{"id":"https://openalex.org/W3109761237","doi":"https://doi.org/10.1177/1352458520978218","title":"Oral nomegestrol acetate and transdermal 17-beta-estradiol for preventing post-partum relapses in multiple sclerosis: The POPARTMUS study","display_name":"Oral nomegestrol acetate and transdermal 17-beta-estradiol for preventing post-partum relapses in multiple sclerosis: The POPARTMUS study","publication_year":2020,"publication_date":"2020-12-03","ids":{"openalex":"https://openalex.org/W3109761237","doi":"https://doi.org/10.1177/1352458520978218","mag":"3109761237","pmid":"https://pubmed.ncbi.nlm.nih.gov/33269975"},"language":"en","primary_location":{"id":"doi:10.1177/1352458520978218","doi":"https://doi.org/10.1177/1352458520978218","is_oa":false,"landing_page_url":"https://doi.org/10.1177/1352458520978218","pdf_url":null,"source":{"id":"https://openalex.org/S136332993","display_name":"Multiple Sclerosis Journal","issn_l":"1352-4585","issn":["1352-4585","1477-0970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Multiple Sclerosis Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025662371","display_name":"Sandra Vukusic","orcid":"https://orcid.org/0000-0001-7337-7122","observed_orcids":["https://orcid.org/0000-0001-7337-7122"]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210095118","display_name":"Centre de Recherche en Neurosciences de Lyon","ror":"https://ror.org/00pdd0432","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I4210095118","https://openalex.org/I4210096427","https://openalex.org/I4405259976"]},{"id":"https://openalex.org/I4210100596","display_name":"Hospices Civils de Lyon","ror":"https://ror.org/01502ca60","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596"]},{"id":"https://openalex.org/I4210104295","display_name":"Observatoire Fran\u00e7ais de la Scl\u00e9rose en Plaques","ror":"https://ror.org/01a0pgd23","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210104295"]},{"id":"https://openalex.org/I4210105768","display_name":"H\u00f4pital Pierre Wertheimer","ror":"https://ror.org/01q046q46","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596","https://openalex.org/I4210105768"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sandra Vukusic","raw_affiliation_strings":["Service de neurologie, scl\u00e9rose en plaques, pathologies de la my\u00e9line et neuro-inflammation et Fondation Eug\u00e8ne Devic EDMUS pour la Scl\u00e9rose en Plaques, H\u00f4pital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Lyon-Bron, France/Centre des Neurosciences de Lyon, INSERM 1028 et CNRS UMR5292, Observatoire Fran\u00e7ais de la Scl\u00e9rose en Plaques, Lyon, France/Universit\u00e9 Claude Bernard Lyon 1, Villeurbanne, France"],"raw_orcid":"https://orcid.org/0000-0001-7337-7122","affiliations":[{"raw_affiliation_string":"Service de neurologie, scl\u00e9rose en plaques, pathologies de la my\u00e9line et neuro-inflammation et Fondation Eug\u00e8ne Devic EDMUS pour la Scl\u00e9rose en Plaques, H\u00f4pital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Lyon-Bron, France/Centre des Neurosciences de Lyon, INSERM 1028 et CNRS UMR5292, Observatoire Fran\u00e7ais de la Scl\u00e9rose en Plaques, Lyon, France/Universit\u00e9 Claude Bernard Lyon 1, Villeurbanne, France","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210095118","https://openalex.org/I4210100596","https://openalex.org/I4210104295","https://openalex.org/I4210105768"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108257243","display_name":"Iuliana Ionescu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100596","display_name":"Hospices Civils de Lyon","ror":"https://ror.org/01502ca60","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596"]},{"id":"https://openalex.org/I4210104295","display_name":"Observatoire Fran\u00e7ais de la Scl\u00e9rose en Plaques","ror":"https://ror.org/01a0pgd23","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210104295"]},{"id":"https://openalex.org/I4210105768","display_name":"H\u00f4pital Pierre Wertheimer","ror":"https://ror.org/01q046q46","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596","https://openalex.org/I4210105768"]},{"id":"https://openalex.org/I4405278896","display_name":"Fondation des Hospices Civils de Lyon","ror":"https://ror.org/00qkezx35","country_code":"FR","type":"funder","lineage":["https://openalex.org/I4405278896"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Iuliana Ionescu","raw_affiliation_strings":["Service de neurologie, scl\u00e9rose en plaques, pathologies de la my\u00e9line et neuro-inflammation et Fondation Eug\u00e8ne Devic EDMUS pour la Scl\u00e9rose en Plaques, H\u00f4pital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Lyon-Bron, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de neurologie, scl\u00e9rose en plaques, pathologies de la my\u00e9line et neuro-inflammation et Fondation Eug\u00e8ne Devic EDMUS pour la Scl\u00e9rose en Plaques, H\u00f4pital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Lyon-Bron, France","institution_ids":["https://openalex.org/I4210100596","https://openalex.org/I4210104295","https://openalex.org/I4210105768","https://openalex.org/I4405278896"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086968740","display_name":"Catherine