{"id":"https://openalex.org/W3109855652","doi":null,"title":"Gut microbiota, lipid metabolism and systemic inflammation in common variable immunodeficiency: A translational research approach","display_name":"Gut microbiota, lipid metabolism and systemic inflammation in common variable immunodeficiency: A translational research approach","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W3109855652","mag":"3109855652"},"language":"en","primary_location":{"id":"pmh:oai:www.duo.uio.no:10852/79521","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10852/79521","pdf_url":null,"source":{"id":"https://openalex.org/S7407064446","display_name":"NORA - Norwegian Open Research Archives","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10852/79521","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028016570","display_name":"Magnhild Eide Macpherson","orcid":"https://orcid.org/0000-0002-1436-1937","observed_orcids":["https://orcid.org/0000-0002-1436-1937"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Magnhild E. Macpherson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1436-1937","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5028016570"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/common-variable-immunodeficiency","display_name":"common variable immunodeficiency","score":1.0},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.984000027179718},{"id":"https://openalex.org/keywords/systemic-inflammation","display_name":"systemic inflammation","score":0.8809999823570251},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.8659999966621399},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":0.8859999775886536},{"id":"https://openalex.org/keywords/reverse-cholesterol-transport","display_name":"reverse cholesterol transport","score":0.9959999918937683},{"id":"https://openalex.org/keywords/trimethylamine-n-oxide","display_name":"trimethylamine N-oxide","score":0.878000020980835},{"id":"https://openalex.org/keywords/gammaproteobacteria","display_name":"Gammaproteobacteria","score":0.8690000176429749},{"id":"https://openalex.org/keywords/rifaximin","display_name":"rifaximin","score":0.9010000228881836},{"id":"https://openalex.org/keywords/gut-dysbiosis","display_name":"gut dysbiosis","score":0.7129999995231628},{"id":"https://openalex.org/keywords/leaky-gut","display_name":"leaky gut","score":0.675000011920929},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9259999990463257},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.47600001096725464},{"id":"https://openalex.org/keywords/dietary-metabolites","display_name":"dietary metabolites","score":0.46399998664855957},{"id":"https://openalex.org/keywords/autoimmune-complications","display_name":"autoimmune complications","score":0.4699999988079071}],"concepts":[{"id":"https://openalex.org/C2776252253","wikidata":"https://www.wikidata.org/wiki/Q7663815","display_name":"Systemic inflammation","level":3,"score":0.739177942276001},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.6150280237197876},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5717923045158386},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4328327775001526},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.4246505796909332},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4231393337249756},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33500999212265015},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.139864981174469}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:www.duo.uio.no:10852/79521","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10852/79521","pdf_url":null,"source":{"id":"https://openalex.org/S7407064446","display_name":"NORA - Norwegian Open Research Archives","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:3109855652","doi":null,"is_oa":false,"landing_page_url":"https://www.duo.uio.no/handle/10852/79521","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:www.duo.uio.no:10852/79521","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10852/79521","pdf_url":null,"source":{"id":"https://openalex.org/S7407064446","display_name":"NORA - Norwegian Open Research