{"id":"https://openalex.org/W3103570545","doi":"https://doi.org/10.1016/s0021-5198(19)36866-0","title":"Chronic nicotine treatment delays the developmental increase in brain muscarinic receptors in rat neonate","display_name":"Chronic nicotine treatment delays the developmental increase in brain muscarinic receptors in rat neonate","publication_year":1996,"publication_date":"1996-01-01","ids":{"openalex":"https://openalex.org/W3103570545","doi":"https://doi.org/10.1016/s0021-5198(19)36866-0","mag":"3103570545"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-5198(19)36866-0","doi":"https://doi.org/10.1016/s0021-5198(19)36866-0","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-5198(19)36866-0","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0021519819368660/pdf","source":{"id":"https://openalex.org/S190179609","display_name":"The Japanese Journal of Pharmacology","issn_l":"0021-5198","issn":["0021-5198","1347-3506"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310313602","host_organization_name":"Japanese Pharmacological Society","host_organization_lineage":["https://openalex.org/P4310313602"],"host_organization_lineage_names":["Japanese Pharmacological Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Journal of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.sciencedirect.com/science/article/pii/S0021519819368660/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083522997","display_name":"Jun Zhu","orcid":"https://orcid.org/0000-0001-9075-4866","observed_orcids":["https://orcid.org/0000-0001-9075-4866"]},"institutions":[{"id":"https://openalex.org/I111966504","display_name":"University of Fukui","ror":"https://ror.org/00msqp585","country_code":"JP","type":"education","lineage":["https://openalex.org/I111966504"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jun Zhu","raw_affiliation_strings":["Departments of Pediatrics and Pharmacology a , Fukui Medical School , Matsuoka , Fukui 910-","Department of Pediatrics, Fukui Medical School, Matsuoka, Fukui 910-11, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pediatrics and Pharmacology a , Fukui Medical School , Matsuoka , Fukui 910-","institution_ids":["https://openalex.org/I111966504"]},{"raw_affiliation_string":"Department of Pediatrics, Fukui Medical School, Matsuoka, Fukui 910-11, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079117338","display_name":"Manabu Takita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111966504","display_name":"University of Fukui","ror":"https://ror.org/00msqp585","country_code":"JP","type":"education","lineage":["https://openalex.org/I111966504"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Manabu Takita","raw_affiliation_strings":["Department of Pharmacology, Fukui Medical School, Matsuoka, Fukui 910-11, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Fukui Medical School, Matsuoka, Fukui 910-11, Japan","institution_ids":["https://openalex.org/I111966504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103399337","display_name":"Yukuo Konishi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111966504","display_name":"University of Fukui","ror":"https://ror.org/00msqp585","country_code":"JP","type":"education","lineage":["https://openalex.org/I111966504"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yukuo Konishi","raw_affiliation_strings":["Departments of Pediatrics and Pharmacology a , Fukui Medical School , Matsuoka , Fukui 910-","Department of Pediatrics, Fukui Medical School, Matsuoka, Fukui 910-11, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pediatrics and Pharmacology a , Fukui Medical School , Matsuoka , Fukui 910-","institution_ids":["https://openalex.org/I111966504"]},{"raw_affiliation_string":"Department of Pediatrics, Fukui Medical School, Matsuoka, Fukui 910-11, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111663851","display_name":"Masakatsu Sudo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111966504","display_name":"University of Fukui","ror":"https://ror.org/00msqp585","country_code":"JP","type":"education","lineage":["https://openalex.org/I111966504"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masakatsu Sudo","raw_affiliation_strings":["Departments of Pediatrics and Pharmacology a , Fukui Medical School , Matsuoka , Fukui 910-","Department of Pediatrics, Fukui Medical School, Matsuoka, Fukui 910-11, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pediatrics and Pharmacology a , Fukui Medical School , Matsuoka , Fukui 910-","institution_ids":["https://openalex.org/I111966504"]},{"raw_affiliation_string":"Department of Pediatrics, Fukui Medical School, Matsuoka, Fukui 910-11, Japan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062876325","display_name":"Ikunobu Muramatsu","orcid":"https://orcid.org/0000-0002-6881-5391","observed_orcids":["https://orcid.org/0000-0002-6881-5391"]},"institutions":[{"id":"https://openalex.org/I111966504","display_name":"University of Fukui","ror":"https://ror.org/00msqp585","country_code":"JP","type":"education","lineage":["https://openalex.org/I111966504"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ikunobu Muramatsu","raw_affiliation_strings":["Department of Pharmacology, Fukui Medical School, Matsuoka, Fukui 910-11, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Fukui Medical School, Matsuoka, Fukui 910-11, Japan","institution_ids":["https://openalex.org/I111966504"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I111966504"],"apc_list":null,"apc_paid":null,"fwci":0.1189,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.4393949,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"71","issue":null,"first_page":"157","last_page":"157"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.9150000214576721,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.9150000214576721,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11633","display_name":"Prenatal Substance Exposure Effects","score":0.07620000094175339,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nicotine","display_name":"nicotine","score":0.8019999861717224},{"id":"https://openalex.org/keywords/muscarinic-receptors","display_name":"muscarinic