{"id":"https://openalex.org/W3103379966","doi":"https://doi.org/10.1016/j.celrep.2020.108401","title":"Atypical UV Photoproducts Induce Non-canonical Mutation Classes Associated with Driver Mutations in Melanoma","display_name":"Atypical UV Photoproducts Induce Non-canonical Mutation Classes Associated with Driver Mutations in Melanoma","publication_year":2020,"publication_date":"2020-11-01","ids":{"openalex":"https://openalex.org/W3103379966","doi":"https://doi.org/10.1016/j.celrep.2020.108401","mag":"3103379966","pmid":"https://pubmed.ncbi.nlm.nih.gov/33207206","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7709870"},"language":"en","primary_location":{"id":"doi:10.1016/j.celrep.2020.108401","doi":"https://doi.org/10.1016/j.celrep.2020.108401","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2020.108401","pdf_url":"http://www.cell.com/article/S2211124720313905/pdf","source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.cell.com/article/S2211124720313905/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053201742","display_name":"Marian F. Laughery","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marian F. Laughery","raw_affiliation_strings":["School of Molecular Biosciences, Washington State University, Pullman, WA 99164, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Molecular Biosciences, Washington State University, Pullman, WA 99164, USA","institution_ids":["https://openalex.org/I72951846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061387346","display_name":"Alexander Brown","orcid":"https://orcid.org/0000-0001-5818-0225","observed_orcids":["https://orcid.org/0000-0001-5818-0225"]},"institutions":[{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander J. Brown","raw_affiliation_strings":["School of Molecular Biosciences, Washington State University, Pullman, WA 99164, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Molecular Biosciences, Washington State University, Pullman, WA 99164, USA","institution_ids":["https://openalex.org/I72951846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028092811","display_name":"Kaitlynne A. Bohm","orcid":"https://orcid.org/0000-0001-5110-7703","observed_orcids":["https://orcid.org/0000-0001-5110-7703"]},"institutions":[{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kaitlynne A. Bohm","raw_affiliation_strings":["School of Molecular Biosciences, Washington State University, Pullman, WA 99164, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Molecular Biosciences, Washington State University, Pullman, WA 99164, USA","institution_ids":["https://openalex.org/I72951846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091514944","display_name":"Smitha Sivapragasam","orcid":"https://orcid.org/0000-0002-5599-9988","observed_orcids":["https://orcid.org/0000-0002-5599-9988"]},"institutions":[{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Smitha Sivapragasam","raw_affiliation_strings":["School of Molecular Biosciences, Washington State University, Pullman, WA 99164, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Molecular Biosciences, Washington State University, Pullman, WA 99164, USA","institution_ids":["https://openalex.org/I72951846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004642796","display_name":"Haley S. Morris","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haley S. Morris","raw_affiliation_strings":["School of Molecular Biosciences, Washington State University, Pullman, WA 99164, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Molecular Biosciences, Washington State University, Pullman, WA 99164, USA","institution_ids":["https://openalex.org/I72951846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054348157","display_name":"Mila Tchmola","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mila Tchmola","raw_affiliation_strings":["School of Molecular Biosciences, Washington State University, Pullman, WA 99164, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Molecular Biosciences, Washington State University, Pullman, WA 99164, USA","institution_ids":["https://openalex.org/I72951846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032633199","display_name":"Angelica D. Washington","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angelica D. Washington","raw_affiliation_strings":["School of Molecular Biosciences, Washington State University, Pullman, WA 99164, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Molecular Biosciences, Washington State University, Pullman, WA 99164, USA","institution_ids":["https://openalex.org/I72951846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031226014","display_name":"Debra