{"id":"https://openalex.org/W3108566705","doi":"https://doi.org/10.1515/labmed-2020-0050","title":"Association of endothelin-1 and cell surface adhesion molecules levels in patients with systemic sclerosis","display_name":"Association of endothelin-1 and cell surface adhesion molecules levels in patients with systemic sclerosis","publication_year":2020,"publication_date":"2020-09-17","ids":{"openalex":"https://openalex.org/W3108566705","doi":"https://doi.org/10.1515/labmed-2020-0050","mag":"3108566705"},"language":"en","primary_location":{"id":"doi:10.1515/labmed-2020-0050","doi":"https://doi.org/10.1515/labmed-2020-0050","is_oa":true,"landing_page_url":"https://doi.org/10.1515/labmed-2020-0050","pdf_url":null,"source":{"id":"https://openalex.org/S4210201932","display_name":"Journal of Laboratory Medicine","issn_l":"0342-3026","issn":["0342-3026","1439-0477","2567-9430","2567-9449"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310313990","host_organization_name":"De Gruyter","host_organization_lineage":["https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Laboratory Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1515/labmed-2020-0050","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067341408","display_name":"Monika Mauli\u016bt\u0117","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173212132","display_name":"Vilnius University","ror":"https://ror.org/03nadee84","country_code":"LT","type":"education","lineage":["https://openalex.org/I173212132"]}],"countries":["LT"],"is_corresponding":false,"raw_author_name":"Monika Mauli\u016bt\u0117","raw_affiliation_strings":["Department of Physiology, Biochemistry, Microbiology and Laboratory Medicine of Biomedical Sciences , Institute of Biomedical Sciences, Faculty of Medicine, Vilnius University , Vilnius , Lithuania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Biochemistry, Microbiology and Laboratory Medicine of Biomedical Sciences , Institute of Biomedical Sciences, Faculty of Medicine, Vilnius University , Vilnius , Lithuania","institution_ids":["https://openalex.org/I173212132"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035707137","display_name":"Rita Rugien\u0117","orcid":"https://orcid.org/0000-0002-2670-647X","observed_orcids":["https://orcid.org/0000-0002-2670-647X"]},"institutions":[{"id":"https://openalex.org/I173212132","display_name":"Vilnius University","ror":"https://ror.org/03nadee84","country_code":"LT","type":"education","lineage":["https://openalex.org/I173212132"]}],"countries":["LT"],"is_corresponding":false,"raw_author_name":"Rita Rugien\u0117","raw_affiliation_strings":["Clinic of Rheumatology, Orthopaedics Traumatology and Reconstructive Surgery , Institute of Clinical Medicine, Faculty of Medicine, Vilnius University , Vilnius , Lithuania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinic of Rheumatology, Orthopaedics Traumatology and Reconstructive Surgery , Institute of Clinical Medicine, Faculty of Medicine, Vilnius University , Vilnius , Lithuania","institution_ids":["https://openalex.org/I173212132"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102941894","display_name":"Vytautas \u017d\u0117kas","orcid":"https://orcid.org/0000-0002-4650-2597","observed_orcids":["https://orcid.org/0000-0002-4650-2597"]},"institutions":[{"id":"https://openalex.org/I173212132","display_name":"Vilnius University","ror":"https://ror.org/03nadee84","country_code":"LT","type":"education","lineage":["https://openalex.org/I173212132"]}],"countries":["LT"],"is_corresponding":true,"raw_author_name":"Vytautas \u017d\u0117kas","raw_affiliation_strings":["Department of Physiology, Biochemistry, Microbiology and Laboratory Medicine of Biomedical Sciences , Institute of Biomedical Sciences, Faculty of Medicine, Vilnius University , Vilnius , Lithuania"],"raw_orcid":"https://orcid.org/0000-0002-4650-2597","affiliations":[{"raw_affiliation_string":"Department of Physiology, Biochemistry, Microbiology and Laboratory Medicine of Biomedical Sciences , Institute of Biomedical Sciences, Faculty of Medicine, Vilnius University , Vilnius , Lithuania","institution_ids":["https://openalex.org/I173212132"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048277936","display_name":"Loreta Bagdonait\u0117","orcid":"https://orcid.org/0000-0003-1221-3487","observed_orcids":["https://orcid.org/0000-0003-1221-3487"]},"institutions":[{"id":"https://openalex.org/I173212132","display_name":"Vilnius