{"id":"https://openalex.org/W3108345840","doi":"https://doi.org/10.3389/fphar.2020.569373","title":"Multispecies Evaluation of a Long-Acting Tenofovir Alafenamide Subdermal Implant for HIV Prophylaxis","display_name":"Multispecies Evaluation of a Long-Acting Tenofovir Alafenamide Subdermal Implant for HIV Prophylaxis","publication_year":2020,"publication_date":"2020-11-25","ids":{"openalex":"https://openalex.org/W3108345840","doi":"https://doi.org/10.3389/fphar.2020.569373","mag":"3108345840","pmid":"https://pubmed.ncbi.nlm.nih.gov/33536904","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7849190"},"language":"en","primary_location":{"id":"doi:10.3389/fphar.2020.569373","doi":"https://doi.org/10.3389/fphar.2020.569373","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2020.569373","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphar.2020.569373/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fphar.2020.569373/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075413650","display_name":"Manjula Gunawardana","orcid":"https://orcid.org/0000-0002-3137-8669","observed_orcids":["https://orcid.org/0000-0002-3137-8669"]},"institutions":[{"id":"https://openalex.org/I4210086937","display_name":"Oak Crest Institute of Science","ror":"https://ror.org/0006n3612","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210086937"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Manjula Gunawardana","raw_affiliation_strings":["Department of Chemistry, Oak Crest Institute of Science, Monrovia, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Oak Crest Institute of Science, Monrovia, CA, United States","institution_ids":["https://openalex.org/I4210086937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075507401","display_name":"Mariana Remedios-Chan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086937","display_name":"Oak Crest Institute of Science","ror":"https://ror.org/0006n3612","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210086937"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mariana Remedios-Chan","raw_affiliation_strings":["Department of Chemistry, Oak Crest Institute of Science, Monrovia, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Oak Crest Institute of Science, Monrovia, CA, United States","institution_ids":["https://openalex.org/I4210086937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088807876","display_name":"Debbie Sanchez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086937","display_name":"Oak Crest Institute of Science","ror":"https://ror.org/0006n3612","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210086937"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Debbie Sanchez","raw_affiliation_strings":["Department of Chemistry, Oak Crest Institute of Science, Monrovia, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Oak Crest Institute of Science, Monrovia, CA, United States","institution_ids":["https://openalex.org/I4210086937"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Simon Webster","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086937","display_name":"Oak Crest Institute of Science","ror":"https://ror.org/0006n3612","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210086937"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Simon Webster","raw_affiliation_strings":["Department of Chemistry, Oak Crest Institute of Science, Monrovia, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Oak Crest Institute of Science, Monrovia, CA, United States","institution_ids":["https://openalex.org/I4210086937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059201728","display_name":"Patricia Galv\u00e1n","orcid":"https://orcid.org/0000-0002-8153-0307","observed_orcids":["https://orcid.org/0000-0002-8153-0307"]},"institutions":[{"id":"https://openalex.org/I4210086937","display_name":"Oak Crest Institute of Science","ror":"https://ror.org/0006n3612","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210086937"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patricia Galvan","raw_affiliation_strings":["Department of Chemistry, Oak Crest Institute of Science, Monrovia, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Oak Crest Institute of Science, Monrovia, CA, United States","institution_ids":["https://openalex.org/I4210086937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072333256","display_name":"Rob K. Fanter","orcid":"https://orcid.org/0000-0003-2981-4182","observed_orcids":["https://orcid.org/0000-0003-2981-4182"]},"institutions":[{"id":"https://openalex.org/I4210086937","display_name":"Oak Crest Institute of Science","ror":"https://ror.org/0006n3612","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210086937"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rob Fanter","raw_affiliation_strings":["Department of Chemistry, Oak Crest Institute of Science, Monrovia, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Oak Crest Institute of Science, Monrovia, CA, United States","institution_ids":["https://openalex.org/I4210086937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056241558","display_name":"Amalia