{"id":"https://openalex.org/W3110693683","doi":"https://doi.org/10.3389/fcell.2020.573727","title":"Plasma Inorganic Pyrophosphate Deficiency Links Multiparity to Cardiovascular Disease Risk","display_name":"Plasma Inorganic Pyrophosphate Deficiency Links Multiparity to Cardiovascular Disease Risk","publication_year":2020,"publication_date":"2020-12-09","ids":{"openalex":"https://openalex.org/W3110693683","doi":"https://doi.org/10.3389/fcell.2020.573727","mag":"3110693683","pmid":"https://pubmed.ncbi.nlm.nih.gov/33363139"},"language":"en","primary_location":{"id":"doi:10.3389/fcell.2020.573727","doi":"https://doi.org/10.3389/fcell.2020.573727","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2020.573727","pdf_url":"https://www.frontiersin.org/articles/10.3389/fcell.2020.573727/pdf","source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fcell.2020.573727/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052065231","display_name":"Almudena Veiga\u2010Lopez","orcid":"https://orcid.org/0000-0002-0308-7231","observed_orcids":["https://orcid.org/0000-0002-0308-7231"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]},{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Almudena Veiga-Lopez","raw_affiliation_strings":["Department of Animal Science, Michigan State University, East Lansing, MI, United States","Department of Pathology, The University of Illinois at Chicago, Chicago, IL, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Science, Michigan State University, East Lansing, MI, United States","institution_ids":["https://openalex.org/I87216513"]},{"raw_affiliation_string":"Department of Pathology, The University of Illinois at Chicago, Chicago, IL, United States","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113925444","display_name":"Visalakshi Sethuraman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]},{"id":"https://openalex.org/I926076166","display_name":"Texas Tech University Health Sciences Center","ror":"https://ror.org/033ztpr93","country_code":"US","type":"education","lineage":["https://openalex.org/I926076166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Visalakshi Sethuraman","raw_affiliation_strings":["Department of Pediatrics and Human Development, Michigan State University, Lansing, MI, United States","Department of Pediatrics, Texas Tech University Health Sciences Center, Odessa, TX, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics and Human Development, Michigan State University, Lansing, MI, United States","institution_ids":["https://openalex.org/I87216513"]},{"raw_affiliation_string":"Department of Pediatrics, Texas Tech University Health Sciences Center, Odessa, TX, United States","institution_ids":["https://openalex.org/I926076166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075315199","display_name":"Nastassia M. Navasiolava","orcid":"https://orcid.org/0000-0002-6405-6498","observed_orcids":["https://orcid.org/0000-0002-6405-6498"]},"institutions":[{"id":"https://openalex.org/I4210112910","display_name":"Centre Hospitalier Universitaire d'Angers","ror":"https://ror.org/0250ngj72","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210112910"]},{"id":"https://openalex.org/I49451733","display_name":"Universit\u00e9 d'Angers","ror":"https://ror.org/04yrqp957","country_code":"FR","type":"education","lineage":["https://openalex.org/I49451733"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nastassia Navasiolava","raw_affiliation_strings":["PXE Reference Centre (MAGEC Nord), University Hospital of Angers, Angers, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PXE Reference Centre (MAGEC Nord), University Hospital of Angers, Angers, France","institution_ids":["https://openalex.org/I4210112910","https://openalex.org/I49451733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037544021","display_name":"Barbara Makela","orcid":"https://orcid.org/0009-0000-9785-0279","observed_orcids":["https://orcid.org/0009-0000-9785-0279"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barbara Makela","raw_affiliation_strings":["Department of Animal Science, Michigan State University, East Lansing, MI, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Science, Michigan State University, East Lansing, MI, United States","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033907234","display_name":"Isoken Nicholas Olomu","orcid":"https://orcid.org/0000-0002-2774-6879","observed_orcids":["https://orcid.org/0000-0002-2774-6879"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Isoken Olomu","raw_affiliation_strings":["Department of Pediatrics and Human