{"id":"https://openalex.org/W3110146473","doi":"https://doi.org/10.5055/jom.2020.0593","title":"In vitro evaluation of a novel immediate-release formulation of oxycodone (RoxyBond\u2122) for the potential for abuse via injection","display_name":"In vitro evaluation of a novel immediate-release formulation of oxycodone (RoxyBond\u2122) for the potential for abuse via injection","publication_year":2020,"publication_date":"2020-09-01","ids":{"openalex":"https://openalex.org/W3110146473","doi":"https://doi.org/10.5055/jom.2020.0593","mag":"3110146473","pmid":"https://pubmed.ncbi.nlm.nih.gov/33226095"},"language":"en","primary_location":{"id":"doi:10.5055/jom.2020.0593","doi":"https://doi.org/10.5055/jom.2020.0593","is_oa":false,"landing_page_url":"https://doi.org/10.5055/jom.2020.0593","pdf_url":null,"source":{"id":"https://openalex.org/S2764961062","display_name":"Journal of Opioid Management","issn_l":"1551-7489","issn":["1551-7489","2375-0146"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Opioid Management","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088188722","display_name":"Eric R. Kinzler","orcid":"https://orcid.org/0000-0001-6601-0699","observed_orcids":["https://orcid.org/0000-0001-6601-0699"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eric R. Kinzler, PhD","raw_affiliation_strings":["Inspirion Delivery Sciences, LLC, Morristown, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inspirion Delivery Sciences, LLC, Morristown, New Jersey","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076825536","display_name":"Carmela Pantaleon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carmela Pantaleon, BS","raw_affiliation_strings":["Inspirion Delivery Sciences, LLC, Morristown, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inspirion Delivery Sciences, LLC, Morristown, New Jersey","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019944133","display_name":"Matthew Iverson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matthew Iverson, MPH","raw_affiliation_strings":["Inspirion Delivery Sciences, LLC, Morristown, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inspirion Delivery Sciences, LLC, Morristown, New Jersey","institution_ids":[]}]},{"author_position":"last","author":{"id":null,"display_name":"Stefan Aigner, MD","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stefan Aigner, MD","raw_affiliation_strings":["Inspirion Delivery Sciences, LLC, Morristown, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inspirion Delivery Sciences, LLC, Morristown, New Jersey","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.2235653,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"16","issue":"5","first_page":"383","last_page":"390"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10576","display_name":"Opioid Use Disorder Treatment","score":0.9580000042915344,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10576","display_name":"Opioid Use Disorder Treatment","score":0.9580000042915344,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.033399999141693115,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oxycodone","display_name":"oxycodone","score":0.9980000257492065},{"id":"https://openalex.org/keywords/abuse-deterrent-formulations","display_name":"abuse-deterrent formulations","score":0.9390000104904175},{"id":"https://openalex.org/keywords/immediate-release-formulation","display_name":"immediate-release formulation","score":0.7749999761581421},{"id":"https://openalex.org/keywords/syringeability","display_name":"syringeability","score":0.7250000238418579},{"id":"https://openalex.org/keywords/opioid-abuse-potential","display_name":"opioid abuse potential","score":0.5389999747276306}],"concepts":[{"id":"https://openalex.org/C2776029756","wikidata":"https://www.wikidata.org/wiki/Q407535","display_name":"Oxycodone","level":4,"score":0.9906272292137146},{"id":"https://openalex.org/C2778571141","wikidata":"https://www.wikidata.org/wiki/Q273318","display_name":"Syringe","level":2,"score":0.7737864255905151},{"id":"https://openalex.org/C3019981671","wikidata":"https://www.wikidata.org/wiki/Q5165929","display_name":"Immediate