{"id":"https://openalex.org/W3106972347","doi":"https://doi.org/10.1371/journal.pcbi.1008464","title":"Drug2ways: Reasoning over causal paths in biological networks for drug discovery","display_name":"Drug2ways: Reasoning over causal paths in biological networks for drug discovery","publication_year":2020,"publication_date":"2020-12-02","ids":{"openalex":"https://openalex.org/W3106972347","doi":"https://doi.org/10.1371/journal.pcbi.1008464","mag":"3106972347","pmid":"https://pubmed.ncbi.nlm.nih.gov/33264280","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7735677"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1008464","doi":"https://doi.org/10.1371/journal.pcbi.1008464","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008464","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008464&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","ccf-b","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008464&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073216957","display_name":"Daniel Rivas-Barragan","orcid":"https://orcid.org/0000-0003-0163-7890","observed_orcids":["https://orcid.org/0000-0003-0163-7890"]},"institutions":[{"id":"https://openalex.org/I2799803557","display_name":"Barcelona Supercomputing Center","ror":"https://ror.org/05sd8tv96","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2799803557","https://openalex.org/I9617848"]},{"id":"https://openalex.org/I9617848","display_name":"Universitat Polit\u00e8cnica de Catalunya","ror":"https://ror.org/03mb6wj31","country_code":"ES","type":"education","lineage":["https://openalex.org/I9617848"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Daniel Rivas-Barragan","raw_affiliation_strings":["Barcelona Supercomputing Center, Barcelona 08034, Spain","Computer Architecture Department, Universitat Polit\u00e8cnica de Catalunya, Barcelona 08034, Spain","Barcelona Supercomputing Center, Barcelona, Spain","Computer Architecture Department, Universitat Polit\u00e8cnica de Catalunya, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Barcelona Supercomputing Center, Barcelona 08034, Spain","institution_ids":["https://openalex.org/I2799803557"]},{"raw_affiliation_string":"Computer Architecture Department, Universitat Polit\u00e8cnica de Catalunya, Barcelona 08034, Spain","institution_ids":["https://openalex.org/I9617848"]},{"raw_affiliation_string":"Barcelona Supercomputing Center, Barcelona, Spain","institution_ids":["https://openalex.org/I2799803557"]},{"raw_affiliation_string":"Computer Architecture Department, Universitat Polit\u00e8cnica de Catalunya, Barcelona, Spain","institution_ids":["https://openalex.org/I9617848"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012235619","display_name":"Sarah Mubeen","orcid":"https://orcid.org/0000-0002-9858-3755","observed_orcids":["https://orcid.org/0000-0002-9858-3755"]},"institutions":[{"id":"https://openalex.org/I4210098248","display_name":"Fraunhofer Institute for Algorithms and Scientific Computing","ror":"https://ror.org/00trw9c49","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210098248","https://openalex.org/I4923324"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sarah Mubeen","raw_affiliation_strings":["Department of Bioinformatics, Fraunhofer Institute for Algorithms and Scientific Computing, Sankt Augustin 53757, Germany","Fraunhofer Center for Machine Learning, Germany","Department of Bioinformatics, Fraunhofer Institute for Algorithms and Scientific Computing, Sankt Augustin, Germany"],"raw_orcid":"https://orcid.org/0000-0002-9858-3755","affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, Fraunhofer Institute for Algorithms and Scientific Computing, Sankt Augustin 53757, Germany","institution_ids":["https://openalex.org/I4210098248"]},{"raw_affiliation_string":"Fraunhofer Center for Machine Learning, Germany","institution_ids":[]},{"raw_affiliation_string":"Department of Bioinformatics, Fraunhofer Institute for Algorithms and Scientific Computing, Sankt Augustin, Germany","institution_ids":["https://openalex.org/I4210098248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077749049","display_name":"Francesc Guim","orcid":"https://orcid.org/0009-0001-4900-9984","observed_orcids":["https://orcid.org/0009-0001-4900-9984"]},"institutions":[{"id":"https://openalex.org/I1343180700","display_name":"Intel (United States)","ror":"https://ror.org/01ek73717","country_code":"US","type":"company","lineage":["https://openalex.org/I1343180700"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francesc Guim Bernat","raw_affiliation_strings":["Intel Corporation Iberia, Madrid 28020, Spain","Intel Corporation