{"id":"https://openalex.org/W3103545179","doi":"https://doi.org/10.1111/hepr.13590","title":"Hypofractionated radiotherapy for hepatocellular carcinomas adjacent to the gastrointestinal tract","display_name":"Hypofractionated radiotherapy for hepatocellular carcinomas adjacent to the gastrointestinal tract","publication_year":2020,"publication_date":"2020-11-17","ids":{"openalex":"https://openalex.org/W3103545179","doi":"https://doi.org/10.1111/hepr.13590","mag":"3103545179","pmid":"https://pubmed.ncbi.nlm.nih.gov/33201542"},"language":"en","primary_location":{"id":"doi:10.1111/hepr.13590","doi":"https://doi.org/10.1111/hepr.13590","is_oa":false,"landing_page_url":"https://doi.org/10.1111/hepr.13590","pdf_url":null,"source":{"id":"https://openalex.org/S110399111","display_name":"Hepatology Research","issn_l":"1386-6346","issn":["1386-6346","1872-034X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068785157","display_name":"Yuichiro Tsurugai","orcid":"https://orcid.org/0000-0003-0872-2000","observed_orcids":["https://orcid.org/0000-0003-0872-2000"]},"institutions":[{"id":"https://openalex.org/I4405256203","display_name":"Ofuna Chuo Hospital","ror":"https://ror.org/03wm0hx40","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405256203"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuichiro Tsurugai","raw_affiliation_strings":["Radiation Oncology Center, Ofuna Chuo Hospital, Kamakura, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiation Oncology Center, Ofuna Chuo Hospital, Kamakura, Kanagawa, Japan","institution_ids":["https://openalex.org/I4405256203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005198830","display_name":"Atsuya Takeda","orcid":"https://orcid.org/0000-0003-2820-0760","observed_orcids":["https://orcid.org/0000-0003-2820-0760"]},"institutions":[{"id":"https://openalex.org/I4405256203","display_name":"Ofuna Chuo Hospital","ror":"https://ror.org/03wm0hx40","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405256203"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Atsuya Takeda","raw_affiliation_strings":["Radiation Oncology Center, Ofuna Chuo Hospital, Kamakura, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiation Oncology Center, Ofuna Chuo Hospital, Kamakura, Kanagawa, Japan","institution_ids":["https://openalex.org/I4405256203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074860810","display_name":"Takahisa Eriguchi","orcid":"https://orcid.org/0000-0001-6818-2240","observed_orcids":["https://orcid.org/0000-0001-6818-2240"]},"institutions":[{"id":"https://openalex.org/I4405256203","display_name":"Ofuna Chuo Hospital","ror":"https://ror.org/03wm0hx40","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405256203"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takahisa Eriguchi","raw_affiliation_strings":["Radiation Oncology Center, Ofuna Chuo Hospital, Kamakura, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiation Oncology Center, Ofuna Chuo Hospital, Kamakura, Kanagawa, Japan","institution_ids":["https://openalex.org/I4405256203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083977768","display_name":"Naoko Sanuki","orcid":"https://orcid.org/0000-0003-0274-9771","observed_orcids":["https://orcid.org/0000-0003-0274-9771"]},"institutions":[{"id":"https://openalex.org/I4405256203","display_name":"Ofuna Chuo Hospital","ror":"https://ror.org/03wm0hx40","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405256203"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naosko Sanuki","raw_affiliation_strings":["Radiation Oncology Center, Ofuna Chuo Hospital, Kamakura, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiation Oncology Center, Ofuna Chuo Hospital, Kamakura, Kanagawa, Japan","institution_ids":["https://openalex.org/I4405256203"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074237565","display_name":"Yousuke