{"id":"https://openalex.org/W3106819829","doi":"https://doi.org/10.13201/j.issn.2096-7993.2020.12.023","title":"[Research advances on umbilical cord blood derived mesenchymal stem cell in therapy of sensorineural hearing loss].","display_name":"[Research advances on umbilical cord blood derived mesenchymal stem cell in therapy of sensorineural hearing loss].","publication_year":2020,"publication_date":"2020-12-01","ids":{"openalex":"https://openalex.org/W3106819829","doi":"https://doi.org/10.13201/j.issn.2096-7993.2020.12.023","mag":"3106819829","pmid":"https://pubmed.ncbi.nlm.nih.gov/33254356"},"language":"en","primary_location":{"id":"pmid:33254356","doi":"https://doi.org/10.13201/j.issn.2096-7993.2020.12.023","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33254356","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10127781/pdf/lcebyhtjwkzz-34-12-1149.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029565391","display_name":"Xiayu Sun","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiayu Sun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5112536336","display_name":"Jun Yang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jun Yang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0788,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.40629771,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"34","issue":"12","first_page":"1149","last_page":"1152"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.8330000042915344,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.8330000042915344,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.16189999878406525,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10542","display_name":"Vestibular and auditory disorders","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sensorineural-hearing-loss","display_name":"sensorineural hearing loss","score":0.9589999914169312},{"id":"https://openalex.org/keywords/umbilical-cord-mesenchymal-stem-cells","display_name":"human umbilical cord mesenchymal stem cells","score":0.9089999794960022},{"id":"https://openalex.org/keywords/stem-cell-transplantation","display_name":"stem cell transplantation","score":0.8450000286102295},{"id":"https://openalex.org/keywords/inner-ear-regeneration","display_name":"inner ear regeneration","score":0.8579999804496765},{"id":"https://openalex.org/keywords/hearing-restoration","display_name":"hearing restoration","score":0.8429999947547913},{"id":"https://openalex.org/keywords/therapeutic-mechanisms","display_name":"therapeutic mechanisms","score":0.5109999775886536},{"id":"https://openalex.org/keywords/clinical-safety","display_name":"clinical safety","score":0.6949999928474426}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8383952379226685},{"id":"https://openalex.org/C2780607864","wikidata":"https://www.wikidata.org/wiki/Q928697","display_name":"Sensorineural hearing loss","level":3,"score":0.8117806911468506},{"id":"https://openalex.org/C2776955114","wikidata":"https://www.wikidata.org/wiki/Q172563","display_name":"Umbilical cord","level":2,"score":0.7259420156478882},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.7000640630722046},{"id":"https://openalex.org/C2780493683","wikidata":"https://www.wikidata.org/wiki/Q16035842","display_name":"Hearing loss","level":2,"score":0.572547972202301},{"id":"https://openalex.org/C2778500370","wikidata":"https://www.wikidata.org/wiki/Q212344","display_name":"Inner ear","level":2,"score":0.5396388173103333},{"id":"https://openalex.org/C2779389132","wikidata":"https://www.wikidata.org/wiki/Q1533033","display_name":"Stem-cell therapy","level":3,"score":0.537125289440155},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5124481320381165},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.49218955636024475},{"id":"https://openalex.org/C540533750","wikidata":"https://www.wikidata.org/wiki/Q1640326","display_name":"Otology","level":2,"score":0.4861859679222107},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4316997826099396},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.4191245436668396},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2970770597457886},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.23734089732170105},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.10623407363891602},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06431776285171509},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005312","descriptor_name":"Fetal Blood","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005312","descriptor_name":"Fetal Blood","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005312","descriptor_name":"Fetal Blood","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006319","descriptor_name":"Hearing Loss, Sensorineural","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006319","descriptor_name":"Hearing Loss, Sensorineural","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006319","descriptor_name":"Hearing