{"id":"https://openalex.org/W310491812","doi":null,"title":"The \u03b17\u03b21 integrin accelerates exercise-induced myogenesis","display_name":"The \u03b17\u03b21 integrin accelerates exercise-induced myogenesis","publication_year":2010,"publication_date":"2010-05-18","ids":{"openalex":"https://openalex.org/W310491812","mag":"310491812"},"language":"en","primary_location":{"id":"pmh:oai:www.ideals.illinois.edu:2142/16000","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2142/16000","pdf_url":"http://hdl.handle.net/2142/16000","source":{"id":"https://openalex.org/S4306401358","display_name":"Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801919071","host_organization_name":"University of Illinois System","host_organization_lineage":["https://openalex.org/I2801919071"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/2142/16000","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023442573","display_name":"Tara N. Lueders","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Tara N. Lueders","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5023442573"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.015300000086426735,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11399","display_name":"Muscle metabolism and nutrition","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha7beta1-integrin","display_name":"alpha7beta1 integrin","score":0.984000027179718},{"id":"https://openalex.org/keywords/myogenesis","display_name":"myogenesis","score":0.8799999952316284},{"id":"https://openalex.org/keywords/eccentric-exercise","display_name":"eccentric exercise","score":0.9430000185966492},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.6389999985694885},{"id":"https://openalex.org/keywords/transgene-overexpression","display_name":"transgenic overexpression","score":0.734000027179718},{"id":"https://openalex.org/keywords/embryonic-myosin-heavy-chain","display_name":"embryonic myosin heavy chain","score":0.9350000023841858},{"id":"https://openalex.org/keywords/muscle-injury","display_name":"muscle damage","score":0.48500001430511475},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.949999988079071},{"id":"https://openalex.org/keywords/gastrocnemius-soleus","display_name":"gastrocnemius-soleus","score":0.847000002861023},{"id":"https://openalex.org/keywords/downhill-running","display_name":"downhill running","score":0.8159999847412109}],"concepts":[{"id":"https://openalex.org/C3763915","wikidata":"https://www.wikidata.org/wiki/Q3331437","display_name":"Myogenesis","level":3,"score":0.7417534589767456},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.4442829191684723},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.36728978157043457},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36517608165740967},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3372182250022888},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3145335614681244},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.29306215047836304},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.09543055295944214}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:www.ideals.illinois.edu:2142/16000","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2142/16000","pdf_url":"http://hdl.handle.net/2142/16000","source":{"id":"https://openalex.org/S4306401358","display_name":"Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801919071","host_organization_name":"University of Illinois System","host_organization_lineage":["https://openalex.org/I2801919071"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"mag:310491812","doi":null,"is_oa":false,"landing_page_url":"https://www.ideals.illinois.edu/bitstream/2142/16000/2/Lueders_Tara.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:www.ideals.illinois.edu:2142/16000","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2142/16000","pdf_url":"http://hdl.handle.net/2142/16000","source":{"id":"https://openalex.org/S4306401358","display_name":"Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801919071","host_organization_name":"University of Illinois System","host_organization_lineage":["https://openalex.org/I2801919071"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W310491812.pdf","grobid_xml":"https://content.openalex.org/works/W310491812.grobid-xml"},"referenced_works_count":132,"referenced_works":["https://openalex.org/W16614004","https://openalex.org/W125021021","https://openalex.org/W162490457","https://openalex.org/W170435100","https://openalex.org/W178640469","https://openalex.org/W652257723","https://openalex.org/W1481780101","https://openalex.org/W1487016719","https://openalex.org/W1530583566","https://openalex.org/W1573129821","https://openalex.org/W1607217555","https://openalex.org/W1806632103","https://openalex.org/W1888941810","https://openalex.org/W1899737965","https://openalex.org/W1966786218","https://openalex.org/W1967968546","https://openalex.org/W1972609799","https://openalex.org/W1978522449","https://openalex.org/W1983216013","https://openalex.org/W1988393390","https://openalex.org/W1988452929","https://openalex.org/W1988668250","https://openalex.org/W1992050281","https://openalex.org/W1994481920","https://openalex.org/W1997932087","https://openalex.org/W1998316378","https://openalex.org/W1999382977","https://openalex.org/W2003605917","https://openalex.org/W2003816645","https://openalex.org/W2006541131","https://openalex.org/W2007790958","https://openalex.org/W2008087967","https://openalex.org/W2010253303","https://openalex.org/W2013621644","https://openalex.org/W2014363686","https://openalex.org/W2014382700","https://openalex.org/W2015332685","https://openalex.org/W2016965630","https://openalex.org/W2022487205","https://openalex.org/W2024612038","https://openalex.org/W2026609639","https://openalex.org/W2028358008","https://openalex.org/W2029231027","https://openalex.org/W2029914169","https://openalex.org/W2030190455","https://