{"id":"https://openalex.org/W3108310482","doi":"https://doi.org/10.1016/j.msec.2020.111748","title":"Osteogenic differentiation cues of the bone morphogenetic protein-9 (BMP-9) and its recent advances in bone tissue regeneration","display_name":"Osteogenic differentiation cues of the bone morphogenetic protein-9 (BMP-9) and its recent advances in bone tissue regeneration","publication_year":2020,"publication_date":"2020-11-27","ids":{"openalex":"https://openalex.org/W3108310482","doi":"https://doi.org/10.1016/j.msec.2020.111748","mag":"3108310482","pmid":"https://pubmed.ncbi.nlm.nih.gov/33545890","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7867678"},"language":"en","primary_location":{"id":"doi:10.1016/j.msec.2020.111748","doi":"https://doi.org/10.1016/j.msec.2020.111748","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.msec.2020.111748","pdf_url":null,"source":{"id":"https://openalex.org/S43139658","display_name":"Materials Science and Engineering C","issn_l":"0928-4931","issn":["0928-4931","1873-0191"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Materials Science and Engineering: C","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7867678","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032553657","display_name":"Angshuman Bharadwaz","orcid":"https://orcid.org/0000-0001-5348-7252","observed_orcids":["https://orcid.org/0000-0001-5348-7252"]},"institutions":[{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angshuman Bharadwaz","raw_affiliation_strings":["Biomedical Engineering Program, Department of Bioengineering, College of Engineering, The University of Toledo, Toledo, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Engineering Program, Department of Bioengineering, College of Engineering, The University of Toledo, Toledo, OH, USA","institution_ids":["https://openalex.org/I90871651"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072845022","display_name":"Ambalangodage Champa Jayasuriya","orcid":"https://orcid.org/0000-0001-6171-5569","observed_orcids":["https://orcid.org/0000-0001-6171-5569"]},"institutions":[{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ambalangodage C. Jayasuriya","raw_affiliation_strings":["Biomedical Engineering Program, Department of Bioengineering, College of Engineering, The University of Toledo, Toledo, OH, USA; Department of Orthopaedic Surgery, College of Medicine and Life Sciences, The University of Toledo, Toledo, OH, USA. Electronic address: a.jayasuriya@utoledo.edu","Biomedical Engineering Program, Department of Bioengineering, College of Engineering, The University of Toledo, Toledo, OH, USA","Department of Orthopaedic Surgery, College of Medicine and Life Sciences, The University of Toledo, Toledo, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Engineering Program, Department of Bioengineering, College of Engineering, The University of Toledo, Toledo, OH, USA; Department of Orthopaedic Surgery, College of Medicine and Life Sciences, The University of Toledo, Toledo, OH, USA. Electronic address: a.jayasuriya@utoledo.edu","institution_ids":["https://openalex.org/I90871651"]},{"raw_affiliation_string":"Biomedical Engineering Program, Department of Bioengineering, College of Engineering, The University of Toledo, Toledo, OH, USA","institution_ids":["https://openalex.org/I90871651"]},{"raw_affiliation_string":"Department of Orthopaedic Surgery, College of Medicine and Life Sciences, The University of Toledo, Toledo, OH, USA","institution_ids":["https://openalex.org/I90871651"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5072845022"],"corresponding_institution_ids":["https://openalex.org/I90871651"],"apc_list":{"value":3300,"currency":"USD","value_usd":3300},"apc_paid":null,"fwci":0.5649,"has_fulltext":false,"cited_by_count":61,"citation_normalized_percentile":{"value":0.49211909,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"120","issue":null,"first_page":"111748","last_page":"111748"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.011699999682605267,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bmp9","display_name":"BMP9","score":0.9490000009536743},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.9330000281333923},{"id":"https://openalex.org/keywords/bone-regeneration","display_name":"bone regeneration","score":0.875},{"id":"https://openalex.org/keywords/smad-signaling","display_name":"Smad signaling","score":0.9769999980926514},{"id":"https://openalex.org/keywords/bmp-receptors","display_name":"BMP receptors","score":0.753000020980835},{"id":"https://openalex.org/keywords/osteoprogenitor-cells","display_name":"osteoprogenitor cells","score":0.9129999876022339},{"id":"https://openalex.org/keywords/preosteoblasts","display_name":"preosteoblasts","score":0.7590000033378601},{"id":"https://openalex.org/keywords/osteoblasts","display_name":"osteoblasts","score":0.753000020980835},{"id":"https://openalex.org/keywords/biomaterial-scaffolds","display_name":"biomaterial