Mitchell","orcid":"https://orcid.org/0000-0002-9343-075X","observed_orcids":["https://orcid.org/0000-0002-9343-075X"]},"institutions":[{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Debra Mitchell","raw_affiliation_strings":["School of Molecular Biosciences, Washington State University, Pullman, WA 99164, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Molecular Biosciences, Washington State University, Pullman, WA 99164, USA","institution_ids":["https://openalex.org/I72951846"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Stephen Mather","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen Mather","raw_affiliation_strings":["School of Molecular Biosciences, Washington State University, Pullman, WA 99164, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Molecular Biosciences, Washington State University, Pullman, WA 99164, USA","institution_ids":["https://openalex.org/I72951846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012890881","display_name":"Ewa P. Malc","orcid":"https://orcid.org/0000-0002-4596-1142","observed_orcids":["https://orcid.org/0000-0002-4596-1142"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ewa P. Malc","raw_affiliation_strings":["Department of Genetics, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090151610","display_name":"Piotr A. Mieczkowski","orcid":"https://orcid.org/0000-0003-2418-0096","observed_orcids":["https://orcid.org/0000-0003-2418-0096"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Piotr A. Mieczkowski","raw_affiliation_strings":["Department of Genetics, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045510214","display_name":"Steven A. Roberts","orcid":"https://orcid.org/0000-0002-3628-5808","observed_orcids":["https://orcid.org/0000-0002-3628-5808"]},"institutions":[{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Steven A. Roberts","raw_affiliation_strings":["School of Molecular Biosciences, Washington State University, Pullman, WA 99164, USA; Center for Reproductive Biology, Washington State University, Pullman, WA 99164, USA. Electronic address: steven.roberts2@wsu.edu","Center for Reproductive Biology, Washington State University, Pullman, WA 99164, USA","School of Molecular Biosciences, Washington State University, Pullman, WA 99164, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Molecular Biosciences, Washington State University, Pullman, WA 99164, USA; Center for Reproductive Biology, Washington State University, Pullman, WA 99164, USA. Electronic address: steven.roberts2@wsu.edu","institution_ids":["https://openalex.org/I72951846"]},{"raw_affiliation_string":"Center for Reproductive Biology, Washington State University, Pullman, WA 99164, USA","institution_ids":["https://openalex.org/I72951846"]},{"raw_affiliation_string":"School of Molecular Biosciences, Washington State University, Pullman, WA 99164, USA","institution_ids":["https://openalex.org/I72951846"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052037019","display_name":"John J. Wyrick","orcid":"https://orcid.org/0000-0002-7911-3803","observed_orcids":["https://orcid.org/0000-0002-7911-3803"]},"institutions":[{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John J. Wyrick","raw_affiliation_strings":["School of Molecular Biosciences, Washington State University, Pullman, WA 99164, USA; Center for Reproductive Biology, Washington State University, Pullman, WA 99164, USA. Electronic address: jwyrick@wsu.edu","Center for Reproductive Biology, Washington State University, Pullman, WA 99164, USA","School of Molecular Biosciences, Washington State University, Pullman, WA 99164, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Molecular Biosciences, Washington State University, Pullman, WA 99164, USA; Center for Reproductive Biology, Washington State University, Pullman, WA 99164, USA. Electronic address: jwyrick@wsu.edu","institution_ids":["https://openalex.org/I72951846"]},{"raw_affiliation_string":"Center for Reproductive Biology, Washington State University, Pullman, WA 99164, USA","institution_ids":["https://openalex.org/I72951846"]},{"raw_affiliation_string":"School of Molecular Biosciences, Washington State University, Pullman, WA 99164, USA","institution_ids":["https://openalex.org/I72951846"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5045510214","https://openalex.org/A5052037019"],"corresponding_institution_ids":["https://openalex.org/I72951846"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":{"value":5200,"currency":"USD","value_usd":5200},"fwci":1.0496,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.74313811,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"33","issue":"7","first_page":"108401","last_page":"108401"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.8026999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.8026999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.02669999934732914,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.01979999989271164,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/uv-photoproducts","display_name":"UV