Development, Michigan State University, Lansing, MI, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics and Human Development, Michigan State University, Lansing, MI, United States","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034900254","display_name":"Robert Long","orcid":"https://orcid.org/0000-0002-2532-7734","observed_orcids":["https://orcid.org/0000-0002-2532-7734"]},"institutions":[{"id":"https://openalex.org/I1308791923","display_name":"Sparrow Health System","ror":"https://ror.org/00y30az25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1308791923"]},{"id":"https://openalex.org/I2800531617","display_name":"Sparrow Hospital","ror":"https://ror.org/018dx8725","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800531617"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Long","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Sparrow Hospital, Lansing, MI, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Sparrow Hospital, Lansing, MI, United States","institution_ids":["https://openalex.org/I1308791923","https://openalex.org/I2800531617"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069555361","display_name":"Koen van de Wetering","orcid":"https://orcid.org/0000-0003-1905-2743","observed_orcids":["https://orcid.org/0000-0003-1905-2743"]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Koen van de Wetering","raw_affiliation_strings":["Department of Dermatology and Cutaneous Biology, PXE International Center of Excellence in Research and Clinical Care, Thomas Jefferson University, Philadelphia, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology and Cutaneous Biology, PXE International Center of Excellence in Research and Clinical Care, Thomas Jefferson University, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ludovic Martin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I926076166","display_name":"Texas Tech University Health Sciences Center","ror":"https://ror.org/033ztpr93","country_code":"US","type":"education","lineage":["https://openalex.org/I926076166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ludovic Martin","raw_affiliation_strings":["Department of Pediatrics, Texas Tech University Health Sciences Center, Odessa, TX, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Texas Tech University Health Sciences Center, Odessa, TX, United States","institution_ids":["https://openalex.org/I926076166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041466906","display_name":"Tam\u00e1s Ar\u00e1nyi","orcid":"https://orcid.org/0000-0002-2087-6275","observed_orcids":["https://orcid.org/0000-0002-2087-6275"]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]},{"id":"https://openalex.org/I4210151515","display_name":"Institute of Molecular Life Sciences","ror":"https://ror.org/04t4pws42","country_code":"HU","type":"facility","lineage":["https://openalex.org/I4210151515","https://openalex.org/I4387152226","https://openalex.org/I80251312"]},{"id":"https://openalex.org/I80251312","display_name":"HUN-REN Research Centre for Natural Sciences","ror":"https://ror.org/03zwxja46","country_code":"HU","type":"facility","lineage":["https://openalex.org/I4387152226","https://openalex.org/I80251312"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Tamas Aranyi","raw_affiliation_strings":["Department of Molecular Biology, Semmelweis University, Budapest, Hungary","Institute of Enzymology, Research Centre for Natural Sciences, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Semmelweis University, Budapest, Hungary","institution_ids":["https://openalex.org/I101202996"]},{"raw_affiliation_string":"Institute of Enzymology, Research Centre for Natural Sciences, Budapest, Hungary","institution_ids":["https://openalex.org/I4210151515","https://openalex.org/I80251312"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016576159","display_name":"Fl\u00f3ra Szeri","orcid":"https://orcid.org/0000-0003-2572-6820","observed_orcids":["https://orcid.org/0000-0003-2572-6820"]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]},{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]},{"id":"https://openalex.org/I4210151515","display_name":"Institute of Molecular Life Sciences","ror":"https://ror.org/04t4pws42","country_code":"HU","type":"facility","lineage":["https://openalex.org/I4210151515","https://openalex.org/I4387152226","https://openalex.org/I80251312"]},{"id":"https://openalex.org/I80251312","display_name":"HUN-REN Research Centre for Natural Sciences","ror":"https://ror.org/03zwxja46","country_code":"HU","type":"facility","lineage":["https://openalex.org/I4387152226","https://openalex.org/I80251312"]}],"countries":["HU","US"],"is_corresponding":true,"raw_author_name":"Flora