E. Castonguay","orcid":"https://orcid.org/0000-0002-6358-1784","observed_orcids":["https://orcid.org/0000-0002-6358-1784"]},"institutions":[{"id":"https://openalex.org/I4210086937","display_name":"Oak Crest Institute of Science","ror":"https://ror.org/0006n3612","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210086937"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amalia E. Castonguay","raw_affiliation_strings":["Department of Chemistry, Oak Crest Institute of Science, Monrovia, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Oak Crest Institute of Science, Monrovia, CA, United States","institution_ids":["https://openalex.org/I4210086937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058439987","display_name":"Paul Christopher Webster","orcid":"https://orcid.org/0000-0002-1980-6931","observed_orcids":["https://orcid.org/0000-0002-1980-6931"]},"institutions":[{"id":"https://openalex.org/I4210086937","display_name":"Oak Crest Institute of Science","ror":"https://ror.org/0006n3612","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210086937"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Webster","raw_affiliation_strings":["Department of Chemistry, Oak Crest Institute of Science, Monrovia, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Oak Crest Institute of Science, Monrovia, CA, United States","institution_ids":["https://openalex.org/I4210086937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000453333","display_name":"John A. Moss","orcid":"https://orcid.org/0000-0001-8091-3245","observed_orcids":["https://orcid.org/0000-0001-8091-3245"]},"institutions":[{"id":"https://openalex.org/I4210086937","display_name":"Oak Crest Institute of Science","ror":"https://ror.org/0006n3612","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210086937"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John A. Moss","raw_affiliation_strings":["Department of Chemistry, Oak Crest Institute of Science, Monrovia, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Oak Crest Institute of Science, Monrovia, CA, United States","institution_ids":["https://openalex.org/I4210086937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101585042","display_name":"Joseph Kuo","orcid":"https://orcid.org/0000-0001-8532-9048","observed_orcids":["https://orcid.org/0000-0001-8532-9048"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Kuo","raw_affiliation_strings":["Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, United States","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060217430","display_name":"Philippe A. Gallay","orcid":"https://orcid.org/0000-0002-6151-4764","observed_orcids":["https://orcid.org/0000-0002-6151-4764"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philippe A. Gallay","raw_affiliation_strings":["Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, United States","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027079293","display_name":"Kathleen L. Vincent","orcid":"https://orcid.org/0000-0003-3051-9551","observed_orcids":["https://orcid.org/0000-0003-3051-9551"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathleen L. Vincent","raw_affiliation_strings":["Center for Biomedical Engineering, University of Texas Medical Branch at Galveston, Galveston, TX, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biomedical Engineering, University of Texas Medical Branch at Galveston, Galveston, TX, United States","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014674134","display_name":"Massoud Motamedi","orcid":"https://orcid.org/0000-0003-0733-2588","observed_orcids":["https://orcid.org/0000-0003-0733-2588"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Massoud Motamedi","raw_affiliation_strings":["Center for Biomedical Engineering, University of Texas Medical Branch at Galveston, Galveston, TX, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biomedical Engineering, University of Texas Medical Branch at Galveston, Galveston, TX, United States","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006541191","display_name":"Dana A. Weinberger","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dana Weinberger","raw_affiliation_strings":["Approva Consulting LLC, Boulder, CO, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Approva Consulting LLC, Boulder, CO, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082007029","display_name":"Mark A. Marzinke","orcid":"https://orcid.org/0000-0003-1670-8786","observed_orcids":["https://orcid.org/0000-0003-1670-8786"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark A. Marzinke","raw_affiliation_strings":["Department of Medicine, Johns Hopkins University, Baltimore, MD, United States","Department of Pathology, Johns Hopkins University, Baltimore, MD, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Johns Hopkins University, Baltimore, MD, United States","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Department of Pathology, Johns Hopkins University, Baltimore, MD, United