{"id":"https://openalex.org/W3107092571","doi":"https://doi.org/10.3389/fonc.2020.607502","title":"Multiple Microinvasion Foci in Ductal Carcinoma In Situ Is Associated With an Increased Risk of Recurrence and Worse Survival Outcome","display_name":"Multiple Microinvasion Foci in Ductal Carcinoma In Situ Is Associated With an Increased Risk of Recurrence and Worse Survival Outcome","publication_year":2020,"publication_date":"2020-12-03","ids":{"openalex":"https://openalex.org/W3107092571","doi":"https://doi.org/10.3389/fonc.2020.607502","mag":"3107092571","pmid":"https://pubmed.ncbi.nlm.nih.gov/33344258","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7744719"},"language":"en","primary_location":{"id":"doi:10.3389/fonc.2020.607502","doi":"https://doi.org/10.3389/fonc.2020.607502","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2020.607502","pdf_url":"https://www.frontiersin.org/articles/10.3389/fonc.2020.607502/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fonc.2020.607502/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083465905","display_name":"Jing Si","orcid":"https://orcid.org/0000-0003-4540-6859","observed_orcids":["https://orcid.org/0000-0003-4540-6859"]},"institutions":[{"id":"https://openalex.org/I4210092870","display_name":"Jiaxing University","ror":"https://ror.org/00j2a7k55","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210092870"]},{"id":"https://openalex.org/I4210139237","display_name":"First Hospital of Jiaxing","ror":"https://ror.org/03q5hbn76","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210139237"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jing Si","raw_affiliation_strings":["Cancer Research Center, The First Hospital of Jiaxing & The Affiliated Hospital of Jiaxing University, Jiaxing, China","Department of Breast Disease, The First Hospital of Jiaxing & The Affiliated Hospital of Jiaxing University, Jiaxing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Center, The First Hospital of Jiaxing & The Affiliated Hospital of Jiaxing University, Jiaxing, China","institution_ids":["https://openalex.org/I4210092870","https://openalex.org/I4210139237"]},{"raw_affiliation_string":"Department of Breast Disease, The First Hospital of Jiaxing & The Affiliated Hospital of Jiaxing University, Jiaxing, China","institution_ids":["https://openalex.org/I4210092870","https://openalex.org/I4210139237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101539426","display_name":"Rong Guo","orcid":"https://orcid.org/0000-0002-7342-3237","observed_orcids":["https://orcid.org/0000-0002-7342-3237"]},"institutions":[{"id":"https://openalex.org/I26080491","display_name":"Kunming Medical University","ror":"https://ror.org/038c3w259","country_code":"CN","type":"education","lineage":["https://openalex.org/I26080491"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rong Guo","raw_affiliation_strings":["Department of Breast Surgery, Breast Cancer Center of the Third Affiliated Hospital of Kunming Medical University, Cancer Hospital of Yunnan Province, Kunming, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Surgery, Breast Cancer Center of the Third Affiliated Hospital of Kunming Medical University, Cancer Hospital of Yunnan Province, Kunming, China","institution_ids":["https://openalex.org/I26080491"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102381988","display_name":"Huan Pan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092870","display_name":"Jiaxing University","ror":"https://ror.org/00j2a7k55","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210092870"]},{"id":"https://openalex.org/I4210139237","display_name":"First Hospital of Jiaxing","ror":"https://ror.org/03q5hbn76","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210139237"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huan Pan","raw_affiliation_strings":["Department of Central Laboratory, The First Hospital of Jiaxing & The Affiliated Hospital of Jiaxing University, Jiaxing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Central Laboratory, The First Hospital of Jiaxing & The Affiliated Hospital of Jiaxing University, Jiaxing, China","institution_ids":["https://openalex.org/I4210092870","https://openalex.org/I4210139237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052291615","display_name":"Xiang Lu","orcid":"https://orcid.org/0000-0002-1176-5389","observed_orcids":["https://orcid.org/0000-0002-1176-5389","https://orcid.org/0000-0002-6041-8586"]},"institutions":[{"id":"https://openalex.org/I4210092870","display_name":"Jiaxing