Szeri","raw_affiliation_strings":["Department of Biochemistry, Semmelweis University, Budapest, Hungary","Department of Dermatology and Cutaneous Biology, PXE International Center of Excellence in Research and Clinical Care, Thomas Jefferson University, Philadelphia, PA, United States","Institute of Enzymology, Research Centre for Natural Sciences, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Semmelweis University, Budapest, Hungary","institution_ids":["https://openalex.org/I101202996"]},{"raw_affiliation_string":"Department of Dermatology and Cutaneous Biology, PXE International Center of Excellence in Research and Clinical Care, Thomas Jefferson University, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I149251103"]},{"raw_affiliation_string":"Institute of Enzymology, Research Centre for Natural Sciences, Budapest, Hungary","institution_ids":["https://openalex.org/I4210151515","https://openalex.org/I80251312"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5016576159","https://openalex.org/A5052065231"],"corresponding_institution_ids":["https://openalex.org/I101202996","https://openalex.org/I149251103","https://openalex.org/I39422238","https://openalex.org/I4210151515","https://openalex.org/I80251312","https://openalex.org/I87216513"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":2.086,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.88216433,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"8","issue":null,"first_page":"573727","last_page":"573727"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13453","display_name":"Alkaline Phosphatase Research Studies","score":0.6187000274658203,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13453","display_name":"Alkaline Phosphatase Research Studies","score":0.6187000274658203,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12924","display_name":"Dermatological and Skeletal Disorders","score":0.33079999685287476,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.04569999873638153,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inorganic-pyrophosphate","display_name":"inorganic pyrophosphate","score":0.9760000109672546},{"id":"https://openalex.org/keywords/multiparity","display_name":"multiparity","score":0.8389999866485596},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.8949999809265137},{"id":"https://openalex.org/keywords/alkaline-phosphatase","display_name":"alkaline phosphatase","score":0.9800000190734863},{"id":"https://openalex.org/keywords/vascular-calcification","display_name":"vascular calcification","score":0.921999990940094},{"id":"https://openalex.org/keywords/pregnancy","display_name":"pregnancy","score":0.7670000195503235},{"id":"https://openalex.org/keywords/pseudoxanthoma-elasticum","display_name":"pseudoxanthoma elasticum","score":0.8730000257492065},{"id":"https://openalex.org/keywords/maternal-cardiovascular-health","display_name":"maternal cardiovascular health","score":0.6470000147819519},{"id":"https://openalex.org/keywords/sheep-model","display_name":"sheep model","score":0.6340000033378601}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6703293323516846},{"id":"https://openalex.org/C2776043855","wikidata":"https://www.wikidata.org/wiki/Q55506489","display_name":"Pyrophosphate","level":3,"score":0.599524736404419},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.5770249962806702},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5645537972450256},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5528627038002014},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.523076593875885},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.49339571595191956},{"id":"https://openalex.org/C2780309369","wikidata":"https://www.wikidata.org/wiki/Q933382","display_name":"Calcification","level":2,"score":0.44113877415657043},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3856956958770752},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.3582991361618042},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1340540051460266},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11458706855773926},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.06794935464859009},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.3389/fcell.2020.573727","doi":"https://doi.org/10.3389/fcell.2020.573727","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2020.573727","pdf_url":"https://www.frontiersin.org/articles/10.3389/fcell.2020.573727/pdf","source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},{"id":"pmid:33363139","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33363139","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in