{"id":"https://openalex.org/W3106785508","doi":"https://doi.org/10.3390/cancers12123566","title":"Combined CDK2 and CDK4/6 Inhibition Overcomes Palbociclib Resistance in Breast Cancer by Enhancing Senescence","display_name":"Combined CDK2 and CDK4/6 Inhibition Overcomes Palbociclib Resistance in Breast Cancer by Enhancing Senescence","publication_year":2020,"publication_date":"2020-11-29","ids":{"openalex":"https://openalex.org/W3106785508","doi":"https://doi.org/10.3390/cancers12123566","mag":"3106785508","pmid":"https://pubmed.ncbi.nlm.nih.gov/33260316","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7768442"},"language":"en","primary_location":{"id":"doi:10.3390/cancers12123566","doi":"https://doi.org/10.3390/cancers12123566","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers12123566","pdf_url":"https://www.mdpi.com/2072-6694/12/12/3566/pdf?version=1606889101","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2072-6694/12/12/3566/pdf?version=1606889101","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003066179","display_name":"Kamal Pandey","orcid":"https://orcid.org/0000-0003-2144-0577","observed_orcids":["https://orcid.org/0000-0003-2144-0577"]},"institutions":[{"id":"https://openalex.org/I4210134376","display_name":"CHA University Bundang Medical Center","ror":"https://ror.org/04nbqb988","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210134376","https://openalex.org/I4210148737","https://openalex.org/I4405258985"]},{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kamal Pandey","raw_affiliation_strings":["Department of Biomedical Science, CHA University, Seongnam 13488, Korea","Hematology and Oncology, Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam 13488, Korea"],"raw_orcid":"https://orcid.org/0000-0003-2144-0577","affiliations":[{"raw_affiliation_string":"Department of Biomedical Science, CHA University, Seongnam 13488, Korea","institution_ids":["https://openalex.org/I4210148737"]},{"raw_affiliation_string":"Hematology and Oncology, Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam 13488, Korea","institution_ids":["https://openalex.org/I4210134376","https://openalex.org/I4210148737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020822943","display_name":"Nahee Park","orcid":"https://orcid.org/0000-0003-2146-6996","observed_orcids":["https://orcid.org/0000-0003-2146-6996"]},"institutions":[{"id":"https://openalex.org/I4210134376","display_name":"CHA University Bundang Medical Center","ror":"https://ror.org/04nbqb988","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210134376","https://openalex.org/I4210148737","https://openalex.org/I4405258985"]},{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Nahee Park","raw_affiliation_strings":["Hematology and Oncology, Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam 13488, Korea"],"raw_orcid":"https://orcid.org/0000-0003-2146-6996","affiliations":[{"raw_affiliation_string":"Hematology and Oncology, Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam 13488, Korea","institution_ids":["https://openalex.org/I4210134376","https://openalex.org/I4210148737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108140359","display_name":"Kyung\u2010Soon Park","orcid":"https://orcid.org/0000-0002-0615-4313","observed_orcids":["https://orcid.org/0000-0002-0615-4313"]},"institutions":[{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kyung-Soon Park","raw_affiliation_strings":["Department of Biomedical Science, CHA University, Seongnam 13488, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Science, CHA University, Seongnam 13488, Korea","institution_ids":["https://openalex.org/I4210148737"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jin Hur","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134376","display_name":"CHA University Bundang Medical Center","ror":"https://ror.org/04nbqb988","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210134376","https://openalex.org/I4210148737","https://openalex.org/I4405258985"]},{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jin Hur","raw_affiliation_strings":["Department of Biomedical Science, CHA University, Seongnam 13488, Korea","Hematology and Oncology, Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam 13488, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Science, CHA University, Seongnam 13488, Korea","institution_ids":["https://openalex.org/I4210148737"]},{"raw_affiliation_string":"Hematology and Oncology, Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam 13488, Korea","institution_ids":["https://openalex.org/I4210134376","https://openalex.org/I4210148737"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yong Bin Cho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134376","display_name":"CHA University Bundang Medical Center","ror":"https://ror.org/04nbqb988","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210134376","https://openalex.org/I4210148737","https://openalex.org/I4405258985"]},{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yong Bin Cho","raw_affiliation_strings":["Hematology and Oncology, Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam 13488, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology and Oncology, Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam 13488, Korea","institution_ids":["https://openalex.org/I4210134376","https://openalex.org/I4210148737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084467955","display_name":"Minsil Kang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134376","display_name":"CHA University Bundang Medical Center","ror":"https://ror.org/04nbqb988","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210134376","https://openalex.org/I4210148737","https://openalex.org/I4405258985"]},{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Minsil Kang","raw_affiliation_strings":["Hematology and Oncology, Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam 13488, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology and Oncology, Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam 13488, Korea","institution_ids":["https://openalex.org/I4210134376","https://openalex.org/I4210148737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102166036","display_name":"Hee\u2010Jung An","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134376","display_name":"CHA University Bundang Medical Center","ror":"https://ror.org/04nbqb988","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210134376","https://openalex.org/I4210148737","https://openalex.org/I4405258985"]},{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hee-Jung An","raw_affiliation_strings":["Department of Pathology, CHA Bundang Medical Center, CHA University, Seongnam 13488, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, CHA Bundang Medical Center, CHA University, Seongnam 13488, Korea","institution_ids":["https://openalex.org/I4210134376","https://openalex.org/I4210148737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016237198","display_name":"Sewha Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134376","display_name":"CHA University Bundang Medical Center","ror":"https://ror.org/04nbqb988","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210134376","https://openalex.org/I4210148737","https://openalex.org/I4405258985"]},{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sewha Kim","raw_affiliation_strings":["Department of Pathology, CHA Bundang Medical Center, CHA University, Seongnam 13488, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, CHA Bundang Medical Center, CHA University, Seongnam 13488, Korea","institution_ids":["https://openalex.org/I4210134376","https://openalex.org/I4210148737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028639165","display_name":"Sohyun Hwang","orcid":"https://orcid.org/0000-0003-2461-6806","observed_orcids":["https://orcid.org/0000-0003-2461-6806"]},"institutions":[{"id":"https://openalex.org/I4210134376","display_name":"CHA University Bundang Medical Center","ror":"https://ror.org/04nbqb988","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210134376","https://openalex.org/I4210148737","https://openalex.org/I4405258985"]},{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sohyun Hwang","raw_affiliation_strings":["Department of Biomedical Science, CHA University, Seongnam 13488, Korea","Department of Pathology, CHA Bundang Medical Center, CHA University, Seongnam 13488, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Science, CHA University, Seongnam 13488, Korea","institution_ids":["https://openalex.org/I4210148737"]},{"raw_affiliation_string":"Department of Pathology, CHA Bundang Medical Center, CHA University, Seongnam 13488, Korea","institution_ids":["https://openalex.org/I4210134376","https://openalex.org/I4210148737"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073849119","display_name":"Yong Wha Moon","orcid":"https://orcid.org/0000-0002-7943-974X","observed_orcids":["https://orcid.org/0000-0002-7943-974X"]},"institutions":[{"id":"https://openalex.org/I4210134376","display_name":"CHA University Bundang Medical Center","ror":"https://ror.org/04nbqb988","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210134376","https://openalex.org/I4210148737","https://openalex.org/I4405258985"]},{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Yong Wha Moon","raw_affiliation_strings":["Hematology and Oncology, Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam 13488, Korea"],"raw_orcid":"https://orcid.org/0000-0002-7943-974X","affiliations":[{"raw_affiliation_string":"Hematology and Oncology, Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam 13488, Korea","institution_ids":["https://openalex.org/I4210134376","https://openalex.org/I4210148737"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5073849119"],"corresponding_institution_ids":["https://openalex.org/I4210134376","https://openalex.org/I4210148737"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2324},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2324},"fwci":6.6376,"has_fulltext":true,"cited_by_count":138,"citation_normalized_percentile":{"value":0.97920959,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"12","issue":"12","first_page":"3566","last_page":"3566"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/palbociclib-resistance","display_name":"palbociclib