University","ror":"https://ror.org/00j2a7k55","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210092870"]},{"id":"https://openalex.org/I4210139237","display_name":"First Hospital of Jiaxing","ror":"https://ror.org/03q5hbn76","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210139237"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiang Lu","raw_affiliation_strings":["Department of Breast Disease, The First Hospital of Jiaxing & The Affiliated Hospital of Jiaxing University, Jiaxing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Disease, The First Hospital of Jiaxing & The Affiliated Hospital of Jiaxing University, Jiaxing, China","institution_ids":["https://openalex.org/I4210092870","https://openalex.org/I4210139237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102811339","display_name":"Zhiqin Guo","orcid":"https://orcid.org/0000-0003-4311-326X","observed_orcids":["https://orcid.org/0000-0003-4311-326X"]},"institutions":[{"id":"https://openalex.org/I4210092870","display_name":"Jiaxing University","ror":"https://ror.org/00j2a7k55","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210092870"]},{"id":"https://openalex.org/I4210139237","display_name":"First Hospital of Jiaxing","ror":"https://ror.org/03q5hbn76","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210139237"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiqin Guo","raw_affiliation_strings":["Department of Pathology, The First Hospital of Jiaxing & The Affiliated Hospital of Jiaxing University, Jiaxing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, The First Hospital of Jiaxing & The Affiliated Hospital of Jiaxing University, Jiaxing, China","institution_ids":["https://openalex.org/I4210092870","https://openalex.org/I4210139237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042238696","display_name":"Chao Han","orcid":"https://orcid.org/0000-0002-6869-0701","observed_orcids":["https://orcid.org/0000-0002-6869-0701"]},"institutions":[{"id":"https://openalex.org/I4210092870","display_name":"Jiaxing University","ror":"https://ror.org/00j2a7k55","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210092870"]},{"id":"https://openalex.org/I4210139237","display_name":"First Hospital of Jiaxing","ror":"https://ror.org/03q5hbn76","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210139237"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chao Han","raw_affiliation_strings":["Department of Breast Disease, The First Hospital of Jiaxing & The Affiliated Hospital of Jiaxing University, Jiaxing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Disease, The First Hospital of Jiaxing & The Affiliated Hospital of Jiaxing University, Jiaxing, China","institution_ids":["https://openalex.org/I4210092870","https://openalex.org/I4210139237"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Li Xue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092870","display_name":"Jiaxing University","ror":"https://ror.org/00j2a7k55","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210092870"]},{"id":"https://openalex.org/I4210139237","display_name":"First Hospital of Jiaxing","ror":"https://ror.org/03q5hbn76","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210139237"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Xue","raw_affiliation_strings":["Department of Breast Disease, The First Hospital of Jiaxing & The Affiliated Hospital of Jiaxing University, Jiaxing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Disease, The First Hospital of Jiaxing & The Affiliated Hospital of Jiaxing University, Jiaxing, China","institution_ids":["https://openalex.org/I4210092870","https://openalex.org/I4210139237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084508357","display_name":"Dan Xing","orcid":"https://orcid.org/0009-0008-9778-445X","observed_orcids":["https://orcid.org/0009-0008-9778-445X"]},"institutions":[{"id":"https://openalex.org/I4210092870","display_name":"Jiaxing University","ror":"https://ror.org/00j2a7k55","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210092870"]},{"id":"https://openalex.org/I4210139237","display_name":"First Hospital of Jiaxing","ror":"https://ror.org/03q5hbn76","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210139237"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dan Xing","raw_affiliation_strings":["Department of Breast Disease, The First Hospital of Jiaxing & The Affiliated Hospital of Jiaxing University, Jiaxing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Disease, The First Hospital of Jiaxing & The Affiliated Hospital of Jiaxing University, Jiaxing, China","institution_ids":["https://openalex.org/I4210092870","https://openalex.org/I4210139237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024331174","display_name":"Wanxin