Archives","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W1584774122","https://openalex.org/W1707729952","https://openalex.org/W1968105193","https://openalex.org/W1978562653","https://openalex.org/W1995839977","https://openalex.org/W2006069224","https://openalex.org/W2025324713","https://openalex.org/W2033239478","https://openalex.org/W2035451300","https://openalex.org/W2044638285","https://openalex.org/W2046971089","https://openalex.org/W2052044919","https://openalex.org/W2078599166","https://openalex.org/W2090711753","https://openalex.org/W2103658609","https://openalex.org/W2104296550","https://openalex.org/W2104792420","https://openalex.org/W2115944543","https://openalex.org/W2117457769","https://openalex.org/W2119611594","https://openalex.org/W2129401794","https://openalex.org/W2157846073","https://openalex.org/W2162078360","https://openalex.org/W2166562121","https://openalex.org/W2167637859","https://openalex.org/W2207436601","https://openalex.org/W2231380317","https://openalex.org/W2232990799","https://openalex.org/W2288501492","https://openalex.org/W2298390267","https://openalex.org/W2342943125","https://openalex.org/W2407875089","https://openalex.org/W2550560946","https://openalex.org/W2556034984","https://openalex.org/W2559332652","https://openalex.org/W2598218405","https://openalex.org/W2600079312","https://openalex.org/W2626783532","https://openalex.org/W2751157908","https://openalex.org/W2755539188","https://openalex.org/W2767806634","https://openalex.org/W2800130846","https://openalex.org/W2884821735","https://openalex.org/W2892844483","https://openalex.org/W2905026338","https://openalex.org/W2912153799","https://openalex.org/W2912980869","https://openalex.org/W2922018554","https://openalex.org/W2953962533"],"related_works":["https://openalex.org/W3086564962","https://openalex.org/W3188048417","https://openalex.org/W2298390267","https://openalex.org/W4384928395","https://openalex.org/W2564714625","https://openalex.org/W4361277651","https://openalex.org/W2953962533","https://openalex.org/W3178107643","https://openalex.org/W4406466866","https://openalex.org/W3208763690"],"abstract_inverted_index":{"Patients":[0],"with":[1,29,117,138,185],"common":[2],"variable":[3],"immunodeficiency":[4],"(CVID)":[5],"have":[6],"a":[7,69,200,239],"dysfunctional":[8],"immune":[9],"system":[10],"leading":[11],"to":[12,38,59,63,149,166,182,218,249,268],"recurrent":[13],"infections":[14],"while":[15],"also":[16,115],"frequently":[17],"suffering":[18],"non-infectious":[19,25],"autoimmune":[20,65],"and":[21,43,66,85,122,143,194,196,206,225,257,259],"inflammatory":[22,67,140,191],"complications.":[23],"These":[24],"complications":[26],"are":[27,161],"connected":[28],"higher":[30],"mortality":[31],"rates.\\n\\nThe":[32],"aim":[33],"of":[34,52,107,120,132,179,189,242],"this":[35],"thesis":[36],"was":[37],"explore":[39],"the":[40,49,76,118,130,168,222,235],"gut":[41,82,97,111,164,180,203,210,236,260],"microbiome":[42],"novel":[44,265],"molecular":[45],"mechanisms":[46],"involved":[47],"in":[48,55,57,90,129,156,208,213,253,273],"underlying":[50],"pathogenesis":[51],"systemic":[53,88,108,219,251,271],"inflammation":[54,89,109,207,220,252,272],"CVID":[56,91,133,157,173,214],"order":[58],"identify":[60],"therapeutic":[61,266],"targets":[62,267],"reduce":[64,269],"manifestations.\\n\\nThrough":[68],"randomized":[70],"controlled":[71],"trial,":[72],"we":[73,123,175],"tested":[74],"if":[75],"oral":[77,243],"antibiotic":[78,244],"rifaximin":[79,94,245],"would":[80],"alter":[81],"microbial":[83,98,211,261],"composition":[84,262],"thereby":[86],"modulate":[87],"patients.":[92,134,158],"Indeed,":[93],"decreased":[95],"their":[96],"diversity,":[99],"but":[100],"did":[101],"not":[102,247],"significantly":[103,154],"change":[104],"any":[105],"markers":[106,141,192],"or":[110],"leakage.":[112],"\\n\\nGut":[113],"microbes":[114,165],"interact":[116],"regulation":[119],"lipids":[121],"found":[124,176],"reduced":[125,230],"HDL":[126,136,146,255],"cholesterol":[127,151,232],"levels":[128,188,256],"plasma":[131,187],"Low":[135],"correlated":[137],"raised":[139,186],"CRP":[142],"sCD25.":[144],"Important":[145],"functions,":[147],"related":[148],"reverse":[150,231],"transport,":[152],"were":[153],"impaired":[155],"\\nDietary":[159],"nutrients":[160],"metabolized":[162],"by":[163],"form":[167],"organic":[169],"compound":[170],"TMAO.":[171],"In":[172],"patients,":[174],"an":[177],"abundance":[178],"Gammaproteobacteria":[181],"be":[183],"associated":[184],"TMAO,":[190],"TNF":[193],"IL-12":[195],"lipopolysaccharide.":[197],"This":[198],"indicates":[199],"connection":[201],"between":[202],"leakage,":[204],"TMAO":[205,224],"CVID.\\nOverall,":[209],"dysbiosis":[212],"patients":[215],"appears":[216],"linked":[217],"through":[221],"metabolite":[223],"altered":[226],"lipid":[227],"metabolism":[228],"via":[229],"transport.":[233],"Modulating":[234],"microbiota":[237],"using":[238],"short-term":[240],"course":[241],"is":[246],"sufficient":[248],"affect":[250],"CVID.":[254,274],"function":[258],"emerge":[263],"as":[264],"sterile":[270]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2020-12-07T00:00:00"}
