{"id":"https://openalex.org/W3110748160","doi":"https://doi.org/10.1024/0300-9831/a000691","title":"The role of vitamin D in metabolic and reproductive disturbances of polycystic ovary syndrome: A narrative mini-review","display_name":"The role of vitamin D in metabolic and reproductive disturbances of polycystic ovary syndrome: A narrative mini-review","publication_year":2020,"publication_date":"2020-12-07","ids":{"openalex":"https://openalex.org/W3110748160","doi":"https://doi.org/10.1024/0300-9831/a000691","mag":"3110748160","pmid":"https://pubmed.ncbi.nlm.nih.gov/33284035"},"language":"en","primary_location":{"id":"doi:10.1024/0300-9831/a000691","doi":"https://doi.org/10.1024/0300-9831/a000691","is_oa":false,"landing_page_url":"https://doi.org/10.1024/0300-9831/a000691","pdf_url":null,"source":{"id":"https://openalex.org/S12740033","display_name":"International Journal for Vitamin and Nutrition Research","issn_l":"0020-9406","issn":["0020-9406","0300-9831","1664-2821"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319871","host_organization_name":"Hogrefe Verlag","host_organization_lineage":["https://openalex.org/P4310319871"],"host_organization_lineage_names":["Hogrefe Verlag"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal for Vitamin and Nutrition Research","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/11380/1250024","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013295304","display_name":"Daniela Menichini","orcid":"https://orcid.org/0000-0002-8531-7124","observed_orcids":["https://orcid.org/0000-0002-8531-7124"]},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Daniela Menichini","raw_affiliation_strings":["International Doctorate School in Clinical and Experimental Medicine, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Italy","Unit of Obstetrics and Gynecology, Mother-Infant Department, University of Modena and Reggio Emilia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Doctorate School in Clinical and Experimental Medicine, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Italy","institution_ids":["https://openalex.org/I122346577"]},{"raw_affiliation_string":"Unit of Obstetrics and Gynecology, Mother-Infant Department, University of Modena and Reggio Emilia, Italy","institution_ids":["https://openalex.org/I122346577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059228993","display_name":"Gianpiero Forte","orcid":"https://orcid.org/0000-0003-4720-4054","observed_orcids":["https://orcid.org/0000-0003-4720-4054"]},"institutions":[{"id":"https://openalex.org/I4405267981","display_name":"Lo.Li. Pharma S.r.l. (Italy)","ror":"https://ror.org/058hnt048","country_code":"IT","type":"company","lineage":["https://openalex.org/I4405267981"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gianpiero Forte","raw_affiliation_strings":["Medical Affairs Department, Lo.Li. Pharma, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Affairs Department, Lo.Li. Pharma, Rome, Italy","institution_ids":["https://openalex.org/I4405267981"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082871188","display_name":"Beatrice Orr\u00f9","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405267981","display_name":"Lo.Li. Pharma S.r.l. (Italy)","ror":"https://ror.org/058hnt048","country_code":"IT","type":"company","lineage":["https://openalex.org/I4405267981"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Beatrice Orr\u00f9","raw_affiliation_strings":["Medical Affairs Department, Lo.Li. Pharma, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Affairs Department, Lo.Li. Pharma, Rome, Italy","institution_ids":["https://openalex.org/I4405267981"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049440330","display_name":"Giuseppe Gullo","orcid":"https://orcid.org/0000-0003-4269-4269","observed_orcids":["https://orcid.org/0000-0003-4269-4269"]},"institutions":[{"id":"https://openalex.org/I4210099059","display_name":"Ospedale Vincenzo Cervello","ror":"https://ror.org/00twmyj12","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210099059"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giuseppe Gullo","raw_affiliation_strings":["IVF Public Center, AOOR Villa Sofia Cervello, University Hospital, Palermo, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IVF Public Center, AOOR Villa Sofia Cervello, University Hospital, Palermo, Italy","institution_ids":["https://openalex.org/I4210099059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061261875","display_name":"Vittorio Unfer","orcid":"https://orcid.org/0000-0002-1805-3181","observed_orcids":["https://orcid.org/0000-0002-1805-3181"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Vittorio Unfer","raw_affiliation_strings":["Department of Experimental Medicine, Sapienza University, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine, Sapienza University, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038206846","display_name":"Fabio