Wu","orcid":"https://orcid.org/0009-0008-7022-8496","observed_orcids":["https://orcid.org/0009-0008-7022-8496"]},"institutions":[{"id":"https://openalex.org/I4210092870","display_name":"Jiaxing University","ror":"https://ror.org/00j2a7k55","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210092870"]},{"id":"https://openalex.org/I4210139237","display_name":"First Hospital of Jiaxing","ror":"https://ror.org/03q5hbn76","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210139237"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wanxin Wu","raw_affiliation_strings":["Department of Pathology, The First Hospital of Jiaxing & The Affiliated Hospital of Jiaxing University, Jiaxing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, The First Hospital of Jiaxing & The Affiliated Hospital of Jiaxing University, Jiaxing, China","institution_ids":["https://openalex.org/I4210092870","https://openalex.org/I4210139237"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103069871","display_name":"Caiping Chen","orcid":"https://orcid.org/0009-0003-2355-8568","observed_orcids":["https://orcid.org/0009-0003-2355-8568"]},"institutions":[{"id":"https://openalex.org/I4210092870","display_name":"Jiaxing University","ror":"https://ror.org/00j2a7k55","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210092870"]},{"id":"https://openalex.org/I4210139237","display_name":"First Hospital of Jiaxing","ror":"https://ror.org/03q5hbn76","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210139237"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Caiping Chen","raw_affiliation_strings":["Cancer Research Center, The First Hospital of Jiaxing & The Affiliated Hospital of Jiaxing University, Jiaxing, China","Department of Breast Disease, The First Hospital of Jiaxing & The Affiliated Hospital of Jiaxing University, Jiaxing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Center, The First Hospital of Jiaxing & The Affiliated Hospital of Jiaxing University, Jiaxing, China","institution_ids":["https://openalex.org/I4210092870","https://openalex.org/I4210139237"]},{"raw_affiliation_string":"Department of Breast Disease, The First Hospital of Jiaxing & The Affiliated Hospital of Jiaxing University, Jiaxing, China","institution_ids":["https://openalex.org/I4210092870","https://openalex.org/I4210139237"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5083465905"],"corresponding_institution_ids":["https://openalex.org/I4210092870","https://openalex.org/I4210139237"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":1.1781,"has_fulltext":true,"cited_by_count":26,"citation_normalized_percentile":{"value":0.74268252,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"10","issue":null,"first_page":"607502","last_page":"607502"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9253000020980835,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9253000020980835,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":0.07349999994039536,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11885","display_name":"MRI in cancer diagnosis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ductal-carcinoma-in-situ","display_name":"ductal carcinoma in situ","score":0.9419999718666077},{"id":"https://openalex.org/keywords/microinvasion","display_name":"microinvasion","score":0.7129999995231628},{"id":"https://openalex.org/keywords/multiple-foci","display_name":"multiple foci","score":0.6700000166893005},{"id":"https://openalex.org/keywords/axillary-lymph-node-metastasis","display_name":"axillary lymph node metastasis","score":0.781000018119812},{"id":"https://openalex.org/keywords/disease-free-survival","display_name":"disease-free survival","score":0.8370000123977661},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.48399999737739563},{"id":"https://openalex.org/keywords/tumor-size","display_name":"tumor size","score":0.7710000276565552},{"id":"https://openalex.org/keywords/lymphovascular-invasion","display_name":"lymphovascular invasion","score":0.8989999890327454},{"id":"https://openalex.org/keywords/her2","display_name":"HER2","score":0.7720000147819519},{"id":"https://openalex.org/keywords/ki-67","display_name":"Ki-67","score":0.9810000061988831},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"chemotherapy","score":0.48899999260902405},{"id":"https://openalex.org/keywords/sentinel-lymph-node-biopsy","display_name":"sentinel lymph node biopsy","score":0.7509999871253967},{"id":"https://openalex.org/keywords/axillary-lymph-node-dissection","display_name":"axillary