{"id":"https://openalex.org/W3105628935","doi":"https://doi.org/10.1080/14786419.2020.1849200","title":"The effect of emodin on melanogenesis through the modulation of ERK and MITF signaling pathway","display_name":"The effect of emodin on melanogenesis through the modulation of ERK and MITF signaling pathway","publication_year":2020,"publication_date":"2020-11-18","ids":{"openalex":"https://openalex.org/W3105628935","doi":"https://doi.org/10.1080/14786419.2020.1849200","mag":"3105628935","pmid":"https://pubmed.ncbi.nlm.nih.gov/33205668"},"language":"en","primary_location":{"id":"doi:10.1080/14786419.2020.1849200","doi":"https://doi.org/10.1080/14786419.2020.1849200","is_oa":false,"landing_page_url":"https://doi.org/10.1080/14786419.2020.1849200","pdf_url":null,"source":{"id":"https://openalex.org/S205999849","display_name":"Natural Product Research","issn_l":"1478-6419","issn":["1478-6419","1478-6427"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Natural Product Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://figshare.com/articles/journal_contribution/The_effect_of_emodin_on_melanogenesis_through_the_modulation_of_ERK_and_MITF_signaling_pathway/13251843","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100649967","display_name":"Jae Ho Kim","orcid":"https://orcid.org/0000-0003-4323-4790","observed_orcids":["https://orcid.org/0000-0003-4323-4790"]},"institutions":[{"id":"https://openalex.org/I204974687","display_name":"Dong-Eui University","ror":"https://ror.org/059g69b28","country_code":"KR","type":"education","lineage":["https://openalex.org/I204974687"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jaeho Kim","raw_affiliation_strings":["Department of Chemistry & Biology, Dong-Eui University, Busan, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry & Biology, Dong-Eui University, Busan, Republic of Korea","institution_ids":["https://openalex.org/I204974687"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050297855","display_name":"Moon\u2010Moo Kim","orcid":"https://orcid.org/0000-0001-5887-266X","observed_orcids":["https://orcid.org/0000-0001-5887-266X"]},"institutions":[{"id":"https://openalex.org/I204974687","display_name":"Dong-Eui University","ror":"https://ror.org/059g69b28","country_code":"KR","type":"education","lineage":["https://openalex.org/I204974687"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Moon-Moo Kim","raw_affiliation_strings":["Department of Applied Chemistry, Dong-Eui University, Busan, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Chemistry, Dong-Eui University, Busan, Republic of Korea","institution_ids":["https://openalex.org/I204974687"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5050297855"],"corresponding_institution_ids":["https://openalex.org/I204974687"],"apc_list":null,"apc_paid":null,"fwci":1.1218,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.73985621,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"36","issue":"4","first_page":"1084","last_page":"1088"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12673","display_name":"Microbial Metabolism and Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/emodin","display_name":"emodin","score":1.0},{"id":"https://openalex.org/keywords/polygonum-multiflorum","display_name":"Polygonum multiflorum","score":0.9620000123977661},{"id":"https://openalex.org/keywords/melanin-synthesis","display_name":"melanogenesis","score":0.9890000224113464},{"id":"https://openalex.org/keywords/tyrosinase","display_name":"tyrosinase","score":0.9150000214576721},{"id":"https://openalex.org/keywords/mitf","display_name":"MITF","score":0.6840000152587891},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.9169999957084656},{"id":"https://openalex.org/keywords/sirt1","display_name":"SIRT1","score":0.972000002861023},{"id":"https://openalex.org/keywords/foxo1","display_name":"FOXO1","score":0.9409999847412109},{"id":"https://openalex.org/keywords/hydrogen-peroxide-scavenging","display_name":"hydrogen peroxide scavenging","score":0.8360000252723694},{"id":"https://openalex.org/keywords/trp-1","display_name":"TRP-1","score":0.9169999957084656},{"id":"https://openalex.org/keywords/trp-2","display_name":"TRP-2","score":1.0},{"id":"https://openalex.org/keywords/hair-graying","display_name":"hair graying","score":0.7070000171661377},{"id":"https://openalex.org/keywords/b16f1-melanoma-cells","display_name":"B16F1 melanoma cells","score":0.9020000100135803}],"concepts":[{"id":"https://openalex.org/C2778248515","wikidata":"https://www.wikidata.org/wiki/Q4348178","display_name":"Emodin","level":2,"score":0.9855036735534668},{"id":"https://openalex.org/C177504595","wikidata":"https://www.wikidata.org/wiki/Q336500","display_name":"Microphthalmia-associated transcription factor","level":4,"score":0.8901365995407104},{"id":"https://openalex.org/C87554066","wikidata":"https://www.wikidata.org/wiki/Q85942926","display_name":"Tyrosinase","level":3,"score":0.8139680624008179},{"id":"https://openalex.org/C2779078452","wikidata":"https://www.wikidata.org/wiki/Q1416124","display_name":"Skin