{"id":"https://openalex.org/W3110693913","doi":"https://doi.org/10.1016/j.jcmgh.2020.12.009","title":"Predicting HCC Response to Multikinase Inhibitors With In Vivo Cirrhotic Mouse Model for Personalized Therapy","display_name":"Predicting HCC Response to Multikinase Inhibitors With In Vivo Cirrhotic Mouse Model for Personalized Therapy","publication_year":2020,"publication_date":"2020-12-17","ids":{"openalex":"https://openalex.org/W3110693913","doi":"https://doi.org/10.1016/j.jcmgh.2020.12.009","mag":"3110693913","pmid":"https://pubmed.ncbi.nlm.nih.gov/33340714","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8020437"},"language":"en","primary_location":{"id":"doi:10.1016/j.jcmgh.2020.12.009","doi":"https://doi.org/10.1016/j.jcmgh.2020.12.009","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jcmgh.2020.12.009","pdf_url":"http://www.cmghjournal.org/article/S2352345X20302083/pdf","source":{"id":"https://openalex.org/S2764889447","display_name":"Cellular and Molecular Gastroenterology and Hepatology","issn_l":"2352-345X","issn":["2352-345X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and Molecular Gastroenterology and Hepatology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W3110693913"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.cmghjournal.org/article/S2352345X20302083/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009193858","display_name":"Daniel Q. Huang","orcid":"https://orcid.org/0000-0002-5165-5061","observed_orcids":["https://orcid.org/0000-0002-5165-5061"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4210150261","display_name":"National University Health System","ror":"https://ror.org/05tjjsh18","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I4210150261"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Daniel Q. Huang","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Department of Medicine, National University Health System, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore","Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore","Division of Gastroenterology and Hepatology, Department of Medicine, National University Health System, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Department of Medicine, National University Health System, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210150261"]},{"raw_affiliation_string":"Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Department of Medicine, National University Health System, Singapore","institution_ids":["https://openalex.org/I4210150261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058087480","display_name":"Mark Dhinesh Muthiah","orcid":"https://orcid.org/0000-0002-9724-4743","observed_orcids":["https://orcid.org/0000-0002-9724-4743"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4210150261","display_name":"National University Health System","ror":"https://ror.org/05tjjsh18","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I4210150261"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Mark D. Muthiah","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Department of Medicine, National University Health System, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore","Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore","Division of Gastroenterology and Hepatology, Department of Medicine, National University Health System, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Department of Medicine, National University Health System, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210150261"]},{"raw_affiliation_string":"Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Department of Medicine, National University Health System, Singapore","institution_ids":["https://openalex.org/I4210150261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100674991","display_name":"Lei Zhou","orcid":"https://orcid.org/0000-0001-5893-6002","observed_orcids":["https://orcid.org/0000-0001-5893-6002","https://orcid.org/0000-0001-8251-3974","https://orcid.org/0009-0007-9394-309X"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Lei Zhou","raw_affiliation_strings":["Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003588326","display_name":"Nur Halisah Binte Jumat","orcid":"https://orcid.org/0000-0003-0068-9576","observed_orcids":["https://orcid.org/0000-0003-0068-9576"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Halisah Jumat","raw_affiliation_strings":["Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101096797","display_name":"Wan Xin Tan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Wan Xin Tan","raw_affiliation_strings":["Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075008412","display_name":"Guan Huei Lee","orcid":"https://orcid.org/0000-0002-8652-6403","observed_orcids":["https://orcid.org/0000-0002-8652-6403"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4210150261","display_name":"National University Health System","ror":"https://ror.org/05tjjsh18","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I4210150261"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Guan Huei Lee","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Department of Medicine, National University Health System, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore","Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore","Division of Gastroenterology and Hepatology, Department of Medicine, National University Health System, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Department of Medicine, National University Health System, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210150261"]},{"raw_affiliation_string":"Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Department of Medicine, National University Health System, Singapore","institution_ids":["https://openalex.org/I4210150261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007996484","display_name":"Seng Gee Lim","orcid":"https://orcid.org/0000-0003-0994-4932","observed_orcids":["https://orcid.org/0000-0003-0994-4932"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4210150261","display_name":"National University Health System","ror":"https://ror.org/05tjjsh18","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I4210150261"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Seng Gee Lim","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Department of Medicine, National University Health System, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore","Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore","Division of Gastroenterology and Hepatology, Department of Medicine, National University Health System, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Department of Medicine, National University Health System, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210150261"]},{"raw_affiliation_string":"Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Department of Medicine, National University Health System, Singapore","institution_ids":["https://openalex.org/I4210150261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001029365","display_name":"Alfred Wei Chieh Kow","orcid":"https://orcid.org/0000-0001-8942-8262","observed_orcids":["https://orcid.org/0000-0001-8942-8262"]},"institutions":[{"id":"https://openalex.org/I4210150261","display_name":"National University Health System","ror":"https://ror.org/05tjjsh18","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I4210150261"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Alfred Kow","raw_affiliation_strings":["Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, National University Health System, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, National University Health System, Singapore","institution_ids":["https://openalex.org/I4210150261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035873423","display_name":"Glenn Kunnath Bonney","orcid":"https://orcid.org/0000-0002-9034-3255","observed_orcids":["https://orcid.org/0000-0002-9034-3255"]},"institutions":[{"id":"https://openalex.org/I4210150261","display_name":"National University Health System","ror":"https://ror.org/05tjjsh18","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I4210150261"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Glenn Bonney","raw_affiliation_strings":["Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, National University Health System, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, National University Health System, Singapore","institution_ids":["https://openalex.org/I4210150261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078777866","display_name":"Shridhar Ganpathi Iyer","orcid":"https://orcid.org/0000-0002-4630-9842","observed_orcids":["https://orcid.org/0000-0002-4630-9842"]},"institutions":[{"id":"https://openalex.org/I4210150261","display_name":"National University Health System","ror":"https://ror.org/05tjjsh18","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I4210150261"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Iyer Shridhar","raw_affiliation_strings":["Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, National University Health System, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, National University Health System, Singapore","institution_ids":["https://openalex.org/I4210150261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081839614","display_name":"Yi Ting Lim","orcid":"https://orcid.org/0000-0002-3241-4561","observed_orcids":["https://orcid.org/0000-0002-3241-4561"]},"institutions":[{"id":"https://openalex.org/I4210150261","display_name":"National University Health System","ror":"https://ror.org/05tjjsh18","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I4210150261"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Yi Ting Lim","raw_affiliation_strings":["Department of Diagnostic Imaging, National University Health System, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Diagnostic Imaging, National University Health System, Singapore","institution_ids":["https://openalex.org/I4210150261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102764629","display_name":"Aileen Wee","orcid":"https://orcid.org/0000-0003-3107-7599","observed_orcids":["https://orcid.org/0000-0003-3107-7599"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4210146690","display_name":"National University Hospital","ror":"https://ror.org/04fp9fm22","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I165932596","https://openalex.org/I4210146690","https://openalex.org/I4210150261"]},{"id":"https://openalex.org/I4210150261","display_name":"National University Health System","ror":"https://ror.org/05tjjsh18","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I4210150261"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Aileen Wee","raw_affiliation_strings":["Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, National University