{"id":"https://openalex.org/W3111036615","doi":"https://doi.org/10.21203/rs.3.rs-122151/v1","title":"How to Predict SARS-COV2 Infection in Patient Admitted in Emergency Department: A Prospective Cohort Study.","display_name":"How to Predict SARS-COV2 Infection in Patient Admitted in Emergency Department: A Prospective Cohort Study.","publication_year":2020,"publication_date":"2020-12-09","ids":{"openalex":"https://openalex.org/W3111036615","doi":"https://doi.org/10.21203/rs.3.rs-122151/v1","mag":"3111036615"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-122151/v1","doi":"https://doi.org/10.21203/rs.3.rs-122151/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-122151/v1","pdf_url":"https://www.researchsquare.com/article/rs-122151/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-122151/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072372267","display_name":"Fr\u00e9d\u00e9ric Balen","orcid":"https://orcid.org/0000-0002-4340-7391","observed_orcids":["https://orcid.org/0000-0002-4340-7391"]},"institutions":[{"id":"https://openalex.org/I3019448017","display_name":"Centre Hospitalier Universitaire de Toulouse","ror":"https://ror.org/017h5q109","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Frederic BALEN","raw_affiliation_strings":["CHU Toulouse: Centre Hospitalier Universitaire de Toulouse"],"raw_orcid":"https://orcid.org/0000-0002-4340-7391","affiliations":[{"raw_affiliation_string":"CHU Toulouse: Centre Hospitalier Universitaire de Toulouse","institution_ids":["https://openalex.org/I3019448017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023467698","display_name":"Sandrine CHAPENTIER","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019448017","display_name":"Centre Hospitalier Universitaire de Toulouse","ror":"https://ror.org/017h5q109","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sandrine CHAPENTIER","raw_affiliation_strings":["CHU Toulouse"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHU Toulouse","institution_ids":["https://openalex.org/I3019448017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082945434","display_name":"Paul-Henri Auboiroux","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019448017","display_name":"Centre Hospitalier Universitaire de Toulouse","ror":"https://ror.org/017h5q109","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Paul-Henri AUBOIROUX","raw_affiliation_strings":["CHU Toulouse"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHU Toulouse","institution_ids":["https://openalex.org/I3019448017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110723525","display_name":"Elise No\u00ebl\u2010Savina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019448017","display_name":"Centre Hospitalier Universitaire de Toulouse","ror":"https://ror.org/017h5q109","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Elise NOEL-SAVINA","raw_affiliation_strings":["CHU Toulouse"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHU Toulouse","institution_ids":["https://openalex.org/I3019448017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086537100","display_name":"N. Sans","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019448017","display_name":"Centre Hospitalier Universitaire de Toulouse","ror":"https://ror.org/017h5q109","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nicolas SANS","raw_affiliation_strings":["CHU Toulouse"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHU Toulouse","institution_ids":["https://openalex.org/I3019448017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041805693","display_name":"Gaspard Grouteau","orcid":"https://orcid.org/0000-0002-4890-6982","observed_orcids":["https://orcid.org/0000-0002-4890-6982"]},"institutions":[{"id":"https://openalex.org/I3019448017","display_name":"Centre Hospitalier Universitaire de Toulouse","ror":"https://ror.org/017h5q109","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Gaspard GROUTEAU","raw_affiliation_strings":["CHU Toulouse"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHU Toulouse","institution_ids":["https://openalex.org/I3019448017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032917179","display_name":"Anne Raynaud","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019448017","display_name":"Centre Hospitalier Universitaire de Toulouse","ror":"https://ror.org/017h5q109","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Anne RAYNAUD","raw_affiliation_strings":["CHU Toulouse"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHU