{"id":"https://openalex.org/W3107621626","doi":"https://doi.org/10.1002/mrm.28612","title":"Comparison of hyperpolarized 13C and non\u2010hyperpolarized deuterium MRI approaches for imaging cerebral glucose metabolism at 4.7 T","display_name":"Comparison of hyperpolarized 13C and non\u2010hyperpolarized deuterium MRI approaches for imaging cerebral glucose metabolism at 4.7 T","publication_year":2020,"publication_date":"2020-11-28","ids":{"openalex":"https://openalex.org/W3107621626","doi":"https://doi.org/10.1002/mrm.28612","mag":"3107621626","pmid":"https://pubmed.ncbi.nlm.nih.gov/33247884"},"language":"en","primary_location":{"id":"doi:10.1002/mrm.28612","doi":"https://doi.org/10.1002/mrm.28612","is_oa":false,"landing_page_url":"https://doi.org/10.1002/mrm.28612","pdf_url":null,"source":{"id":"https://openalex.org/S111160002","display_name":"Magnetic Resonance in Medicine","issn_l":"0740-3194","issn":["0740-3194","1522-2594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-2","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Magnetic Resonance in Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8018714","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049673874","display_name":"Cornelius von Morze","orcid":"https://orcid.org/0000-0002-3992-1793","observed_orcids":["https://orcid.org/0000-0002-3992-1793"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Cornelius von Morze","raw_affiliation_strings":["Mallinckrodt Institute of Radiology Washington University St. Louis Missouri USA","Mallinckrodt Institute of Radiology, Washington University, St. Louis, Missouri, USA"],"raw_orcid":"https://orcid.org/0000-0002-3992-1793","affiliations":[{"raw_affiliation_string":"Mallinckrodt Institute of Radiology Washington University St. Louis Missouri USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Mallinckrodt Institute of Radiology, Washington University, St. Louis, Missouri, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056508268","display_name":"John A. Engelbach","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John A. Engelbach","raw_affiliation_strings":["Mallinckrodt Institute of Radiology Washington University St. Louis Missouri USA","Mallinckrodt Institute of Radiology, Washington University, St. Louis, Missouri, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mallinckrodt Institute of Radiology Washington University St. Louis Missouri USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Mallinckrodt Institute of Radiology, Washington University, St. Louis, Missouri, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030504800","display_name":"Tyler Blazey","orcid":"https://orcid.org/0000-0002-3402-0654","observed_orcids":["https://orcid.org/0000-0002-3402-0654"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tyler Blazey","raw_affiliation_strings":["Mallinckrodt Institute of Radiology Washington University St. Louis Missouri USA","Mallinckrodt Institute of Radiology, Washington University, St. Louis, Missouri, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mallinckrodt Institute of Radiology Washington University St. Louis Missouri USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Mallinckrodt Institute of Radiology, Washington University, St. Louis, Missouri, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052796916","display_name":"James D. Quirk","orcid":"https://orcid.org/0000-0002-6118-7097","observed_orcids":["https://orcid.org/0000-0002-6118-7097"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James D. Quirk","raw_affiliation_strings":["Mallinckrodt Institute of Radiology Washington University St. Louis Missouri USA","Mallinckrodt Institute of Radiology, Washington University, St. Louis, Missouri, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mallinckrodt Institute of Radiology Washington University St. Louis Missouri USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Mallinckrodt Institute of Radiology, Washington University, St. Louis, Missouri, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033201306","display_name":"Galen D. Reed","orcid":"https://orcid.org/0000-0002-2346-8429","observed_orcids":["https://orcid.org/0000-0002-2346-8429"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Galen D. Reed","raw_affiliation_strings":["GE Healthcare Dallas Texas USA","GE Healthcare, Dallas, Texas, USA"],"raw_orcid":"https://orcid.org/0000-0002-2346-8429","affiliations":[{"raw_affiliation_string":"GE Healthcare Dallas Texas USA","institution_ids":[]},{"raw_affiliation_string":"GE Healthcare, Dallas, Texas, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010134057","display_name":"Joseph E. Ippolito","orcid":"https://orcid.org/0000-0003-1913-5573","observed_orcids":["https://orcid.org/0000-0003-1913-5573"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph E. Ippolito","raw_affiliation_strings":["Mallinckrodt Institute of Radiology Washington University St. Louis Missouri USA","Mallinckrodt Institute of Radiology, Washington University, St. Louis, Missouri, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mallinckrodt Institute of Radiology Washington University St. Louis Missouri USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Mallinckrodt Institute of Radiology, Washington University, St. Louis, Missouri, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077021350","display_name":"Joel Richard Garbow","orcid":"https://orcid.org/0000-0002-0654-2703","observed_orcids":["https://orcid.org/0000-0002-0654-2703"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joel R. Garbow","raw_affiliation_strings":["Mallinckrodt Institute of Radiology Washington University St. Louis Missouri USA","Mallinckrodt Institute of Radiology, Washington University, St. Louis, Missouri, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mallinckrodt Institute of Radiology Washington University