Cornu","orcid":"https://orcid.org/0000-0002-1829-812X","observed_orcids":["https://orcid.org/0000-0002-1829-812X"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210100596","display_name":"Hospices Civils de Lyon","ror":"https://ror.org/01502ca60","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596"]},{"id":"https://openalex.org/I4210135640","display_name":"Laboratoire de Biom\u00e9trie et Biologie Evolutive","ror":"https://ror.org/03skt0t88","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I1326498283","https://openalex.org/I203339264","https://openalex.org/I4210100596","https://openalex.org/I4210104684","https://openalex.org/I4210107625","https://openalex.org/I4210135640"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Catherine Cornu","raw_affiliation_strings":["Centre d\u2019Investigation Clinique INSERM1407, Hospices Civils de Lyon, Lyon, France/Service de Pharmaco-toxicologie, Lyon, France/UMR5558, Claude Bernard University, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre d\u2019Investigation Clinique INSERM1407, Hospices Civils de Lyon, Lyon, France/Service de Pharmaco-toxicologie, Lyon, France/UMR5558, Claude Bernard University, Lyon, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210100596","https://openalex.org/I4210135640"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071020046","display_name":"Nadine Bossard","orcid":"https://orcid.org/0000-0001-8643-9169","observed_orcids":["https://orcid.org/0000-0001-8643-9169"]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I203339264","display_name":"Universit\u00e9 de Lyon","ror":"https://ror.org/01rk35k63","country_code":"FR","type":"education","lineage":["https://openalex.org/I203339264"]},{"id":"https://openalex.org/I4210100596","display_name":"Hospices Civils de Lyon","ror":"https://ror.org/01502ca60","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596"]},{"id":"https://openalex.org/I4210135640","display_name":"Laboratoire de Biom\u00e9trie et Biologie Evolutive","ror":"https://ror.org/03skt0t88","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I1326498283","https://openalex.org/I203339264","https://openalex.org/I4210100596","https://openalex.org/I4210104684","https://openalex.org/I4210107625","https://openalex.org/I4210135640"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nadine Bossard","raw_affiliation_strings":["Hospices Civils de Lyon, P\u00f4le Sant\u00e9 Publique, Service de Biostatistique\u2013Bioinformatique, Lyon, France/Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, CNRS, UMR 5558, Laboratoire de Biom\u00e9trie et Biologie \u00c9volutive, \u00c9quipe Biostatistique-Sant\u00e9, Villeurbanne, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospices Civils de Lyon, P\u00f4le Sant\u00e9 Publique, Service de Biostatistique\u2013Bioinformatique, Lyon, France/Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, CNRS, UMR 5558, Laboratoire de Biom\u00e9trie et Biologie \u00c9volutive, \u00c9quipe Biostatistique-Sant\u00e9, Villeurbanne, France","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I203339264","https://openalex.org/I4210100596","https://openalex.org/I4210135640"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101518202","display_name":"Fran\u00e7oise Durand\u2010Dubief","orcid":"https://orcid.org/0000-0002-2860-1700","observed_orcids":["https://orcid.org/0000-0002-2860-1700"]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I203339264","display_name":"Universit\u00e9 de Lyon","ror":"https://ror.org/01rk35k63","country_code":"FR","type":"education","lineage":["https://openalex.org/I203339264"]},{"id":"https://openalex.org/I4210100596","display_name":"Hospices Civils de Lyon","ror":"https://ror.org/01502ca60","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596"]},{"id":"https://openalex.org/I4210105768","display_name":"H\u00f4pital Pierre Wertheimer","ror":"https://ror.org/01q046q46","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596","https://openalex.org/I4210105768"]},{"id":"https://openalex.org/I4210138704","display_name":"Centre de Recherche en Acquisition et Traitement de l'Image pour la Sant\u00e9","ror":"https://ror.org/03smk3872","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I4210095849","https://openalex.org/I4210100596","https://openalex.org/I4210105738","https://openalex.org/I4210138704","https://openalex.org/I4210159245","https://openalex.org/I4405259976","https://openalex.org/I48430043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fran\u00e7oise Durand-Dubief","raw_affiliation_strings":["Service de neurologie, scl\u00e9rose en plaques, pathologies de la my\u00e9line et neuro-inflammation et Fondation Eug\u00e8ne Devic EDMUS pour la Scl\u00e9rose en Plaques, H\u00f4pital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Lyon-Bron, France/CREATIS, UMR 5220 CNRS & U1044 Inserm, Universit\u00e9 Claude Bernard Lyon1, Universit\u00e9 de Lyon, Villeurbanne, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de neurologie, scl\u00e9rose en plaques, pathologies de la my\u00e9line et neuro-inflammation et Fondation Eug\u00e8ne Devic EDMUS pour la Scl\u00e9rose en Plaques, H\u00f4pital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Lyon-Bron, France/CREATIS, UMR 