{"id":"https://openalex.org/W3104596","doi":null,"title":"Highly sensitive target-based whole-cell antibacterial discovery strategy by antisense RNA silencing.","display_name":"Highly sensitive target-based whole-cell antibacterial discovery strategy by antisense RNA silencing.","publication_year":2007,"publication_date":"2007-03-01","ids":{"openalex":"https://openalex.org/W3104596","mag":"3104596","pmid":"https://pubmed.ncbi.nlm.nih.gov/17436551"},"language":"en","primary_location":{"id":"pmid:17436551","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17436551","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in drug discovery & development","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040571641","display_name":"Sheo Bux Singh","orcid":"https://orcid.org/0000-0002-6393-3583","observed_orcids":["https://orcid.org/0000-0002-6393-3583"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sheo B Singh","raw_affiliation_strings":["Merck Research Laboratories, RY80Y-350, 126 E Lincoln Avenue, Rahway, NJ 07065, USA. sheo_singh@merck.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories, RY80Y-350, 126 E Lincoln Avenue, Rahway, NJ 07065, USA. sheo_singh@merck.com","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":null,"display_name":"John W Phillips","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John W Phillips","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Jun Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jun Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.2423,"has_fulltext":false,"cited_by_count":61,"citation_normalized_percentile":{"value":0.9063817,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"10","issue":"2","first_page":"160","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.8931000232696533,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.8931000232696533,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.026399999856948853,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.025299999862909317,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.9309999942779541},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.5329999923706055},{"id":"https://openalex.org/keywords/drug-resistant-bacteria","display_name":"drug-resistant bacteria","score":0.6230000257492065},{"id":"https://openalex.org/keywords/natural-extracts","display_name":"natural extracts","score":0.6869999766349792},{"id":"https://openalex.org/keywords/fatty-acid-synthesis","display_name":"fatty acid synthesis","score":0.781000018119812},{"id":"https://openalex.org/keywords/platensimycin","display_name":"platensimycin","score":0.8690000176429749},{"id":"https://openalex.org/keywords/antibiotic-discovery","display_name":"antibiotic discovery","score":0.4699999988079071}],"concepts":[{"id":"https://openalex.org/C2779396153","wikidata":"https://www.wikidata.org/wiki/Q901227","display_name":"Natural product","level":2,"score":0.7042770981788635},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.6902840733528137},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5424545407295227},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.5290963649749756},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.524461030960083},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44248780608177185},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.42837679386138916},{"id":"https://openalex.org/C121587506","wikidata":"https://www.wikidata.org/wiki/Q6888113","display_name":"Mode of action","level":2,"score":0.4167463481426239},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36146247386932373},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.36000245809555054},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06544661521911621}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016372","descriptor_name":"RNA, Antisense","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016372","descriptor_name":"RNA, Antisense","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D020868","descriptor_name":"Gene Silencing","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:17436551","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17436551","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in drug discovery & development","raw_type":"Journal Article"},{"id":"mag:3104596","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17436551","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1557633902","https://openalex.org/W1974299093","https://openalex.org/W2003348299","https://openalex.org/W2009156161","https://openalex.org/W2010796305","https://openalex.org/W2039048991","https://openalex.org/W2040226264","https://openalex.org/W2046348365","https://openalex.org/W2052486912","https://openalex.org/W2071797648","https://openalex.org/W2077857321","https://openalex.org/W2098340463","https://openalex.org/W2101030517","https://openalex.org/W2120419643","https://openalex.org/W2125311076","https://openalex.org/W2129436053","https://openalex.org/W2152238416","https://openalex.org/W2164667097","https://openalex.org/W2164698321","https://openalex.org/W2164997719","https://openalex.org/W2415656026","https://openalex.org/W2512262428"],"related_works":["https://openalex.org/W2164667097","https://openalex.org/W2042856986","https://openalex.org/W2071797648","https://openalex.org/W2052486912","https://openalex.org/W2101645363","https://openalex.org/W2125311076","https://openalex.org/W2087456897","https://openalex.org/W1985318956","https://openalex.org/W2392302471","https://openalex.org/W2120419643"],"abstract_inverted_index":{"Examples":[0],"of":[1,9,15,24,32,43,54,59,66,74,84,87,110,116,121,128],"drug-resistant":[2,101],"bacteria":[3],"are":[4,134],"increasing":[5],"while":[6],"the":[7,33,41,75,82,91,114,126],"discovery":[8,83,105,127],"new":[10,13,34],"antibiotics":[11,45],"with":[12],"mechanisms":[14],"action":[16],"has":[17,96],"been":[18],"essentially":[19],"nonexistent.":[20],"The":[21,57,103],"antisense-based":[22,104],"sensitization":[23],"bacterial":[25],"targets":[26,73],"in":[27,136],"Staphylococcus":[28],"aureus":[29],"is":[30],"one":[31],"approaches":[35],"that":[36],"provides":[37],"increased":[38],"sensitivity":[39,53],"for":[40,69,119],"detection":[42],"target-specific":[44,88],"and":[46,108,113,125],"whole-cell":[47],"screening":[48,58,111,120],"assays":[49,118],"based":[50],"on":[51],"differential":[52],"target-depleted":[55],"strains.":[56],"natural":[60,122],"product":[61,123],"extracts":[62,124],"using":[63],"this":[64,137],"type":[65],"assay":[67],"designed":[68],"condensing":[70,131],"enzyme":[71,132],"(FabH/FabF)":[72],"fatty":[76,129],"acid":[77,130],"biosynthesis":[78],"pathway":[79],"led":[80],"to":[81],"a":[85],"number":[86],"inhibitors":[89,133],"including":[90],"novel":[92],"antibiotic":[93],"platensimycin,":[94],"which":[95],"displayed":[97],"activity":[98],"against":[99],"various":[100],"bacteria.":[102],"strategy,":[106],"rationale":[107],"design":[109],"assays,":[112],"application":[115],"such":[117],"reviewed":[135],"article.":[138]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
