{"id":"https://openalex.org/W3103330820","doi":null,"title":"Potential roles of PBRM1 on immune infiltration in cholangiocarcinoma.","display_name":"Potential roles of PBRM1 on immune infiltration in cholangiocarcinoma.","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W3103330820","mag":"3103330820","pmid":"https://pubmed.ncbi.nlm.nih.gov/33165423","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7642697"},"language":"en","primary_location":{"id":"pmid:33165423","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33165423","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental pathology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7642697/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100435361","display_name":"Ling Li","orcid":"https://orcid.org/0000-0002-9245-7387","observed_orcids":["https://orcid.org/0000-0002-9245-7387"]},"institutions":[{"id":"https://openalex.org/I2802390878","display_name":"Sir Run Run Shaw Hospital","ror":"https://ror.org/00ka6rp58","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802390878"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ling Li","raw_affiliation_strings":["Laboratory of Cancer Biology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, Medical School of Zhejiang University Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cancer Biology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, Medical School of Zhejiang University Hangzhou, China","institution_ids":["https://openalex.org/I2802390878","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079202247","display_name":"Yadan Li","orcid":"https://orcid.org/0000-0003-4825-7887","observed_orcids":["https://orcid.org/0000-0003-4825-7887"]},"institutions":[{"id":"https://openalex.org/I2802390878","display_name":"Sir Run Run Shaw Hospital","ror":"https://ror.org/00ka6rp58","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802390878"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yadan Li","raw_affiliation_strings":["Laboratory of Cancer Biology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, Medical School of Zhejiang University Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cancer Biology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, Medical School of Zhejiang University Hangzhou, China","institution_ids":["https://openalex.org/I2802390878","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017172677","display_name":"Yan Guo","orcid":"https://orcid.org/0009-0009-6978-7300","observed_orcids":["https://orcid.org/0009-0009-6978-7300"]},"institutions":[{"id":"https://openalex.org/I2802390878","display_name":"Sir Run Run Shaw Hospital","ror":"https://ror.org/00ka6rp58","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802390878"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Guo","raw_affiliation_strings":["Laboratory of Cancer Biology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, Medical School of Zhejiang University Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cancer Biology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, Medical School of Zhejiang University Hangzhou, China","institution_ids":["https://openalex.org/I2802390878","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100399433","display_name":"Jingyi Li","orcid":"https://orcid.org/0000-0002-3126-7889","observed_orcids":["https://orcid.org/0000-0002-3126-7889","https://orcid.org/0000-0001-9968-9933"]},"institutions":[{"id":"https://openalex.org/I2802390878","display_name":"Sir Run Run Shaw Hospital","ror":"https://ror.org/00ka6rp58","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802390878"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingyi Li","raw_affiliation_strings":["Laboratory of Cancer Biology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, Medical School of Zhejiang University Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cancer Biology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, Medical School of Zhejiang University Hangzhou, China","institution_ids":["https://openalex.org/I2802390878","https://openalex.org/I76130692"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078313825","display_name":"Hongchuan Jin","orcid":"https://orcid.org/0000-0002-6697-3097","observed_orcids":["https://orcid.org/0000-0002-6697-3097"]},"institutions":[{"id":"https://openalex.org/I2802390878","display_name":"Sir Run Run Shaw Hospital","ror":"https://ror.org/00ka6rp58","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802390878"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongchuan Jin","raw_affiliation_strings":["Laboratory of Cancer Biology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, Medical School of Zhejiang University Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cancer Biology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, Medical School of Zhejiang University Hangzhou, China","institution_ids":["https://openalex.org/I2802390878","https://openalex.org/I76130692"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8929,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.70447936,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"13","issue":"10","first_page":"2661","last_page":"2676"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12460","display_name":"Pediatric Hepatobiliary Diseases and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pbrm1","display_name":"PBRM1","score":0.9800000190734863},{"id":"https://openalex.org/keywords/cholangiocarcinoma","display_name":"cholangiocarcinoma","score":1.0},{"id":"https://openalex.org/keywords/tumor-immune-infiltration","display_name":"tumor immune infiltration","score":0.9259999990463257},{"id":"https://openalex.org/keywords/cancer-associated-fibroblasts","display_name":"cancer-associated