openalex.org/W2030805703","https://openalex.org/W2030897641","https://openalex.org/W2032846449","https://openalex.org/W2035553802","https://openalex.org/W2037382054","https://openalex.org/W2038894878","https://openalex.org/W2039396493","https://openalex.org/W2043818547","https://openalex.org/W2043848247","https://openalex.org/W2049193450","https://openalex.org/W2049654830","https://openalex.org/W2050405000","https://openalex.org/W2050511526","https://openalex.org/W2050872152","https://openalex.org/W2060136332","https://openalex.org/W2060723028","https://openalex.org/W2061315835","https://openalex.org/W2062578421","https://openalex.org/W2063286211","https://openalex.org/W2067906234","https://openalex.org/W2070068952","https://openalex.org/W2070347432","https://openalex.org/W2072784433","https://openalex.org/W2075152774","https://openalex.org/W2075303668","https://openalex.org/W2075505332","https://openalex.org/W2077546694","https://openalex.org/W2077664599","https://openalex.org/W2077802763","https://openalex.org/W2078250589","https://openalex.org/W2079351435","https://openalex.org/W2084080535","https://openalex.org/W2084149383","https://openalex.org/W2084334139","https://openalex.org/W2084936584","https://openalex.org/W2086989005","https://openalex.org/W2089432984","https://openalex.org/W2089739115","https://openalex.org/W2090544280","https://openalex.org/W2091545998","https://openalex.org/W2091907737","https://openalex.org/W2093306205","https://openalex.org/W2093560632","https://openalex.org/W2094807296","https://openalex.org/W2096622475","https://openalex.org/W2098940221","https://openalex.org/W2102753121","https://openalex.org/W2103103443","https://openalex.org/W2108723188","https://openalex.org/W2112371560","https://openalex.org/W2112513572","https://openalex.org/W2115044953","https://openalex.org/W2116500923","https://openalex.org/W2116944462","https://openalex.org/W2117594901","https://openalex.org/W2118942329","https://openalex.org/W2119263162","https://openalex.org/W2122795085","https://openalex.org/W2124699186","https://openalex.org/W2129296423","https://openalex.org/W2131291167","https://openalex.org/W2131333364","https://openalex.org/W2134014721","https://openalex.org/W2136918383","https://openalex.org/W2137658965","https://openalex.org/W2138871947","https://openalex.org/W2142158928","https://openalex.org/W2143079720","https://openalex.org/W2146774835","https://openalex.org/W2147518638","https://openalex.org/W2148349633","https://openalex.org/W2154194129","https://openalex.org/W2154964493","https://openalex.org/W2158763021","https://openalex.org/W2168140872","https://openalex.org/W2170313716","https://openalex.org/W2184776738","https://openalex.org/W2189080257","https://openalex.org/W2193417403","https://openalex.org/W2223742570","https://openalex.org/W2237724905","https://openalex.org/W2277867090","https://openalex.org/W2323748919","https://openalex.org/W2334247659","https://openalex.org/W2398941971","https://openalex.org/W2418371497","https://openalex.org/W2441191617"],"related_works":["https://openalex.org/W7043259649","https://openalex.org/W2104821101","https://openalex.org/W2137658965","https://openalex.org/W2016383197","https://openalex.org/W2784233652","https://openalex.org/W2318852041","https://openalex.org/W2131333364","https://openalex.org/W2958762868","https://openalex.org/W2593466938","https://openalex.org/W2785773947"],"abstract_inverted_index":{"Muscle-specific":[0],"transgenic":[1,64],"overexpression":[2,35,201],"of":[3,16,28,36,51,71,104,160,193],"the":[4,14,37,102,186,216,220],"\u03b17\u03b21":[5,38,199,221],"integrin":[6,39,63,200,222],"can":[7],"protect":[8],"against":[9],"exercise":[10,74,145],"induced-injury":[11],"and":[12,61,80,87,101,190],"promote":[13],"appearance":[15,192],"multipotent":[17],"mesenchymal-like":[18],"(Sca-1+CD45-)":[19],"stem":[20,195],"cells":[21,196],"in":[22,42,113,118,126,135,158,173,224],"skeletal":[23],"muscle.":[24],"PURPOSE:":[25],"The":[26],"purpose":[27],"this":[29,151],"study":[30,183,214],"was":[31,92,129],"to":[32,139,207],"determine":[33],"if":[34],"also":[40],"results":[41],"enhanced":[43],"and/or":[44],"accelerated":[45,208],"myogenesis":[46,209,225],"following":[47,121,210],"a":[48,68,123,170],"single":[49,69],"bout":[50,70],"eccentric":[52,211],"exercise.":[53,212],"METHODS:":[54],"5-wk":[55],"old,":[56],"female":[57],"wild":[58],"type":[59],"(WT)":[60],"\u03b17":[62],"(\u03b17Tg)":[65],"mice":[66,120,137,141,154,168],"completed":[67],"downhill":[72],"running":[73],"(-20o,":[75],"17":[76],"m/min,":[77],"60":[78],"min)":[79],"gastrocnemius-soleus":[81],"complexes":[82],"were":[83,116],"collected":[84],"2,":[85],"4,":[86],"7":[88,163],"d":[89,133,164,178],"post-exercise.":[90],"Myogenesis":[91],"quantified":[93],"using":[94],"embryonic":[95],"myosin":[96],"heavy":[97],"chain":[98],"(eMHC)":[99],"expression":[100,115],"presence":[103],"centrally":[105],"located":[106],"nuclei":[107],"(CLN).":[108],"RESULTS:":[109],"Whereas":[110],"gradual":[111,156],"increases":[112,157],"eMHC":[114],"detected":[117],"WT":[119,153],"exercise,":[122],"5-fold":[124,171],"increase":[125,172],"eMHC+":[127],"fibers":[128],"present":[130],"at":[131,176],"2":[132,177],"post-exercise":[134,179],"\u03b17Tg":[136,140,167],"compared":[138],"that":[142,185,219],"did":[143],"not":[144],"(P":[146],"<":[147],"0.001).":[148],"Consistent":[149],"with":[150,198],"adaptation,":[152],"had":[155,169],"numbers":[159],"CLN":[161,174],"until":[162],"post-exercise,":[165],"whereas":[166],"levels":[175],"(P<0.001).":[180],"CONCLUSION:":[181],"This":[182,213],"suggests":[184],"protection":[187],"from":[188],"injury":[189],"increased":[191],"mesenchymal":[194],"observed":[197],"may":[202],"directly":[203],"or":[204],"indirectly":[205],"contribute":[206],"provides":[215],"first":[217],"evidence":[218],"participates":[223],"acceleration.":[226]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}