Iberia, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intel Corporation Iberia, Madrid 28020, Spain","institution_ids":["https://openalex.org/I1343180700"]},{"raw_affiliation_string":"Intel Corporation Iberia, Madrid, Spain","institution_ids":["https://openalex.org/I1343180700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003139478","display_name":"Martin Hofmann\u2010Apitius","orcid":"https://orcid.org/0000-0001-9012-6720","observed_orcids":["https://orcid.org/0000-0001-9012-6720"]},"institutions":[{"id":"https://openalex.org/I4210098248","display_name":"Fraunhofer Institute for Algorithms and Scientific Computing","ror":"https://ror.org/00trw9c49","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210098248","https://openalex.org/I4923324"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martin Hofmann-Apitius","raw_affiliation_strings":["Department of Bioinformatics, Fraunhofer Institute for Algorithms and Scientific Computing, Sankt Augustin 53757, Germany","Department of Bioinformatics, Fraunhofer Institute for Algorithms and Scientific Computing, Sankt Augustin, Germany"],"raw_orcid":"https://orcid.org/0000-0001-9012-6720","affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, Fraunhofer Institute for Algorithms and Scientific Computing, Sankt Augustin 53757, Germany","institution_ids":["https://openalex.org/I4210098248"]},{"raw_affiliation_string":"Department of Bioinformatics, Fraunhofer Institute for Algorithms and Scientific Computing, Sankt Augustin, Germany","institution_ids":["https://openalex.org/I4210098248"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043459521","display_name":"Daniel Domingo\u2010Fern\u00e1nd\u00e9z","orcid":"https://orcid.org/0000-0002-2046-6145","observed_orcids":["https://orcid.org/0000-0002-2046-6145"]},"institutions":[{"id":"https://openalex.org/I4210098248","display_name":"Fraunhofer Institute for Algorithms and Scientific Computing","ror":"https://ror.org/00trw9c49","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210098248","https://openalex.org/I4923324"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Daniel Domingo-Fern\u00e1ndez","raw_affiliation_strings":["Department of Bioinformatics, Fraunhofer Institute for Algorithms and Scientific Computing, Sankt Augustin 53757, Germany","Fraunhofer Center for Machine Learning, Germany","Department of Bioinformatics, Fraunhofer Institute for Algorithms and Scientific Computing, Sankt Augustin, Germany"],"raw_orcid":"https://orcid.org/0000-0002-2046-6145","affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, Fraunhofer Institute for Algorithms and Scientific Computing, Sankt Augustin 53757, Germany","institution_ids":["https://openalex.org/I4210098248"]},{"raw_affiliation_string":"Fraunhofer Center for Machine Learning, Germany","institution_ids":[]},{"raw_affiliation_string":"Department of Bioinformatics, Fraunhofer Institute for Algorithms and Scientific Computing, Sankt Augustin, Germany","institution_ids":["https://openalex.org/I4210098248"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5043459521"],"corresponding_institution_ids":["https://openalex.org/I4210098248"],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":{"value":2500,"currency":"USD","value_usd":2500},"fwci":1.254,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.80980147,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"16","issue":"12","first_page":"e1008464","last_page":"e1008464"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.6284000277519226,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.6284000277519226,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.3617999851703644,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/2718","display_name":"Health Informatics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/causal-pathways","display_name":"causal pathways","score":0.6859999895095825},{"id":"https://openalex.org/keywords/biological-networks","display_name":"biological networks","score":0.9599999785423279},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"drug discovery","score":0.7300000190734863},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.9179999828338623},{"id":"https://openalex.org/keywords/drug-candidate-prediction","display_name":"drug candidate prediction","score":0.7210000157356262},{"id":"https://openalex.org/keywords/polypharmacology","display_name":"polypharmacology","score":0.859000027179718},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.9769999980926514},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.656000018119812},{"id":"https://openalex.org/keywords/clinical-trial-data","display_name":"clinical