Hospital, National University Health System, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, National University Hospital, National University Health System, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210146690","https://openalex.org/I4210150261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039995917","display_name":"Yin Huei Pang","orcid":"https://orcid.org/0000-0003-0751-0612","observed_orcids":["https://orcid.org/0000-0003-0751-0612"]},"institutions":[{"id":"https://openalex.org/I4210146690","display_name":"National University Hospital","ror":"https://ror.org/04fp9fm22","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I165932596","https://openalex.org/I4210146690","https://openalex.org/I4210150261"]},{"id":"https://openalex.org/I4210150261","display_name":"National University Health System","ror":"https://ror.org/05tjjsh18","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I4210150261"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Yin Huei Pang","raw_affiliation_strings":["Department of Pathology, National University Hospital, National University Health System, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, National University Hospital, National University Health System, Singapore","institution_ids":["https://openalex.org/I4210146690","https://openalex.org/I4210150261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039842094","display_name":"Gwyneth Shook Ting Soon","orcid":"https://orcid.org/0000-0001-5318-9327","observed_orcids":["https://orcid.org/0000-0001-5318-9327"]},"institutions":[{"id":"https://openalex.org/I4210146690","display_name":"National University Hospital","ror":"https://ror.org/04fp9fm22","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I165932596","https://openalex.org/I4210146690","https://openalex.org/I4210150261"]},{"id":"https://openalex.org/I4210150261","display_name":"National University Health System","ror":"https://ror.org/05tjjsh18","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I4210150261"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Gwyneth Soon","raw_affiliation_strings":["Department of Pathology, National University Hospital, National University Health System, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, National University Hospital, National University Health System, Singapore","institution_ids":["https://openalex.org/I4210146690","https://openalex.org/I4210150261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061027234","display_name":"Pierce K. H. Chow","orcid":"https://orcid.org/0000-0003-0584-2584","observed_orcids":["https://orcid.org/0000-0003-0584-2584"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I2251586001","display_name":"Singapore General Hospital","ror":"https://ror.org/036j6sg82","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I2251586001"]},{"id":"https://openalex.org/I4210126319","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210126319"]},{"id":"https://openalex.org/I4210137145","display_name":"National Cancer Centre Singapore","ror":"https://ror.org/03bqk3e80","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I4210137145"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Pierce Chow","raw_affiliation_strings":["Division of Surgical Oncology, National Cancer Center Singapore, Singapore; Department of Hepato-Pancreato-Biliary and Transplant Surgery, Singapore General Hospital, Singapore; Duke-NUS Medical School Singapore, Singapore","Department of Hepato-Pancreato-Biliary and Transplant Surgery, Singapore General Hospital, Singapore","Division of Surgical Oncology, National Cancer Center Singapore, Singapore","Duke-NUS Medical School Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Surgical Oncology, National Cancer Center Singapore, Singapore; Department of Hepato-Pancreato-Biliary and Transplant Surgery, Singapore General Hospital, Singapore; Duke-NUS Medical School Singapore, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I2251586001","https://openalex.org/I4210126319","https://openalex.org/I4210137145"]},{"raw_affiliation_string":"Department of Hepato-Pancreato-Biliary and Transplant Surgery, Singapore General Hospital, Singapore","institution_ids":["https://openalex.org/I2251586001"]},{"raw_affiliation_string":"Division of Surgical Oncology, National Cancer Center Singapore, Singapore","institution_ids":["https://openalex.org/I4210137145"]},{"raw_affiliation_string":"Duke-NUS Medical School Singapore, Singapore","institution_ids":["https://openalex.org/I4210126319"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028905834","display_name":"Yock Young Dan","orcid":"https://orcid.org/0000-0002-7546-2117","observed_orcids":["https://orcid.org/0000-0002-7546-2117"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4210150261","display_name":"National University Health System","ror":"https://ror.org/05tjjsh18","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I4210150261"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Yock Young Dan","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Department of Medicine, National University Health System, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address: mdcdyy@nus.edu.sg","Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore","Division of Gastroenterology and Hepatology, Department of Medicine, National University Health System, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Department