resistance","score":0.9259999990463257},{"id":"https://openalex.org/keywords/cdk4-6-inhibitors","display_name":"CDK4/6 inhibitors","score":0.9089999794960022},{"id":"https://openalex.org/keywords/cdk2-inhibition","display_name":"CDK2 inhibition","score":0.9789999723434448},{"id":"https://openalex.org/keywords/cyclin-e","display_name":"cyclin E","score":0.9710000157356262},{"id":"https://openalex.org/keywords/cyclin-e1","display_name":"cyclin E1","score":0.8610000014305115},{"id":"https://openalex.org/keywords/senescence","display_name":"senescence","score":0.7770000100135803},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.9399999976158142},{"id":"https://openalex.org/keywords/hormone-receptor-positive-breast-cancer","display_name":"hormone receptor-positive breast cancer","score":0.9409999847412109},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.5619999766349792},{"id":"https://openalex.org/keywords/pleural-effusion","display_name":"pleural effusion","score":0.7710000276565552},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7160000205039978},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.6209999918937683}],"concepts":[{"id":"https://openalex.org/C2779744173","wikidata":"https://www.wikidata.org/wiki/Q15269707","display_name":"Palbociclib","level":5,"score":0.9691094160079956},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6214033961296082},{"id":"https://openalex.org/C82495950","wikidata":"https://www.wikidata.org/wiki/Q14911732","display_name":"Cyclin-dependent kinase 2","level":4,"score":0.5905008912086487},{"id":"https://openalex.org/C94561458","wikidata":"https://www.wikidata.org/wiki/Q24724860","display_name":"Cyclin E","level":5,"score":0.5628446340560913},{"id":"https://openalex.org/C124320809","wikidata":"https://www.wikidata.org/wiki/Q46292","display_name":"Cyclin-dependent kinase","level":4,"score":0.5584706664085388},{"id":"https://openalex.org/C120089663","wikidata":"https://www.wikidata.org/wiki/Q59250999","display_name":"Cyclin","level":4,"score":0.5381020307540894},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5376545190811157},{"id":"https://openalex.org/C51853150","wikidata":"https://www.wikidata.org/wiki/Q14911754","display_name":"Cyclin-dependent kinase 4","level":5,"score":0.5305084586143494},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5161341428756714},{"id":"https://openalex.org/C11882975","wikidata":"https://www.wikidata.org/wiki/Q24781041","display_name":"Cyclin D","level":5,"score":0.48765766620635986},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.47190290689468384},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4564225673675537},{"id":"https://openalex.org/C2780360765","wikidata":"https://www.wikidata.org/wiki/Q5198275","display_name":"Cyclin E1","level":5,"score":0.4190168082714081},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.38156676292419434},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36747264862060547},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.21006789803504944}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/cancers12123566","doi":"https://doi.org/10.3390/cancers12123566","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers12123566","pdf_url":"https://www.mdpi.com/2072-6694/12/12/3566/pdf?version=1606889101","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},{"id":"pmid:33260316","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33260316","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7768442","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7768442/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers (Basel)","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:aadba353a88140b3abeb1c633fdb4aa4","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/aadba353a88140b3abeb1c633fdb4aa4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancers, Vol 12, Iss 3566, p 3566 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/cancers12123566","doi":"https://doi.org/10.3390/cancers12123566","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers12123566","pdf_url":"https://www.mdpi.com/2072-6694/12/12/3566/pdf?version=1606889101","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3737273117","display_name":null,"funder_award_id":"NRF-2017R1C1B2003618","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G4117332865","display_name":null,"funder_award_id":"NRF-2020R1F1A1065234","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G4900341305","display_name":null,"funder_award_id":"HI16C1559","funder_id":"https://openalex.org/F4320322107","funder_display_name":"Korea Health Industry Development Institute"},{"id":"https://openalex.org/G5195843859","display_name":null,"funder_award_id":"HI16C1559","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G795589043","display_name":null,"funder_award_id":"HI16C1559","funder_id":"https://openalex.org/F4320322030","funder_display_name":"Ministry of Science, ICT and Future Planning"}],"funders":[{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322030","display_name":"Ministry of Science, ICT and Future Planning","ror":"https://ror.org/032e49973"},{"id":"https://openalex.org/F4320322107","display_name":"Korea Health Industry Development Institute","ror":"https://ror.org/00fdzyk40"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3106785508.pdf","grobid_xml":"https://content.openalex.org/works/W3106785508.