{"id":"https://openalex.org/W3111081995","doi":"https://doi.org/10.1007/978-3-030-56905-1_12","title":"Targeting Suppressor T Cells","display_name":"Targeting Suppressor T Cells","publication_year":2020,"publication_date":"2020-12-03","ids":{"openalex":"https://openalex.org/W3111081995","doi":"https://doi.org/10.1007/978-3-030-56905-1_12","mag":"3111081995"},"language":"en","primary_location":{"id":"doi:10.1007/978-3-030-56905-1_12","doi":"https://doi.org/10.1007/978-3-030-56905-1_12","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-030-56905-1_12","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Host-Directed Therapies Against Tuberculosis","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4236764546","display_name":"Advances in Host-Directed Therapies Against Tuberculosis"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075472009","display_name":"L\u00e9anie Kleynhans","orcid":"https://orcid.org/0000-0003-1635-253X","observed_orcids":["https://orcid.org/0000-0003-1635-253X"]},"institutions":[{"id":"https://openalex.org/I10947320","display_name":"South African Medical Research Council","ror":"https://ror.org/05q60vz69","country_code":"ZA","type":"other","lineage":["https://openalex.org/I10947320"]},{"id":"https://openalex.org/I26092322","display_name":"Stellenbosch University","ror":"https://ror.org/05bk57929","country_code":"ZA","type":"education","lineage":["https://openalex.org/I26092322"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"L\u00e9anie Kleynhans","raw_affiliation_strings":["DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, Cape Town, South Africa","Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa","South African Medical Research Council Centre for Tuberculosis Research, Cape Town, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, Cape Town, South Africa","institution_ids":[]},{"raw_affiliation_string":"Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa","institution_ids":["https://openalex.org/I26092322"]},{"raw_affiliation_string":"South African Medical Research Council Centre for Tuberculosis Research, Cape Town, South Africa","institution_ids":["https://openalex.org/I10947320"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022897595","display_name":"Gerhard Walzl","orcid":"https://orcid.org/0000-0003-2487-125X","observed_orcids":["https://orcid.org/0000-0003-2487-125X"]},"institutions":[{"id":"https://openalex.org/I10947320","display_name":"South African Medical Research Council","ror":"https://ror.org/05q60vz69","country_code":"ZA","type":"other","lineage":["https://openalex.org/I10947320"]},{"id":"https://openalex.org/I26092322","display_name":"Stellenbosch University","ror":"https://ror.org/05bk57929","country_code":"ZA","type":"education","lineage":["https://openalex.org/I26092322"]}],"countries":["ZA"],"is_corresponding":true,"raw_author_name":"Gerhard Walzl","raw_affiliation_strings":["DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, Cape Town, South Africa","Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa","South African Medical Research Council Centre for Tuberculosis Research, Cape Town, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, Cape Town, South Africa","institution_ids":[]},{"raw_affiliation_string":"Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa","institution_ids":["https://openalex.org/I26092322"]},{"raw_affiliation_string":"South African Medical Research Council Centre for Tuberculosis Research, Cape Town, South Africa","institution_ids":["https://openalex.org/I10947320"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5022897595"],"corresponding_institution_ids":["https://openalex.org/I10947320","https://openalex.org/I26092322"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.34395366,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"205","last_page":"210"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9940000176429749},{"id":"https://openalex.org/keywords/foxp3","display_name":"Foxp3","score":0.9819999933242798},{"id":"https://openalex.org/keywords/cd4-cd25-regulatory-t-cells","display_name":"CD4+CD25+ T cells","score":0.8769999742507935},{"id":"https://openalex.org/keywords/tr1-cells","display_name":"Tr1 cells","score":0.8140000104904175},{"id":"https://openalex.org/keywords/th3-cells","display_name":"Th3 cells","score":0.9819999933242798},{"id":"https://openalex.org/keywords/nkt-cells","display_name":"NKT cells","score":0.859000027179718},{"id":"https://openalex.org/keywords/gamma-delta-t-cells","display_name":"\u03b3\u03b4 T cells","score":0.8619999885559082},{"id":"https://openalex.org/keywords/t-cell-suppression","display_name":"T cell suppression","score":0.671999990940094},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.9139999747276306},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.8539999723434448}],"concepts":[{"id":"https://openalex.org/C2779727006","wikidata":"https://www.wikidata.org/wiki/Q426188","display_name":"FOXP3","level":3,"score":0.7416508197784424},{"id":"https://openalex.org/C79484868","wikidata":"https://www.wikidata.org/wiki/Q5971673","display_name":"IL-2 receptor","level":4,"score":0.7232953310012817},{"id":"https://openalex.org/C139563560","wikidata":"https://www.wikidata.org/wiki/Q224930","display_name":"Natural killer T cell","level":4,"score":0.6543120741844177},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5817976593971252},{"id":"https://openalex.org/C129374314","wikidata":"https://www.wikidata.org/wiki/Q909381","display_name":"Interleukin 21","level":4,"score":0.535923957824707},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.510349690914154},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.4921940863132477},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46052154898643494},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4454944431781769},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.4346469044685364},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.36074721813201904},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.30287373065948486},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2099190056324005},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.11183494329452515},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06813135743141174},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06579691171646118}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-3-030-56905-1_12","doi":"https://doi.org/10.1007/978-3-030-56905-1_12","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-030-56905-1_12","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Host-Directed Therapies Against Tuberculosis","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1483831487","https://openalex.org/W1952515964","https://openalex.org/W1964607061","https://openalex.org/W1966922635","https://openalex.org/W1968436458","https://openalex.org/W1991344211","https://openalex.org/W1998007093","https://openalex.org/W1999227421","https://openalex.org/W2014915517","https://openalex.org/W2021037655","https://openalex.org/W2026426963","https://openalex.org/W2034393533","https://openalex.org/W2037467064","https://openalex.org/W2040549498","https://openalex.org/W2042227130","https://openalex.org/W2045994875","https://openalex.org/W2048140313","https://openalex.org/W2049371736","https://openalex.org/W2050340355","https://openalex.org/W2063679726","https://openalex.org/W2093070846","https://openalex.org/W2095060469","https://openalex.org/W2097509788","https://openalex.org/W2101230909","https://openalex.org/W2105245343","https://openalex.org/W2127946912","https://openalex.org/W2133816387","https://openalex.org/W2151002373","https://openalex.org/W2152772601","https://openalex.org/W2161784221","https://openalex.org/W2162819001","https://openalex.org/W2163437751","https://openalex.org/W2359306646","https://openalex.org/W2430164946","https://openalex.org/W2571956115","https://openalex.org/W2603409754","https://openalex.org/W2610428854","https://openalex.org/W2756104107","https://openalex.org/W2793177103"],"related_works":["https://openalex.org/W4251786843","https://openalex.org/W2116246536","https://openalex.org/W2028727579","https://openalex.org/W2358024694","https://openalex.org/W2104825853","https://openalex.org/W1993002158","https://openalex.org/W2022431898","https://openalex.org/W2117955296","https://openalex.org/W7100729411","https://openalex.org/W7099360686"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2020-12-21T00:00:00"}