cell and developmental biology","raw_type":"Journal Article"},{"id":"pmh:oai:real.mtak.hu:130864","doi":null,"is_oa":false,"landing_page_url":"http://real.mtak.hu/130864/1/VeigaLopezfcell-08-573727.pdf","pdf_url":"http://real.mtak.hu/130864/1/VeigaLopezfcell-08-573727.pdf","source":{"id":"https://openalex.org/S4306400081","display_name":"Repository of the Academy's Library (Library of the Hungarian Academy of Sciences)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210140733","host_organization_name":"Library and Information Centre of the Hungarian Academy of Sciences","host_organization_lineage":["https://openalex.org/I4210140733"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7755719","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7755719","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Cell Dev Biol","raw_type":"Text"},{"id":"pmh:oai:jdc.jefferson.edu:dcbfp-1157","doi":null,"is_oa":true,"landing_page_url":"https://jdc.jefferson.edu/dcbfp/146","pdf_url":null,"source":{"id":"https://openalex.org/S4210178181","display_name":"The Medicine Forum","issn_l":"2325-2863","issn":["2325-2863"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Department of Dermatology and Cutaneous Biology Faculty Papers","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:0e19ec4c0e4646a7a51ae27de92c76b0","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/0e19ec4c0e4646a7a51ae27de92c76b0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cell and Developmental Biology, Vol 8 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fcell.2020.573727","doi":"https://doi.org/10.3389/fcell.2020.573727","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2020.573727","pdf_url":"https://www.frontiersin.org/articles/10.3389/fcell.2020.573727/pdf","source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8500000238418579}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1338257073","display_name":null,"funder_award_id":"FK131946","funder_id":"https://openalex.org/F4320326762","funder_display_name":"Nemzeti Kutat\u00e1si Fejleszt\u00e9si \u00e9s Innov\u00e1ci\u00f3s Hivatal"},{"id":"https://openalex.org/G1771284032","display_name":null,"funder_award_id":"R01 AR072695","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G1891623479","display_name":null,"funder_award_id":"CA16115","funder_id":"https://openalex.org/F4320320366","funder_display_name":"European Cooperation in Science and Technology"},{"id":"https://openalex.org/G4248390578","display_name":null,"funder_award_id":"Bolyai J\u00e1nos Fellowship BO/00730/19/8","funder_id":"https://openalex.org/F4320322192","funder_display_name":"Magyar Tudom\u00e1nyos Akad\u00e9mia"},{"id":"https://openalex.org/G5250730805","display_name":null,"funder_award_id":"BO/00730/19/8","funder_id":"https://openalex.org/F4320322192","funder_display_name":"Magyar Tudom\u00e1nyos Akad\u00e9mia"},{"id":"https://openalex.org/G864042303","display_name":null,"funder_award_id":"R01 ES027863","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G9000064758","display_name":null,"funder_award_id":"R01ES027863","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000163837","display_name":null,"funder_award_id":"R01AR072695","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306113","display_name":"U.S. Department of State","ror":"https://ror.org/03vvynj75"},{"id":"https://openalex.org/F4320306114","display_name":"U.S. Department of Agriculture","ror":"https://ror.org/01na82s61"},{"id":"https://openalex.org/F4320310016","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993"},{"id":"https://openalex.org/F4320320366","display_name":"European Cooperation in Science and Technology","ror":"https://ror.org/01bstzn19"},{"id":"https://openalex.org/F4320322192","display_name":"Magyar Tudom\u00e1nyos Akad\u00e9mia","ror":"https://ror.org/02ks8qq67"},{"id":"https://openalex.org/F4320326762","display_name":"Nemzeti Kutat\u00e1si Fejleszt\u00e9si \u00e9s Innov\u00e1ci\u00f3s Hivatal","ror":null},{"id":"https://openalex.org/F4320328991","display_name":"Innov\u00e1ci\u00f3s \u00e9s Technol\u00f3giai Miniszt\u00e9rium","ror":"https://ror.org/02ey3ab96"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332431","display_name":"College of Engineering, Michigan State University","ror":"https://ror.org/05hs6h993"},{"id":"https://openalex.org/F4320335908","display_name":"Nemzeti Kutat\u00e1si, Fejleszt\u00e9si \u00e9s Innovaci\u00f3s Alap","ror":null},{"id":"https://openalex.org/F4320336675","display_name":"National Research, Development and Innovation Office","ror":null},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3110693683.pdf","grobid_xml":"https://content.openalex.org/works/W3110693683.