Facchinetti","orcid":"https://orcid.org/0000-0003-4694-9564","observed_orcids":["https://orcid.org/0000-0003-4694-9564"]},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Fabio Facchinetti","raw_affiliation_strings":["Unit of Obstetrics and Gynecology, Mother-Infant Department, University of Modena and Reggio Emilia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Obstetrics and Gynecology, Mother-Infant Department, University of Modena and Reggio Emilia, Italy","institution_ids":["https://openalex.org/I122346577"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7677,"has_fulltext":false,"cited_by_count":56,"citation_normalized_percentile":{"value":0.57352941,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"92","issue":"2","first_page":"126","last_page":"133"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitamin-d","display_name":"vitamin D","score":0.996999979019165},{"id":"https://openalex.org/keywords/polycystic-ovary-syndrome","display_name":"polycystic ovary syndrome","score":0.9869999885559082},{"id":"https://openalex.org/keywords/vitamin-d-deficiency","display_name":"vitamin D deficiency","score":0.9169999957084656},{"id":"https://openalex.org/keywords/vitamin-d-supplementation","display_name":"vitamin D supplementation","score":0.9789999723434448},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9869999885559082},{"id":"https://openalex.org/keywords/endometrial-receptivity","display_name":"endometrial receptivity","score":0.8989999890327454},{"id":"https://openalex.org/keywords/infertility","display_name":"infertility","score":0.7120000123977661},{"id":"https://openalex.org/keywords/oogenesis","display_name":"oogenesis","score":0.9739999771118164},{"id":"https://openalex.org/keywords/embryo-quality","display_name":"embryo quality","score":0.9990000128746033},{"id":"https://openalex.org/keywords/luteal-phase","display_name":"luteal phase","score":0.8939999938011169}],"concepts":[{"id":"https://openalex.org/C3018442814","wikidata":"https://www.wikidata.org/wiki/Q500816","display_name":"Polycystic ovary","level":4,"score":0.9359766840934753},{"id":"https://openalex.org/C2778324911","wikidata":"https://www.wikidata.org/wiki/Q9631","display_name":"Ovary","level":2,"score":0.5900663733482361},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5616356134414673},{"id":"https://openalex.org/C3020000205","wikidata":"https://www.wikidata.org/wiki/Q2412849","display_name":"Narrative review","level":2,"score":0.5517397522926331},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.527590811252594},{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.46737995743751526},{"id":"https://openalex.org/C2776940978","wikidata":"https://www.wikidata.org/wiki/Q34956","display_name":"Vitamin","level":2,"score":0.45259973406791687},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44994229078292847},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.42072346806526184},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4096089005470276},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.33490440249443054},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.24908480048179626},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.14619505405426025},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.09236794710159302}],"mesh":[{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011085","descriptor_name":"Polycystic Ovary Syndrome","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D011085","descriptor_name":"Polycystic Ovary Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014807","descriptor_name":"Vitamin D","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014808","descriptor_name":"Vitamin D Deficiency","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D014808","descriptor_name":"Vitamin D Deficiency","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D014808","descriptor_name":"Vitamin D Deficiency","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014815","descriptor_name":"Vitamins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1024/0300-9831/a000691","doi":"https://doi.org/10.1024/0300-9831/a000691","is_oa":false,"landing_page_url":"https://doi.org/10.1024/0300-9831/a000691","pdf_url":null,"source":{"id":"https://openalex.org/S12740033","display_name":"International Journal for Vitamin and Nutrition Research","issn_l":"0020-9406","issn":["0020-9406","0300-9831","1664-2821"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319871","host_organization_name":"Hogrefe Verlag","host_organization_lineage":["https://openalex.org/P4310319871"],"host_organization_lineage_names":["Hogrefe Verlag"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal for Vitamin and Nutrition Research","raw_type":"journal-article"},{"id":"pmid:33284035","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33284035","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unimore.it:11380/1250024","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11380/1250024","pdf_url":null,"source":{"id":"https://openalex.org/S4306400718","display_name":"IRIS