of Medicine, National University Health System, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address: mdcdyy@nus.edu.sg","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210150261"]},{"raw_affiliation_string":"Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Department of Medicine, National University Health System, Singapore","institution_ids":["https://openalex.org/I4210150261"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5028905834"],"corresponding_institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210150261"],"apc_list":{"value":2000,"currency":"USD","value_usd":2000},"apc_paid":{"value":2000,"currency":"USD","value_usd":2000},"fwci":1.3468,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.79033382,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"11","issue":"5","first_page":"1313","last_page":"1325"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":1.0},{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.8399999737739563},{"id":"https://openalex.org/keywords/multikinase-inhibitor","display_name":"multikinase inhibitor","score":0.8840000033378601},{"id":"https://openalex.org/keywords/patient-derived-xenografts","display_name":"patient-derived xenografts","score":0.9010000228881836},{"id":"https://openalex.org/keywords/thioacetamide-induced-cirrhosis","display_name":"thioacetamide-induced cirrhosis","score":0.8360000252723694},{"id":"https://openalex.org/keywords/sorafenib","display_name":"sorafenib","score":0.718999981880188},{"id":"https://openalex.org/keywords/lenvatinib","display_name":"lenvatinib","score":1.0},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.6650000214576721},{"id":"https://openalex.org/keywords/treatment-response-prediction","display_name":"treatment response prediction","score":0.7799999713897705},{"id":"https://openalex.org/keywords/personalized-treatment","display_name":"personalized treatment","score":0.7300000190734863},{"id":"https://openalex.org/keywords/tumor-vasculature","display_name":"tumor vasculature","score":0.7250000238418579},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.8109999895095825},{"id":"https://openalex.org/keywords/hcc-recurrence","display_name":"HCC recurrence","score":0.7590000033378601},{"id":"https://openalex.org/keywords/vegfr2","display_name":"VEGFR2","score":0.7870000004768372},{"id":"https://openalex.org/keywords/cd34","display_name":"CD34","score":0.8769999742507935},{"id":"https://openalex.org/keywords/nsg-mice","display_name":"NSG mice","score":0.6980000138282776}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7471240162849426},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5996838808059692},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5176796913146973},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3831394612789154},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.35360538959503174},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.350607693195343},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.34692928194999695},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17050406336784363},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06588858366012573}],"mesh":[{"descriptor_ui":"D000077157","descriptor_name":"Sorafenib","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010671","descriptor_name":"Phenylurea Compounds","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011804","descriptor_name":"Quinolines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013853","descriptor_name":"Thioacetamide","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016513","descriptor_name":"Mice, SCID","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016688","descriptor_name":"Mice, Inbred NOD","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1016/j.jcmgh.2020.12.009","doi":"https://doi.org/10.1016/j.jcmgh.2020.12.009","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jcmgh.2020.12.009","pdf_url":"http://www.cmghjournal.org/article/S2352345X20302083/pdf","source":{"id":"https://openalex.org/S2764889447","display_name":"Cellular and Molecular Gastroenterology and Hepatology","issn_l":"2352-345X","issn":["2352-345X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and Molecular Gastroenterology and Hepatology","raw_type":"journal-article"},{"id":"pmid:33340714","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33340714","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and molecular gastroenterology and hepatology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8020437","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8020437/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Mol Gastroenterol Hepatol","raw_type":"Text"},{"id":"pmh:oai:scholarbank.nus.edu.sg:10635/207536","doi":null,"is_oa":false,"landing_page_url":"https://scholarbank.nus.edu.sg/handle/10635/207536","pdf_url":null,"source":{"id":"https://openalex.org/S7407052290","display_name":"National University of Singapore","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Elements","raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:7ba8b6da13ae443ebf3680b9ffa1d1a7","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7ba8b6da13ae443ebf3680b9ffa1d1a7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 5, Pp 1313-1325 