Loss, Sensorineural","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D019929","descriptor_name":"Cochlear Implantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019929","descriptor_name":"Cochlear Implantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019929","descriptor_name":"Cochlear Implantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D045164","descriptor_name":"Mesenchymal Stem Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D045164","descriptor_name":"Mesenchymal Stem Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D045164","descriptor_name":"Mesenchymal Stem Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:33254356","doi":"https://doi.org/10.13201/j.issn.2096-7993.2020.12.023","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33254356","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10127781","doi":"https://doi.org/10.13201/j.issn.2096-7993.2020.12.023","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10127781","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10127781/pdf/lcebyhtjwkzz-34-12-1149.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi","raw_type":"Text"},{"id":"mag:3106819829","doi":"https://doi.org/10.13201/j.issn.2096-7993.2020.12.023","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33254356","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10127781","doi":"https://doi.org/10.13201/j.issn.2096-7993.2020.12.023","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10127781","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10127781/pdf/lcebyhtjwkzz-34-12-1149.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8399999737739563}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3106819829.pdf","grobid_xml":"https://content.openalex.org/works/W3106819829.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W108875151","https://openalex.org/W653307310","https://openalex.org/W936467062","https://openalex.org/W1989250399","https://openalex.org/W1989454036","https://openalex.org/W2020160476","https://openalex.org/W2046124242","https://openalex.org/W2063687595","https://openalex.org/W2110551673","https://openalex.org/W2160596461","https://openalex.org/W2239955975","https://openalex.org/W2511760972","https://openalex.org/W2774988437","https://openalex.org/W2781940317","https://openalex.org/W2796599499","https://openalex.org/W2801017572","https://openalex.org/W2806504837","https://openalex.org/W2814246515","https://openalex.org/W2886443304","https://openalex.org/W2888334620","https://openalex.org/W2900546533","https://openalex.org/W2903755418","https://openalex.org/W2924634363","https://openalex.org/W2927991383","https://openalex.org/W2946082176","https://openalex.org/W2947573218","https://openalex.org/W2951464551","https://openalex.org/W2992056589","https://openalex.org/W3000524743"],"related_works":["https://openalex.org/W4312304759","https://openalex.org/W3032240238","https://openalex.org/W4280572140","https://openalex.org/W3114022144","https://openalex.org/W2097452330","https://openalex.org/W2040037095","https://openalex.org/W2042494701","https://openalex.org/W2439880177","https://openalex.org/W3031622208","https://openalex.org/W3106819829"],"abstract_inverted_index":{"Sensorineural":[0],"hearing":[1,27,87],"loss\uff08SNHL\uff09":[2],"is":[3],"a":[4],"difficult":[5],"and":[6,31,68,86,113,122,132],"hot":[7],"issue":[8],"in":[9,78,117],"the":[10,19,35,47,80,83,97,107,111,118,123,129],"field":[11],"of":[12,16,21,43,50,82,99,109,115,120,125,135],"otology.":[13],"The":[14],"effect":[15],"medications":[17],"targeting":[18],"mechanism":[20,114],"SNHL":[22],"are":[23,34],"often":[24],"unsatisfactory":[25],"for":[26,75],"improvement.":[28],"Hearing":[29],"aids":[30],"cochlear":[32],"implants":[33],"mainstream":[36],"treatment":[37,119],"methods":[38],"at":[39],"present,":[40],"but":[41],"neither":[42],"them":[44],"can":[45],"reverse":[46],"pathological":[48],"changes":[49],"affected":[51],"inner":[52,84],"ear.":[53],"In":[54,92],"recent":[55],"years,":[56],"mesenchymal":[57,104],"stem":[58,105],"cells":[59],"transplantation":[60],"has":[61],"been":[62],"confirmed":[63],"by":[64],"several":[65],"animal":[66],"studies":[67],"clinical":[69,76,126],"trials":[70],"to":[71,89],"have":[72],"great":[73],"potential":[74],"applications":[77],"restoring":[79],"structure":[81],"ear":[85],"improvement":[88],"some":[90],"extent.":[91],"this":[93,136],"review,":[94],"we":[95],"review":[96],"characteristics":[98],"umbilical":[100],"cord":[101],"blood":[102],"derived":[103],"cells\uff08UCBMSCs\uff09,":[106],"approaches":[108],"transplantation,":[110],"efficacy":[112],"UCBMSCs":[116],"SNHL,":[121],"safety":[124],"application,":[127],"covering":[128],"existing":[130],"problems":[131],"future":[133],"prospects":[134],"rising":[137],"treatment.":[138]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2020-12-07T00:00:00"}