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1965619867","https://openalex.org/W1973502690","https://openalex.org/W1975186650","https://openalex.org/W1982422183","https://openalex.org/W2002768681","https://openalex.org/W2012626912","https://openalex.org/W2037718729","https://openalex.org/W2054738756","https://openalex.org/W2056015402","https://openalex.org/W2065837798","https://openalex.org/W2066269649","https://openalex.org/W2084422700","https://openalex.org/W2113307617","https://openalex.org/W2116723865","https://openalex.org/W2131795083","https://openalex.org/W2157925286","https://openalex.org/W2224966037","https://openalex.org/W2248110638","https://openalex.org/W2283362891","https://openalex.org/W2321867365","https://openalex.org/W2340055652","https://openalex.org/W2395029293","https://openalex.org/W2489404621","https://openalex.org/W2563005444","https://openalex.org/W2578005842","https://openalex.org/W2601866644","https://openalex.org/W2735738388","https://openalex.org/W2751563717","https://openalex.org/W2752153892","https://openalex.org/W2782451939","https://openalex.org/W2799304124","https://openalex.org/W2802439049","https://openalex.org/W2902796317","https://openalex.org/W2903427490","https://openalex.org/W2904176273","https://openalex.org/W2907975318","https://openalex.org/W2910000388","https://openalex.org/W2910132592","https://openalex.org/W2951942625","https://openalex.org/W2986301094","https://openalex.org/W6712422267"],"related_works":["https://openalex.org/W2340781906","https://openalex.org/W1978473874","https://openalex.org/W2617529330","https://openalex.org/W4283744405","https://openalex.org/W4220871738","https://openalex.org/W2010333723","https://openalex.org/W2063357786","https://openalex.org/W1997425710","https://openalex.org/W1980328948","https://openalex.org/W2117802681"],"abstract_inverted_index":{"Epidemiological":[0],"studies":[1],"indicate":[2],"that":[3,19,37,74,141,156],"elevated":[4,69],"alkaline":[5,62,65,114],"phosphatase":[6,66,115],"activity":[7,67],"is":[8,58,68,122],"associated":[9,123],"with":[10,124],"increased":[11,28,82,125,145],"cardiovascular":[12,33,87,171,201],"disease":[13,88,172,202],"risk.":[14],"Other":[15],"epidemiological":[16],"data":[17],"demonstrate":[18],"mothers":[20],"giving":[21],"multiple":[22,152],"childbirths":[23],"(multipara)":[24],"are":[25,184],"also":[26],"at":[27,103],"risk":[29,89,173,203],"of":[30,50,61,159,176,178],"developing":[31],"late-onset":[32],"disease.":[34],"We":[35,92,139,154],"hypothesized":[36,73],"these":[38,142],"two":[39],"associations":[40],"stem":[41],"from":[42],"a":[43,59,194],"common":[44],"cause,":[45],"the":[46,51],"insufficient":[47],"plasma":[48,94,136],"level":[49],"ectopic":[52],"mineralization":[53],"inhibitor":[54],"inorganic":[55],"pyrophosphate,":[56],"which":[57],"substrate":[60],"phosphatase.":[63],"As":[64],"in":[70,90,100,105,111,128,204],"pregnancy,":[71,112],"we":[72,118],"pyrophosphate":[75,95,137,160,190],"concentrations":[76],"decrease":[77],"gestationally,":[78],"potentially":[79],"leading":[80],"to":[81,166,186,198],"maternal":[83,200],"vascular":[84,126,146,167],"calcification":[85,127,147,168],"and":[86,98,102,107,169],"multipara.":[91],"investigated":[93],"kinetics":[96],"pre-":[97],"postpartum":[99],"sheep":[101],"term":[104],"humans":[106],"demonstrated":[108,140],"its":[109],"shortage":[110],"mirroring":[113],"activity.":[116],"Next,":[117],"tested":[119],"whether":[120],"multiparity":[121],"pseudoxanthoma":[129],"elasticum":[130],"patients,":[131],"characterized":[132],"by":[133],"low":[134],"intrinsic":[135],"levels.":[138],"patients":[143],"had":[144],"when":[148],"they":[149],"give":[150],"birth":[151],"times.":[153],"propose":[155],"transient":[157],"shortages":[158],"during":[161],"repeated":[162],"pregnancies":[163],"might":[164,192],"contribute":[165],"multiparity-associated":[170],"threatening":[174],"hundreds":[175],"millions":[177],"healthy":[179],"women":[180],"worldwide.":[181],"Future":[182],"trials":[183],"needed":[185],"assess":[187],"if":[188],"gestational":[189],"supplementation":[191],"be":[193],"suitable":[195],"prophylactic":[196],"treatment":[197],"mitigate":[199],"multiparous":[205],"women.":[206]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":3}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2025-10-10T00:00:00"}