Aoki","orcid":"https://orcid.org/0000-0001-6146-8502","observed_orcids":["https://orcid.org/0000-0001-6146-8502"]},"institutions":[{"id":"https://openalex.org/I4405256203","display_name":"Ofuna Chuo Hospital","ror":"https://ror.org/03wm0hx40","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405256203"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yousuke Aoki","raw_affiliation_strings":["Radiation Oncology Center, Ofuna Chuo Hospital, Kamakura, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiation Oncology Center, Ofuna Chuo Hospital, Kamakura, Kanagawa, Japan","institution_ids":["https://openalex.org/I4405256203"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5005198830"],"corresponding_institution_ids":["https://openalex.org/I4405256203"],"apc_list":{"value":3100,"currency":"USD","value_usd":3100},"apc_paid":null,"fwci":0.8571,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.72244811,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"51","issue":"3","first_page":"294","last_page":"302"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.8799999952316284},{"id":"https://openalex.org/keywords/hypofractionated-radiotherapy","display_name":"hypofractionated radiotherapy","score":1.0},{"id":"https://openalex.org/keywords/gastrointestinal-tract","display_name":"gastrointestinal tract","score":0.5400000214576721},{"id":"https://openalex.org/keywords/proton-pump-inhibitors","display_name":"proton pump inhibitors","score":0.5789999961853027},{"id":"https://openalex.org/keywords/gastroduodenal-bleeding","display_name":"gastroduodenal bleeding","score":0.8090000152587891},{"id":"https://openalex.org/keywords/local-recurrence","display_name":"local recurrence","score":0.8149999976158142},{"id":"https://openalex.org/keywords/liver-related-mortality","display_name":"liver-related mortality","score":0.7319999933242798},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.6909999847412109},{"id":"https://openalex.org/keywords/inoperable-liver-cancer","display_name":"inoperable liver cancer","score":0.6399999856948853},{"id":"https://openalex.org/keywords/definitive-radiotherapy","display_name":"definitive radiotherapy","score":0.5759999752044678}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9315130710601807},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.7822299003601074},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.58273845911026},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.48496341705322266},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48447132110595703},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.4481734335422516},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3667352497577667},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1111/hepr.13590","doi":"https://doi.org/10.1111/hepr.13590","is_oa":false,"landing_page_url":"https://doi.org/10.1111/hepr.13590","pdf_url":null,"source":{"id":"https://openalex.org/S110399111","display_name":"Hepatology Research","issn_l":"1386-6346","issn":["1386-6346","1872-034X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology Research","raw_type":"journal-article"},{"id":"pmid:33201542","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33201542","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology research : the official journal of the Japan Society of Hepatology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W47310543","https://openalex.org/W1563283949","https://openalex.org/W1573400168","https://openalex.org/W1606647501","https://openalex.org/W1971747664","https://openalex.org/W1981779460","https://openalex.org/W2001034503","https://openalex.org/W2031213807","https://openalex.org/W2068648834","https://openalex.org/W2074999567","https://openalex.org/W2079586464","https://openalex.org/W2094100835","https://openalex.org/W2097512974","https://openalex.org/W2103694935","https://openalex.org/W2121960517","https://openalex.org/W2148692928","https://openalex.org/W2150206931","https://openalex.org/W2160455370","https://openalex.org/W2161643865","https