5220 CNRS & U1044 Inserm, Universit\u00e9 Claude Bernard Lyon1, Universit\u00e9 de Lyon, Villeurbanne, France","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I4210100596","https://openalex.org/I4210105768","https://openalex.org/I4210138704"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007107044","display_name":"Fran\u00e7ois Cotton","orcid":"https://orcid.org/0000-0003-0046-2478","observed_orcids":["https://orcid.org/0000-0003-0046-2478"]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I203339264","display_name":"Universit\u00e9 de Lyon","ror":"https://ror.org/01rk35k63","country_code":"FR","type":"education","lineage":["https://openalex.org/I203339264"]},{"id":"https://openalex.org/I4210100596","display_name":"Hospices Civils de Lyon","ror":"https://ror.org/01502ca60","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596"]},{"id":"https://openalex.org/I4210113288","display_name":"H\u00f4pital Lyon Sud","ror":"https://ror.org/023xgd207","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596","https://openalex.org/I4210113288"]},{"id":"https://openalex.org/I4210138704","display_name":"Centre de Recherche en Acquisition et Traitement de l'Image pour la Sant\u00e9","ror":"https://ror.org/03smk3872","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I4210095849","https://openalex.org/I4210100596","https://openalex.org/I4210105738","https://openalex.org/I4210138704","https://openalex.org/I4210159245","https://openalex.org/I4405259976","https://openalex.org/I48430043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fran\u00e7ois Cotton","raw_affiliation_strings":["CREATIS, UMR 5220 CNRS & U1044 Inserm, Universit\u00e9 Claude Bernard Lyon1, Universit\u00e9 de Lyon, Villeurbanne, France/Service de Radiologie, Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon, Lyon, France"],"raw_orcid":"https://orcid.org/0000-0003-0046-2478","affiliations":[{"raw_affiliation_string":"CREATIS, UMR 5220 CNRS & U1044 Inserm, Universit\u00e9 Claude Bernard Lyon1, Universit\u00e9 de Lyon, Villeurbanne, France/Service de Radiologie, Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon, Lyon, France","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I4210100596","https://openalex.org/I4210113288","https://openalex.org/I4210138704"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071503464","display_name":"Luca Durelli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luca Durelli","raw_affiliation_strings":["Clinical and Biological Sciences Department, University of Torino, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical and Biological Sciences Department, University of Torino, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091582045","display_name":"Romain Marignier","orcid":"https://orcid.org/0000-0002-5967-2800","observed_orcids":["https://orcid.org/0000-0002-5967-2800"]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210095118","display_name":"Centre de Recherche en Neurosciences de Lyon","ror":"https://ror.org/00pdd0432","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I4210095118","https://openalex.org/I4210096427","https://openalex.org/I4405259976"]},{"id":"https://openalex.org/I4210100596","display_name":"Hospices Civils de Lyon","ror":"https://ror.org/01502ca60","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596"]},{"id":"https://openalex.org/I4210105768","display_name":"H\u00f4pital Pierre Wertheimer","ror":"https://ror.org/01q046q46","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596","https://openalex.org/I4210105768"]},{"id":"https://openalex.org/I4405278896","display_name":"Fondation des Hospices Civils de Lyon","ror":"https://ror.org/00qkezx35","country_code":"FR","type":"funder","lineage":["https://openalex.org/I4405278896"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Romain Marignier","raw_affiliation_strings":["Service de neurologie, scl\u00e9rose en plaques, pathologies de la my\u00e9line et neuro-inflammation et Fondation Eug\u00e8ne Devic EDMUS pour la Scl\u00e9rose en Plaques, H\u00f4pital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Lyon-Bron, France/Universit\u00e9 Claude Bernard Lyon 1, Villeurbanne, France/Centre des Neurosciences de Lyon, INSERM 1028 et CNRS UMR5292, Fluid team, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de neurologie, scl\u00e9rose en plaques, pathologies de la my\u00e9line et neuro-inflammation et Fondation Eug\u00e8ne Devic EDMUS pour la Scl\u00e9rose en Plaques, H\u00f4pital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Lyon-Bron, France/Universit\u00e9 Claude Bernard Lyon 1, Villeurbanne, France/Centre des Neurosciences de Lyon, INSERM 1028 et CNRS UMR5292, Fluid team, Lyon, France","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210095118","https://openalex.org/I4210100596","https://openalex.org/I4210105768","https://openalex.org/I4405278896"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036619456","display_name":"Laurence Gignoux","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100596","display_name":"Hospices Civils de Lyon","ror":"https://ror.org/01502ca60","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596"]},{"id":"https://openalex.org/I4210104295","display_name":"Observatoire