scaffolds","score":0.8460000157356262},{"id":"https://openalex.org/keywords/bmp-2","display_name":"BMP-2","score":0.6970000267028809},{"id":"https://openalex.org/keywords/bone-defect-reconstruction","display_name":"bone defect repair","score":0.6639999747276306}],"concepts":[{"id":"https://openalex.org/C2778761762","wikidata":"https://www.wikidata.org/wiki/Q18252680","display_name":"Noggin","level":4,"score":0.7705027461051941},{"id":"https://openalex.org/C31507581","wikidata":"https://www.wikidata.org/wiki/Q425383","display_name":"Bone morphogenetic protein","level":3,"score":0.7585616111755371},{"id":"https://openalex.org/C30352789","wikidata":"https://www.wikidata.org/wiki/Q14903153","display_name":"Bone morphogenetic protein 2","level":3,"score":0.6725801825523376},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6569798588752747},{"id":"https://openalex.org/C2781080636","wikidata":"https://www.wikidata.org/wiki/Q700000","display_name":"SMAD","level":3,"score":0.6229047775268555},{"id":"https://openalex.org/C73834784","wikidata":"https://www.wikidata.org/wiki/Q17849752","display_name":"BMPR2","level":4,"score":0.6008191108703613},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.5822609663009644},{"id":"https://openalex.org/C125349252","wikidata":"https://www.wikidata.org/wiki/Q14903102","display_name":"Bone morphogenetic protein 7","level":4,"score":0.5259692668914795},{"id":"https://openalex.org/C8337478","wikidata":"https://www.wikidata.org/wiki/Q1777289","display_name":"Bone healing","level":2,"score":0.47717586159706116},{"id":"https://openalex.org/C10854531","wikidata":"https://www.wikidata.org/wiki/Q1061415","display_name":"Regenerative medicine","level":3,"score":0.4229549765586853},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37480276823043823},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.3511456847190857},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.31613439321517944},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2801893949508667},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.24214699864387512},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.15069562196731567},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10258874297142029},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001861","descriptor_name":"Bone Regeneration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003463","descriptor_name":"Cues","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019485","descriptor_name":"Bone Morphogenetic Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055396","descriptor_name":"Bone Morphogenetic Protein 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055427","descriptor_name":"Growth Differentiation Factor 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.msec.2020.111748","doi":"https://doi.org/10.1016/j.msec.2020.111748","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.msec.2020.111748","pdf_url":null,"source":{"id":"https://openalex.org/S43139658","display_name":"Materials Science and Engineering C","issn_l":"0928-4931","issn":["0928-4931","1873-0191"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Materials Science and Engineering: C","raw_type":"journal-article"},{"id":"pmid:33545890","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33545890","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Materials science & engineering. C, Materials for biological applications","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7867678","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7867678","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Mater Sci Eng C Mater Biol Appl","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7867678","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7867678","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Mater Sci Eng C Mater Biol Appl","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G7084318949","display_name":"Multifunctional bone putty for craniomaxillofacial bone repair","funder_award_id":"R01DE023356","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":159,"referenced_works":["https://openalex.org/W1246491323","https://openalex.org/W1424085260","https://openalex.org/W1543052044","https://openalex.org/W1545578861","https://openalex.org/W1573698030","https://openalex.org/W1594526962","https://openalex.org/W1785139831","https://openalex.org/W1790935257","https://openalex.org/W1897577213","https://openalex.org/W1919667732","https://openalex.org/W1939946462","https://openalex.org/W1962351050","https://openalex.org/W1963564766","https://openalex.org/W1964359505","https://openalex.org/W1965218063","https://openalex.org/W1968822620","https://openalex.org/W1969408413","https://openalex.org/W1970122794","https://openalex.org/W1972392377","https://openalex.org/W1972762014","https://openalex.org/W1977211871","https://openalex.org/W1977642962","https://openalex.org/W1979023229","https://openalex.org/W1981501451","https://openalex.org/W1983165764","https://openalex.org/W1984288177","https://openalex.org/W1986960611","https://openalex.org/W