{"id":"https://openalex.org/W310500325","doi":"https://doi.org/10.1007/978-1-4757-1235-3_40","title":"Molecular Biology of GAP and its Interaction with Oncogenic ras p21","display_name":"Molecular Biology of GAP and its Interaction with Oncogenic ras p21","publication_year":1989,"publication_date":"1989-01-01","ids":{"openalex":"https://openalex.org/W310500325","doi":"https://doi.org/10.1007/978-1-4757-1235-3_40","mag":"310500325"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-4757-1235-3_40","doi":"https://doi.org/10.1007/978-1-4757-1235-3_40","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4757-1235-3_40","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ras Oncogenes","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4243912776","display_name":"ras Oncogenes"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025760662","display_name":"Ursula S. Vogel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"U. S. Vogel","raw_affiliation_strings":["Department of Molecular Biology, Merck Sharp and Dohme Research Laboratories, 19486, West Point, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Merck Sharp and Dohme Research Laboratories, 19486, West Point, PA, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077508511","display_name":"Ronald E. Diehl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. E. Diehl","raw_affiliation_strings":["Department of Molecular Biology, Merck Sharp and Dohme Research Laboratories, 19486, West Point, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Merck Sharp and Dohme Research Laboratories, 19486, West Point, PA, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105726613","display_name":"Mark S. Marshall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. S. Marshall","raw_affiliation_strings":["Department of Molecular Biology, Merck Sharp and Dohme Research Laboratories, 19486, West Point, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Merck Sharp and Dohme Research Laboratories, 19486, West Point, PA, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110284682","display_name":"Michael D. Schaber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. D. Schaber","raw_affiliation_strings":["Department of Molecular Biology, Merck Sharp and Dohme Research Laboratories, 19486, West Point, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Merck Sharp and Dohme Research Laboratories, 19486, West Point, PA, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028387607","display_name":"R B Register","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. B. Register","raw_affiliation_strings":["Department of Molecular Biology, Merck Sharp and Dohme Research Laboratories, 19486, West Point, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Merck Sharp and Dohme Research Laboratories, 19486, West Point, PA, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073270276","display_name":"Wendy S. Hill","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. S. Hill","raw_affiliation_strings":["Department of Molecular Biology, Merck Sharp and Dohme Research Laboratories, 19486, West Point, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Merck Sharp and Dohme Research Laboratories, 19486, West Point, PA, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111110374","display_name":"A. S. Ng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Ng","raw_affiliation_strings":["Department of Molecular Biology, Merck Sharp and Dohme Research Laboratories, 19486, West Point, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Merck Sharp and Dohme Research Laboratories, 19486, West Point, PA, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053626123","display_name":"Edward M. Scolnick","orcid":"https://orcid.org/0000-0001-9429-1547","observed_orcids":["https://orcid.org/0000-0001-9429-1547"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. M. Scolnick","raw_affiliation_strings":["Department of Molecular Biology, Merck Sharp and Dohme Research Laboratories, 19486, West Point, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Merck Sharp and Dohme Research Laboratories, 19486, West Point, PA, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060164161","display_name":"Richard A. F. Dixon","orcid":"https://orcid.org/0000-0002-8138-7256","observed_orcids":["https://orcid.org/0000-0002-8138-7256"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. A. F. Dixon","raw_affiliation_strings":["Department of Molecular Biology, Merck Sharp and Dohme Research Laboratories, 19486, West Point, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Merck Sharp and Dohme Research Laboratories, 19486, West Point, PA, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029756305","display_name":"Irving S. Sigal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"I. S. Sigal","raw_affiliation_strings":["Department of Molecular Biology, Merck Sharp and Dohme Research Laboratories, 19486, West Point, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Merck Sharp and Dohme Research Laboratories, 19486, West