lymph node dissection","score":0.984000027179718},{"id":"https://openalex.org/keywords/isolated-tumor-cells","display_name":"isolated tumor cells","score":0.9089999794960022},{"id":"https://openalex.org/keywords/breast-cancer-recurrence","display_name":"breast cancer recurrence","score":0.6269999742507935},{"id":"https://openalex.org/keywords/nuclear-grade","display_name":"nuclear grade","score":0.6570000052452087}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8583400249481201},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6458442211151123},{"id":"https://openalex.org/C2780862961","wikidata":"https://www.wikidata.org/wiki/Q5311598","display_name":"Ductal carcinoma","level":4,"score":0.5904517769813538},{"id":"https://openalex.org/C2777649267","wikidata":"https://www.wikidata.org/wiki/Q340695","display_name":"Axillary lymph nodes","level":4,"score":0.5676185488700867},{"id":"https://openalex.org/C144301174","wikidata":"https://www.wikidata.org/wiki/Q7893852","display_name":"Univariate analysis","level":3,"score":0.556290328502655},{"id":"https://openalex.org/C2778740770","wikidata":"https://www.wikidata.org/wiki/Q6708283","display_name":"Lymphovascular invasion","level":4,"score":0.5181385278701782},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.4970257580280304},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.4628990888595581},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.4601458013057709},{"id":"https://openalex.org/C2908949552","wikidata":"https://www.wikidata.org/wiki/Q1809305","display_name":"Axillary Lymph Node Dissection","level":5,"score":0.42325618863105774},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3847353756427765},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37643641233444214},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.37605905532836914},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.3112424612045288},{"id":"https://openalex.org/C2780212769","wikidata":"https://www.wikidata.org/wiki/Q776290","display_name":"Sentinel lymph node","level":4,"score":0.30947110056877136},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.266945481300354}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fonc.2020.607502","doi":"https://doi.org/10.3389/fonc.2020.607502","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2020.607502","pdf_url":"https://www.frontiersin.org/articles/10.3389/fonc.2020.607502/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},{"id":"pmid:33344258","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33344258","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in oncology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7744719","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7744719/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Oncol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:80f70760d3a24c58a9f8072bce1ddbdc","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/80f70760d3a24c58a9f8072bce1ddbdc","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Oncology, Vol 10 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fonc.2020.607502","doi":"https://doi.org/10.3389/fonc.2020.607502","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2020.607502","pdf_url":"https://www.frontiersin.org/articles/10.3389/fonc.2020.607502/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G2759957389","display_name":null,"funder_award_id":"81902674","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3107092571.pdf","grobid_xml":"https://content.openalex.org/works/W3107092571.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1558500912","https://openalex.org/W1573272474","https://openalex.org/W1859184337","https://openalex.org/W1979823178","https://openalex.org/W1988143173","https://openalex.org/W1991809109","https://openalex.org/W2002846764","https://openalex.org/W2004916922","https://openalex.org/W2008658656","https://openalex.org/W2029574551","https://openalex.org/W2031647200","https://openalex.org/W2047221409","https://openalex.org/W2053953532","https://openalex.org/W2054758317","https://openalex.org/W2060266705","https://openalex.org/W2060871308","https://openalex.org/W2062976040","https://openalex.org/W2068228843","https://openalex.org/W2078834139","https://openalex.org/W2083681189","https://openalex.org/W2088060537","https://openalex.org/W2095799175","https://openalex.org/W2119975486","https://openalex.org/W2122261747","https://openalex.org/W2132434084","https://openalex.org/W2140978771","https://openalex.org/W2151878939","https://openalex.org/W2160986504","https://openalex.org/W2168611530","https