Fran\u00e7ais de la Scl\u00e9rose en Plaques","ror":"https://ror.org/01a0pgd23","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210104295"]},{"id":"https://openalex.org/I4210105768","display_name":"H\u00f4pital Pierre Wertheimer","ror":"https://ror.org/01q046q46","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596","https://openalex.org/I4210105768"]},{"id":"https://openalex.org/I4405278896","display_name":"Fondation des Hospices Civils de Lyon","ror":"https://ror.org/00qkezx35","country_code":"FR","type":"funder","lineage":["https://openalex.org/I4405278896"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Laurence Gignoux","raw_affiliation_strings":["Service de neurologie, scl\u00e9rose en plaques, pathologies de la my\u00e9line et neuro-inflammation et Fondation Eug\u00e8ne Devic EDMUS pour la Scl\u00e9rose en Plaques, H\u00f4pital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Lyon-Bron, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de neurologie, scl\u00e9rose en plaques, pathologies de la my\u00e9line et neuro-inflammation et Fondation Eug\u00e8ne Devic EDMUS pour la Scl\u00e9rose en Plaques, H\u00f4pital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Lyon-Bron, France","institution_ids":["https://openalex.org/I4210100596","https://openalex.org/I4210104295","https://openalex.org/I4210105768","https://openalex.org/I4405278896"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064342215","display_name":"David Axel Laplaud","orcid":"https://orcid.org/0000-0001-6113-6938","observed_orcids":["https://orcid.org/0000-0001-6113-6938"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I3019204325","display_name":"Centre Hospitalier Universitaire de Nantes","ror":"https://ror.org/05c1qsg97","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019204325"]},{"id":"https://openalex.org/I4210128055","display_name":"Centre d'Investigation Clinique de Nantes","ror":"https://ror.org/02ct41845","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I3019204325","https://openalex.org/I4210105774","https://openalex.org/I4210128055"]},{"id":"https://openalex.org/I4392021198","display_name":"Center for Research in Transplantation and Translational Immunology","ror":"https://ror.org/01165k395","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4392021198","https://openalex.org/I97188460"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"David-Axel Laplaud","raw_affiliation_strings":["CHU de Nantes, Service de Neurologie & CIC015 INSERM, Nantes, France, INSERM CR1064, Nantes, France","Centre de Recherche en Transplantation et Immunologie"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHU de Nantes, Service de Neurologie & CIC015 INSERM, Nantes, France, INSERM CR1064, Nantes, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I3019204325","https://openalex.org/I4210128055"]},{"raw_affiliation_string":"Centre de Recherche en Transplantation et Immunologie","institution_ids":["https://openalex.org/I4392021198"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109136521","display_name":"Thibault Moreau","orcid":"https://orcid.org/0009-0001-1130-7214","observed_orcids":["https://orcid.org/0009-0001-1130-7214","https://orcid.org/0009-0000-2965-0400"]},"institutions":[{"id":"https://openalex.org/I4210116240","display_name":"CHU Dijon Bourgogne","ror":"https://ror.org/0377z4z10","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210116240"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Thibault Moreau","raw_affiliation_strings":["Department of Neurology, EA4184, University Hospital of Dijon, Dijon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, EA4184, University Hospital of Dijon, Dijon, France","institution_ids":["https://openalex.org/I4210116240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047268222","display_name":"Pierre Clavelou","orcid":"https://orcid.org/0000-0003-2363-9352","observed_orcids":["https://orcid.org/0000-0003-2363-9352"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I198244214","display_name":"Universit\u00e9 Clermont Auvergne","ror":"https://ror.org/01a8ajp46","country_code":"FR","type":"education","lineage":["https://openalex.org/I198244214"]},{"id":"https://openalex.org/I4210123525","display_name":"Physiopathologie et pharmacologie de la douleur et de la migraine","ror":"https://ror.org/028m9sy08","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210123525","https://openalex.org/I4210155509"]},{"id":"https://openalex.org/I4210128870","display_name":"Centre Hospitalier Universitaire de Clermont-Ferrand","ror":"https://ror.org/02tcf7a68","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210128870"]},{"id":"https://openalex.org/I4405259134","display_name":"Universit\u00e9 de Clermont I","ror":"https://ror.org/01stqnn06","country_code":"FR","type":"education","lineage":["https://openalex.org/I198244214","https://openalex.org/I4405259134"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pierre Clavelou","raw_affiliation_strings":["Service de Neurologie, CHU Clermont-Ferrand, Clermont-Ferrand, France/Inserm U1107, Clermont Universit\u00e9, Universit\u00e9 d\u2019Auvergne, Neuro-Dol, Clermont-Ferrand, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de