Point, PA, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055481417","display_name":"W. Wayt Gibbs","orcid":"https://orcid.org/0000-0003-4757-7336","observed_orcids":["https://orcid.org/0000-0003-4757-7336"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. B. Gibbs","raw_affiliation_strings":["Department of Molecular Biology, Merck Sharp and Dohme Research Laboratories, 19486, West Point, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Merck Sharp and Dohme Research Laboratories, 19486, West Point, PA, USA","institution_ids":["https://openalex.org/I1285764155"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1285764155"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.18432639,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"303","last_page":"309"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ras-p21","display_name":"p21ras","score":0.828000009059906},{"id":"https://openalex.org/keywords/oncogenic-ras","display_name":"oncogenic Ras","score":0.6299999952316284},{"id":"https://openalex.org/keywords/gap","display_name":"GaP","score":0.546999990940094},{"id":"https://openalex.org/keywords/guanine-nucleotide-exchange","display_name":"guanine nucleotide exchange","score":0.8090000152587891},{"id":"https://openalex.org/keywords/gtpase-activity","display_name":"GTPase activity","score":0.8489999771118164},{"id":"https://openalex.org/keywords/gtp-gdp-binding","display_name":"GTP/GDP binding","score":0.6499999761581421},{"id":"https://openalex.org/keywords/cell-transformation","display_name":"cell transformation","score":0.6449999809265137},{"id":"https://openalex.org/keywords/ras1","display_name":"Ras1","score":0.7369999885559082},{"id":"https://openalex.org/keywords/ras2","display_name":"RAS2","score":1.0},{"id":"https://openalex.org/keywords/yeast","display_name":"yeast","score":0.5130000114440918},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.7149999737739563}],"concepts":[{"id":"https://openalex.org/C207332259","wikidata":"https://www.wikidata.org/wiki/Q769143","display_name":"GTPase","level":2,"score":0.8971840739250183},{"id":"https://openalex.org/C118716","wikidata":"https://www.wikidata.org/wiki/Q5514725","display_name":"GTP'","level":3,"score":0.8840139508247375},{"id":"https://openalex.org/C126619667","wikidata":"https://www.wikidata.org/wiki/Q901088","display_name":"Guanine nucleotide exchange factor","level":3,"score":0.6736652255058289},{"id":"https://openalex.org/C163181125","wikidata":"https://www.wikidata.org/wiki/Q408592","display_name":"GTPase-activating protein","level":4,"score":0.6318542957305908},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5850969552993774},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.5673863291740417},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5470465421676636},{"id":"https://openalex.org/C85771745","wikidata":"https://www.wikidata.org/wiki/Q5514732","display_name":"GTP-binding protein regulators","level":4,"score":0.524472713470459},{"id":"https://openalex.org/C2779817904","wikidata":"https://www.wikidata.org/wiki/Q422582","display_name":"Guanosine diphosphate","level":5,"score":0.47081834077835083},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.44491708278656006},{"id":"https://openalex.org/C2778301229","wikidata":"https://www.wikidata.org/wiki/Q169313","display_name":"Guanine","level":4,"score":0.4353322386741638},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4347769618034363},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.4331657290458679},{"id":"https://openalex.org/C2776638253","wikidata":"https://www.wikidata.org/wiki/Q392227","display_name":"Guanosine triphosphate","level":4,"score":0.4175404906272888},{"id":"https://openalex.org/C80631254","wikidata":"https://www.wikidata.org/wiki/Q407438","display_name":"G protein","level":3,"score":0.3628700077533722},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2597963213920593},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22764936089515686},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.08683779835700989}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-1-4757-1235-3_40","doi":"https://doi.org/10.1007/978-1-4757-1235-3_40","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4757-1235-3_40","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ras Oncogenes","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1525004818","https://openalex.org/W1605851497","https://openalex.org/W1783564364","https://openalex.org/W1859718968","https://openalex.org/W1988970153","https://openalex.org/W1998023125","https://openalex.org/W2058511768","https://openalex.org/W2063228215","https://openalex.org/W2080910520","https://openalex.org/W2264315731"],"related_works":["https://openalex.org/W2137359064","https://openalex.org/W3126729737","https://openalex.org/W1605851497","https://openalex.org/W276827932","https://openalex.org/W2058511768","https://openalex.org/W2159024007","https://openalex.org/W110944715","https://openalex.org/W1998023125","https://openalex.org/W2057852517","https://openalex.org/W277019319"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}