UNIMORE (University of Modena and Reggio Emilia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122346577","host_organization_name":"University of Modena and Reggio Emilia","host_organization_lineage":["https://openalex.org/I122346577"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:iris.unimore.it:11380/1250024","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11380/1250024","pdf_url":null,"source":{"id":"https://openalex.org/S4306400718","display_name":"IRIS UNIMORE (University of Modena and Reggio Emilia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122346577","host_organization_name":"University of Modena and Reggio Emilia","host_organization_lineage":["https://openalex.org/I122346577"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1968230639","https://openalex.org/W1985978903","https://openalex.org/W1986902166","https://openalex.org/W1987572639","https://openalex.org/W1990505546","https://openalex.org/W1994956110","https://openalex.org/W1997301608","https://openalex.org/W2005599584","https://openalex.org/W2058294720","https://openalex.org/W2072460398","https://openalex.org/W2073427932","https://openalex.org/W2083487075","https://openalex.org/W2084282123","https://openalex.org/W2102425423","https://openalex.org/W2104285596","https://openalex.org/W2118346717","https://openalex.org/W2121201490","https://openalex.org/W2130162886","https://openalex.org/W2130462088","https://openalex.org/W2137050072","https://openalex.org/W2141936301","https://openalex.org/W2149170067","https://openalex.org/W2150903452","https://openalex.org/W2161276145","https://openalex.org/W2163104239","https://openalex.org/W2165975054","https://openalex.org/W2167589457","https://openalex.org/W2171750463","https://openalex.org/W2319224462","https://openalex.org/W2401541591","https://openalex.org/W2470919245","https://openalex.org/W2555520907","https://openalex.org/W2769274215","https://openalex.org/W2769371508","https://openalex.org/W2785340875","https://openalex.org/W2803223043","https://openalex.org/W2810246872","https://openalex.org/W2810832714","https://openalex.org/W2899140719","https://openalex.org/W2921026386"],"related_works":["https://openalex.org/W7117459389","https://openalex.org/W4388833089","https://openalex.org/W2020165313","https://openalex.org/W4383709879","https://openalex.org/W4391685860","https://openalex.org/W4410049687","https://openalex.org/W1994956110","https://openalex.org/W2382703218","https://openalex.org/W2895768078","https://openalex.org/W3032218623"],"abstract_inverted_index":{"Vitamin":[0],"D":[1,26,44,67,119,165,183],"is":[2],"a":[3,8,48,71,123,144,156],"secosteroid":[4],"hormone":[5],"that":[6,168],"plays":[7],"pivotal":[9],"role":[10,23,50,73,125,146],"in":[11,17,28,33,99,106,163,185],"several":[12],"metabolic":[13,29,109,170],"and":[14,31,55,77,111,130,136,150,205,219],"reproductive":[15,178],"pathways":[16],"humans.":[18],"Increasing":[19],"evidence":[20,88],"supports":[21],"the":[22,59,81,86,90,95,115,177,193,198,208,213],"of":[24,65,139,192,207],"vitamin":[25,43,66,118,164,182],"deficiency":[27],"disturbances":[30,110,171],"infertility":[32],"women":[34,100,167],"with":[35,42,101,108],"polycystic":[36],"ovary":[37],"syndrome":[38],"(PCOS).":[39],"Indeed,":[40],"supplementation":[41,97,159,184,209],"seems":[45,120],"to":[46,69,93,121,142,196,217],"have":[47,122,143],"beneficial":[49,124],"on":[51,74,114,126,147],"insulin":[52,128],"resistance":[53],"(IR)":[54],"endometrial":[56,131],"receptivity.":[57],"On":[58],"other":[60],"hand,":[61],"exceedingly":[62],"high":[63,134],"levels":[64,135],"appear":[68],"play":[70],"detrimental":[72,145],"oocytes":[75,148],"development":[76,149],"embryo":[78,151],"quality.":[79,152],"In":[80],"current":[82],"review,":[83],"we":[84,154,180],"summarize":[85],"available":[87],"about":[89,203],"topic,":[91],"aiming":[92],"suggest":[94],"best":[96],"strategy":[98],"PCOS":[102],"or,":[103],"more":[104],"generally,":[105],"those":[107],"infertility.":[112],"Based":[113],"retrieved":[116],"data,":[117],"IR,":[127],"sensitivity":[129],"receptivity,":[132],"but":[133],"incorrect":[137],"timing":[138,206],"administration":[140],"seem":[141],"Therefore,":[153],"encourage":[155],"low":[157],"dose":[158],"(400-800":[160],"IU/day)":[161],"particularly":[162],"deficient":[166],"present":[169],"like":[172],"PCOS.":[173],"As":[174],"far":[175],"as":[176],"health,":[179],"advise":[181],"selected":[186],"populations,":[187],"only":[188],"during":[189],"specific":[190],"moments":[191],"ovarian":[194],"cycle,":[195],"support":[197],"luteal":[199],"phase.":[200],"However,":[201],"ambiguities":[202],"dosage":[204],"still":[210],"emerge":[211],"from":[212],"clinical":[214],"studies":[215,221],"published":[216],"date":[218],"further":[220],"are":[222],"required.":[223]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":21},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2020-12-21T00:00:00"}