://openalex.org/W2189712549","https://openalex.org/W2191470295","https://openalex.org/W2507667886","https://openalex.org/W2586701783","https://openalex.org/W2590386562","https://openalex.org/W2739727794","https://openalex.org/W2767899580","https://openalex.org/W2804305296","https://openalex.org/W2901075300","https://openalex.org/W2946909199","https://openalex.org/W2963140894","https://openalex.org/W2963457916"],"related_works":["https://openalex.org/W1979823178","https://openalex.org/W3115783714","https://openalex.org/W2109187617","https://openalex.org/W2943982578","https://openalex.org/W4285742503","https://openalex.org/W2793936413","https://openalex.org/W2963140894","https://openalex.org/W3205830109","https://openalex.org/W2088060537","https://openalex.org/W2071864189"],"abstract_inverted_index":{"Background":[0],"Ductal":[1],"carcinoma":[2],"in":[3,36,68,164,247,253,380],"situ":[4],"with":[5,31,38,56,70,78,193,203,249,266,292,302,322,342,344,351,362],"microinvasion":[6,53,132,317,326,366],"(DCISM)":[7],"was":[8,172,188,289,334],"defined":[9],"as":[10,97],"one":[11,98,129,194,345],"or":[12,64,100],"more":[13,270,372],"foci":[14,51,102,205,268,295,324,354,364],"of":[15,26,45,52,60,131,224,234,316,325,338,347,365,377],"invasion":[16,227],"beyond":[17],"the":[18,107,232,314,369],"basement":[19],"membrane":[20],"within":[21],"1":[22],"mm.":[23],"The":[24],"size":[25,211,258],"primary":[27],"lesion":[28],"is":[29,44,383],"associated":[30,55],"axillary":[32,62,83,112,153,169,175,182,339],"status":[33,63],"and":[34,114,120,133,142,152,168,196,221,240,320],"prognosis":[35],"patients":[37,69,77,145,167,192,202,248,304,321,343,350,361,382],"invasive":[39],"breast":[40],"cancer;":[41],"thus,":[42],"it":[43],"interest":[46],"to":[47,91,106,207,272,328],"determine":[48],"whether":[49],"multiple":[50,101,137,197,204,250,267,293,323,352,363],"are":[54],"a":[57],"higher":[58,215,222,336],"risk":[59,337],"positive":[61,235],"worse":[65,297,356],"long-term":[66],"outcomes":[67],"DCISM.":[71],"Methods":[72],"This":[73],"study":[74],"identified":[75],"359":[76,124],"DCISM":[79,360,381],"who":[80],"had":[81,128,136,296,355],"undergone":[82],"evaluation":[84,176],"at":[85],"our":[86],"institute":[87],"from":[88],"January":[89],"2006":[90],"December":[92],"2015.":[93],"Patients":[94,265,291],"were":[95,118,162,269,318],"categorized":[96],"focus":[99,130,195,346],"(\u22652":[103],"foci)":[104],"according":[105],"pathological":[108],"results.":[109],"Clinicopathological":[110],"features,":[111],"status,":[113],"disease-free":[115,298],"survival":[116,287,299],"rate":[117,171,184,223,288,300],"obtained":[119],"analyzed.":[121],"Results":[122],"Of":[123],"patients,":[125],"233":[126],"(64.90%)":[127],"126":[134],"(35.10%)":[135],"foci.":[138,198],"Overall,":[139],"242":[140],"(67.41%)":[141],"117":[143],"(32.59%)":[144],"underwent":[146],"sentinel":[147],"lymph":[148,154],"nodes":[149,155],"biopsy":[150],"(SLNB)":[151],"dissection":[156],"(ALND),":[157],"respectively.":[158],"Isolated":[159],"tumor":[160,210,257,331],"cells":[161],"found":[163],"four":[165],"(1.11%)":[166],"metastasis":[170,183],"2.51%.":[173],"Neither":[174],"methods":[177],"(P":[178,185,212,218,228,237,243,262],"=":[179,186,219,229,238,244,263,279,309],"0.244)":[180],"nor":[181],"0.559)":[187],"significantly":[189],"different":[190,319],"between":[191],"In":[199],"univariate":[200],"analysis,":[201,255],"tended":[206,327],"have":[208,329],"larger":[209,330],"<":[213],"0.001),":[214,220],"nuclear":[216],"grade":[217],"lymphatic":[225],"vascular":[226],"0.034).":[230],"Also,":[231],"proportion":[233],"HER2":[236],"0.027)":[239],"Ki67":[241],"level":[242],"0.004)":[245],"increased":[246],"foci,":[251],"while":[252,349],"multivariate":[254],"only":[256],"showed":[259],"significant":[260],"difference":[261],"0.009).":[264],"likely":[271],"receive":[273],"chemotherapy":[274],"(56.35":[275],"vs":[276,306],"40.77%;":[277],"P":[278,308],"0.028).":[280],"At":[281],"median":[282],"5.11":[283],"years":[284],"follow-up,":[285],"overall":[286],"99.36%.":[290],"microinvasive":[294,353],"compared":[301,341],"one-focus":[303],"(98.29":[305],"93.01%,":[307],"0.032).":[310],"Conclusion":[311],"Even":[312],"though":[313],"numbers":[315],"size,":[332],"there":[333],"no":[335],"involvement":[340],"microinvasion,":[348],"DFS":[357],"rate.":[358],"Thus,":[359],"may":[367],"be":[368],"criterion":[370],"for":[371],"aggressive":[373],"local\u2013regional":[374],"treatment.":[375],"Optimization":[376],"adjuvant":[378],"therapy":[379],"required.":[384]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-12-07T00:00:00"}