{"id":"https://openalex.org/W3108900765","doi":"https://doi.org/10.1038/s41598-020-77916-z","title":"Changes of protein levels in human urine reflect the dysregulation of signaling pathways of chronic kidney disease and its complications","display_name":"Changes of protein levels in human urine reflect the dysregulation of signaling pathways of chronic kidney disease and its complications","publication_year":2020,"publication_date":"2020-11-27","ids":{"openalex":"https://openalex.org/W3108900765","doi":"https://doi.org/10.1038/s41598-020-77916-z","mag":"3108900765","pmid":"https://pubmed.ncbi.nlm.nih.gov/33247215","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7699629"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-020-77916-z","doi":"https://doi.org/10.1038/s41598-020-77916-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-020-77916-z","pdf_url":"https://www.nature.com/articles/s41598-020-77916-z.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-020-77916-z.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017482403","display_name":"Yiming Hao","orcid":"https://orcid.org/0000-0001-9374-2369","observed_orcids":["https://orcid.org/0000-0001-9374-2369"]},"institutions":[{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiming Hao","raw_affiliation_strings":["Shanghai Key Laboratory of Health Identification and Assessment/Laboratory of TCM Four Diagnostic Information, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Key Laboratory of Health Identification and Assessment/Laboratory of TCM Four Diagnostic Information, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China","institution_ids":["https://openalex.org/I4210098460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011552333","display_name":"Luis Ta\u00f1\u00f3n Reyes","orcid":"https://orcid.org/0000-0002-2067-2571","observed_orcids":["https://orcid.org/0000-0002-2067-2571"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luis Tanon Reyes","raw_affiliation_strings":["Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL, 33612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL, 33612, USA","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083088049","display_name":"Robert Morris","orcid":"https://orcid.org/0000-0002-6994-0602","observed_orcids":["https://orcid.org/0000-0002-6994-0602"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Morris","raw_affiliation_strings":["Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL, 33612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL, 33612, USA","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101613293","display_name":"Yifeng Xu","orcid":"https://orcid.org/0000-0002-0403-1141","observed_orcids":["https://orcid.org/0000-0002-0403-1141"]},"institutions":[{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yifeng Xu","raw_affiliation_strings":["Shanghai Key Laboratory of Health Identification and Assessment/Laboratory of TCM Four Diagnostic Information, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Key Laboratory of Health Identification and Assessment/Laboratory of TCM Four Diagnostic Information, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China","institution_ids":["https://openalex.org/I4210098460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100662109","display_name":"Yiqin Wang","orcid":"https://orcid.org/0000-0002-0280-7495","observed_orcids":["https://orcid.org/0000-0002-0280-7495"]},"institutions":[{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yiqin Wang","raw_affiliation_strings":["Shanghai Key Laboratory of Health Identification and Assessment/Laboratory of TCM Four Diagnostic Information, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. wangyiqin2380@sina.com","Shanghai Key Laboratory of Health Identification and Assessment/Laboratory of TCM Four Diagnostic Information, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Key Laboratory of Health Identification and Assessment/Laboratory of TCM Four Diagnostic Information, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. wangyiqin2380@sina.com","institution_ids":["https://openalex.org/I4210098460"]},{"raw_affiliation_string":"Shanghai Key Laboratory of Health Identification and Assessment/Laboratory of TCM Four Diagnostic Information, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China","institution_ids":["https://openalex.org/I4210098460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001475931","display_name":"Feng Cheng","orcid":"https://orcid.org/0000-0003-3619-8090","observed_orcids":["https://orcid.org/0000-0003-3619-8090"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Feng