Neurologie, CHU Clermont-Ferrand, Clermont-Ferrand, France/Inserm U1107, Clermont Universit\u00e9, Universit\u00e9 d\u2019Auvergne, Neuro-Dol, Clermont-Ferrand, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210123525","https://openalex.org/I4210128870","https://openalex.org/I4405259134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011213325","display_name":"Jerome De Seze","orcid":"https://orcid.org/0000-0002-7197-7578","observed_orcids":["https://orcid.org/0000-0002-7197-7578"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J\u00e9r\u00f4me De Seze","raw_affiliation_strings":["Department of Neurology and Clinical Investigation Center, CHU de Strasbourg, INSERM, Strasbourg, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology and Clinical Investigation Center, CHU de Strasbourg, INSERM, Strasbourg, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105838820","display_name":"Marc Debouverie","orcid":"https://orcid.org/0000-0002-6659-6148","observed_orcids":["https://orcid.org/0000-0002-6659-6148"]},"institutions":[{"id":"https://openalex.org/I4210100260","display_name":"Centre Hospitalier R\u00e9gional et Universitaire de Nancy","ror":"https://ror.org/016ncsr12","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100260"]},{"id":"https://openalex.org/I4387156389","display_name":"Interdisciplinarit\u00e9 en Sant\u00e9 Publique Interventions et Instruments de mesure complexes \u2013 R\u00e9gion Est","ror":"https://ror.org/04dx32582","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4387156389","https://openalex.org/I90183372"]},{"id":"https://openalex.org/I90183372","display_name":"Universit\u00e9 de Lorraine","ror":"https://ror.org/04vfs2w97","country_code":"FR","type":"education","lineage":["https://openalex.org/I90183372"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marc Debouverie","raw_affiliation_strings":["EA 4360 Apemac, Lorraine University, Nancy, France/Department of Neurology, Nancy University Hospital, Nancy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EA 4360 Apemac, Lorraine University, Nancy, France/Department of Neurology, Nancy University Hospital, Nancy, France","institution_ids":["https://openalex.org/I4210100260","https://openalex.org/I4387156389","https://openalex.org/I90183372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103222133","display_name":"David Brassat","orcid":"https://orcid.org/0000-0001-6430-305X","observed_orcids":["https://orcid.org/0000-0001-6430-305X"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4387153827","display_name":"Institut Toulousain des Maladies Infectieuses et Inflammatoires","ror":"https://ror.org/00n90tt57","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4387153827","https://openalex.org/I4405258862"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"David Brassat","raw_affiliation_strings":["P\u00f4le Neurosciences, CHU Toulouse Purpan, Toulouse, France/INSERM U1043-CNRS UMR 5282, Universit\u00e9 Toulouse III, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"P\u00f4le Neurosciences, CHU Toulouse Purpan, Toulouse, France/INSERM U1043-CNRS UMR 5282, Universit\u00e9 Toulouse III, Toulouse, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I134560555","https://openalex.org/I154526488","https://openalex.org/I4387153827"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054006135","display_name":"Jean Pelletier","orcid":"https://orcid.org/0000-0001-9730-7567","observed_orcids":["https://orcid.org/0000-0001-9730-7567"]},"institutions":[{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210162909","display_name":"H\u00f4pital de la Timone","ror":"https://ror.org/05jrr4320","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I21491767","https://openalex.org/I4210087487","https://openalex.org/I4210162909"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean Pelletier","raw_affiliation_strings":["Aix Marseille Univ, APHM, H\u00f4pital de la Timone, P\u00f4le de Neurosciences Cliniques, Service de Neurologie, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aix Marseille Univ, APHM, H\u00f4pital de la Timone, P\u00f4le de Neurosciences Cliniques, Service de Neurologie, Marseille, France","institution_ids":["https://openalex.org/I21491767","https://openalex.org/I4210162909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079607840","display_name":"Christine Lebrun\u2010Fr\u00e9nay","orcid":"https://orcid.org/0000-0002-3713-2416","observed_orcids":["https://orcid.org/0000-0002-3713-2416"]},"institutions":[{"id":"https://openalex.org/I4400573299","display_name":"Unit\u00e9 de Recherche Clinique C\u00f4te d'Azur","ror":"https://ror.org/059h7s745","country_code":"FR","type":"facility","lineage":["https://openalex.org/I201841394","https://openalex.org/I4400573299"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Christine Lebrun-Frenay","raw_affiliation_strings":["CRCSEP Department of Neurology, UR2CA URRIS, Nice, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CRCSEP Department of Neurology, UR2CA URRIS, Nice, France","institution_ids":["https://openalex.org/I4400573299"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002642951","display_name":"Emmanuelle Le