://openalex.org/W2185023695","https://openalex.org/W2189641269","https://openalex.org/W2277004004","https://openalex.org/W2300443796","https://openalex.org/W2338748777","https://openalex.org/W2408413663","https://openalex.org/W2532166168","https://openalex.org/W2576419792","https://openalex.org/W2582878252","https://openalex.org/W2617182253","https://openalex.org/W2784224076","https://openalex.org/W2796067155","https://openalex.org/W2906772125","https://openalex.org/W2909212000","https://openalex.org/W2916183782","https://openalex.org/W2991491795","https://openalex.org/W3010693465","https://openalex.org/W3012452195","https://openalex.org/W3013647611","https://openalex.org/W4245784696"],"related_works":["https://openalex.org/W3136366915","https://openalex.org/W3005363820","https://openalex.org/W1922131944","https://openalex.org/W2898540319","https://openalex.org/W2134558634","https://openalex.org/W1996273421","https://openalex.org/W2756685870","https://openalex.org/W3209385823","https://openalex.org/W2081233574","https://openalex.org/W3167605908"],"abstract_inverted_index":{"AIM:":[0],"Decisions":[1],"regarding":[2],"therapeutic":[3],"plans":[4],"for":[5,58,97,130,237],"inoperable":[6],"patients":[7,75,145,181,212],"with":[8,77,79,114,146,213,220],"hepatocellular":[9],"carcinoma":[10],"(HCC)":[11],"adjacent":[12,215],"to":[13,48,100,216],"the":[14,24,31,64,95,102,105,217],"gastrointestinal":[15],"(GI)":[16],"tract":[17,107],"are":[18],"challenging":[19],"because":[20],"radiofrequency":[21],"ablation":[22],"has":[23],"potential":[25],"risk":[26],"of":[27,34,68,94,104,118,143],"thermal":[28],"injury.":[29],"Moreover,":[30],"response":[32],"rate":[33],"transcatheter":[35],"arterial":[36],"chemoembolization":[37],"is":[38,46],"relatively":[39],"low":[40,221],"and":[41,66,87,108,124,136,165,176,193,199],"stereotactic":[42],"body":[43],"radiotherapy":[44,56,78],"(SBRT)":[45],"believed":[47],"be":[49,231],"too":[50],"toxic.":[51],"We":[52],"have":[53],"applied":[54],"hypofractionated":[55],"(HFRT)":[57],"such":[59],"lesions.":[60,238],"This":[61],"study":[62,226],"investigated":[63],"outcomes":[65,135],"toxicities":[67,137],"this":[69],"treatment.":[70,191],"METHODS:":[71],"Among":[72],"consecutive":[73],"HCC":[74,214],"treated":[76,111],"curative":[80,234],"intent":[81],"at":[82,169],"our":[83],"institution":[84],"between":[85],"2015":[86],"2019,":[88],"we":[89],"retrospectively":[90],"extracted":[91],"those":[92],"outside":[93],"indication":[96],"SBRT":[98],"due":[99],"exceeding":[101],"constraint":[103],"GI":[106,218,222],"who":[109],"were":[110,138,149,172],"using":[112],"HFRT":[113,205,229],"a":[115,232],"prescription":[116],"dose":[117],"42":[119],"Gy":[120],"in":[121,211],"14":[122],"fractions":[123],"prophylactic":[125],"proton":[126],"pump":[127],"inhibitor":[128],"administration":[129],"6":[131,188],"months.":[132,157],"The":[133,151,158],"oncological":[134],"investigated.":[139],"RESULTS:":[140],"A":[141],"total":[142],"66":[144],"73":[147],"lesions":[148],"eligible.":[150],"median":[152],"follow-up":[153],"period":[154],"was":[155],"24.0":[156],"local":[159,209],"recurrence,":[160,162],"intrahepatic":[161],"liver-related":[163],"death,":[164],"overall":[166],"survival":[167],"rates":[168],"2":[170,198],"years":[171],"11.3%,":[173],"50.6%,":[174],"15.9%,":[175],"60.4%,":[177],"respectively.":[178,203],"Six":[179],"(9.1%)":[180],"experienced":[182],"Child-Pugh":[183],"score":[184],"deterioration":[185],"\u22652":[186],"within":[187],"months":[189],"following":[190],"Two":[192],"one":[194],"patient":[195],"developed":[196],"grades":[197],"3":[200],"gastroduodenal":[201],"bleeding,":[202],"CONCLUSIONS:":[204],"can":[206,230],"achieve":[207],"good":[208],"control":[210],"tract,":[219],"toxicity":[223],"incidence.":[224],"Our":[225],"demonstrated":[227],"that":[228],"potentially":[233],"treatment":[235],"option":[236]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-11-23T00:00:00"}