photoproducts","score":0.8679999709129333},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.7059999704360962},{"id":"https://openalex.org/keywords/driver-mutations","display_name":"driver mutations","score":0.7680000066757202},{"id":"https://openalex.org/keywords/nucleotide-excision-repair","display_name":"nucleotide excision repair","score":0.8659999966621399},{"id":"https://openalex.org/keywords/uv-mutagenesis","display_name":"UV mutagenesis","score":0.7129999995231628},{"id":"https://openalex.org/keywords/braf-v600e-mutation","display_name":"BRAF V600E mutation","score":0.8740000128746033},{"id":"https://openalex.org/keywords/braf-v600k","display_name":"BRAF V600K","score":0.9769999980926514},{"id":"https://openalex.org/keywords/skin-cancer","display_name":"skin cancer","score":0.6520000100135803}],"concepts":[{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.6532666683197021},{"id":"https://openalex.org/C167975912","wikidata":"https://www.wikidata.org/wiki/Q1018722","display_name":"Pyrimidine dimer","level":4,"score":0.6406975388526917},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5896934866905212},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5781476497650146},{"id":"https://openalex.org/C2777028655","wikidata":"https://www.wikidata.org/wiki/Q415601","display_name":"Endonuclease","level":3,"score":0.4819364547729492},{"id":"https://openalex.org/C104451858","wikidata":"https://www.wikidata.org/wiki/Q2714458","display_name":"Nucleotide excision repair","level":4,"score":0.468422532081604},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.44816139340400696},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.430218905210495},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.42266660928726196},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4046473503112793},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3543711304664612}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014466","descriptor_name":"Ultraviolet Rays","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1016/j.celrep.2020.108401","doi":"https://doi.org/10.1016/j.celrep.2020.108401","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2020.108401","pdf_url":"http://www.cell.com/article/S2211124720313905/pdf","source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},{"id":"pmid:33207206","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33207206","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7709870","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7709870","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cell Rep","raw_type":"Text"},{"id":"pmh:cdr.lib.unc.edu:5h73q7703","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.17615/reqs-9k44","pdf_url":null,"source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Reports, 33(7)","raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:1fe06743de9442ca81716c50b9a5db31","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/1fe06743de9442ca81716c50b9a5db31","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Reports, Vol 33, Iss 7, Pp 108401- (2020)","raw_type":"article"},{"id":"doi:10.17615/reqs-9k44","doi":"https://doi.org/10.17615/reqs-9k44","is_oa":true,"landing_page_url":"https://doi.org/10.17615/reqs-9k44","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1016/j.celrep.2020.108401","doi":"https://doi.org/10.1016/j.celrep.2020.108401","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2020.108401","pdf_url":"http://www.cell.com/article/S2211124720313905/pdf","source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4986845377","display_name":"Genome-wide analysis of UV damage formation, repair, and mutagenesis","funder_award_id":"R21ES027937","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G7264304010","display_name":"UV damage stimulation by ETS transcription factors in skin cancer","funder_award_id":"R21ES029655","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G9000874536","display_name":"Regulation of DNA Excision Repair in Chromatin","funder_award_id":"R01ES028698","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"},{"id":"https://openalex.org/F4320337372","display_name":"U.S. National Library of