{"id":"https://openalex.org/W3111298036","doi":"https://doi.org/10.1093/neuonc/noaa215.949","title":"TAMI-62. ANGIOGENESIS INHIBITORS STRONGLY SYNERGIZE WITH THERAPEUTICS TARGETING TUMOR METABOLISM","display_name":"TAMI-62. ANGIOGENESIS INHIBITORS STRONGLY SYNERGIZE WITH THERAPEUTICS TARGETING TUMOR METABOLISM","publication_year":2020,"publication_date":"2020-11-01","ids":{"openalex":"https://openalex.org/W3111298036","doi":"https://doi.org/10.1093/neuonc/noaa215.949","mag":"3111298036"},"language":"en","primary_location":{"id":"doi:10.1093/neuonc/noaa215.949","doi":"https://doi.org/10.1093/neuonc/noaa215.949","is_oa":false,"landing_page_url":"https://doi.org/10.1093/neuonc/noaa215.949","pdf_url":null,"source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC7651226","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022569521","display_name":"Sunada Khadka","orcid":"https://orcid.org/0000-0002-9844-2530","observed_orcids":["https://orcid.org/0000-0002-9844-2530"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sunada Khadka","raw_affiliation_strings":["University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070096893","display_name":"Yu-Hsi Lin","orcid":"https://orcid.org/0000-0001-5763-1530","observed_orcids":["https://orcid.org/0000-0001-5763-1530"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yu-Hsi Lin","raw_affiliation_strings":["University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073577478","display_name":"Jeffrey J. Ackroyd","orcid":"https://orcid.org/0000-0003-3796-4447","observed_orcids":["https://orcid.org/0000-0003-3796-4447"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey Ackroyd","raw_affiliation_strings":["University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024047574","display_name":"Kenisha Arthur","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenisha Arthur","raw_affiliation_strings":["University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048089308","display_name":"Yasaman Barekatain","orcid":"https://orcid.org/0000-0002-4454-1496","observed_orcids":["https://orcid.org/0000-0002-4454-1496"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yasaman Barekatain","raw_affiliation_strings":["University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038641343","display_name":"Anton H. Poral","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anton Poral","raw_affiliation_strings":["University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112841342","display_name":"Theresa Tammy Tran","orcid":"https://orcid.org/0000-0001-7798-5838","observed_orcids":["https://orcid.org/0000-0001-7798-5838"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Theresa Tran","raw_affiliation_strings":["University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055700997","display_name":"Dimitra K. Georgiou","orcid":"https://orcid.org/0000-0001-8786-2495","observed_orcids":["https://orcid.org/0000-0001-8786-2495"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dimitra Georgiou","raw_affiliation_strings":["University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055183757","display_name":"John de Groot","orcid":"https://orcid.org/0000-0003-1454-6461","observed_orcids":["https://orcid.org/0000-0003-1454-6461"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John de Groot","raw_affiliation_strings":["University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024476694","display_name":"Jason T. Huse","orcid":"https://orcid.org/0000-0003-4514-0640","observed_orcids":["https://orcid.org/0000-0003-4514-0640","https://orcid.org/0000-0003-4933-9120"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason Huse","raw_affiliation_strings":["Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041241925","display_name":"John M. Asara","orcid":"https://orcid.org/0000-0001-7450-2589","observed_orcids":["https://orcid.org/0000-0001-7450-2589"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Asara","raw_affiliation_strings":["Beth Israel Deaconess Medical Center, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beth Israel Deaconess Medical Center, Boston, MA, USA","institution_ids":["https://openalex.org/I1316535847"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091138132","display_name":"Florian L. M\u00fcller","orcid":"https://orcid.org/0000-0001-7568-2948","observed_orcids":["https://orcid.org/0000-0001-7568-2948"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Florian Muller","raw_affiliation_strings":["University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5132,"currency":"USD","value_usd":5132},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"Supplement_2","first_page":"ii227","last_page":"ii227"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.6083999872207642,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.6083999872207642,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.3840000033378601,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angiogenesis-inhibitors","display_name":"angiogenesis inhibitors","score":0.968999981880188},{"id":"https://openalex.org/keywords/tumor-metabolism","display_name":"cancer metabolism","score":0.9399999976158142},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.671999990940094},{"id":"https://openalex.org/keywords/drug-synergy","display_name":"drug synergy","score":0.5149999856948853},{"id":"https://openalex.org/keywords/nutrient-stress","display_name":"nutritional stress","score":0.6859999895095825},{"id":"https://openalex.org/keywords/oxidative-phosphorylation-inhibition","display_name":"oxidative phosphorylation inhibition","score":0.7990000247955322},{"id":"https://openalex.org/keywords/iacs-010759","display_name":"IACS-010759","score":0.9900000095367432},{"id":"https://openalex.org/keywords/tivozanib","display_name":"tivozanib","score":0.8550000190734863},{"id":"https://openalex.org/keywords/bevacizumab","display_name":"bevacizumab","score":0.6990000009536743},{"id":"https://openalex.org/keywords/hex","display_name":"Hex","score":0.6110000014305115},{"id":"https://openalex.org/keywords/methionine-restriction","display_name":"methionine