Toulouse","institution_ids":["https://openalex.org/I3019448017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077020441","display_name":"Manon Hebrard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019448017","display_name":"Centre Hospitalier Universitaire de Toulouse","ror":"https://ror.org/017h5q109","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Manon HEBRARD","raw_affiliation_strings":["CHU Toulouse"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHU Toulouse","institution_ids":["https://openalex.org/I3019448017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065785830","display_name":"Xavier Dubucs","orcid":"https://orcid.org/0000-0003-2513-1448","observed_orcids":["https://orcid.org/0000-0003-2513-1448"]},"institutions":[{"id":"https://openalex.org/I3019448017","display_name":"Centre Hospitalier Universitaire de Toulouse","ror":"https://ror.org/017h5q109","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Xavier DUBUCS","raw_affiliation_strings":["CHU Toulouse"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHU Toulouse","institution_ids":["https://openalex.org/I3019448017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020722091","display_name":"Charles\u2010Henri Houze\u2010Cerfon","orcid":"https://orcid.org/0000-0003-3604-8447","observed_orcids":["https://orcid.org/0000-0003-3604-8447"]},"institutions":[{"id":"https://openalex.org/I3019448017","display_name":"Centre Hospitalier Universitaire de Toulouse","ror":"https://ror.org/017h5q109","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Charles-Henri HOUZE-CERFON","raw_affiliation_strings":["CHU Toulouse"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHU Toulouse","institution_ids":["https://openalex.org/I3019448017"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040290068","display_name":"H\u00e9l\u00e8ne Colineaux","orcid":"https://orcid.org/0000-0001-8164-0293","observed_orcids":["https://orcid.org/0000-0001-8164-0293"]},"institutions":[{"id":"https://openalex.org/I3019448017","display_name":"Centre Hospitalier Universitaire de Toulouse","ror":"https://ror.org/017h5q109","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"H\u00e9l\u00e8ne COLINEAUX","raw_affiliation_strings":["CHU Toulouse"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHU Toulouse","institution_ids":["https://openalex.org/I3019448017"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I3019448017"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11754","display_name":"SARS-CoV-2 detection and testing","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11296","display_name":"COVID-19 and healthcare impacts","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.9829999804496765},{"id":"https://openalex.org/keywords/clinical-prediction-model","display_name":"clinical prediction model","score":0.7519999742507935},{"id":"https://openalex.org/keywords/emergency-department-patients","display_name":"emergency department patients","score":0.8389999866485596},{"id":"https://openalex.org/keywords/respiratory-symptoms","display_name":"respiratory symptoms","score":0.8069999814033508},{"id":"https://openalex.org/keywords/fever-of-unknown-origin","display_name":"fever of unknown origin","score":0.9869999885559082},{"id":"https://openalex.org/keywords/diagnostic-accuracy","display_name":"diagnostic accuracy","score":0.492000013589859},{"id":"https://openalex.org/keywords/hospital-overcrowding","display_name":"hospital overcrowding","score":0.753000020980835}],"concepts":[{"id":"https://openalex.org/C2780724011","wikidata":"https://www.wikidata.org/wiki/Q1295316","display_name":"Emergency department","level":2,"score":0.791267991065979},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5961542129516602},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.5812886953353882},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.5728583335876465},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.5353294610977173},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5092931985855103},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.4991464614868164},{"id":"https://openalex.org/C545542383","wikidata":"https://www.wikidata.org/wiki/Q2751242","display_name":"Medical