trial data","score":0.5619999766349792}],"concepts":[{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.7404957413673401},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.725556492805481},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.6447403430938721},{"id":"https://openalex.org/C519991488","wikidata":"https://www.wikidata.org/wiki/Q28865","display_name":"Python (programming language)","level":2,"score":0.5794677734375},{"id":"https://openalex.org/C199845137","wikidata":"https://www.wikidata.org/wiki/Q145490","display_name":"Network topology","level":2,"score":0.46642595529556274},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.45792704820632935},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4104500114917755},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3079235553741455},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2800107002258301},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11557841300964355},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004358","descriptor_name":"Drug Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D064798","descriptor_name":"Polypharmacology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1371/journal.pcbi.1008464","doi":"https://doi.org/10.1371/journal.pcbi.1008464","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008464","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008464&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","ccf-b","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"doi:10.1101/2020.06.07.138388","doi":"https://doi.org/10.1101/2020.06.07.138388","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2020.06.07.138388","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2020/06/15/2020.06.07.138388.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:7735677","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7735677","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmid:33264280","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33264280","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":"Journal Article"},{"id":"pmh:oai:RePEc:plo:pcbi00:1008464","doi":null,"is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1008464","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:9a0a17cecb874771be76cf296bdc29f6","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/9a0a17cecb874771be76cf296bdc29f6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 16, Iss 12, p e1008464 (2020)","raw_type":"article"},{"id":"pmh:oai:fraunhofer.de:N-618566","doi":null,"is_oa":true,"landing_page_url":"http://publica.fraunhofer.de/documents/N-618566.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306400318","display_name":"Fraunhofer-Publica (Fraunhofer-Gesellschaft)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4923324","host_organization_name":"Fraunhofer-Gesellschaft","host_organization_lineage":["https://openalex.org/I4923324"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Fraunhofer SCAI","raw_type":"Journal Article"},{"id":"pmh:oai:publica.fraunhofer.de:publica/265471","doi":null,"is_oa":true,"landing_page_url":"https://publica.fraunhofer.de/handle/publica/265471","pdf_url":null,"source":{"id":"https://openalex.org/S4306400318","display_name":"Fraunhofer-Publica (Fraunhofer-Gesellschaft)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4923324","host_organization_name":"Fraunhofer-Gesellschaft","host_organization_lineage":["https://openalex.org/I4923324"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:upcommons.upc.edu:2117/342318","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2117/342318","pdf_url":null,"source":{"id":"https://openalex.org/S4377196262","display_name":"UPCommons institutional repository (Universitat Polit\u00e8cnica de Catalunya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I9617848","host_organization_name":"Universitat Polit\u00e8cnica de Catalunya","host_organization_lineage":["https://openalex.org/I9617848"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1008464","doi":"https://doi.org/10.1371/journal.pcbi.1008464","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008464","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008464&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","ccf-b","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321773","display_name":"Fraunhofer-Gesellschaft","ror":"https://ror.org/05hkkdn48"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3106972347.pdf","grobid_xml":"https://content.openalex.org/works/W3106972347.