Page","orcid":"https://orcid.org/0000-0002-7849-2266","observed_orcids":["https://orcid.org/0000-0002-7849-2266"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210116274","display_name":"CIC Rennes","ror":"https://ror.org/02baj6743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210105774","https://openalex.org/I4210116274","https://openalex.org/I4210155724","https://openalex.org/I56067802"]},{"id":"https://openalex.org/I4210124872","display_name":"H\u00f4pital Pontchaillou","ror":"https://ror.org/02r25sw81","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210124872","https://openalex.org/I4210155724"]},{"id":"https://openalex.org/I4210155724","display_name":"Centre Hospitalier Universitaire de Rennes","ror":"https://ror.org/05qec5a53","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210155724"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Emmanuelle Le Page","raw_affiliation_strings":["Clinical Neuroscience Centre, CIC-P 1414 INSERM, Rennes University Hospital, Rennes, France","CHU Pontchaillou [Rennes]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Neuroscience Centre, CIC-P 1414 INSERM, Rennes University Hospital, Rennes, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210116274","https://openalex.org/I4210155724"]},{"raw_affiliation_string":"CHU Pontchaillou [Rennes]","institution_ids":["https://openalex.org/I4210124872","https://openalex.org/I4210155724"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106085645","display_name":"Giovanni Castelnovo","orcid":"https://orcid.org/0000-0002-9796-3529","observed_orcids":["https://orcid.org/0000-0002-9796-3529"]},"institutions":[{"id":"https://openalex.org/I4210104607","display_name":"Centre Hospitalier Universitaire de N\u00eemes","ror":"https://ror.org/0275ye937","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210104607"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Giovanni Castelnovo","raw_affiliation_strings":["Department of Neurology, CHU N\u00eemes, H\u00f4pital Caremeau, N\u00eemes Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, CHU N\u00eemes, H\u00f4pital Caremeau, N\u00eemes Cedex, France","institution_ids":["https://openalex.org/I4210104607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108073441","display_name":"\u00c9ric Berger","orcid":"https://orcid.org/0000-0002-5003-9793","observed_orcids":["https://orcid.org/0000-0002-5003-9793"]},"institutions":[{"id":"https://openalex.org/I4210087978","display_name":"Centre Hospitalier Universitaire de Besan\u00e7on","ror":"https://ror.org/0084te143","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210087978"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Eric Berger","raw_affiliation_strings":["Department of Neurology, CHU Besan\u00e7on, Besan\u00e7on, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, CHU Besan\u00e7on, Besan\u00e7on, France","institution_ids":["https://openalex.org/I4210087978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070134975","display_name":"Patrick Hautec\u0153ur","orcid":"https://orcid.org/0000-0003-4419-6482","observed_orcids":["https://orcid.org/0000-0003-4419-6482"]},"institutions":[{"id":"https://openalex.org/I4210137780","display_name":"Groupe Hospitalier de l'Institut Catholique de Lille","ror":"https://ror.org/03wr2ty35","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I181827316","https://openalex.org/I4210137780"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Patrick Hautecoeur","raw_affiliation_strings":["Service de Neurologie, Groupe Hospitalier de l\u2019Institut Catholique de Lille, Lille Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de Neurologie, Groupe Hospitalier de l\u2019Institut Catholique de Lille, Lille Cedex, France","institution_ids":["https://openalex.org/I4210137780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103979472","display_name":"Olivier Heinzlef","orcid":"https://orcid.org/0000-0002-4634-8542","observed_orcids":["https://orcid.org/0000-0002-4634-8542"]},"institutions":[{"id":"https://openalex.org/I4210109121","display_name":"Centre Hospitalier Intercommunal de Poissy","ror":"https://ror.org/015qy8r18","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210109121"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Olivier Heinzlef","raw_affiliation_strings":["Neurology Department, Hospital of Poissy-St-Germain en Laye, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Department, Hospital of Poissy-St-Germain en Laye, Paris, France","institution_ids":["https://openalex.org/I4210109121"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023725739","display_name":"Mar\u00eda Trojano","orcid":"https://orcid.org/0000-0002-6329-8946","observed_orcids":["https://orcid.org/0000-0002-6329-8946"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria Trojano","raw_affiliation_strings":["Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari, Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari, Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071409158","display_name":"Francesco Patti","orcid":"https://orcid.org/0000-0002-6923-0846","observed_orcids":["https://orcid.org/0000-0002-6923-0846"]},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Patti","raw_affiliation_strings":["Department