1990324466","https://openalex.org/W1990938412","https://openalex.org/W1993649097","https://openalex.org/W1994960912","https://openalex.org/W1997136944","https://openalex.org/W1997812904","https://openalex.org/W2004337957","https://openalex.org/W2005235577","https://openalex.org/W2005463323","https://openalex.org/W2007310752","https://openalex.org/W2007608303","https://openalex.org/W2009508208","https://openalex.org/W2010007223","https://openalex.org/W2011243181","https://openalex.org/W2013515157","https://openalex.org/W2015160990","https://openalex.org/W2019582558","https://openalex.org/W2025046506","https://openalex.org/W2026093174","https://openalex.org/W2030366802","https://openalex.org/W2031883266","https://openalex.org/W2034023141","https://openalex.org/W2035408362","https://openalex.org/W2037142954","https://openalex.org/W2037897781","https://openalex.org/W2041401980","https://openalex.org/W2041924731","https://openalex.org/W2041933568","https://openalex.org/W2042658249","https://openalex.org/W2046184981","https://openalex.org/W2048486538","https://openalex.org/W2050141506","https://openalex.org/W2051424206","https://openalex.org/W2051678123","https://openalex.org/W2057907407","https://openalex.org/W2061379024","https://openalex.org/W2061523453","https://openalex.org/W2065765779","https://openalex.org/W2066255742","https://openalex.org/W2072144071","https://openalex.org/W2073103789","https://openalex.org/W2075484345","https://openalex.org/W2078419961","https://openalex.org/W2079475603","https://openalex.org/W2084294723","https://openalex.org/W2084990113","https://openalex.org/W2087817226","https://openalex.org/W2089162996","https://openalex.org/W2092482435","https://openalex.org/W2092567427","https://openalex.org/W2093854662","https://openalex.org/W2101273023","https://openalex.org/W2101367251","https://openalex.org/W2102059629","https://openalex.org/W2103378167","https://openalex.org/W2105455857","https://openalex.org/W2112278084","https://openalex.org/W2112417973","https://openalex.org/W2112903125","https://openalex.org/W2114239412","https://openalex.org/W2114752142","https://openalex.org/W2116668498","https://openalex.org/W2119483052","https://openalex.org/W2120166815","https://openalex.org/W2122579890","https://openalex.org/W2125164793","https://openalex.org/W2129292492","https://openalex.org/W2129303004","https://openalex.org/W2132051926","https://openalex.org/W2132390861","https://openalex.org/W2132943628","https://openalex.org/W2133421115","https://openalex.org/W2133514604","https://openalex.org/W2144447876","https://openalex.org/W2145492658","https://openalex.org/W2148311963","https://openalex.org/W2148468651","https://openalex.org/W2149193631","https://openalex.org/W2156686622","https://openalex.org/W2159511823","https://openalex.org/W2160301571","https://openalex.org/W2163642886","https://openalex.org/W2266078859","https://openalex.org/W2295972389","https://openalex.org/W2298170290","https://openalex.org/W2324949684","https://openalex.org/W2338107694","https://openalex.org/W2347098498","https://openalex.org/W2396320787","https://openalex.org/W2407318424","https://openalex.org/W2440479702","https://openalex.org/W2514106429","https://openalex.org/W2528505036","https://openalex.org/W2530187156","https://openalex.org/W2532047423","https://openalex.org/W2539206742","https://openalex.org/W2558055293","https://openalex.org/W2570787060","https://openalex.org/W2585353573","https://openalex.org/W2587076878","https://openalex.org/W2588131865","https://openalex.org/W2591459822","https://openalex.org/W2594053300","https://openalex.org/W2598850272","https://openalex.org/W2605187236","https://openalex.org/W2607184165","https://openalex.org/W2610383340","https://openalex.org/W2667417504","https://openalex.org/W2734804059","https://openalex.org/W2737572992","https://openalex.org/W2758110609","https://openalex.org/W2759161944","https://openalex.org/W2791103531","https://openalex.org/W2791374634","https://openalex.org/W2800017558","https://openalex.org/W2801172320","https://openalex.org/W2802593563","https://openalex.org/W2895181916","https://openalex.org/W2895607510","https://openalex.org/W2911052382","https://openalex.org/W2930399801","https://openalex.org/W2935677549","https://openalex.org/W2939611338","https://openalex.org/W2946892631","https://openalex.org/W2962784404","https://openalex.org/W2965994281","https://openalex.org/W3006309755","https://openalex.org/W3028414186","https://openalex.org/W4214954563","https://openalex.org/W6672406034","https://openalex.org/W6681341429","https://openalex.org/W6744605298"],"related_works":["https://openalex.org/W2133421115","https://openalex.org/W2385977447","https://openalex.org/W2599105609","https://openalex.org/W3111274321","https://openalex.org/W4387702709","https://openalex.org/W2295812166","https://openalex.org/W1543052044","https://openalex.org/W2791103531","https://openalex.org/W2987026978","https://openalex.org/W1545578861"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-12-07T00:00:00"}