Medicine","ror":"https://ror.org/0060t0j89"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3103379966.pdf"},"referenced_works_count":63,"referenced_works":["https://openalex.org/W1491876634","https://openalex.org/W1816637173","https://openalex.org/W1973385732","https://openalex.org/W1974736523","https://openalex.org/W1982690685","https://openalex.org/W1988397037","https://openalex.org/W1988508963","https://openalex.org/W1992294575","https://openalex.org/W1993138451","https://openalex.org/W1994245454","https://openalex.org/W2004678494","https://openalex.org/W2009214067","https://openalex.org/W2019399071","https://openalex.org/W2024938749","https://openalex.org/W2026752855","https://openalex.org/W2032320097","https://openalex.org/W2032409312","https://openalex.org/W2041848980","https://openalex.org/W2046082575","https://openalex.org/W2057396801","https://openalex.org/W2064855999","https://openalex.org/W2070312296","https://openalex.org/W2074443651","https://openalex.org/W2076154138","https://openalex.org/W2082139407","https://openalex.org/W2094645941","https://openalex.org/W2096465161","https://openalex.org/W2097124161","https://openalex.org/W2115998813","https://openalex.org/W2117159449","https://openalex.org/W2121377606","https://openalex.org/W2129361946","https://openalex.org/W2132992059","https://openalex.org/W2133676450","https://openalex.org/W2134471382","https://openalex.org/W2137161660","https://openalex.org/W2150677022","https://openalex.org/W2153448038","https://openalex.org/W2158264171","https://openalex.org/W2158266834","https://openalex.org/W2168698826","https://openalex.org/W2170551349","https://openalex.org/W2204454331","https://openalex.org/W2253310320","https://openalex.org/W2266041843","https://openalex.org/W2313953393","https://openalex.org/W2314229414","https://openalex.org/W2505939414","https://openalex.org/W2542991120","https://openalex.org/W2592429281","https://openalex.org/W2611187032","https://openalex.org/W2614902590","https://openalex.org/W2735913246","https://openalex.org/W2810981777","https://openalex.org/W2888020198","https://openalex.org/W2898789672","https://openalex.org/W2906523411","https://openalex.org/W2938255062","https://openalex.org/W2982153301","https://openalex.org/W2997804167","https://openalex.org/W3022071200","https://openalex.org/W4301121981","https://openalex.org/W6638533932"],"related_works":["https://openalex.org/W7213581290","https://openalex.org/W4376226095","https://openalex.org/W4392593920","https://openalex.org/W4314935527","https://openalex.org/W4390732826","https://openalex.org/W7161786219","https://openalex.org/W6902347011","https://openalex.org/W2168302736","https://openalex.org/W4372336060","https://openalex.org/W2041848980"],"abstract_inverted_index":{"Somatic":[0],"mutations":[1,24,40,52,64,111,142],"in":[2,25,41,114,153],"skin":[3,115],"cancers":[4],"and":[5,14,60,122,137],"other":[6],"ultraviolet":[7],"(UV)-exposed":[8],"cells":[9],"are":[10,79,112],"typified":[11],"by":[12,71,81],"C>T":[13],"CC>TT":[15],"substitutions":[16],"at":[17],"dipyrimidine":[18],"sequences;":[19],"however,":[20],"many":[21],"oncogenic":[22],"\"driver\"":[23],"melanoma":[26],"do":[27],"not":[28],"fit":[29],"this":[30],"UV":[31,46,82,89,147],"signature.":[32],"Here,":[33],"we":[34,94],"use":[35],"genome":[36],"sequencing":[37,86,92],"to":[38],"characterize":[39],"yeast":[42],"repeatedly":[43],"irradiated":[44],"with":[45],"light.":[47],"Analysis":[48],"of":[49,98],"~50,000":[50],"UV-induced":[51,106],"reveals":[53],"abundant":[54],"non-canonical":[55,110],"mutations,":[56,130],"including":[57],"T>C,":[58],"T>A,":[59],"AC>TT":[61],"substitutions.":[62,108],"These":[63,126],"display":[65,119],"transcriptional":[66,120],"asymmetry":[67,121],"that":[68,77,141],"is":[69],"modulated":[70],"nucleotide":[72],"excision":[73],"repair":[74],"(NER),":[75],"indicating":[76],"they":[78],"caused":[80],"photoproducts.":[83],"Using":[84],"a":[85,151],"method":[87],"called":[88],"DNA":[90],"endonuclease":[91],"(UVDE-seq),":[93],"confirm":[95],"the":[96,133],"existence":[97],"an":[99],"atypical":[100,146],"thymine-adenine":[101],"photoproduct":[102],"likely":[103],"responsible":[104],"for":[105],"T>A":[107],"Similar":[109],"present":[113],"cancers,":[116],"which":[117],"also":[118],"dependence":[123],"on":[124],"NER.":[125],"include":[127],"multiple":[128],"driver":[129],"most":[131],"prominently":[132],"recurrent":[134],"BRAF":[135],"V600E":[136],"V600K":[138],"substitutions,":[139],"suggesting":[140],"arising":[143],"from":[144],"rare,":[145],"photoproducts":[148],"may":[149],"play":[150],"role":[152],"melanomagenesis.":[154]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2020-11-23T00:00:00"}