St. Louis Missouri USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Mallinckrodt Institute of Radiology, Washington University, St. Louis, Missouri, USA","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5049673874"],"corresponding_institution_ids":["https://openalex.org/I204465549"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":2.3169,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.90406297,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"85","issue":"4","first_page":"1795","last_page":"1804"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.6664999723434448,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.6664999723434448,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11809","display_name":"Advanced NMR Techniques and Applications","score":0.31049999594688416,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11993","display_name":"Atomic and Subatomic Physics Research","score":0.010099999606609344,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyperpolarized-13c-mri","display_name":"hyperpolarized 13C MRI","score":0.9980000257492065},{"id":"https://openalex.org/keywords/deuterium-metabolic-imaging","display_name":"deuterium metabolic imaging","score":0.9750000238418579},{"id":"https://openalex.org/keywords/cerebral-glucose-metabolism","display_name":"brain glucose metabolism","score":0.9980000257492065},{"id":"https://openalex.org/keywords/1-13c-pyruvate","display_name":"[1-13C]pyruvate","score":0.9010000228881836},{"id":"https://openalex.org/keywords/lactate","display_name":"lactate","score":0.6959999799728394},{"id":"https://openalex.org/keywords/glutamate-glutamine","display_name":"glutamate/glutamine","score":0.8989999890327454},{"id":"https://openalex.org/keywords/spectroscopic-imaging","display_name":"spectroscopic imaging","score":0.7149999737739563},{"id":"https://openalex.org/keywords/low-rank-reconstruction","display_name":"low-rank reconstruction","score":0.7490000128746033},{"id":"https://openalex.org/keywords/rat-brain","display_name":"rat brain","score":0.5509999990463257},{"id":"https://openalex.org/keywords/signal-to-noise-ratio","display_name":"signal-to-noise ratio","score":0.6650000214576721},{"id":"https://openalex.org/keywords/spatial-resolution","display_name":"spatial resolution","score":0.46799999475479126}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6290903687477112},{"id":"https://openalex.org/C2779349466","wikidata":"https://www.wikidata.org/wiki/Q181619","display_name":"Glutamine","level":3,"score":0.5889692306518555},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.5329775810241699},{"id":"https://openalex.org/C96781048","wikidata":"https://www.wikidata.org/wiki/Q6731601","display_name":"Magnetic resonance spectroscopic imaging","level":3,"score":0.507916271686554},{"id":"https://openalex.org/C58364064","wikidata":"https://www.wikidata.org/wiki/Q102296","display_name":"Deuterium","level":2,"score":0.49554574489593506},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.4676097631454468},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.35226163268089294},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.33777672052383423},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.2311861515045166},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21116670966148376},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18498912453651428},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.10133060812950134},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002247","descriptor_name":"Carbon Isotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002247","descriptor_name":"Carbon Isotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002247","descriptor_name":"Carbon Isotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002247","descriptor_name":"Carbon Isotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003903","descriptor_name":"Deuterium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003903","descriptor_name":"Deuterium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003903","descriptor_name":"Deuterium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003903","descriptor_name":"Deuterium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019289","descriptor_name":"Pyruvic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019289","descriptor_name":"Pyruvic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019289","descriptor_name":"Pyruvic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019289","descriptor_name":"Pyruvic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/mrm.28612","doi":"https://doi.org/10.1002/mrm.28612","is_oa":false,"landing_page_url":"https://doi.org/10.1002/mrm.28612","pdf_url":null,"source":{"id":"https://openalex.org/S111160002","display_name":"Magnetic Resonance in Medicine","issn_l":"0740-3194","issn":["0740-3194","1522-2594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-2","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Magnetic Resonance in Medicine","raw_type":"journal-article"},{"id":"pmid:33247884","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33247884","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Magnetic resonance in medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8018714","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8018714","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Magn Reson Med","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:8018714","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8018714","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Magn Reson Med","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/16","score":0.6899999976158142,"display_name":"Peace, justice, and strong institutions"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G151374072","display_name":null,"funder_award_id":"P30-DK056341","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2525762720","display_name":null,"funder_award_id":"R01 