release","level":2,"score":0.5536957383155823},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5292325019836426},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.497531920671463},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4596436023712158},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3579829931259155},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.2842852473258972},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.26540905237197876},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1224023699760437},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.08310899138450623},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003692","descriptor_name":"Delayed-Action Preparations","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D003692","descriptor_name":"Delayed-Action Preparations","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007267","descriptor_name":"Injections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009293","descriptor_name":"Opioid-Related Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010098","descriptor_name":"Oxycodone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D013607","descriptor_name":"Tablets","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.5055/jom.2020.0593","doi":"https://doi.org/10.5055/jom.2020.0593","is_oa":false,"landing_page_url":"https://doi.org/10.5055/jom.2020.0593","pdf_url":null,"source":{"id":"https://openalex.org/S2764961062","display_name":"Journal of Opioid Management","issn_l":"1551-7489","issn":["1551-7489","2375-0146"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Opioid Management","raw_type":"journal-article"},{"id":"pmid:33226095","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33226095","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of opioid management","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2280346282","https://openalex.org/W2903043895","https://openalex.org/W2937626026","https://openalex.org/W2804595659","https://openalex.org/W2325448898","https://openalex.org/W1837086671","https://openalex.org/W2780688192","https://openalex.org/W2757607441","https://openalex.org/W2526766920","https://openalex.org/W2269673358"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Immediate-release":[1],"(IR)":[2],"oxycodone":[3,37,44,117,140,158,170,196,217,223],"formulations":[4],"may":[5,229],"be":[6,108],"manipulated":[7,54,86,139,220],"for":[8,67],"nonoral":[9],"routes":[10],"of":[11,23,36,63,70,96,115,155,161,177,194],"administration.":[12],"Oxycodone":[13],"abuse-resistant":[14],"immediate-release":[15],"(ARIR)":[16],"is":[17],"a":[18,89,94,111,134,183],"novel":[19],"abuse-deterrent":[20,226],"formulation":[21],"(ADF)":[22],"IR":[24,43,169],"oxycodone.":[25],"This":[26],"study":[27],"aimed":[28],"to":[29,40,80,100,129,211],"assess":[30],"the":[31,78,104,113,186,195],"intravenous":[32],"(IV)":[33],"abuse":[34],"potential":[35],"ARIR":[38,141,218,224],"relative":[39],"commercially":[41],"available":[42],"tablets":[45,55,87,142],"using":[46],"in":[47,58,174],"vitro":[48],"laboratory":[49],"studies.":[50],"DESIGN:":[51],"Intact":[52],"or":[53,60,85],"were":[56,179],"incubated":[57],"5":[59],"10":[61,101],"mL":[62],"room":[64],"temperature":[65],"water":[66],"increasing":[68],"amounts":[69],"time.":[71],"For":[72],"each":[73],"timepoint,":[74],"syringeability,":[75],"defined":[76],"as":[77],"ability":[79],"draw":[81,130],"up":[82],"water-immersed":[83],"intact":[84],"into":[88,110,133,182],"syringe,":[90,112],"was":[91,118,126,198],"assessed":[92],"on":[93],"scale":[95],"1":[97],"(very":[98],"easy)":[99],"(impossible).":[102],"If":[103],"prepared":[105],"sample":[106,162,203],"could":[107],"drawn":[109,181],"proportion":[114],"syringeable":[116],"measured":[119],"analytically.":[120],"RESULTS:":[121],"In":[122,164],"all":[123],"conditions,":[124],"it":[125],"nearly":[127],"impossible":[128],"any":[131],"liquid":[132],"syringe":[135,184],"from":[136,200,216],"samples":[137,148,166],"containing":[138,167],"(N":[143,171],"=":[144,172],"5/group),":[145],"and":[146,189],"most":[147],"released":[149,199],"very":[150],"low":[151],"concentrations":[152],"(<10":[153],"percent)":[154],"their":[156],"total":[157],"content,":[159],"regardless":[160],"volume.":[163],"contrast,":[165],"crushed":[168],"5/group)":[173],"small":[175,202],"volumes":[176,204],"fluid":[178],"easily":[180],"through":[185],"smallest":[187],"needle,":[188],"more":[190],"than":[191],"90":[192],"percent":[193],"content":[197],"relatively":[201],"(5":[205],"mL).":[206],"CONCLUSION:":[207],"The":[208],"difficulty":[209],"required":[210],"prepare":[212],"an":[213],"injectable":[214],"solution":[215],"when":[219],"suggests":[221],"that":[222,228],"has":[225],"properties":[227],"deter":[230],"IV":[231],"abuse.":[232]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-12-07T00:00:00"}