{"id":"https://openalex.org/W3104884286","doi":null,"title":"Fliposomes with a pH-sensitive conformational switch for anticancer drug delivery against triple negative breast cancer","display_name":"Fliposomes with a pH-sensitive conformational switch for anticancer drug delivery against triple negative breast cancer","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W3104884286","mag":"3104884286"},"language":"en","primary_location":{"id":"pmh:oai:scholarlycommons.pacific.edu:uop_etds-4584","doi":null,"is_oa":true,"landing_page_url":"https://scholarlycommons.pacific.edu/uop_etds/3593","pdf_url":"https://scholarlycommons.pacific.edu/cgi/viewcontent.cgi?article=4584&context=uop_etds","source":{"id":"https://openalex.org/S4306400314","display_name":"Scholarly Commons (University of the Pacific)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I119942576","host_organization_name":"University of the Pacific","host_organization_lineage":["https://openalex.org/I119942576"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"University of the Pacific Theses and Dissertations","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://scholarlycommons.pacific.edu/cgi/viewcontent.cgi?article=4584&context=uop_etds","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005189869","display_name":"Yifan Lu","orcid":"https://orcid.org/0000-0003-3285-2964","observed_orcids":["https://orcid.org/0000-0003-3285-2964"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Yifan Lu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3285-2964","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5005189869"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0655,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.26838219,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ph-sensitive-liposomes","display_name":"pH-sensitive liposomes","score":0.9169999957084656},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.8920000195503235},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.7649999856948853},{"id":"https://openalex.org/keywords/ph-responsive-drug-release","display_name":"pH-responsive drug release","score":0.9359999895095825},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.7549999952316284},{"id":"https://openalex.org/keywords/3d-spheroids","display_name":"multicellular spheroids","score":0.8230000138282776},{"id":"https://openalex.org/keywords/liposome-formulation-optimization","display_name":"liposome formulation optimization","score":0.6179999709129333},{"id":"https://openalex.org/keywords/cholesterol","display_name":"cholesterol","score":0.41499999165534973},{"id":"https://openalex.org/keywords/anticancer-drug-delivery","display_name":"anticancer drug delivery","score":0.7570000290870667}],"concepts":[{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.6446689367294312},{"id":"https://openalex.org/C2780110267","wikidata":"https://www.wikidata.org/wiki/Q7843332","display_name":"Triple-negative breast cancer","level":4,"score":0.5947501063346863},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5578723549842834},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5280906558036804},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4393239915370941},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4177539050579071},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.4153793156147003},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.33506566286087036},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33124271035194397},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.32251453399658203},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1819879710674286},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:scholarlycommons.pacific.edu:uop_etds-4584","doi":null,"is_oa":true,"landing_page_url":"https://scholarlycommons.pacific.edu/uop_etds/3593","pdf_url":"https://scholarlycommons.pacific.edu/cgi/viewcontent.cgi?article=4584&context=uop_etds","source":{"id":"https://openalex.org/S4306400314","display_name":"Scholarly Commons (University of the Pacific)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I119942576","host_organization_name":"University of the Pacific","host_organization_lineage":["https://openalex.org/I119942576"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"University of the Pacific Theses and