of Medical and Surgical Sciences, and Advanced Technologies, GF Ingrassia, Multiple Sclerosis Center, University of Catania, Catania, Italy"],"raw_orcid":"https://orcid.org/0000-0002-6923-0846","affiliations":[{"raw_affiliation_string":"Department of Medical and Surgical Sciences, and Advanced Technologies, GF Ingrassia, Multiple Sclerosis Center, University of Catania, Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105781312","display_name":"\u00c9tienne-\u00c9mile Baulieu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4405254696","display_name":"Maladies et hormones du syst\u00e8me nerveux","ror":"https://ror.org/024c3xj78","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I277688954","https://openalex.org/I4405254696"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Etienne-Emile Baulieu","raw_affiliation_strings":["INSERM U 1195, Le Kremlin-Bic\u00eatre, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U 1195, Le Kremlin-Bic\u00eatre, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4405254696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047805728","display_name":"Laurent Remontet","orcid":"https://orcid.org/0000-0003-3393-4216","observed_orcids":["https://orcid.org/0000-0003-3393-4216"]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I203339264","display_name":"Universit\u00e9 de Lyon","ror":"https://ror.org/01rk35k63","country_code":"FR","type":"education","lineage":["https://openalex.org/I203339264"]},{"id":"https://openalex.org/I4210100596","display_name":"Hospices Civils de Lyon","ror":"https://ror.org/01502ca60","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596"]},{"id":"https://openalex.org/I4210135640","display_name":"Laboratoire de Biom\u00e9trie et Biologie Evolutive","ror":"https://ror.org/03skt0t88","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I1326498283","https://openalex.org/I203339264","https://openalex.org/I4210100596","https://openalex.org/I4210104684","https://openalex.org/I4210107625","https://openalex.org/I4210135640"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Laurent Remontet","raw_affiliation_strings":["Hospices Civils de Lyon, P\u00f4le Sant\u00e9 Publique, Service de Biostatistique\u2013Bioinformatique, Lyon, France/Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, CNRS, UMR 5558, Laboratoire de Biom\u00e9trie et Biologie \u00c9volutive, \u00c9quipe Biostatistique-Sant\u00e9, Villeurbanne, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospices Civils de Lyon, P\u00f4le Sant\u00e9 Publique, Service de Biostatistique\u2013Bioinformatique, Lyon, France/Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, CNRS, UMR 5558, Laboratoire de Biom\u00e9trie et Biologie \u00c9volutive, \u00c9quipe Biostatistique-Sant\u00e9, Villeurbanne, France","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I203339264","https://openalex.org/I4210100596","https://openalex.org/I4210135640"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103541336","display_name":"Martine El\u2010Etr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4405254696","display_name":"Maladies et hormones du syst\u00e8me nerveux","ror":"https://ror.org/024c3xj78","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I277688954","https://openalex.org/I4405254696"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Martine El-Etr","raw_affiliation_strings":["INSERM U 1195, Le Kremlin-Bic\u00eatre, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U 1195, Le Kremlin-Bic\u00eatre, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4405254696"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":39,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":1.1425,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.77780218,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"27","issue":"9","first_page":"1458","last_page":"1463"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11964","display_name":"Pregnancy and Medication Impact","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10786","display_name":"Maternal Mental Health During Pregnancy and Postpartum","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.9929999709129333},{"id":"https://openalex.org/keywords/postpartum-relapse","display_name":"postpartum relapse","score":0.8379999995231628},{"id":"https://openalex.org/keywords/nomegestrol-acetate","display_name":"nomegestrol acetate","score":0.9359999895095825},{"id":"https://openalex.org/keywords/transdermal-estradiol","display_name":"transdermal estradiol","score":0.8870000243186951},{"id":"https://openalex.org/keywords/sex-steroids","display_name":"sex steroids","score":0.9139999747276306},{"id":"https://openalex.org/keywords/pregnancy","display_name":"pregnancy","score":0.6919999718666077},{"id":"https://openalex.org/keywords/annualized-relapse-rate","display_name":"annualized relapse rate","score":0.8830000162124634},{"id":"https://openalex.org/keywords/relapse-prevention","display_name":"relapse