Cheng","raw_affiliation_strings":["Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL, 33612, USA. fcheng1@usf.edu","Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL, 33612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL, 33612, USA. fcheng1@usf.edu","institution_ids":["https://openalex.org/I2613432"]},{"raw_affiliation_string":"Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL, 33612, USA","institution_ids":["https://openalex.org/I2613432"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5001475931","https://openalex.org/A5100662109"],"corresponding_institution_ids":["https://openalex.org/I2613432","https://openalex.org/I4210098460"],"apc_list":{"value":1870,"currency":"USD","value_usd":1870},"apc_paid":{"value":1870,"currency":"USD","value_usd":1870},"fwci":0.3138,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.61765303,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"10","issue":"1","first_page":"20743","last_page":"20743"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.6557999849319458,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.6557999849319458,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.08749999850988388,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.08089999854564667,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":1.0},{"id":"https://openalex.org/keywords/signaling-pathways","display_name":"signaling pathways","score":0.4959999918937683},{"id":"https://openalex.org/keywords/chemokine-signaling","display_name":"chemokine signaling","score":0.7689999938011169},{"id":"https://openalex.org/keywords/cytokine-cytokine-receptor-interaction","display_name":"cytokine-cytokine receptor interaction","score":0.9980000257492065},{"id":"https://openalex.org/keywords/oxidative-phosphorylation","display_name":"oxidative phosphorylation","score":0.9829999804496765},{"id":"https://openalex.org/keywords/ckd-complications","display_name":"CKD complications","score":0.7519999742507935},{"id":"https://openalex.org/keywords/non-invasive-diagnosis","display_name":"non-invasive diagnosis","score":0.6859999895095825},{"id":"https://openalex.org/keywords/differential-protein-abundance","display_name":"differential protein abundance","score":0.6610000133514404},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"pathogenesis","score":0.37599998712539673}],"concepts":[{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.5836787223815918},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5455779433250427},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4738260507583618},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.4716818928718567},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4352218210697174},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3800731599330902},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3338492512702942},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.20239561796188354},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19190871715545654},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.15223053097724915}],"mesh":[{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/s41598-020-77916-z","doi":"https://doi.org/10.1038/s41598-020-77916-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-020-77916-z","pdf_url":"https://www.nature.com/articles/s41598-020-77916-z.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7699629","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7699629","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:33247215","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33247215","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/s41598-020-77916-z","doi":"https://doi.org/10.1038/s41598-020-77916-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-020-77916-z","pdf_url":"https://www.nature.com/articles/s41598-020-77916-z.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.7400000095367432,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G4857466348","display_name":null,"funder_award_id":"81703982","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321881","display_name":"Shanghai Municipal Education Commission","ror":"https://ror.org/05tewj457"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3108900765.pdf","grobid_xml":"https://content.openalex.org/works/W3108900765.