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W1489520413","https://openalex.org/W1493523706","https://openalex.org/W1544009106","https://openalex.org/W1970263201","https://openalex.org/W1971224531","https://openalex.org/W1989277387","https://openalex.org/W2043764521","https://openalex.org/W2061061337","https://openalex.org/W2062533676","https://openalex.org/W2106474670","https://openalex.org/W2118953105","https://openalex.org/W2132022337","https://openalex.org/W2137052779","https://openalex.org/W2140239055","https://openalex.org/W2150196286","https://openalex.org/W2154784840","https://openalex.org/W2160533336","https://openalex.org/W2161811803","https://openalex.org/W2223833389","https://openalex.org/W2259760037","https://openalex.org/W2263739890","https://openalex.org/W2280966365","https://openalex.org/W2345781825","https://openalex.org/W2402506318","https://openalex.org/W2551649149","https://openalex.org/W2557154264","https://openalex.org/W2559588208","https://openalex.org/W2584349229","https://openalex.org/W2586637063","https://openalex.org/W2603650601","https://openalex.org/W2624021832","https://openalex.org/W2678824027","https://openalex.org/W2767914218","https://openalex.org/W2771798633","https://openalex.org/W2790756470","https://openalex.org/W2793215279","https://openalex.org/W2797985113","https://openalex.org/W2807869290","https://openalex.org/W2809079142","https://openalex.org/W2896002881","https://openalex.org/W2909240409","https://openalex.org/W2910111050","https://openalex.org/W2910283844","https://openalex.org/W2912257116","https://openalex.org/W2917858269","https://openalex.org/W2922229918","https://openalex.org/W2923363662","https://openalex.org/W2938214930","https://openalex.org/W2939519112","https://openalex.org/W2945265384","https://openalex.org/W2951651936","https://openalex.org/W2951846550","https://openalex.org/W2980462907","https://openalex.org/W2981350712","https://openalex.org/W2982940349","https://openalex.org/W2983166786","https://openalex.org/W3006936835","https://openalex.org/W3009491148","https://openalex.org/W3017271475","https://openalex.org/W4231254854","https://openalex.org/W4237335579","https://openalex.org/W6813094581"],"related_works":["https://openalex.org/W2016914833","https://openalex.org/W4221048327","https://openalex.org/W7098926390","https://openalex.org/W7203582073","https://openalex.org/W2032348348","https://openalex.org/W2901238493","https://openalex.org/W3081676766","https://openalex.org/W2228293239","https://openalex.org/W4415126929","https://openalex.org/W2094791588"],"abstract_inverted_index":{"Elucidating":[0],"the":[1,24,31,44,51,69,73,162],"causal":[2,88,102],"mechanisms":[3,75],"responsible":[4],"for":[5,12,46,63,90,112,131,153],"disease":[6,48],"can":[7,29,128,146],"reveal":[8,30],"potential":[9],"therapeutic":[10],"targets":[11],"pharmacological":[13],"intervention":[14],"and,":[15],"accordingly,":[16],"guide":[17],"drug":[18,34,92,110,138],"repositioning":[19],"and":[20,50,124,150],"discovery.":[21],"In":[22],"essence,":[23],"topology":[25],"of":[26,53],"a":[27,33,39,82,113,166],"network":[28,177],"impact":[32],"candidate":[35],"may":[36],"have":[37],"on":[38,174],"given":[40,114],"biological":[41,106],"state,":[42],"leading":[43],"way":[45],"enhanced":[47],"characterization":[49],"design":[52],"advanced":[54],"therapies.":[55],"Network-based":[56],"approaches,":[57],"in":[58,104],"particular,":[59],"are":[60],"highly":[61],"suited":[62],"these":[64,172],"purposes":[65],"as":[66,165],"they":[67],"hold":[68],"capacity":[70],"to":[71,108,134,161],"identify":[72],"molecular":[74],"underlying":[76],"disease.":[77,115],"Here,":[78],"we":[79,157],"present":[80],"drug2ways,":[81],"novel":[83],"methodology":[84],"that":[85,145,169],"leverages":[86],"multimodal":[87],"networks":[89,107],"predicting":[91],"candidates.":[93],"Drug2ways":[94],"implements":[95],"an":[96],"efficient":[97],"algorithm":[98],"which":[99],"reasons":[100],"over":[101],"paths":[103],"large-scale":[105],"propose":[109],"candidates":[111,141,152],"We":[116],"validate":[117],"our":[118],"approach":[119],"using":[120],"clinical":[121],"trial":[122],"information":[123],"demonstrate":[125],"how":[126],"drug2ways":[127,159],"be":[129],"used":[130],"multiple":[132,148,175],"applications":[133,173],"identify:":[135],"i)":[136],"single-target":[137],"candidates,":[139],"ii)":[140],"with":[142],"polypharmacological":[143],"properties":[144],"optimize":[147],"targets,":[149],"iii)":[151],"combination":[154],"therapy.":[155],"Finally,":[156],"make":[158],"available":[160],"scientific":[163],"community":[164],"Python":[167],"package":[168],"enables":[170],"conducting":[171],"standard":[176],"formats.":[178]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-12-07T00:00:00"}