prevention","score":0.4970000088214874}],"concepts":[{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.773292601108551},{"id":"https://openalex.org/C205679159","wikidata":"https://www.wikidata.org/wiki/Q3375179","display_name":"Transdermal","level":2,"score":0.7581636905670166},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.705866813659668},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.6772910356521606},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.4871787428855896},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.444327175617218},{"id":"https://openalex.org/C3018745865","wikidata":"https://www.wikidata.org/wiki/Q749115","display_name":"Postpartum period","level":3,"score":0.41536980867385864},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3658550977706909},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.3392640948295593},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.26612067222595215},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.08442619442939758},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008535","descriptor_name":"Megestrol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009649","descriptor_name":"Norpregnadienes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049590","descriptor_name":"Postpartum Period","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1177/1352458520978218","doi":"https://doi.org/10.1177/1352458520978218","is_oa":false,"landing_page_url":"https://doi.org/10.1177/1352458520978218","pdf_url":null,"source":{"id":"https://openalex.org/S136332993","display_name":"Multiple Sclerosis Journal","issn_l":"1352-4585","issn":["1352-4585","1477-0970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Multiple Sclerosis Journal","raw_type":"journal-article"},{"id":"pmid:33269975","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33269975","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Multiple sclerosis (Houndmills, Basingstoke, England)","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-03101890v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-03101890","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Multiple Sclerosis Journal, 2021, 27 (9), pp.1458-1463. ⟨10.1177/1352458520978218⟩","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G720919035","display_name":"Infrastructure de Recherche Translationnelle pour les Bioth\u00e9rapies en Neurosciences","funder_award_id":"ANR-11-INBS-0011","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G8113336368","display_name":"Observatoire Fran\u00e7ais de la Scl\u00e9rose en Plaques","funder_award_id":"ANR-10-COHO-0002","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"}],"funders":[{"id":"https://openalex.org/F4320307357","display_name":"Myelin Project","ror":"https://ror.org/03z8jr008"},{"id":"https://openalex.org/F4320309737","display_name":"Fondation pour l'Aide \u00e0 la Recherche sur la Scl\u00e9rose en Plaques","ror":"https://ror.org/04gyrp304"},{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320322734","display_name":"Minist\u00e8re des Affaires Sociales et de la Sant\u00e9","ror":"https://ror.org/01wp0c315"},{"id":"https://openalex.org/F4320325321","display_name":"Association Europ\u00e9enne contre les Leucodystrophies","ror":"https://ror.org/03wtxje77"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1974728262","https://openalex.org/W1990877903","https://openalex.org/W2010369234","https://openalex.org/W2015885823","https://openalex.org/W2063591769","https://openalex.org/W2105490558","https://openalex.org/W2106115061","https://openalex.org/W2135551891","https://openalex.org/W2142710970","https://openalex.org/W2319459971"],"related_works":["https://openalex.org/W2074791447","https://openalex.org/W2211297114","https://openalex.org/W2175470508","https://openalex.org/W4283321184","https://openalex.org/W2008586010","https://openalex.org/W1968741714","https://openalex.org/W4389437196","https://openalex.org/W2291440747","https://openalex.org/W2169936175","https://openalex.org/W2183243867"],"abstract_inverted_index":{"Background:":[0],"Sex":[1],"steroids":[2,83],"could":[3],"explain":[4],"the":[5,16],"course":[6],"of":[7,100],"multiple":[8],"sclerosis":[9],"(MS)":[10],"in":[11,24,43,104],"pregnancy.":[12],"Objective:":[13],"To":[14],"compare":[15],"annualized":[17],"relapse":[18],"rate":[19],"(ARR)":[20],"12":[21,80],"weeks":[22,81],"post-partum":[23,106],"women":[25,44],"treated":[26],"with":[27,45],"nomegestrol":[28],"acetate":[29],"(NOMAc)":[30],"and":[31,52],"17-beta-estradiol":[32],"(E2)":[33],"versus":[34],"placebo.":[35,58],"Methods:":[36],"POPARTMUS":[37,96],"is":[38],"a":[39,101],"randomized,":[40],"proof-of-concept":[41],"trial":[42],"MS,":[46],"receiving":[47],"oral":[48],"NOMAc":[49],"10":[50],"mg/day":[51],"transdermal":[53],"estradiol":[54],"75":[55],"\u00b5g/week,":[56],"or":[57],"Results:":[59],"Recruitment":[60],"was":[61,75],"stopped":[62],"prematurely":[63],"due":[64],"to":[65],"slow":[66],"inclusions":[67],"(":[68,91],"n":[69],"=":[70,84,88,93],"202).":[71],"No":[72],"treatment":[73],"effect":[74],"observed":[76],"on":[77],"ARR":[78],"after":[79],"(sex":[82],"0.90":[85],"(0.58\u20131.39),":[86],"placebo":[87],"0.97":[89],"(0.63\u20131.50)":[90],"p":[92],"0.79)).":[94],"Conclusion:":[95],"failed":[97],"showing":[98],"efficacy":[99],"NOMAc\u2013E2":[102],"combination":[103],"preventing":[105],"relapses.":[107]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2020-12-07T00:00:00"}