restriction","score":0.8989999890327454},{"id":"https://openalex.org/keywords/ampk-inhibitors","display_name":"AMPK inhibitors","score":0.8109999895095825},{"id":"https://openalex.org/keywords/vegf-a","display_name":"VEGF-A","score":0.5130000114440918},{"id":"https://openalex.org/keywords/cancer-metabolomics","display_name":"cancer metabolomics","score":0.5379999876022339}],"concepts":[{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.9084118604660034},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6323240995407104},{"id":"https://openalex.org/C2776056115","wikidata":"https://www.wikidata.org/wiki/Q574834","display_name":"Angiogenesis inhibitor","level":3,"score":0.6287444829940796},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.48579978942871094},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.42429226636886597},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3779486417770386},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30717331171035767},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2836236357688904}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1093/neuonc/noaa215.949","doi":"https://doi.org/10.1093/neuonc/noaa215.949","is_oa":false,"landing_page_url":"https://doi.org/10.1093/neuonc/noaa215.949","pdf_url":null,"source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:7461071","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC7651226","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:7651226","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7651226","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro Oncol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:7461071","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC7651226","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":0.979200005531311,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3180724244","https://openalex.org/W4282969770","https://openalex.org/W4376113923","https://openalex.org/W2067651585","https://openalex.org/W4247193766","https://openalex.org/W2347416769","https://openalex.org/W1994912456","https://openalex.org/W1986022136","https://openalex.org/W2025539366","https://openalex.org/W1967028437"],"abstract_inverted_index":{"Abstract":[0],"Angiogenesis":[1,258],"inhibition":[2,21,78,87,98],"has":[3],"become":[4],"a":[5,102,241],"mainstay":[6],"of":[7,13,31,55,76,85,104,109,123,165,172,186,191,244,270,274],"oncology":[8],"despite":[9],"having":[10],"fallen":[11],"short":[12],"its":[14],"early":[15],"promise.":[16],"As":[17],"originally":[18],"envisioned,":[19],"angiogenesis":[20,47,77,86,97,206,287],"would":[22],"cut":[23],"off":[24],"the":[25,73,83,107,200,205,217,222,229,268,271],"blood":[26],"supply,":[27],"deprive":[28],"tumor":[29,90,148,193,245],"cells":[30],"key":[32],"nutrients,":[33],"leading":[34],"to":[35,64,138],"their":[36],"demise.":[37],"In":[38],"practice,":[39],"while":[40],"there":[41],"is":[42,59,61],"evidence":[43],"that":[44,72,257],"tumors":[45,95],"under":[46,96],"treatment":[48],"do":[49],"in":[50,101,141,175,240],"fact":[51],"exhibit":[52],"some":[53],"degree":[54],"metabolic":[56],"stress,":[57,106],"this":[58,158],"stress":[60,124,174],"not":[62],"sufficient":[63],"induce":[65],"significant":[66],"cancer":[67,263,296],"cell":[68],"death.":[69],"We":[70],"posit":[71],"full":[74,272],"potential":[75,273],"can":[79],"be":[80,226],"realized":[81],"by":[82],"combination":[84,283],"with":[88,216,228,233,262],"emerging":[89,294],"metabolism":[91,132],"targeting":[92,265],"therapies.":[93,297],"Because":[94],"are":[99],"already":[100],"state":[103,171],"nutrient":[105,173],"effects":[108],"metabolically":[110],"targeted":[111],"therapies":[112,264],"such":[113],"as":[114,170,291,293],"amino":[115],"acid":[116],"depletion":[117],"(e.g.":[118,133],"asparginase,":[119],"methionine":[120],"restriction),":[121],"inhibitors":[122,259,288],"adaption":[125],"(AMPK":[126],"and":[127,204,221,289],"GCN2":[128],"inhibitors)":[129],"or":[130],"energy":[131],"IACS-010759,":[134],"Metformin,":[135],"POMHEX)":[136],"stand":[137],"dramatically":[139],"increase":[140],"potency":[142],"whilst":[143],"remaining":[144],"selective":[145],"for":[146,157],"(angiogenic)":[147],"versus":[149],"(non-angiogenic)":[150],"normal":[151],"tissue.":[152],"Here,":[153],"we":[154,161,179],"provide":[155],"proof-of-principal":[156],"thesis.":[159],"First,":[160],"performed":[162],"metabolomic":[163],"profiling":[164],"angiogenesis-inhibited":[166,176],"tumors,":[167],"which":[168],"corroborates":[169],"tumors.":[177],"Second,":[178],"demonstrate":[180],"dramatic":[181],"anti-neoplastic":[182],"synergy":[183,237],"(effectively":[184],"curing":[185],"xenografted":[187],"tumor-bearing":[188],"mice,":[189],"irrespective":[190],"initial":[192],"size),":[194],"without":[195,249],"enhanced":[196],"adverse":[197],"toxicities,":[198],"between":[199,286],"OxPhos":[201,223],"inhibitor":[202,224,231],"IACS-010759":[203],"tyrosine":[207],"kinase":[208],"inhibitor,":[209],"Tivozanib.":[210],"The":[211,236],"same":[212],"results":[213,255,280],"were":[214],"recapitulated":[215],"anti-VEGFA":[218],"antibody,":[219],"Avastin,":[220],"could":[225],"substituted":[227],"Enolase":[230],"HEX,":[232],"similar":[234],"effects.":[235],"was":[238],"observed":[239],"broad":[242],"range":[243],"types,":[246],"even":[247],"those":[248],"clear":[250],"genetic":[251],"susceptibilities.":[252],"Together,":[253],"these":[254,275],"suggest":[256],"synergize":[260],"broadly":[261],"metabolism,":[266],"allowing":[267],"realization":[269],"previously":[276],"disappointing":[277],"drugs.":[278],"Our":[279],"warrant":[281],"systematic":[282],"clinical":[284],"trials":[285],"established,":[290],"well":[292],"anti-metabolic":[295]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2020-12-21T00:00:00"}
