":[5,52],"the":[6,73,118,151,155,177,214,222,230,257,290,299],"most":[7],"common":[8],"form":[9],"of":[10,18,60,76,150,209,221,262,272,276,292,298,305,318],"dementia":[11],"without":[12],"an":[13,266],"effective":[14],"treatment.":[15],"Animal":[16],"models":[17,59,86,275,321],"AD":[19,49,62,173,263,293,306],"have":[20,34,81],"been":[21,36],"valuable":[22],"tools":[23],"to":[24,32,68,84,117,264,288],"understand":[25],"familial":[26],"or":[27],"early":[28,77],"onset":[29,78],"AD,":[30,79],"but":[31],"date":[33],"not":[35],"predictive":[37],"for":[38,47,269,315,326],"translational":[39],"research.":[40],"The":[41],"Model":[42],"Organism":[43],"Development":[44],"and":[45,55,98,101,126,130,145,154,180,184,206,244,283,295,302,322],"Evaluation":[46],"Late\u2010onset":[48],"(MODEL\u2010AD)":[50],"Center":[51],"developing,":[53],"validating,":[54],"distributing":[56],"novel":[57,70,273,281,313],"mouse":[58,231,274,320],"late\u2010onset":[61],"(LOAD)":[63],"that":[64],"can":[65],"be":[66],"used":[67],"develop":[69,265],"therapeutics.":[71],"Using":[72],"5XFAD":[74,223,260],"model":[75,224,261],"we":[80,163,171,201],"established":[82],"pipelines":[83],"characterize":[85],"across":[87,286],"multiple":[88],"sites":[89,287],"using":[90,176,213],"biochemistry,":[91,238],"histology,":[92,237],"functional":[93,282,303],"assays,":[94],"in":[95,127,229,241],"vivo":[96,128,242],"MRI":[97,129],"PET":[99,131],"imaging,":[100,243],"Serial":[102],"Two\u2010Photon":[103],"(STP)":[104],"tomography":[105],"whole":[106,203,246],"brain":[107,152,204,247],"imaging.":[108],"Methods":[109],"At":[110],"designated":[111],"time":[112],"points,":[113],"animals":[114],"were":[115,142],"subjected":[116],"following":[119,178],"assays:":[120],"Functional":[121],"\u2010":[122,140,195],"behavioral":[123],"testing":[124],"paradigms,":[125],"scanning":[132],"followed":[133],"by":[134],"secondary":[135],"validation":[136],"with":[137,148],"autoradiography.":[138],"Biochemistry/Histology":[139],"mice":[141],"sacrificed,":[143],"perfused,":[144],"tissue":[146,161,169,199],"harvested,":[147],"half":[149,157],"frozen":[153,160],"other":[156],"fixed.":[158],"On":[159,167],"samples":[162,200],"performed":[164,202],"bulk":[165],"RNA\u2010seq.":[166],"fixed":[168,198],"samples,":[170],"assessed":[172],"relevant":[174],"changes":[175,228],"stains":[179],"antibodies:":[181],"X34":[182],"(plaques":[183],"NFTs),":[185],"Lamp1":[186],"(dystrophic":[187],"neurites),":[188],"Iba1":[189],"(microglia).":[190],"STP":[191,245],"Whole":[192],"Brain":[193],"Imaging":[194],"on":[196],"additional":[197],"imaging":[205,216],"regional":[207],"analysis":[208,248],"Methoxy\u2010X04":[210],"labeled":[211],"plaques":[212],"TissueCyte\u00ae":[215],"platform.":[217],"Results":[218],"Combined":[219],"assessment":[220],"revealed":[225],"systematic":[226],"neurodegenerative":[227],"brain.":[232],"Multiple":[233],"data":[234],"sets":[235],"including":[236],"RNA\u2010seq,":[239],"transcriptomics,":[240],"show":[249],"differences":[250],"throughout":[251],"progression.":[253],"Conclusions":[254],"We":[255],"utilized":[256],"well":[258],"characterized":[259],"integrated":[267],"pipeline":[268,279,310],"deep":[270],"phenotyping":[271],"AD.":[277,327],"This":[278],"combines":[280],"anatomical":[284],"assays":[285],"track":[289],"ontology":[291],"progression,":[294],"targeted":[296],"understanding":[297,317],"molecular,":[300],"biochemical":[301],"progression":[304],"pathology.":[307],"Together,":[308],"this":[309],"provides":[311],"a":[312],"platform":[314],"greater":[316],"LOAD":[319],"potential":[323],"therapeutic":[324],"approaches":[325]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-12-21T00:00:00"}