{"id":"https://openalex.org/W3104097947","doi":"https://doi.org/10.1166/jbn.2020.2934","title":"Graphene Oxide Quantum Dots-Induced Mineralization via the Reactive Oxygen Species-Dependent Autophagy Pathway in Dental Pulp Stem Cells","display_name":"Graphene Oxide Quantum Dots-Induced Mineralization via the Reactive Oxygen Species-Dependent Autophagy Pathway in Dental Pulp Stem Cells","publication_year":2020,"publication_date":"2020-06-01","ids":{"openalex":"https://openalex.org/W3104097947","doi":"https://doi.org/10.1166/jbn.2020.2934","mag":"3104097947","pmid":"https://pubmed.ncbi.nlm.nih.gov/33187591"},"language":"en","primary_location":{"id":"doi:10.1166/jbn.2020.2934","doi":"https://doi.org/10.1166/jbn.2020.2934","is_oa":false,"landing_page_url":"https://doi.org/10.1166/jbn.2020.2934","pdf_url":null,"source":{"id":"https://openalex.org/S15497777","display_name":"Journal of Biomedical Nanotechnology","issn_l":"1550-7033","issn":["1550-7033","1550-7041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310321646","host_organization_name":"American Scientific Publishers","host_organization_lineage":["https://openalex.org/P4310321646"],"host_organization_lineage_names":["American Scientific Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedical Nanotechnology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020750854","display_name":"Xincong Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xincong Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085154966","display_name":"Hanxiao Liu","orcid":"https://orcid.org/0000-0003-3106-7542","observed_orcids":["https://orcid.org/0000-0003-3106-7542"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hanxiao Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004409259","display_name":"Yijun Yu","orcid":"https://orcid.org/0000-0002-1007-3102","observed_orcids":["https://orcid.org/0000-0002-1007-3102"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yijun Yu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100333986","display_name":"Lan Ma","orcid":"https://orcid.org/0000-0003-3458-1758","observed_orcids":["https://orcid.org/0000-0003-3458-1758"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lan Ma","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100362887","display_name":"Chao Liu","orcid":"https://orcid.org/0000-0001-6637-1689","observed_orcids":["https://orcid.org/0000-0001-6637-1689"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chao Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5059633886","display_name":"Leiying Miao","orcid":"https://orcid.org/0000-0001-6915-8218","observed_orcids":["https://orcid.org/0000-0001-6915-8218"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Leiying Miao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8004,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.63954305,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"16","issue":"6","first_page":"965","last_page":"974"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.2912999987602234,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.2912999987602234,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.26100000739097595,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.12309999763965607,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/graphene-oxide-quantum-dots","display_name":"graphene oxide quantum dots","score":1.0},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.8700000047683716},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9929999709129333},{"id":"https://openalex.org/keywords/dental-pulp-stem-cells","display_name":"dental pulp stem cells","score":0.9900000095367432},{"id":"https://openalex.org/keywords/odontoblast-differentiation","display_name":"odontoblast differentiation","score":0.9399999976158142},{"id":"https://openalex.org/keywords/mineralization","display_name":"mineralization","score":0.9300000071525574},{"id":"https://openalex.org/keywords/beclin-1","display_name":"Beclin-1","score":0.9570000171661377},{"id":"https://openalex.org/keywords/autophagy-inhibition","display_name":"autophagy inhibition","score":0.7570000290870667},{"id":"https://openalex.org/keywords/3-methyladenine","display_name":"3-methyladenine","score":0.8460000157356262},{"id":"https://openalex.org/keywords/bafilomycin-a1","display_name":"bafilomycin A1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/stem-cell-differentiation","display_name":"stem cell