{"id":"https://openalex.org/W3105580127","doi":"https://doi.org/10.1016/s0021-5198(19)62789-7","title":"Hypotensive effects of long-term oral administration of angiotensin converting enzyme inhibitor, MC-838, in various models of experimentally hypertensive rats","display_name":"Hypotensive effects of long-term oral administration of angiotensin converting enzyme inhibitor, MC-838, in various models of experimentally hypertensive rats","publication_year":1984,"publication_date":"1984-01-01","ids":{"openalex":"https://openalex.org/W3105580127","doi":"https://doi.org/10.1016/s0021-5198(19)62789-7","mag":"3105580127"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-5198(19)62789-7","doi":"https://doi.org/10.1016/s0021-5198(19)62789-7","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-5198(19)62789-7","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0021519819627897/pdf","source":{"id":"https://openalex.org/S190179609","display_name":"The Japanese Journal of Pharmacology","issn_l":"0021-5198","issn":["0021-5198","1347-3506"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310313602","host_organization_name":"Japanese Pharmacological Society","host_organization_lineage":["https://openalex.org/P4310313602"],"host_organization_lineage_names":["Japanese Pharmacological Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Journal of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.sciencedirect.com/science/article/pii/S0021519819627897/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017245983","display_name":"Minako Yoshizawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Minako Yoshizawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113922236","display_name":"Tamotsu Yamazaki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tamotsu Yamazaki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110048113","display_name":"Kazushige Sakai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kazushige Sakai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.50703279,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"36","issue":null,"first_page":"291","last_page":"291"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ace-inhibitors","display_name":"ACE inhibitors","score":0.859000027179718},{"id":"https://openalex.org/keywords/long-term-oral-administration","display_name":"long-term oral administration","score":0.7020000219345093},{"id":"https://openalex.org/keywords/antihypertensive-effect","display_name":"antihypertensive effect","score":0.8679999709129333},{"id":"https://openalex.org/keywords/experimental-hypertension","display_name":"experimental hypertension","score":0.9480000138282776},{"id":"https://openalex.org/keywords/hypertensive-rats","display_name":"hypertensive rats","score":0.703000009059906},{"id":"https://openalex.org/keywords/antihypertensive-drugs","display_name":"antihypertensive drugs","score":0.8009999990463257}],"concepts":[{"id":"https://openalex.org/C27016395","wikidata":"https://www.wikidata.org/wiki/Q128861","display_name":"Angiotensin-converting enzyme","level":3,"score":0.6370837092399597},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5863785147666931},{"id":"https://openalex.org/C61797465","wikidata":"https://www.wikidata.org/wiki/Q1188986","display_name":"Term (time)","level":2,"score":0.543351948261261},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4457380473613739},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4452112913131714},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.43631711602211},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.4309638738632202},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35294803977012634},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.35082656145095825},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3167726397514343},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17008435726165771},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.05477619171142578},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.03738588094711304},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/s0021-5198(19)62789-7","doi":"https://doi.org/10.1016/s0021-5198(19)62789-7","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-5198(19)62789-7","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0021519819627897/pdf","source":{"id":"https://openalex.org/S190179609","display_name":"The Japanese Journal of Pharmacology","issn_l":"0021-5198","issn":["0021-5198","1347-3506"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310313602","host_organization_name":"Japanese Pharmacological Society","host_organization_lineage":["https://openalex.org/P4310313602"],"host_organization_lineage_names":["Japanese Pharmacological Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Journal of Pharmacology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/s0021-5198(19)62789-7","doi":"https://doi.org/10.1016/s0021-5198(19)62789-7","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-5198(19)62789-7","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0021519819627897/pdf","source":{"id":"https://openalex.org/S190179609","display_name":"The Japanese Journal of Pharmacology","issn_l":"0021-5198","issn":["0021-5198","1347-3506"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310313602","host_organization_name":"Japanese Pharmacological Society","host_organization_lineage":["https://openalex.org/P4310313602"],"host_organization_lineage_names":["Japanese Pharmacological Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Journal of Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W3105580127.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3098940705","https://openalex.org/W3104231978","https://openalex.org/W2061425901","https://openalex.org/W2319216549","https://openalex.org/W2042894786","https://openalex.org/W2406452794","https://openalex.org/W2035668439","https://openalex.org/W3098913001","https://openalex.org/W3165815713","https://openalex.org/W2088515575"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-08-18T07:49:30.821534","created_date":"2020-11-23T00:00:00"}