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.jcmgh.2020.12.009","doi":"https://doi.org/10.1016/j.jcmgh.2020.12.009","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jcmgh.2020.12.009","pdf_url":"http://www.cmghjournal.org/article/S2352345X20302083/pdf","source":{"id":"https://openalex.org/S2764889447","display_name":"Cellular and Molecular Gastroenterology and Hepatology","issn_l":"2352-345X","issn":["2352-345X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and Molecular Gastroenterology and Hepatology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307811","display_name":"Exxon Mobil Corporation","ror":"https://ror.org/01xcepn55"},{"id":"https://openalex.org/F4320308573","display_name":"Gilead Sciences","ror":"https://ror.org/056546b03"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334737","display_name":"National Medical Research Council","ror":"https://ror.org/04x3cxs03"},{"id":"https://openalex.org/F4320335846","display_name":"Biomedical Research Council","ror":"https://ror.org/03xy0wx88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3110693913.pdf","grobid_xml":"https://content.openalex.org/works/W3110693913.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1501411211","https://openalex.org/W1905968574","https://openalex.org/W1921932579","https://openalex.org/W1963920328","https://openalex.org/W1970682511","https://openalex.org/W1971837077","https://openalex.org/W1998931253","https://openalex.org/W2009671859","https://openalex.org/W2015789993","https://openalex.org/W2022169488","https://openalex.org/W2027850944","https://openalex.org/W2031355226","https://openalex.org/W2064511649","https://openalex.org/W2098870104","https://openalex.org/W2140765540","https://openalex.org/W2152685914","https://openalex.org/W2156808522","https://openalex.org/W2169262427","https://openalex.org/W2279725427","https://openalex.org/W2524442417","https://openalex.org/W2569389775","https://openalex.org/W2588082084","https://openalex.org/W2727497670","https://openalex.org/W2787358630","https://openalex.org/W2801671963","https://openalex.org/W2883204623","https://openalex.org/W2893868814","https://openalex.org/W2903509048","https://openalex.org/W2957800813","https://openalex.org/W2969802526","https://openalex.org/W2981804680","https://openalex.org/W2997661360","https://openalex.org/W3017849569","https://openalex.org/W3025022288","https://openalex.org/W3139763557"],"related_works":["https://openalex.org/W4387952263","https://openalex.org/W2049956331","https://openalex.org/W1905968574","https://openalex.org/W4405766960","https://openalex.org/W1988614457","https://openalex.org/W2957800813","https://openalex.org/W2997410760","https://openalex.org/W4255739478","https://openalex.org/W3021208687","https://openalex.org/W1993980100"],"abstract_inverted_index":{"BACKGROUND":[0],"&":[1],"AIMS:":[2],"Hepatocellular":[3],"carcinoma":[4],"(HCC)":[5],"arises":[6],"in":[7,57,124,138,147,154,160,172,209,216,224],"a":[8,15,35],"cirrhotic,":[9],"pro-angiogenic":[10],"microenvironment.":[11],"Inhibiting":[12],"angiogenesis":[13,246],"is":[14],"key":[16],"mode":[17],"of":[18,20,40,47,65,76,93,104,118,133,183,186,250],"action":[19],"multikinase":[21,253],"inhibitors":[22,254],"and":[23,49,83,88,165,202,206,227,231,247],"current":[24],"non-cirrhotic":[25,81,89,141,156],"models":[26],"are":[27],"unable":[28],"to":[29,199,204,214,252],"predict":[30,200],"treatment":[31],"response.":[32],"We":[33],"present":[34],"novel":[36],"mouse":[37],"cirrhotic":[38,87,94,126,149,162,195,218,241],"model":[39,127,150,196,243],"xenotransplant":[41],"that":[42,136],"predicts":[43],"the":[44,125,139,148,155,187,210,217],"natural":[45],"biology":[46],"HCC":[48,78,122,170],"allows":[50,248],"personalized":[51,256],"therapy.":[52,257],"METHODS:":[53],"Cirrhosis":[54],"was":[55,99,111,145,152,166,197,220],"induced":[56],"NOD":[58],"Scid":[59],"gamma":[60],"mice":[61,82],"with":[62,101,129,168,179,222],"4":[63],"months":[64],"thioacetamide":[66],"administration.":[67],"Patient":[68],"derived":[69],"xenografts":[70],"(PDXs)":[71],"were":[72],"created":[73],"by":[74,113],"transplant":[75],"human":[77,121],"subcutaneously":[79],"into":[80,85],"intra-hepatically":[84],"both":[86],"mice.":[90],"The":[91,194],"applicability":[92],"PDXs":[95],"for":[96,255],"drug":[97],"testing":[98],"tested":[100],"16":[102,184],"days":[103],"either":[105],"sorafenib":[106,207],"or":[107],"lenvatinib.":[108],"Treatment":[109],"response":[110,201,251],"evaluated":[112],"MRI.":[114],"RESULTS:":[115],"8":[116],"out":[117,132,182],"19":[119,134],"(42%)":[120],"engrafted":[123,137],"compared":[128,178],"only":[130,180],"3":[131,161,174],"(16%)":[135],"subcutaneous":[140],"model.":[142],"Tumor":[143],"vasculature":[144],"preserved":[146],"but":[151],"diminished":[153],"models.":[157],"Metastasis":[158],"developed":[159],"PDX":[163,189,219,242],"lines":[164],"associated":[167,221],"early":[169],"recurrence":[171],"all":[173],"corresponding":[175,211],"patients":[176],"(100%),":[177],"5":[181],"(31%)":[185],"other":[188],"lines,":[190],"P":[191,234],"=":[192],".027.":[193],"able":[198],"non-response":[203],"lenvatinib":[205,215],"respectively":[208],"patients.":[212],"Response":[213],"reduction":[223],"CD34,":[225],"VEGFR2":[226],"CLEC4G":[228],"immunofluorescence":[229],"area":[230],"intensity":[232],"(all":[233],"\u2264":[235],".03).":[236],"CONCLUSIONS:":[237],"A":[238],"clinically":[239],"relevant":[240],"preserves":[244],"tumor":[245],"prediction":[249]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-12-21T00:00:00"}