differentiation","score":0.5870000123977661}],"concepts":[{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.9649052619934082},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.7164439558982849},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6887354850769043},{"id":"https://openalex.org/C2777400515","wikidata":"https://www.wikidata.org/wiki/Q5259430","display_name":"Dental pulp stem cells","level":3,"score":0.660840630531311},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6041090488433838},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4466903507709503},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2550833523273468},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.20855993032455444},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19678276777267456}],"mesh":[{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003782","descriptor_name":"Dental Pulp","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006108","descriptor_name":"Graphite","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009804","descriptor_name":"Odontoblasts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D045663","descriptor_name":"Quantum Dots","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1166/jbn.2020.2934","doi":"https://doi.org/10.1166/jbn.2020.2934","is_oa":false,"landing_page_url":"https://doi.org/10.1166/jbn.2020.2934","pdf_url":null,"source":{"id":"https://openalex.org/S15497777","display_name":"Journal of Biomedical Nanotechnology","issn_l":"1550-7033","issn":["1550-7033","1550-7041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310321646","host_organization_name":"American Scientific Publishers","host_organization_lineage":["https://openalex.org/P4310321646"],"host_organization_lineage_names":["American Scientific Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedical Nanotechnology","raw_type":"journal-article"},{"id":"pmid:33187591","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33187591","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biomedical nanotechnology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4321503491","https://openalex.org/W2926811056","https://openalex.org/W7221185986","https://openalex.org/W3126421994","https://openalex.org/W2295054127","https://openalex.org/W4393221416","https://openalex.org/W4378530522","https://openalex.org/W2981874810","https://openalex.org/W6902437949","https://openalex.org/W4223948328"],"abstract_inverted_index":{"As":[0],"an":[1],"important":[2],"recycling":[3],"and":[4,65,83,102,123,138],"degradation":[5],"system,":[6],"autophagy":[7,48,100,120,152],"is":[8],"considered":[9],"to":[10,70,89,128,133],"be":[11,162],"critical":[12],"in":[13,49,153],"regulating":[14,50],"stem":[15,35],"cell":[16],"differentiation.":[17,93,147],"It":[18],"has":[19],"been":[20],"shown":[21],"that":[22],"graphene":[23],"oxide":[24],"quantum":[25],"dots":[26],"(GOQDs)":[27],"are":[28],"a":[29,154],"robust":[30],"biological":[31],"labelling":[32],"tool":[33],"for":[34],"cells":[36],"with":[37],"little":[38],"cytotoxicity.":[39],"In":[40],"this":[41],"study,":[42],"we":[43],"explored":[44],"the":[45,51,56,72],"role":[46],"of":[47,53,59,75,96],"impact":[52],"GOQDs":[54,134,157],"on":[55,99],"odontoblastic":[57,92,146],"differentiation":[58],"DPSCs":[60],"during":[61],"autophagy.":[62,130,166],"Western":[63],"blotting":[64],"immunofluorescence":[66],"staining":[67,86],"were":[68,87,108,126],"used":[69,88,127],"evaluate":[71],"autophagic":[73,136],"activity":[74,137],"DPSCs.":[76],"Quantitative":[77],"PCR,":[78],"alizarin":[79],"red":[80],"S":[81],"staining,":[82],"alkaline":[84],"phosphatase":[85],"examine":[90],"DPSC":[91,140],"The":[94],"impacts":[95],"ROS":[97],"scavengers":[98],"induction":[101],"reactive":[103],"oxygen":[104],"species":[105],"(ROS)":[106],"levels":[107],"also":[109],"measured.":[110],"Lentiviral":[111],"vectors":[112],"carrying":[113],"Beclin1":[114],"siRNA":[115],"sequences,":[116],"as":[117,119],"well":[118],"inhibitors":[121],"(3-MA":[122],"bafilomycin":[124],"A1),":[125],"inhibit":[129],"Initial":[131],"exposure":[132],"increased":[135],"enhanced":[139],"mineralization.":[141],"Autophagy":[142],"inhibition":[143],"suppressed":[144],"GOQD-induced":[145],"Moreover,":[148],"GOQD":[149],"treatment":[150],"induced":[151],"ROS-dependent":[155],"manner.":[156],"promoted":[158],"differentiation,":[159],"which":[160],"could":[161],"modulated":[163],"via":[164],"ROS-induced":[165]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2020-11-23T00:00:00"}