emergency","level":1,"score":0.47070905566215515},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.4127236306667328},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2727898955345154},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.10971054434776306},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.08614945411682129},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.05936071276664734}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-122151/v1","doi":"https://doi.org/10.21203/rs.3.rs-122151/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-122151/v1","pdf_url":"https://www.researchsquare.com/article/rs-122151/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-122151/v1","doi":"https://doi.org/10.21203/rs.3.rs-122151/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-122151/v1","pdf_url":"https://www.researchsquare.com/article/rs-122151/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3111036615.pdf","grobid_xml":"https://content.openalex.org/works/W3111036615.grobid-xml"},"referenced_works_count":13,"referenced_works":["https://openalex.org/W2582743722","https://openalex.org/W3001118548","https://openalex.org/W3008827533","https://openalex.org/W3009276095","https://openalex.org/W3009885589","https://openalex.org/W3012413426","https://openalex.org/W3012830776","https://openalex.org/W3014294089","https://openalex.org/W3016484923","https://openalex.org/W3016535995","https://openalex.org/W3017201241","https://openalex.org/W3175417087","https://openalex.org/W7033251610"],"related_works":["https://openalex.org/W4397011790","https://openalex.org/W3110053050","https://openalex.org/W3165258265","https://openalex.org/W3136252605","https://openalex.org/W4225775346","https://openalex.org/W4200494085","https://openalex.org/W3191727033","https://openalex.org/W3153793652","https://openalex.org/W3199612922","https://openalex.org/W4390122833"],"abstract_inverted_index":{"Abstract":[0],"Background.":[1],"In":[2,194],"order":[3],"to":[4,17,21,30],"rapidly":[5],"identifying":[6],"patients":[7,41,54,137,146,245],"with":[8],"a":[9,32,129,175,238],"low":[10],"probability":[11],"of":[12,26,36,62,67,86,88,117,151,202,241],"being":[13],"infected":[14],"by":[15,38,99],"COVID19":[16,39,95,152,203,242,255],"quickly":[18],"refer":[19],"them":[20],"specialized":[22],"departments,":[23],"the":[24,43,63,104,111,118,124,133,160,167,179,183,188,200,209,217,220,224,229,247],"objective":[25],"our":[27],"study":[28],"was":[29,97,121,153,169,181,185,192,204,211,222,226,233],"develop":[31],"clinical":[33,113],"predictive":[34,239],"model":[35,120],"infection":[37,96,243],"in":[40,60,132,159,254,258],"attending":[42,246],"ED":[44,259],"for":[45,77,244],"respiratory":[46,78],"symptoms":[47,79],"or":[48,82],"unexplained":[49],"fever.Methods.":[50],"We":[51,127,235],"included":[52,138],"all":[53],"over":[55],"15":[56],"years":[57],"old,":[58],"admitted":[59],"one":[61],"2":[64],"emergency":[65],"departments":[66],"Toulouse":[68],"University":[69],"Hospital":[70],"between":[71,139],"March":[72,75],"13":[73],"and":[74,91,101,142,187,228,260],"31":[76],"(dyspnea,":[80],"cough),":[81],"fever":[83],"(or":[84],"sensation":[85],"fever)":[87],"unknown":[89],"origin,":[90],"potentially":[92],"requiring":[93],"hospitalization.":[94],"assessed":[98],"CT-SCAN":[100],"RT-PCR.":[102],"All":[103],"candidate":[105],"predictors":[106,158],"were":[107,147,156],"variables":[108],"collected":[109],"during":[110],"first":[112],"examination.":[114],"Internal":[115],"validation":[116,131],"final":[119,161],"performed":[122,128],"using":[123],"bootstrap":[125],"procedure.":[126],"temporal":[130],"same":[134,218],"way":[135],"on":[136],"April":[140,143],"1":[141],"13.Results.":[144],"772":[145],"included.":[148],"The":[149,163,206],"prevalence":[150,201],"25.5%.":[154],"There":[155],"19":[157],"model.":[162],"corrected-by-optimism":[164],"area":[165,207],"under":[166,208],"curve":[168,210],"0.86":[170],"(95%CI":[171,213],"=":[172,214],"[0.83;0.89]).":[173],"For":[174,216],"threshold":[176],"at":[177],"10%,":[178],"sensitivity":[180,221],"92%.,":[182],"specificity":[184,225],"56%,":[186],"false":[189,230],"negative":[190,231],"rate":[191,232],"5%.":[193],"secondary":[195],"data,":[196],"including":[197],"387":[198],"patients,":[199],"15%.":[205],"0.73":[212],"[0.63;0.83]).":[215],"threshold,":[219],"78%,":[223],"48%,":[227],"7%Conclusion.":[234],"have":[236],"developed":[237],"tool":[240],"ED.":[248],"It":[249],"could":[250],"safely":[251],"reduce":[252],"admission":[253],"dedicated":[256],"unit":[257],"prevent":[261],"its":[262],"overcrowding.Trial":[263],"registration":[264],"number:":[265],"NCT:":[266],"RC31/20/0149":[267]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2020-12-21T00:00:00"}