University","ror":"https://ror.org/03nadee84","country_code":"LT","type":"education","lineage":["https://openalex.org/I173212132"]}],"countries":["LT"],"is_corresponding":false,"raw_author_name":"Loreta Bagdonait\u0117","raw_affiliation_strings":["Department of Physiology, Biochemistry, Microbiology and Laboratory Medicine of Biomedical Sciences , Institute of Biomedical Sciences, Faculty of Medicine, Vilnius University , Vilnius , Lithuania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Biochemistry, Microbiology and Laboratory Medicine of Biomedical Sciences , Institute of Biomedical Sciences, Faculty of Medicine, Vilnius University , Vilnius , Lithuania","institution_ids":["https://openalex.org/I173212132"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5102941894"],"corresponding_institution_ids":["https://openalex.org/I173212132"],"apc_list":{"value":1000,"currency":"EUR","value_usd":1130},"apc_paid":{"value":1000,"currency":"EUR","value_usd":1130},"fwci":0.644,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.68493233,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"44","issue":"6","first_page":"343","last_page":"347"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endothelin-1","display_name":"endothelin-1","score":0.9679999947547913},{"id":"https://openalex.org/keywords/systemic-sclerosis","display_name":"systemic sclerosis","score":0.9649999737739563},{"id":"https://openalex.org/keywords/icam-1","display_name":"ICAM-1","score":0.8759999871253967},{"id":"https://openalex.org/keywords/vcam-1","display_name":"VCAM-1","score":0.9929999709129333},{"id":"https://openalex.org/keywords/cell-surface-adhesion-molecules","display_name":"cell surface adhesion molecules","score":0.8410000205039978},{"id":"https://openalex.org/keywords/serum-biomarkers","display_name":"serum biomarkers","score":0.9430000185966492},{"id":"https://openalex.org/keywords/diagnostic-biomarkers","display_name":"diagnostic biomarkers","score":0.6940000057220459},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.7459999918937683},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.7179999947547913},{"id":"https://openalex.org/keywords/fibrotic-diseases","display_name":"fibrotic diseases","score":0.699999988079071}],"concepts":[{"id":"https://openalex.org/C16224149","wikidata":"https://www.wikidata.org/wiki/Q187637","display_name":"Cell adhesion molecule","level":2,"score":0.7136319875717163},{"id":"https://openalex.org/C2776985958","wikidata":"https://www.wikidata.org/wiki/Q14901827","display_name":"VCAM-1","level":4,"score":0.649695634841919},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.622418999671936},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5768781304359436},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.5516020059585571},{"id":"https://openalex.org/C2776252253","wikidata":"https://www.wikidata.org/wiki/Q7663815","display_name":"Systemic inflammation","level":3,"score":0.509233832359314},{"id":"https://openalex.org/C2909375385","wikidata":"https://www.wikidata.org/wiki/Q187637","display_name":"Intercellular Adhesion Molecule-1","level":3,"score":0.5028061866760254},{"id":"https://openalex.org/C84416704","wikidata":"https://www.wikidata.org/wiki/Q188666","display_name":"Adhesion","level":2,"score":0.4681219160556793},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.4680594801902771},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.44758716225624084},{"id":"https://openalex.org/C149601957","wikidata":"https://www.wikidata.org/wiki/Q390566","display_name":"Endothelin 1","level":3,"score":0.44067448377609253},{"id":"https://openalex.org/C2778674544","wikidata":"https://www.wikidata.org/wiki/Q1414805","display_name":"Systemic disease","level":3,"score":0.44063708186149597},{"id":"https://openalex.org/C132155493","wikidata":"https://www.wikidata.org/wiki/Q7558942","display_name":"Soluble cell adhesion molecules","level":4,"score":0.438772052526474},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.43667012453079224},{"id":"https://openalex.org/C144980905","wikidata":"https://www.wikidata.org/wiki/Q24721308","display_name":"Endothelin receptor","level":3,"score":0.42912307381629944},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.41355279088020325},{"id":"https://openalex.org/C185946421","wikidata":"https://www.wikidata.org/wiki/Q3146527","display_name":"ICAM-1","level":3,"score":0.3905239701271057},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3722101151943207},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2900395393371582},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.25734853744506836},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10180896520614624},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.09918418526649475},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1515/labmed-2020-0050","doi":"https://doi.org/10.1515/labmed-2020-0050","is_oa":true,"landing_page_url":"https://doi.org/10.1515/labmed-2020-0050","pdf_url":null,"source":{"id":"https://openalex.org/S4210201932","display_name":"Journal