whitening","level":3,"score":0.721602201461792},{"id":"https://openalex.org/C107538193","wikidata":"https://www.wikidata.org/wiki/Q187526","display_name":"Melanin","level":2,"score":0.7090889811515808},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6059825420379639},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.48067769408226013},{"id":"https://openalex.org/C2781424683","wikidata":"https://www.wikidata.org/wiki/Q416446","display_name":"Arbutin","level":2,"score":0.4591076374053955},{"id":"https://openalex.org/C2776165026","wikidata":"https://www.wikidata.org/wiki/Q188017","display_name":"Tyrosine","level":2,"score":0.4406777620315552},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.43775755167007446},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.4316234886646271},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4218732416629791},{"id":"https://openalex.org/C2781401929","wikidata":"https://www.wikidata.org/wiki/Q5205953","display_name":"DPPH","level":3,"score":0.4190126061439514},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.29652613401412964},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2629096508026123},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.17802289128303528},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.09851342439651489},{"id":"https://openalex.org/C45904493","wikidata":"https://www.wikidata.org/wiki/Q912807","display_name":"Active ingredient","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000068676","descriptor_name":"Fallopia multiflora","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004642","descriptor_name":"Emodin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008543","descriptor_name":"Melanins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D008546","descriptor_name":"Melanoma, Experimental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014442","descriptor_name":"Monophenol Monooxygenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051739","descriptor_name":"Microphthalmia-Associated Transcription Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1080/14786419.2020.1849200","doi":"https://doi.org/10.1080/14786419.2020.1849200","is_oa":false,"landing_page_url":"https://doi.org/10.1080/14786419.2020.1849200","pdf_url":null,"source":{"id":"https://openalex.org/S205999849","display_name":"Natural Product Research","issn_l":"1478-6419","issn":["1478-6419","1478-6427"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Natural Product Research","raw_type":"journal-article"},{"id":"pmid:33205668","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33205668","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Natural product research","raw_type":"Journal Article"},{"id":"pmh:oai:figshare.com:article/13251843","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/The_effect_of_emodin_on_melanogenesis_through_the_modulation_of_ERK_and_MITF_signaling_pathway/13251843","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"doi:10.6084/m9.figshare.13251843.v1","doi":"https://doi.org/10.6084/m9.figshare.13251843.v1","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.13251843.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"pmh:oai:figshare.com:article/13251843","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/The_effect_of_emodin_on_melanogenesis_through_the_modulation_of_ERK_and_MITF_signaling_pathway/13251843","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5058998013","display_name":null,"funder_award_id":"2017R1D1A3B06028000","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1521411817","https://openalex.org/W1830459440","https://openalex.org/W2108313628","https://openalex.org/W2139775939","https://openalex.org/W2163252506","https://openalex.org/W2167596635","https://openalex.org/W2177715687","https://openalex.org/W2294985544","https://openalex.org/W2505973824","https://openalex.org/W2568402531","https://openalex.org/W2726040815","https://openalex.org/W2782334951","https://openalex.org/W2803375596","https://openalex.org/W2886789921","https://openalex.org/W2912500923","https://openalex.org/W2962362169","https://openalex.org/W2987538033","https://openalex.org/W3020958153","https://openalex.org/W3175499991"],"related_works":["https://openalex.org/W2981636945","https://openalex.org/W2526982120","https://openalex.org/W2294985544","https://openalex.org/W2047814493","https://openalex.org/W1980374748","https://openalex.org/W2170610562","https://openalex.org/W2333187330","https://openalex.org/W3124929683","https://openalex.org/W3013055260","https://openalex.org/W3146055716"],"abstract_inverted_index":{"The":[0],"aim":[1],"of":[2,10,69,95,118,125],"this":[3,23],"study":[4],"was":[5,40],"to":[6,139],"investigate":[7],"the":[8,66,93,116,123],"effect":[9],"emodin":[11,25,43,60,101,110,133],"derived":[12],"from":[13],"Polygonum":[14],"multiflorum":[15],"on":[16],"melanin":[17,55,62,112,136],"production":[18,137],"in":[19,31,57,81,92],"B16F1":[20],"cells.":[21],"In":[22],"study,":[24],"did":[26],"not":[27,49],"show":[28],"antioxidant":[29],"activity":[30,52],"DPPH":[32],"radical":[33],"and":[34,78,98,107],"reducing":[35],"power":[36],"assays.":[37],"However,":[38],"it":[39],"found":[41],"that":[42,132],"scavenged":[44],"intracellular":[45],"H2O2.":[46],"Emodin":[47],"increased":[48],"only":[50],"tyrosinase":[51,70,121],"but":[53],"also":[54],"synthesis":[56,63,113],"vitro.":[58],"Moreover,":[59,100],"enhanced":[61],"by":[64,105,114],"increasing":[65,115],"expression":[67,117],"level":[68],"(TYR),":[71],"tyrosine":[72],"related":[73,138],"protein":[74],"(TRP)-1,":[75],"TRP-2,":[76,120],"MITF":[77,126],"SIRT1":[79,106],"proteins":[80],"live":[82],"cells":[83],"treated":[84],"with":[85,88],"H2O2":[86,89],"compared":[87],"treatment":[90],"group":[91],"analyses":[94],"western":[96],"blot":[97],"immunofluorescence.":[99],"suppressed":[102],"ERK":[103],"activation":[104,124],"FOXO1.":[108],"Thus,":[109],"promoted":[111],"TRP-1,":[119],"through":[122],"transcription":[127],"factor.":[128],"These":[129],"findings":[130],"suggest":[131],"could":[134],"promote":[135],"anti-hair":[140],"graying.":[141]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-11-23T00:00:00"}