States","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053567182","display_name":"Craig W. Hendrix","orcid":"https://orcid.org/0000-0002-5696-8665","observed_orcids":["https://orcid.org/0000-0002-5696-8665"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Craig W. Hendrix","raw_affiliation_strings":["Department of Medicine, Johns Hopkins University, Baltimore, MD, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Johns Hopkins University, Baltimore, MD, United States","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086096371","display_name":"Marc M. Baum","orcid":"https://orcid.org/0000-0003-1558-5649","observed_orcids":["https://orcid.org/0000-0003-1558-5649"]},"institutions":[{"id":"https://openalex.org/I4210086937","display_name":"Oak Crest Institute of Science","ror":"https://ror.org/0006n3612","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210086937"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Marc M. Baum","raw_affiliation_strings":["Department of Chemistry, Oak Crest Institute of Science, Monrovia, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Oak Crest Institute of Science, Monrovia, CA, United States","institution_ids":["https://openalex.org/I4210086937"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5086096371"],"corresponding_institution_ids":["https://openalex.org/I4210086937"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":0.5497,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.81867993,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"11","issue":null,"first_page":"569373","last_page":"569373"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.6542999744415283,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.6542999744415283,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.23559999465942383,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.04650000110268593,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tenofovir-alafenamide","display_name":"tenofovir alafenamide","score":0.9860000014305115},{"id":"https://openalex.org/keywords/subdermal-implants","display_name":"subdermal implants","score":0.9340000152587891},{"id":"https://openalex.org/keywords/long-acting-antiretroviral-therapy","display_name":"long-acting antiretroviral therapy","score":0.8600000143051147},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.7770000100135803},{"id":"https://openalex.org/keywords/drug-metabolites","display_name":"drug metabolites","score":0.9359999895095825},{"id":"https://openalex.org/keywords/implant-safety","display_name":"implant safety","score":0.8259999752044678},{"id":"https://openalex.org/keywords/mice","display_name":"mice","score":0.6019999980926514},{"id":"https://openalex.org/keywords/sheep","display_name":"sheep","score":0.7770000100135803},{"id":"https://openalex.org/keywords/body-weight","display_name":"body weight","score":0.8209999799728394}],"concepts":[{"id":"https://openalex.org/C2911190787","wikidata":"https://www.wikidata.org/wiki/Q22075912","display_name":"Tenofovir alafenamide","level":5,"score":0.892243504524231},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7131246328353882},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6612876653671265},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.6310420036315918},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.6197623610496521},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.5497848391532898},{"id":"https://openalex.org/C2781411149","wikidata":"https://www.wikidata.org/wiki/Q486975","display_name":"Implant","level":2,"score":0.5360235571861267},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5329813361167908},{"id":"https://openalex.org/C2779496540","wikidata":"https://www.wikidata.org/wiki/Q7239230","display_name":"Pre-exposure prophylaxis","level":5,"score":0.4449272155761719},{"id":"https://openalex.org/C149151106","wikidata":"https://www.wikidata.org/wiki/Q4677569","display_name":"Active metabolite","level":3,"score":0.43675458431243896},{"id":"https://openalex.org/C2779778239","wikidata":"https://www.wikidata.org/wiki/Q422604","display_name":"Emtricitabine","level":5,"score":0.4353906214237213},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.29912200570106506},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.24783915281295776},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.22337722778320312},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.21378692984580994},{"id":"https://openalex.org/C2776939746","wikidata":"https://www.wikidata.org/wiki/Q853451","display_name":"Men who have sex with men","level":4,"score":0.059881746768951416},{"id":"https://openalex.org/C2776983459","wikidata":"https://www.wikidata.org/wiki/Q41083","display_name":"Syphilis","level":3,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fphar.2020.569373","doi":"https://doi.org/10.3389/fphar.2020.569373","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2020.569373","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphar.2020.569373/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},{"id":"pmid:33536904","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33536904","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7849190","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7849190/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Pharmacol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:f61e7354b58c4d35828203f2c4470553","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f61e7354b58c4d35828203f2c4470553","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Pharmacology, Vol 