of Laboratory Medicine","issn_l":"0342-3026","issn":["0342-3026","1439-0477","2567-9430","2567-9449"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310313990","host_organization_name":"De Gruyter","host_organization_lineage":["https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Laboratory Medicine","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:2cb0fb028d1b42369676b122cb0a535a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/2cb0fb028d1b42369676b122cb0a535a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Laboratory Medicine, Vol 44, Iss 6, Pp 343-347 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1515/labmed-2020-0050","doi":"https://doi.org/10.1515/labmed-2020-0050","is_oa":true,"landing_page_url":"https://doi.org/10.1515/labmed-2020-0050","pdf_url":null,"source":{"id":"https://openalex.org/S4210201932","display_name":"Journal of Laboratory Medicine","issn_l":"0342-3026","issn":["0342-3026","1439-0477","2567-9430","2567-9449"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310313990","host_organization_name":"De Gruyter","host_organization_lineage":["https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Laboratory Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1943995070","https://openalex.org/W1957936329","https://openalex.org/W1983982569","https://openalex.org/W1989952946","https://openalex.org/W2008702673","https://openalex.org/W2012666847","https://openalex.org/W2025423566","https://openalex.org/W2059156256","https://openalex.org/W2071167496","https://openalex.org/W2091759543","https://openalex.org/W2110647151","https://openalex.org/W2140806503","https://openalex.org/W2162804111","https://openalex.org/W2396463232","https://openalex.org/W2473712726","https://openalex.org/W2749674349","https://openalex.org/W2800282993","https://openalex.org/W4244089942"],"related_works":["https://openalex.org/W2015237288","https://openalex.org/W2161836280","https://openalex.org/W1981403699","https://openalex.org/W29780280","https://openalex.org/W2025423566","https://openalex.org/W2405237752","https://openalex.org/W2390373584","https://openalex.org/W2339259421","https://openalex.org/W2419909250","https://openalex.org/W2889252259"],"abstract_inverted_index":{"Abstract":[0],"Objectives":[1],"Endothelin-1":[2],"(ET-1)":[3],"has":[4],"been":[5],"implicated":[6],"in":[7,61,84,128],"the":[8,45,50,54,62,85,120,123,129,158],"pathogenesis":[9],"of":[10,44,53,56,64,70,89,122,131,141,155,160],"inflammatory":[11],"and":[12,24,37,59,92,113,134,147,157],"fibrotic":[13],"diseases,":[14],"including":[15],"systemic":[16,65,74],"sclerosis.":[17,66],"In":[18],"addition":[19],"to":[20,48],"modulating":[21],"vascular":[22,38],"tone":[23],"extracellular":[25],"matrix":[26],"turnover,":[27],"ET-1":[28,93,100,112,146],"up-regulates":[29],"cell":[30,39],"surface":[31],"adhesion":[32,34,40],"molecules\u2013intercellular":[33],"molecule-1":[35,41],"(ICAM-1)":[36],"(VCAM-1).The":[42],"aim":[43],"study":[46,143],"was":[47,102],"evaluate":[49],"diagnostic":[51],"value":[52],"detection":[55],"ET-1,":[57,132],"VCAM-1":[58,91,105,135,148],"ICAM-1":[60,114,133],"diagnosis":[63],"Methods":[67],"A":[68],"total":[69],"30":[71],"patients":[72,161],"with":[73,104],"sclerosis":[75],"from":[76],"Vilnius":[77],"University":[78],"Hospital":[79],"Santaros":[80],"Clinics":[81],"were":[82,94,116,136],"included":[83],"study.":[86],"Serum":[87],"levels":[88],"ICAM-1,":[90],"assessed":[95,151],"by":[96],"enzyme":[97],"immunoassay.":[98],"Results":[99],"concentration":[101,106],"associated":[103],"(r=0.687;":[107],"p<0.001).":[108],"No":[109],"associations":[110],"between":[111],"concentrations":[115,130],"detected.":[117,137],"Depending":[118],"on":[119],"duration":[121],"disease":[124,166],"no":[125],"significant":[126],"differences":[127],"Conclusions":[138],"The":[139],"results":[140],"this":[142],"indicated":[144],"that":[145],"may":[149],"be":[150],"together":[152],"as":[153],"markers":[154],"inflammation":[156],"identification":[159],"at":[162],"high":[163],"risk":[164],"for":[165],"progression.":[167]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-12-07T00:00:00"}