Dissertations","raw_type":"text"},{"id":"mag:3104884286","doi":null,"is_oa":false,"landing_page_url":"https://scholarlycommons.pacific.edu/uop_etds/3593/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:scholarlycommons.pacific.edu:uop_etds-4584","doi":null,"is_oa":true,"landing_page_url":"https://scholarlycommons.pacific.edu/uop_etds/3593","pdf_url":"https://scholarlycommons.pacific.edu/cgi/viewcontent.cgi?article=4584&context=uop_etds","source":{"id":"https://openalex.org/S4306400314","display_name":"Scholarly Commons (University of the Pacific)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I119942576","host_organization_name":"University of the Pacific","host_organization_lineage":["https://openalex.org/I119942576"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"University of the Pacific Theses and Dissertations","raw_type":"text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9789000153541565,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3104884286.pdf","grobid_xml":"https://content.openalex.org/works/W3104884286.grobid-xml"},"referenced_works_count":170,"referenced_works":["https://openalex.org/W3011556","https://openalex.org/W13190771","https://openalex.org/W22881516","https://openalex.org/W86069980","https://openalex.org/W206644305","https://openalex.org/W1239224350","https://openalex.org/W1504229889","https://openalex.org/W1507261415","https://openalex.org/W1533462164","https://openalex.org/W1543790510","https://openalex.org/W1555009525","https://openalex.org/W1578622010","https://openalex.org/W1585705786","https://openalex.org/W1829738848","https://openalex.org/W1917586431","https://openalex.org/W1961768905","https://openalex.org/W1963618034","https://openalex.org/W1964325639","https://openalex.org/W1964553162","https://openalex.org/W1965133822","https://openalex.org/W1967997862","https://openalex.org/W1968351069","https://openalex.org/W1969209225","https://openalex.org/W1971971117","https://openalex.org/W1973414672","https://openalex.org/W1975799676","https://openalex.org/W1977622321","https://openalex.org/W1980361000","https://openalex.org/W1980424362","https://openalex.org/W1981684516","https://openalex.org/W1981723789","https://openalex.org/W1983466982","https://openalex.org/W1984001852","https://openalex.org/W1989230986","https://openalex.org/W1989353157","https://openalex.org/W1989386811","https://openalex.org/W1995800186","https://openalex.org/W1997787046","https://openalex.org/W1998269774","https://openalex.org/W1998431462","https://openalex.org/W1998575668","https://openalex.org/W2000617155","https://openalex.org/W2003021187","https://openalex.org/W2005408885","https://openalex.org/W2005896720","https://openalex.org/W2006202974","https://openalex.org/W2008156029","https://openalex.org/W2008933737","https://openalex.org/W2009038500","https://openalex.org/W2009475191","https://openalex.org/W2010135478","https://openalex.org/W2010506651","https://openalex.org/W2011244979","https://openalex.org/W2011994791","https://openalex.org/W2012352057","https://openalex.org/W2014507031","https://openalex.org/W2014644083","https://openalex.org/W2015921398","https://openalex.org/W2016151415","https://openalex.org/W2019493845","https://openalex.org/W2019866887","https://openalex.org/W2021635812","https://openalex.org/W2022765714","https://openalex.org/W2025225757","https://openalex.org/W2027137358","https://openalex.org/W2029753193","https://openalex.org/W2029782824","https://openalex.org/W2030487072","https://openalex.org/W2033284075","https://openalex.org/W2033857478","https://openalex.org/W2036453287","https://openalex.org/W2037248548","https://openalex.org/W2037250494","https://openalex.org/W2042075770","https://openalex.org/W2042194419","https://openalex.org/W2046737348","https://openalex.org/W2047375073","https://openalex.org/W2049075059","https://openalex.org/W2051717913","https://openalex.org/W2051961945","https://openalex.org/W2055384999","https://openalex.org/W2055709217","https://openalex.org/W2061510929","https://openalex.org/W2063460913","https://openalex.org/W2065946609","https://openalex.org/W2066864375","https://openalex.org/W2067557497","https://openalex.org/W2068050569","https://openalex.org/W2069289981","https://openalex.org/W2072001961","https://openalex.org/W2072210671","https://openalex.org/W2072534801","https://openalex.org/W2075078368","https://openalex.org/W2075816778","https://openalex.org/W2076226743","https://openalex.org/W2079189662","https://openalex.org/W2079545013","https://openalex.org/W2081424254","https://openalex.org/W2081762553","https://openalex.org/W2084235230","https://openalex.org/W2086163902","https://openalex.org/W2087414776","https://openalex.org/W2089055004","https://openalex.org/W2090453278","https://openalex.org/W2093855538","https://openalex.org/W2093993014","https://openalex.org/W2095492265","https://openalex.org/W2097603366","https://openalex.org/W2100409677","https://openalex.org/W2101044126","https://openalex.org/W2102986767","https://openalex.org/W2103678678","https://openalex.org/W2105166440","https://openalex.org/W2105553762","https://openalex.org/W2106629884","https://openalex.org/W2110094254","https://openalex.org/W2112326782","https://openalex.org/W2112902082","https://openalex.org/W2113953300","https://openalex.org/W2116118767","https://openalex.org/W2116182190","https://openalex.org/W2121415861","https://openalex.org/W2127967682","https://openalex.org/W2132620319","https://openalex.org/W2136226205","https://openalex.org/W2137634849","https://openalex.org/W2139407148","https://openalex.org/W2140723257","https://openalex.org/W2144040368","https://openalex.org/W2147043620","https://openalex.org/W2148812205","https://openalex.org/W2149078229","https://openalex.org/W2149902856","https://openalex.org/W2151058587","https://openalex.org/W2155822241","https://openalex.org/W2157285286","https://openalex.org/W2163737596","https://openalex.org/W2164324841","https://openalex.org/W2165836181","https://openalex.org/W2166308139","https://openalex.org/W2166699632","https://openalex.org/W2175185830","https://openalex.org/W2253380117","https://openalex.org/W2273495465","https://openalex.org/W2288912256","https://openalex.org/W2317055602","https://openalex.org/W2317485478","https://openalex.org/W2397876963","https://openalex.org/W2400600528","https://openalex.org/W2410142412","https://openalex.org/W2430883407","https://openalex.org/W2471940455","https://openalex.org/W2524577335","https://openalex.org/W2531248791","https://openalex.org/W2553124041","https://openalex.org/W2592912788","https://openalex.org/W2595421589","https://openalex.org/W2603077910","https://openalex.org/W2605267422","https://openalex.org/W2606980922","https://openalex.org/W2738785033","https://openalex.org/W2739232270","https://openalex.org/W2759978833","https://openalex.org/W2766532127","https://openalex.org/W2782865216","https://openalex.org/W2787356256","https://openalex.org/W2804846127","https://openalex.org/W2897422388","https://openalex.org/W2914818579","https://openalex.org/W2995512087"],"related_works":["https://openalex.org/W2995512087","https://openalex.org/W4288066813","https://openalex.org/W2909667166","https://openalex.org/W3041876870","https://openalex.org/W2733314730","https://openalex.org/W2747940146","https://openalex.org/W1484166395","https://openalex.org/W3121054617","https://openalex.org/W3165296907","https://openalex.org/W4405015457"],"abstract_inverted_index":{"Cancer":[0],"is":[1,32,40,54,142],"the":[2,9,33,41,62,65,90,94,116,120,127,133,137,148,218,274,301,333,337,358,414,418,433,440,445,459,466,471,494,504,559],"second":[3,42],"leading":[4,43],"cause":[5,44],"of":[6,16,26,45,57,64,67,86,96,122,132,151,176,199,205,256,261,277,303,325,336,371,417,444,470,490,493,558],"death":[7,46],"in":[8,19,47,119,136,160,192,215,340,382,455,467,537,549,552],"US":[10],"and":[11,39,74,84,124,169,208,231,249,266,284,310,318,350,369,389,462,483,516,523,534,551],"worldwide,":[12],"accounting":[13],"for":[14,536],"16%":[15],"deaths":[17],"worldwide":[18],"2015.":[20],"Of":[21],"more":[22],"than":[23],"100":[24],"types":[25],"cancers":[27],"affecting":[28],"humans,":[29],"breast":[30,51,58],"cancer":[31,36,52],"most":[34],"common":[35],"among":[37],"women":[38],"women.":[48],"Triple":[49],"negative":[50],"(TNBC)":[53],"a":[55,143,158,185,393,511],"subtype":[56],"carcinomas":[59],"defined":[60],"by":[61,114,125,379,404,411,429,555],"lack":[63,95],"expression":[66],"estrogen":[68],"receptor":[69,72,79],"(ER),":[70],"progesterone":[71],"(PR)":[73],"human":[75],"epidermal":[76],"growth":[77],"factor":[78],"(HER2":[80],"/neu).":[81],"The":[82,258,342,367,475],"prognosis":[83],"survival":[85],"TNBC":[87,326,401,423,431,548,566],"patients":[88],"remains":[89],"poor":[91],"due":[92],"to":[93,110,146,166,217,233,251,299,331,384,457,520,543],"effective":[97],"targeted":[98],"therapy.":[99],"Nanotechnology-based":[100],"drug":[101,117,152,561],"delivery":[102,153],"systems,":[103],"such":[104,279],"as":[105,184,280,353,355],"liposomes,":[106,278],"are":[107],"widely":[108],"investigated":[109],"enhance":[111,147],"anticancer":[112,149,334,398,419,560],"efficacy":[113,150,335,477,515],"concentrating":[115],"molecules":[118],"tissues":[121],"interest":[123],"altering":[126],"pharmacokinetic":[128,451],"profile.":[129],"Taking":[130],"advantage":[131],"pH":[134,221,460],"gradient":[135],"tumor":[138,442,488],"microenvironment,":[139],"pH-triggered":[140,254],"release":[141,214,245,255,269,415,557],"promising":[144],"strategy":[145,159],"systems":[154],"against":[155,400,547],"TNBC.":[156],"Previously,":[157],"our":[161,193],"lab":[162],"has":[163],"been":[164],"developed":[165,230],"render":[167],"saturated":[168],"pegylated":[170],"liposomes":[171,196,388],"pH-sensitive:":[172],"protonation-induced":[173],"conformational":[174],"switch":[175],"lipid":[177],"tails,":[178],"using":[179],"trans-2-aminocyclohexanol":[180],"lipids":[181],"(TACH,":[182],"flipids)":[183],"molecular":[186],"trigger.":[187],"Based":[188,289],"on":[189,290,315,362],"previous":[190],"work":[191],"lab,":[194],"pH-sensitive":[195,387],"(fliposomes)":[197],"composed":[198],"C-16":[200],"flipids":[201,309],"with":[202,237,305,465,487],"amine":[203],"group":[204],"morpholine":[206],"(MOR)":[207],"azetidine":[209],"(AZE)":[210],"demonstrated":[211],"optimized":[212,232,472,535],"triggered":[213],"response":[216,461],"tumor\u2019s":[219],"low":[220],"microenvironment.":[222],"In":[223,243,502],"this":[224],"study,":[225],"different":[226],"preparation":[227],"methods":[228],"were":[229,247,264,270,287,329,531,541],"produce":[234],"viable":[235],"fliposomes":[236,263,339,373,530],"high":[238],"doxorubicin":[239],"(DOX)":[240],"encapsulation":[241],"efficiency.":[242],"vitro":[244,550],"assays":[246,314],"established":[248,428],"validated":[250],"accurately":[252],"reflect":[253],"fliposomes.":[257],"physicochemical":[259],"properties":[260,464],"DOX-loaded":[262,372,385,484,505,529],"characterized":[265],"their":[267],"pH-dependent":[268],"investigated.":[271],"Factors":[272],"influencing":[273],"desirable":[275],"attributes":[276],"size,":[281],"pH-sensitivity,":[282],"stability":[283,463,469],"drug-loading":[285],"capacity":[286],"explored.":[288],"these":[291],"characterizations,":[292],"central":[293],"composite":[294],"design":[295],"(CCD)":[296],"was":[297,377,427,453,478],"utilized":[298],"optimize":[300],"formulation":[302],"fliposome":[304,395],"two":[306],"critical":[307],"factors,":[308],"cholesterol.":[311],"Cell":[312],"viability":[313],"traditional":[316],"monolayer":[317],"innovative":[319],"three-dimensional":[320],"multicellular":[321],"spheroids":[322],"(3D":[323],"MCS)":[324],"cell":[327],"lines":[328],"conducted":[330,454],"evaluate":[332],"resultant":[338],"vitro.":[341],"constructed":[343],"3D":[344,359,375,402,408],"MCS":[345,360,376,403],"carried":[346],"heterogeneously":[347],"distributed":[348],"live":[349],"apoptotic":[351],"cells,":[352],"well":[354],"acidity":[356],"inside":[357,565],"based":[361],"confocal":[363,380],"microscopic":[364],"imaging":[365],"studies.":[366],"distribution":[368],"penetration":[370,406,564],"into":[374,407,432],"imaged":[378],"microscopy":[381],"comparison":[383],"non":[386],"free":[390,481,521],"DOX.":[391,421],"As":[392],"result,":[394],"manifested":[396],"superior":[397,545],"activity":[399,546],"efficient":[405],"MCS,":[409],"followed":[410],"tuning":[412],"up":[413],"rate":[416],"agent":[420],"A":[422,449],"orthotopic":[424],"xenograft":[425],"model":[426],"transplanting":[430],"murine":[434],"mammalian":[435],"fat":[436],"pad,":[437],"which":[438],"maintains":[439],"organ-specific":[441],"microenvironment":[443],"original":[446],"organ":[447],".":[448],"pilot":[450],"study":[452],"order":[456],"correlate":[458],"vivo":[468,538],"AZE-C16":[473],"fliposome.":[474],"antitumor":[476,514],"comparable":[479],"between":[480],"DOX":[482,522,562],"stealth":[485,524],"liposome":[486,525],"volumes":[489],"~":[491],"80-90%":[492],"control":[495],"treatment":[496],"32":[497],"days":[498],"post":[499],"first":[500],"dose.":[501],"contrast,":[503],"fliposome,":[506,509],"especially":[507],"MOR-C16":[508],"exhibited":[510],"significantly":[512],"higher":[513],"delayed":[517],"progression":[518],"compared":[519],"treatments.":[526],"Taken":[527],"together,":[528],"successfully":[532],"prepared":[533],"application.":[539],"They":[540],"able":[542],"achieve":[544],"vivo,":[553],"facilitated":[554],"enhanced":[556],"after":[563],"tumor.":[567]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-08-31T07:19:18.363097","created_date":"2020-11-23T00:00:00"}