11 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fphar.2020.569373","doi":"https://doi.org/10.3389/fphar.2020.569373","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2020.569373","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphar.2020.569373/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8666543908","display_name":"Systemic Sustained Release Delivery of Antiretroviral Agents for HIV Prevention","funder_award_id":"R01AI120748","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000874350","display_name":"The Johns Hopkins Center for AIDS Research (JHU CFAR)","funder_award_id":"P30AI094189","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000883186","display_name":"Systemic Sustained Release Delivery of Antiretroviral Agents for HIV Prevention","funder_award_id":"R01AI162151","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320308573","display_name":"Gilead Sciences","ror":"https://ror.org/056546b03"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3108345840.pdf","grobid_xml":"https://content.openalex.org/works/W3108345840.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W1538151922","https://openalex.org/W1968724247","https://openalex.org/W1975208950","https://openalex.org/W1982686134","https://openalex.org/W2090044939","https://openalex.org/W2126586950","https://openalex.org/W2163084749","https://openalex.org/W2260141621","https://openalex.org/W2300282509","https://openalex.org/W2318609334","https://openalex.org/W2336093296","https://openalex.org/W2541211369","https://openalex.org/W2603718972","https://openalex.org/W2626393846","https://openalex.org/W2751016010","https://openalex.org/W2789084689","https://openalex.org/W2789526849","https://openalex.org/W2886298684","https://openalex.org/W2893625775","https://openalex.org/W2898749670","https://openalex.org/W2930143524","https://openalex.org/W2945354646","https://openalex.org/W2955223369","https://openalex.org/W2995143937","https://openalex.org/W3035512417"],"related_works":["https://openalex.org/W4280549858","https://openalex.org/W1968724247","https://openalex.org/W4286218975","https://openalex.org/W7155005963","https://openalex.org/W3174556918","https://openalex.org/W4289333731","https://openalex.org/W3024390267","https://openalex.org/W2905268177","https://openalex.org/W4411928208","https://openalex.org/W3112342206"],"abstract_inverted_index":{"New":[0],"HIV-1":[1,31,68,106],"infection":[2,69],"rates":[3],"far":[4],"outpace":[5],"the":[6,18,21,57,77,94,113,119,129,139,142,165],"targets":[7],"set":[8],"by":[9],"global":[10],"health":[11],"organizations,":[12],"despite":[13],"important":[14],"progress":[15],"in":[16,82,124,135,151,156,181],"curbing":[17],"progression":[19],"of":[20,141],"epidemic.":[22],"Long-acting":[23],"(LA)":[24],"formulations":[25],"delivering":[26,56],"antiretroviral":[27],"(ARV)":[28],"agents":[29],"for":[30,70,86,105],"pre-exposure":[32],"prophylaxis":[33],"(PrEP)":[34],"hold":[35,178],"significant":[36,179],"promise,":[37],"potentially":[38],"facilitating":[39],"adherence":[40],"due":[41],"to":[42,47,101,128,164,177],"reduced":[43],"dosing":[44],"frequency":[45],"compared":[46],"oral":[48],"regimens.":[49],"We":[50],"have":[51],"developed":[52],"a":[53],"subdermal":[54,103],"implant":[55],"potent":[58],"ARV":[59],"drug":[60,120,148],"tenofovir":[61],"alafenamide":[62],"that":[63],"could":[64],"provide":[65],"protection":[66],"from":[67,76],"6":[71],"months,":[72],"or":[73],"longer.":[74],"Implants":[75],"same":[78],"lot":[79],"were":[80,131,175],"investigated":[81],"mice":[83],"and":[84,89,112,121,133,147,160],"sheep":[85],"local":[87,158],"safety":[88],"pharmacokinetics":[90],"(PKs).":[91],"Ours":[92],"is":[93],"first":[95],"report":[96],"using":[97],"these":[98],"animal":[99,173],"models":[100,137,174],"evaluate":[102],"implants":[104,130],"PrEP.":[107],"The":[108],"devices":[109],"appeared":[110],"safe,":[111],"plasma":[114],"PKs":[115],"as":[116,118],"well":[117],"metabolite":[122,149],"concentrations":[123,150],"dermal":[125,152],"tissue":[126,153],"adjacent":[127],"studied":[132],"contrasted":[134],"two":[136],"spanning":[138],"extremes":[140],"body":[143],"weight":[144],"spectrum.":[145],"Drug":[146],"are":[154],"key":[155],"assessing":[157],"exposure":[159],"any":[161],"toxicity":[162],"related":[163],"active":[166],"agent.":[167],"Based":[168],"on":[169],"our":[170],"analysis,":[171],"both":[172],"shown":[176],"promise":[180],"LA":[182],"product":[183],"development.":[184]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":7}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-12-07T00:00:00"}