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W780055371","https://openalex.org/W1558687037","https://openalex.org/W1915016592","https://openalex.org/W1970024336","https://openalex.org/W1974003496","https://openalex.org/W1983118617","https://openalex.org/W1992254012","https://openalex.org/W1995922531","https://openalex.org/W2012499933","https://openalex.org/W2031004071","https://openalex.org/W2038713498","https://openalex.org/W2045672578","https://openalex.org/W2074586251","https://openalex.org/W2078214948","https://openalex.org/W2083562156","https://openalex.org/W2085841495","https://openalex.org/W2112441302","https://openalex.org/W2116149725","https://openalex.org/W2120473562","https://openalex.org/W2122312517","https://openalex.org/W2124052044","https://openalex.org/W2136122808","https://openalex.org/W2158195068","https://openalex.org/W2165274104","https://openalex.org/W2176513496","https://openalex.org/W2177819816","https://openalex.org/W2269178061","https://openalex.org/W2273655472","https://openalex.org/W2301237734","https://openalex.org/W2409201598","https://openalex.org/W2560441544","https://openalex.org/W2586512445","https://openalex.org/W2745231208","https://openalex.org/W2890081665","https://openalex.org/W2903023054","https://openalex.org/W2907412628","https://openalex.org/W2939879954","https://openalex.org/W2942094185","https://openalex.org/W2966772964","https://openalex.org/W2981653742","https://openalex.org/W2986999055","https://openalex.org/W4211025575","https://openalex.org/W4313341522"],"related_works":["https://openalex.org/W4307210426","https://openalex.org/W2563511065","https://openalex.org/W4401500429","https://openalex.org/W4399783670","https://openalex.org/W1874421288","https://openalex.org/W2334183852","https://openalex.org/W2518581715","https://openalex.org/W3115766272","https://openalex.org/W4397045489","https://openalex.org/W2529160875"],"abstract_inverted_index":{"The":[0,18,76,219],"increasing":[1],"prevalence":[2],"of":[3,16,20,22,24,62,98,135,234,256],"chronic":[4],"kidney":[5],"disease":[6],"(CKD)":[7],"seriously":[8],"is":[9,50],"threatening":[10],"human":[11],"health":[12],"and":[13,26,36,52,65,95,115,130,137,150,175,202,211,223,236,252,258],"overall":[14],"quality":[15],"life.":[17],"discovery":[19],"biomarkers":[21,43,248],"pathogenesis":[23,233],"CKD":[25,63,83,114,136,160,174,206,235,257],"the":[27,56,60,72,120,127,132,142,156,181,232,250,265],"associated":[28],"complications":[29,139,177,260],"are":[30],"very":[31],"important":[32],"for":[33,231,249],"CDK":[34],"diagnosis":[35,254],"treatment.":[37],"In":[38,205],"this":[39],"paper,":[40],"urine":[41,47,61,109,157,262],"protein":[42,57,68,106,124,221],"were":[44,85,162,178],"investigated":[45],"because":[46],"sample":[48],"collection":[49],"convenient":[51,253],"non-invasive.":[53],"We":[54,90,118],"analyzed":[55],"concentrations":[58],"in":[59,108,155,264],"patients":[64,112,161],"extracted":[66],"abnormal":[67],"signals":[69,222],"comparing":[70,165],"with":[71,113,166],"healthy":[73,116,167],"control":[74],"groups.":[75],"enriched":[77],"signaling":[78,133,188,225],"pathways":[79,134,171,185,226],"that":[80],"may":[81,242],"characterize":[82],"pathology":[84],"identified":[86,131,179],"from":[87,111,159,180],"these":[88],"proteins.":[89,183],"applied":[91],"surface-enhanced":[92],"laser":[93],"desorption":[94],"ionization":[96],"time":[97],"flight":[99],"mass":[100],"spectrometry":[101],"technology":[102],"to":[103,123,173],"detect":[104],"different":[105],"peaks":[107,125],"samples":[110,158],"controls.":[117,168],"searched":[119],"proteins":[121,149,154,214,241],"corresponding":[122],"through":[126,261],"UniProt":[128],"database":[129],"its":[138,176,237,259],"by":[140,164],"using":[141],"NIH":[143],"DAVID":[144],"database.":[145],"42":[146],"low":[147],"abundance":[148,153],"46":[151],"high":[152],"found":[163],"Seven":[169],"KEGG":[170],"related":[172],"regulated":[182,224],"These":[184,239],"included":[186],"chemokine":[187],"pathway,":[189],"cytokine-cytokine":[190],"receptor":[191],"interaction,":[192],"oxidative":[193],"phosphorylation,":[194],"cardiac":[195],"muscle":[196],"contraction,":[197],"Alzheimer's":[198],"disease,":[199,201],"Parkinson's":[200],"salivary":[203],"secretion.":[204],"stages":[207],"2,":[208],"3,":[209],"4,":[210],"5,":[212],"five":[213],"showed":[215],"significantly":[216],"differential":[217,220],"abundances.":[218],"will":[227],"provide":[228],"new":[229],"insight":[230],"complications.":[238],"altered":[240],"also":[243],"be":[244],"used":[245],"as":[246],"novel":[247],"noninvasive":[251],"methods":[255],"testing":[263],"future.":[266]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-12-07T00:00:00"}