receptors","score":0.9539999961853027},{"id":"https://openalex.org/keywords/nicotinic-acetylcholine-receptors","display_name":"nicotinic acetylcholine receptors","score":0.9330000281333923},{"id":"https://openalex.org/keywords/receptor-development","display_name":"receptor development","score":0.6779999732971191},{"id":"https://openalex.org/keywords/prenatal-nicotine-exposure","display_name":"prenatal nicotine exposure","score":0.7149999737739563},{"id":"https://openalex.org/keywords/lactation","display_name":"lactation","score":0.699999988079071},{"id":"https://openalex.org/keywords/newborn-brain","display_name":"neonatal brain","score":0.6660000085830688},{"id":"https://openalex.org/keywords/cerebral-cortex","display_name":"cerebral cortex","score":0.8410000205039978},{"id":"https://openalex.org/keywords/cerebellum","display_name":"cerebellum","score":0.9990000128746033},{"id":"https://openalex.org/keywords/brainstem","display_name":"brainstem","score":0.8579999804496765},{"id":"https://openalex.org/keywords/nicotine-withdrawal","display_name":"nicotine withdrawal","score":0.7070000171661377},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.34700000286102295}],"concepts":[{"id":"https://openalex.org/C2777301948","wikidata":"https://www.wikidata.org/wiki/Q417343","display_name":"Cytisine","level":4,"score":0.9024600982666016},{"id":"https://openalex.org/C2779547902","wikidata":"https://www.wikidata.org/wiki/Q28086552","display_name":"Nicotine","level":2,"score":0.8185877203941345},{"id":"https://openalex.org/C33789571","wikidata":"https://www.wikidata.org/wiki/Q410959","display_name":"Muscarinic acetylcholine receptor","level":3,"score":0.8147501945495605},{"id":"https://openalex.org/C2776659692","wikidata":"https://www.wikidata.org/wiki/Q719426","display_name":"Lactation","level":3,"score":0.6283249855041504},{"id":"https://openalex.org/C188987157","wikidata":"https://www.wikidata.org/wiki/Q7030581","display_name":"Nicotinic agonist","level":3,"score":0.5967478156089783},{"id":"https://openalex.org/C2781041448","wikidata":"https://www.wikidata.org/wiki/Q75839","display_name":"Cerebral cortex","level":2,"score":0.5819732546806335},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5804609656333923},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5503784418106079},{"id":"https://openalex.org/C551621295","wikidata":"https://www.wikidata.org/wiki/Q182228","display_name":"Brainstem","level":2,"score":0.5338788032531738},{"id":"https://openalex.org/C2779652256","wikidata":"https://www.wikidata.org/wiki/Q130983","display_name":"Cerebellum","level":2,"score":0.5255664587020874},{"id":"https://openalex.org/C2908651707","wikidata":"https://www.wikidata.org/wiki/Q223068","display_name":"Quinuclidinyl Benzilate","level":4,"score":0.4513694941997528},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4361709952354431},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35599374771118164},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34717607498168945},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.3185485005378723},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30999937653541565},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/s0021-5198(19)36866-0","doi":"https://doi.org/10.1016/s0021-5198(19)36866-0","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-5198(19)36866-0","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0021519819368660/pdf","source":{"id":"https://openalex.org/S190179609","display_name":"The Japanese Journal of Pharmacology","issn_l":"0021-5198","issn":["0021-5198","1347-3506"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310313602","host_organization_name":"Japanese Pharmacological Society","host_organization_lineage":["https://openalex.org/P4310313602"],"host_organization_lineage_names":["Japanese Pharmacological Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Journal of Pharmacology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/s0021-5198(19)36866-0","doi":"https://doi.org/10.1016/s0021-5198(19)36866-0","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-5198(19)36866-0","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0021519819368660/pdf","source":{"id":"https://openalex.org/S190179609","display_name":"The Japanese Journal of Pharmacology","issn_l":"0021-5198","issn":["0021-5198","1347-3506"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310313602","host_organization_name":"Japanese Pharmacological Society","host_organization_lineage":["https://openalex.org/P4310313602"],"host_organization_lineage_names":["Japanese Pharmacological Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Journal of Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3103570545.pdf","grobid_xml":"https://content.openalex.org/works/W3103570545.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1987028110","https://openalex.org/W2036402431","https://openalex.org/W2082416374","https://openalex.org/W3099462741","https://openalex.org/W1967583846","https://openalex.org/W2079743276","https://openalex.org/W2378837691","https://openalex.org/W2089111872","https://openalex.org/W3173216474","https://openalex.org/W2262358589"],"abstract_inverted_index":{"Developmental":[0],"increase":[1],"in":[2,48,65,83,88],"the":[3,26,35,49,55],"muscarinic":[4,86],"receptors":[5,37],"([3H]quinuclidinyl":[6],"benzylate":[7],"binding":[8,39],"sites)":[9,40],"of":[10,25,34,85],"rat":[11,89],"neonate":[12],"brain":[13],"(cerebral":[14],"cortex":[15,51],"and":[16,30,44,52,60],"cerebellum)":[17],"was":[18,41,46],"significantly":[19],"inhibited":[20,43],"by":[21,54],"chronic":[22],"nicotine":[23,56,74],"treatment":[24,75],"dams":[27],"during":[28,76],"pregnancy":[29],"lactation.":[31],"However,":[32],"development":[33,84],"nicotinic":[36],"([3H]cytisine":[38],"not":[42,63],"rather":[45],"up-regulated":[47],"cerebral":[50],"brainstem":[53],"treatment.":[57],"Such":[58],"inhibition":[59],"up-regulation":[61],"were":[62],"seen":[64],"nicotine-withdrawn":[66],"rats":[67],"after":[68],"birth.":[69],"These":[70],"results":[71],"suggest":[72],"that":[73],"lactation":[77],"may":[78],"cause":[79],"a":[80],"remarkable":[81],"delay":[82],"neurotransmission":[87],"neonates.":[90]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-11-23T00:00:00"}