{"id":"https://openalex.org/W31038604","doi":null,"title":"Sickness-induced cognitive dysfunction : molecular, physiological, and behavioural correlates","display_name":"Sickness-induced cognitive dysfunction : molecular, physiological, and behavioural correlates","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W31038604","mag":"31038604"},"language":"en","primary_location":{"id":"pmh:oai:CiteSeerX.psu:10.1.1.554.9600","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.554.9600","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://www.uleth.ca/dspace/bitstream/handle/10133/623/thomson, lisa.pdf;jsessionid=8AF065CA09FED2823E61F30BDB3993FE?sequence=1","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101985650","display_name":"Lisa M. Thomson","orcid":"https://orcid.org/0000-0003-1157-2656","observed_orcids":["https://orcid.org/0000-0003-1157-2656"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Lisa M. Thomson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1157-2656","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5101985650"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.5795999765396118,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.5795999765396118,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.3792000114917755,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.013500000350177288,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.8629999756813049},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9729999899864197},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9710000157356262},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.9470000267028809},{"id":"https://openalex.org/keywords/memory-consolidation","display_name":"memory consolidation","score":0.8709999918937683},{"id":"https://openalex.org/keywords/learning-and-memory","display_name":"learning and memory","score":0.6209999918937683},{"id":"https://openalex.org/keywords/hippocampal-long-term-potentiation","display_name":"hippocampal long-term potentiation","score":0.9490000009536743},{"id":"https://openalex.org/keywords/hippocampal-cell-proliferation","display_name":"hippocampal cell proliferation","score":0.8690000176429749},{"id":"https://openalex.org/keywords/endotoxin","display_name":"endotoxin","score":0.6919999718666077},{"id":"https://openalex.org/keywords/sickness-behavior","display_name":"sickness behavior","score":0.35100001096725464}],"concepts":[{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.8545774221420288},{"id":"https://openalex.org/C138906646","wikidata":"https://www.wikidata.org/wiki/Q7507668","display_name":"Sickness behavior","level":3,"score":0.741500198841095},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.697763979434967},{"id":"https://openalex.org/C25274449","wikidata":"https://www.wikidata.org/wiki/Q1805481","display_name":"Long-term potentiation","level":3,"score":0.6197056770324707},{"id":"https://openalex.org/C48455012","wikidata":"https://www.wikidata.org/wiki/Q2892593","display_name":"Memory consolidation","level":3,"score":0.5903300046920776},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5634520649909973},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4665066599845886},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.4416918158531189},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.42757341265678406},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.41911107301712036},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.41383036971092224},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3599088191986084},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.2811676859855652},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11875537037849426},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:CiteSeerX.psu:10.1.1.554.9600","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.554.9600","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://www.uleth.ca/dspace/bitstream/handle/10133/623/thomson, lisa.pdf;jsessionid=8AF065CA09FED2823E61F30BDB3993FE?sequence=1","raw_type":"text"},{"id":"pmh:oai:www.uleth.ca:10133/623","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10133/623","pdf_url":null,"source":{"id":"https://openalex.org/S4306401508","display_name":"Open ULeth Scholarship (OPUS) (University of Lethbridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I107949126","host_organization_name":"University of Lethbridge","host_organization_lineage":["https://openalex.org/I107949126"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:31038604","doi":null,"is_oa":false,"landing_page_url":"https://www.uleth.ca/dspace/bitstream/10133/623/1/thomson%2c%20lisa.