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W414995138","https://openalex.org/W1833796513","https://openalex.org/W1917948530","https://openalex.org/W1964596502","https://openalex.org/W2006096599","https://openalex.org/W2031915537","https://openalex.org/W2043398720","https://openalex.org/W2099086526","https://openalex.org/W2101700713","https://openalex.org/W2101904881","https://openalex.org/W2119565091","https://openalex.org/W2139522545","https://openalex.org/W2146915309","https://openalex.org/W2163563958","https://openalex.org/W2164176439","https://openalex.org/W2290950904","https://openalex.org/W2309969893","https://openalex.org/W2318725321","https://openalex.org/W2502603894","https://openalex.org/W2520255934","https://openalex.org/W2528767298","https://openalex.org/W2537675006","https://openalex.org/W2552099557","https://openalex.org/W2620993107","https://openalex.org/W2729251358","https://openalex.org/W2763416106","https://openalex.org/W2771355810","https://openalex.org/W2783121990","https://openalex.org/W2789589528","https://openalex.org/W2791350651","https://openalex.org/W2805575723","https://openalex.org/W2806421539","https://openalex.org/W2806944822","https://openalex.org/W2894607768","https://openalex.org/W2898335174","https://openalex.org/W2898724324","https://openalex.org/W2900043421","https://openalex.org/W2901425242","https://openalex.org/W2902401096","https://openalex.org/W2910972034","https://openalex.org/W2917464640","https://openalex.org/W2922022732","https://openalex.org/W2925017918","https://openalex.org/W2935187964","https://openalex.org/W2938054231","https://openalex.org/W2943966410","https://openalex.org/W2946510052","https://openalex.org/W2967855006","https://openalex.org/W2970349558","https://openalex.org/W2982470286"],"related_works":["https://openalex.org/W3082042358","https://openalex.org/W3082354774","https://openalex.org/W4220762527","https://openalex.org/W7148871533","https://openalex.org/W4323570065","https://openalex.org/W2398150337","https://openalex.org/W4205928549","https://openalex.org/W2400518997","https://openalex.org/W4292866406","https://openalex.org/W4294583800"],"abstract_inverted_index":{"Breast":[0],"cancer":[1,7,97,181],"represents":[2],"the":[3,12,139,149],"number":[4],"one":[5],"global":[6],"burden":[8],"in":[9,28,80,89,125,178],"women":[10],"and":[11,37,63,83,120,146,167],"hormone":[13],"receptor":[14,51],"(HR)-positive":[15],"subtype":[16],"comprises":[17],"approximately":[18],"70%":[19],"of":[20,58,101,117,122,152],"breast":[21,96,180],"cancers.":[22],"Unfortunately,":[23],"acquired":[24],"resistance":[25,59,198],"ultimately":[26],"occurs":[27],"almost":[29],"all":[30],"cases,":[31],"even":[32],"though":[33],"cyclin-dependent":[34],"kinase":[35],"4":[36],"6":[38],"(CDK4/6)":[39],"inhibitors":[40],"are":[41],"a":[42,135,156,190],"highly":[43],"effective":[44],"therapy":[45],"for":[46,194],"HR-positive/human":[47],"epidermal":[48],"growth":[49,121],"factor":[50],"2-negative":[52],"subtype.":[53],"Here,":[54],"we":[55,107,184],"investigated":[56],"mechanisms":[57],"to":[60,199],"CDK4/6":[61,200],"inhibitor":[62],"potential":[64],"therapeutic":[65,157,192],"strategies":[66],"using":[67],"our":[68],"palbociclib-resistant":[69,81,118,123],"preclinical":[70],"model.":[71],"We":[72,127],"observed":[73],"that":[74,130],"cyclin":[75,102,153,186,196],"E":[76,154],"was":[77,86,159],"significantly":[78],"overexpressed":[79],"cells,":[82],"similar":[84],"association":[85,163],"also":[87,128],"confirmed":[88],"pleural":[90],"effusion":[91],"samples":[92],"collected":[93],"from":[94],"HR-positive":[95,179],"patients.":[98,182],"After":[99],"confirmation":[100],"E-CDK2":[103,187],"interaction":[104],"by":[105,142,161],"co-immunoprecipitation,":[106],"demonstrated":[108],"CDK2":[109,145],"inhibition":[110],"combined":[111],"with":[112],"palbociclib":[113],"synergistically":[114],"suppressed":[115],"proliferation":[116],"cells":[119],"xenograft":[124],"mice.":[126],"proved":[129],"enhancing":[131],"C-MYC-mediated":[132],"senescence":[133],"is":[134],"novel":[136],"mechanism":[137],"behind":[138],"synergism":[140],"created":[141],"targeting":[143],"both":[144],"CDK4/6.":[147],"Furthermore,":[148],"clinical":[150],"relevance":[151],"as":[155,189],"target":[158,193],"supported":[160],"significant":[162],"between":[164],"CCNE1":[165],"overexpression":[166],"poor":[168],"prognosis":[169],"based":[170],"on":[171],"large-scale":[172],"public":[173],"gene":[174],"expression":[175],"data":[176],"sets":[177],"Therefore,":[183],"propose":[185],"signaling":[188],"promising":[191],"overcoming":[195],"E-associated":[197],"inhibitor.":[201]},"counts_by_year":[{"year":2026,"cited_by_count":16},{"year":2025,"cited_by_count":29},{"year":2024,"cited_by_count":26},{"year":2023,"cited_by_count":32},{"year":2022,"cited_by_count":20},{"year":2021,"cited_by_count":15}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-12-07T00:00:00"}