fibroblasts","score":0.9869999885559082},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.7440000176429749},{"id":"https://openalex.org/keywords/cd56","display_name":"CD56","score":0.8809999823570251},{"id":"https://openalex.org/keywords/mmp-2","display_name":"MMP-2","score":0.8930000066757202},{"id":"https://openalex.org/keywords/focal-adhesion-kinase","display_name":"focal adhesion kinase","score":0.9929999709129333},{"id":"https://openalex.org/keywords/tumor-stroma","display_name":"tumor stroma","score":0.6729999780654907},{"id":"https://openalex.org/keywords/protein-protein-interaction-network","display_name":"protein-protein interaction network","score":0.7900000214576721},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.574999988079071}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6499718427658081},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.49268823862075806},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4667205214500427},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.42070114612579346},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40267813205718994},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2459133267402649}],"mesh":[],"locations_count":3,"locations":[{"id":"pmid:33165423","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33165423","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental pathology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7642697","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7642697/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Pathol","raw_type":"Text"},{"id":"mag:3103330820","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33165423","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7642697","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7642697/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Pathol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1970368087","https://openalex.org/W1972636666","https://openalex.org/W1989025666","https://openalex.org/W1989642526","https://openalex.org/W2005501957","https://openalex.org/W2027377391","https://openalex.org/W2052071472","https://openalex.org/W2052364863","https://openalex.org/W2062263584","https://openalex.org/W2065202184","https://openalex.org/W2085917589","https://openalex.org/W2091582111","https://openalex.org/W2141872434","https://openalex.org/W2149441684","https://openalex.org/W2152294125","https://openalex.org/W2168251084","https://openalex.org/W2306715392","https://openalex.org/W2340753924","https://openalex.org/W2537623931","https://openalex.org/W2560087117","https://openalex.org/W2607129810","https://openalex.org/W2765224588","https://openalex.org/W2767473306","https://openalex.org/W2782183686","https://openalex.org/W2891525728","https://openalex.org/W2951552683","https://openalex.org/W3023436273","https://openalex.org/W4211005002","https://openalex.org/W4232741423"],"related_works":["https://openalex.org/W4286295784","https://openalex.org/W3137782586","https://openalex.org/W4312785753","https://openalex.org/W3200491795","https://openalex.org/W2979864342","https://openalex.org/W2606503150","https://openalex.org/W2883750346","https://openalex.org/W7119861814","https://openalex.org/W3172920818","https://openalex.org/W4313827489"],"abstract_inverted_index":{"BACKGROUND:":[0],"Cholangiocarcinoma":[1],"(CHOL)":[2],"is":[3,12],"one":[4],"of":[5,39,50,88,105,134,144,166,188,196,214,222],"the":[6,56,142,185,218],"most":[7],"fatal":[8],"malignancies":[9],"worldwide.":[10],"PBRM1":[11,40,46,68,84,106,120,135,152,190,199,232],"a":[13,122,138,235],"tumor":[14,35,70,212,223],"suppressor":[15],"gene":[16,86,174],"in":[17,41,92,149,184,205,239],"diverse":[18],"cancers.":[19],"It":[20],"regulates":[21],"cell":[22,36,71,207],"cycle,":[23],"genomic":[24],"stability,":[25],"centromeric":[26],"cohesion,":[27],"and":[28,48,62,69,85,101,108,114,126,131,158,194,211,220],"apoptosis.":[29],"However,":[30],"its":[31],"relevance":[32],"to":[33],"remodel":[34],"immune":[37,72,90,192,206],"response":[38],"CHOL":[42,51,75,93,118,150],"remains":[43],"unclear.":[44],"METHODS:":[45],"mutation":[47,107,124],"expression":[49,109,133],"patients":[52,76],"were":[53,161],"analyzed":[54,95],"by":[55,79,96,216],"TCGA":[57],"database":[58],"using":[59,112],"R":[60],"packages":[61],"cBioPortal":[63],"site.":[64],"The":[65],"correlation":[66],"between":[67,83],"in\ufb01ltrates":[73],"among":[74],"was":[77,94,110,153],"investigated":[78,111],"TIMER2.0.":[80],"Correlation":[81],"analysis":[82,100],"markers":[87],"tumor-in\ufb01ltrating":[89],"cells":[91,225],"GEPIA.":[97],"Pathway":[98],"enrichment":[99],"protein-protein":[102,169],"interaction":[103,170],"network":[104,171],"STRING":[113],"Cytoscape.":[115],"RESULTS:":[116],"Among":[117],"patients,":[119],"has":[121],"high":[123],"probability":[125],"significant":[127,139],"differential":[128,132],"expression.":[129],"Mutations":[130],"both":[136],"have":[137],"effect":[140],"on":[141],"infiltration":[143,193],"cancer":[145],"associated":[146],"fibroblasts":[147,228],"(CAF)":[148],"patients.":[151],"highly":[154],"correlated":[155],"with":[156,172],"MMP2":[157],"FAK,":[159],"which":[160],"reported":[162],"as":[163],"key":[164,182],"regulators":[165],"CAF.":[167],"Through":[168],"hub":[173],"analysis,":[175],"we":[176],"discovered":[177],"that":[178],"NCAM1":[179],"could":[180],"play":[181,201],"roles":[183],"potential":[186],"mechanism":[187],"how":[189],"affects":[191],"progress":[195],"CHOL.":[197,240],"CONCLUSION:":[198],"may":[200],"an":[202],"important":[203],"role":[204],"infiltration,":[208],"matrix":[209],"formation,":[210],"invasion":[213],"CHOL,":[215],"regulating":[217],"function":[219],"infiltrating":[221],"stromal":[224],"including":[226],"cancer-associated":[227],"through":[229],"NCAM1.":[230],"Therefore,":[231],"might":[233],"be":[234],"new":[236],"therapeutic":[237],"target":[238]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-11-23T00:00:00"}