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.979200005531311,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":106,"referenced_works":["https://openalex.org/W111804031","https://openalex.org/W1504073232","https://openalex.org/W1519245788","https://openalex.org/W1529067373","https://openalex.org/W1689697987","https://openalex.org/W1714742035","https://openalex.org/W1760413495","https://openalex.org/W1900191186","https://openalex.org/W1953537738","https://openalex.org/W1963918819","https://openalex.org/W1964846273","https://openalex.org/W1965899761","https://openalex.org/W1968764682","https://openalex.org/W1971146300","https://openalex.org/W1972511784","https://openalex.org/W1980888861","https://openalex.org/W1981117745","https://openalex.org/W1981293922","https://openalex.org/W1984519488","https://openalex.org/W1988548890","https://openalex.org/W1992405001","https://openalex.org/W1993741388","https://openalex.org/W1996826305","https://openalex.org/W1998532707","https://openalex.org/W2003702865","https://openalex.org/W2006227636","https://openalex.org/W2007531718","https://openalex.org/W2008198095","https://openalex.org/W2010603435","https://openalex.org/W2012835383","https://openalex.org/W2013616388","https://openalex.org/W2014006342","https://openalex.org/W2016261700","https://openalex.org/W2017169966","https://openalex.org/W2017547394","https://openalex.org/W2019304230","https://openalex.org/W2020235439","https://openalex.org/W2024905701","https://openalex.org/W2025801062","https://openalex.org/W2030685002","https://openalex.org/W2032468601","https://openalex.org/W2035121795","https://openalex.org/W2035835440","https://openalex.org/W2039390013","https://openalex.org/W2040430883","https://openalex.org/W2044920392","https://openalex.org/W2045040998","https://openalex.org/W2047057727","https://openalex.org/W2048809344","https://openalex.org/W2049730142","https://openalex.org/W2050235826","https://openalex.org/W2052617294","https://openalex.org/W2055585801","https://openalex.org/W2056200351","https://openalex.org/W2057143757","https://openalex.org/W2057549022","https://openalex.org/W2062790940","https://openalex.org/W2064514476","https://openalex.org/W2064952846","https://openalex.org/W2067404534","https://openalex.org/W2069855822","https://openalex.org/W2073895836","https://openalex.org/W2076211284","https://openalex.org/W2076616859","https://openalex.org/W2078815750","https://openalex.org/W2081100922","https://openalex.org/W2081476431","https://openalex.org/W2081694980","https://openalex.org/W2083283628","https://openalex.org/W2087293363","https://openalex.org/W2087423222","https://openalex.org/W2087658385","https://openalex.org/W2092358120","https://openalex.org/W2092929310","https://openalex.org/W2094032113","https://openalex.org/W2094073595","https://openalex.org/W2094858611","https://openalex.org/W2094909468","https://openalex.org/W2095256251","https://openalex.org/W2095510381","https://openalex.org/W2095741568","https://openalex.org/W2099555137","https://openalex.org/W2099713879","https://openalex.org/W2103081123","https://openalex.org/W2105070448","https://openalex.org/W2111977586","https://openalex.org/W2111989049","https://openalex.org/W2128824580","https://openalex.org/W2131820270","https://openalex.org/W2138529199","https://openalex.org/W2144960514","https://openalex.org/W2145107163","https://openalex.org/W2148634628","https://openalex.org/W2151400960","https://openalex.org/W2163815564","https://openalex.org/W2165303994","https://openalex.org/W2167314970","https://openalex.org/W2168796193","https://openalex.org/W2171314958","https://openalex.org/W2286922506","https://openalex.org/W2315930495","https://openalex.org/W2322104200","https://openalex.org/W2330937221","https://openalex.org/W4214891130","https://openalex.org/W4292340975","https://openalex.org/W7098038332"],"related_works":["https://openalex.org/W2011672325","https://openalex.org/W1974700087","https://openalex.org/W2090350179","https://openalex.org/W2883995902","https://openalex.org/W2951577229","https://openalex.org/W432815271","https://openalex.org/W2094953029","https://openalex.org/W2077122683","https://openalex.org/W7095415614","https://openalex.org/W2061931936"],"abstract_inverted_index":{"Activated":[0],"immune":[1,58],"cells":[2],"secrete":[3],"proinflammatory":[4,21,137],"cytokines":[5],"that":[6,40,54],"induce":[7],"a":[8,56,105],"generalized":[9],"sickness":[10],"response.":[11],"The":[12,45],"following":[13],"experiments":[14],"were":[15],"designed":[16],"to":[17,35,124,142],"determine":[18],"whether":[19],"the":[20,25,37,146],"cytokine":[22],"IL-1\u03b2":[23,49,80,91],"is":[24,102,122],"peripheral":[26,57,119],"mediator":[27],"of":[28,47,107],"sickness-induced":[29,99],"cognitive":[30,38,100],"dysfunction,":[31],"as":[32,34,140],"well":[33],"characterize":[36],"processes":[39],"are":[41,60],"disrupted":[42],"during":[43],"illness.":[44],"effects":[46,83,144],"peripherally-administered":[48],"and":[50,64,67,75,110,127],"LPS,":[51],"an":[52,111],"endotoxin":[53],"induces":[55],"response,":[59],"compared":[61],"across":[62,84],"learning":[63,126],"memory":[65,73,108,128],"tasks,":[66,85],"on":[68,87],"hippocampal":[69,95,114,130],"LTP.":[70,115],"LPS":[71],"impaired":[72],"consolidation":[74,109],"inhibited":[76,94],"EPSP":[77],"expression,":[78],"whereas":[79,118],"had":[81],"no":[82],"nor":[86],"LTP":[88],"expression.":[89],"However,":[90],"plus":[92],"IL-6,":[93,141],"cell":[96],"proliferation.":[97],"Therefore,":[98],"dysfunction":[101],"characterized":[103],"by":[104],"disruption":[106],"inhibition":[112],"in":[113,145],"In":[116],"addition,":[117],"IL-1\u03b2,":[120],"alone,":[121],"insufficient":[123],"disrupt":[125],"or":[129],"physiology,":[131],"it":[132],"may":[133],"work":[134],"with":[135],"other":[136],"cytokines,":[138],"such":[139],"produce":[143],"CNS.":[147]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