DK115987","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2820267466","display_name":null,"funder_award_id":"NIH S10OD023580","funder_id":"https://openalex.org/F4320337349","funder_display_name":"NIH Office of the Director"},{"id":"https://openalex.org/G3250075687","display_name":null,"funder_award_id":"NIH R01DK115987","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4221866235","display_name":"PURCHASE OF A GE SPINLAB HYPERPOLARIZATION UNIT FOR PRECLINICAL IMAGING","funder_award_id":"1s10od023580-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000868406","display_name":"Washington University Nutrition Obesity Research Center","funder_award_id":"5p30dk056341-25","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000907135","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA091842","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337349","display_name":"NIH Office of the Director","ror":"https://ror.org/00fj8a872"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1807985536","https://openalex.org/W1986757721","https://openalex.org/W1999039040","https://openalex.org/W2002190301","https://openalex.org/W2011697491","https://openalex.org/W2019074347","https://openalex.org/W2026024581","https://openalex.org/W2032791743","https://openalex.org/W2035252578","https://openalex.org/W2043768383","https://openalex.org/W2046654159","https://openalex.org/W2047623256","https://openalex.org/W2059900570","https://openalex.org/W2077172876","https://openalex.org/W2080160572","https://openalex.org/W2091723288","https://openalex.org/W2093803728","https://openalex.org/W2093842581","https://openalex.org/W2093970530","https://openalex.org/W2101991516","https://openalex.org/W2114805483","https://openalex.org/W2179644516","https://openalex.org/W2299912327","https://openalex.org/W2497583477","https://openalex.org/W2615708158","https://openalex.org/W2754434286","https://openalex.org/W2806393647","https://openalex.org/W2807705809","https://openalex.org/W2808937127","https://openalex.org/W2888364243","https://openalex.org/W2895021881","https://openalex.org/W2899146703","https://openalex.org/W2910792831","https://openalex.org/W2911493122","https://openalex.org/W2918344699","https://openalex.org/W2947590149","https://openalex.org/W2994813359","https://openalex.org/W2998605141","https://openalex.org/W3001176578","https://openalex.org/W3034032262"],"related_works":["https://openalex.org/W2626000720","https://openalex.org/W1971888917","https://openalex.org/W4281389749","https://openalex.org/W1863698694","https://openalex.org/W1964704628","https://openalex.org/W2774133365","https://openalex.org/W2051080205","https://openalex.org/W2039389118","https://openalex.org/W2103425569","https://openalex.org/W2053334137"],"abstract_inverted_index":{"Purpose":[0],"The":[1,143,215],"purpose":[2],"of":[3,30,57,90,118,148,169,202,234,237],"this":[4,186],"study":[5],"was":[6,99,107,132,151,194],"to":[7,61,109,121,125,153,157],"directly":[8],"compare":[9],"two":[10],"isotopic":[11],"metabolic":[12,21,65,232],"imaging":[13,22,25,139,233],"approaches,":[14],"hyperpolarized":[15],"(HP)":[16],"13C":[17],"MRI":[18,150,217],"and":[19,40,59,123,127,130,145,205,218,227],"deuterium":[20],"(DMI),":[23],"for":[24,80,231],"specific":[26,235],"closely":[27],"related":[28],"segments":[29,236],"cerebral":[31,200],"glucose":[32,238],"metabolism":[33],"at":[34,140,185,224],"4.7":[35,141,225],"T.":[36,142],"Methods":[37],"Comparative":[38],"HP\u201013C":[39,149,216],"DMI":[41,113,154,165,219],"neuroimaging":[42],"experiments":[43],"were":[44,67],"conducted":[45],"consecutively":[46],"in":[47,134],"normal":[48],"rats":[49],"during":[50],"the":[51,81,111,163,190],"same":[52],"scanning":[53],"session.":[54],"Localized":[55,116],"conversions":[56],"[1\u201013C]pyruvate":[58,120],"[6,6\u20102H2]glucose":[60,124],"their":[62],"respective":[63,82],"downstream":[64],"products":[66],"measured":[68],"by":[69,137],"spectroscopic":[70,138],"imaging,":[71],"using":[72],"an":[73,195],"identical":[74],"2D\u2010CSI":[75],"sequence":[76],"with":[77,178,208],"parameters":[78],"optimized":[79],"experiments.":[83],"To":[84],"facilitate":[85],"direct":[86],"comparison,":[87],"a":[88,158,209],"pair":[89],"substantially":[91],"equivalent":[92],"2.5\u2010cm":[93],"double\u2010tuned":[94],"X/1H":[95],"RF":[96],"surface":[97],"coils":[98],"developed.":[100],"For":[101],"improved":[102],"results,":[103],"multidimensional":[104],"low\u2010rank":[105],"reconstruction":[106],"applied":[108],"denoise":[110],"raw":[112],"data.":[114],"Results":[115],"conversion":[117],"HP":[119,203],"[1\u201013C]lactate,":[122],"[3,3\u20102H2]lactate":[126],"Glx\u2010d":[128],"(glutamate":[129],"glutamine),":[131],"detected":[133],"rat":[135],"brain":[136],"SNR":[144],"spatial":[146],"resolution":[147],"superior":[152],"but":[155,173],"limited":[156],"short":[159],"time":[160],"window,":[161],"whereas":[162],"lengthy":[164],"acquisition":[166],"yielded":[167],"maps":[168],"not":[170],"only":[171],"lactate,":[172],"also":[174],"Glx":[175],"production,":[176],"albeit":[177],"relatively":[179],"poor":[180],"spectral":[181],"discrimination":[182],"between":[183,199],"metabolites":[184],"field":[187],"strength.":[188],"Across":[189],"individual":[191],"rats,":[192],"there":[193],"apparent":[196],"inverse":[197],"correlation":[198],"production":[201],"[1\u201013C]lactate":[204],"Glx\u2010d,":[206],"along":[207],"trend":[210],"toward":[211],"increased":[212],"[3,3\u20102H2]lactate.":[213],"Conclusion":[214],"methods":[220],"are":[221],"both":[222],"feasible":[223],"T":[226],"have":[228],"significant":[229],"potential":[230],"metabolism.":[239]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":10}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2020-12-07T00:00:00"}