{"id":"https://openalex.org/W3103100342","doi":"https://doi.org/10.1161/circ.142.suppl_3.16281","title":"Abstract 16281: Non-calcified Coronary Plaque Burden is Related to Epicardial Adipose Tissue and Peri-coronary Adipose Tissue Attenuation in Heart Failure With Preserved Ejection Fraction","display_name":"Abstract 16281: Non-calcified Coronary Plaque Burden is Related to Epicardial Adipose Tissue and Peri-coronary Adipose Tissue Attenuation in Heart Failure With Preserved Ejection Fraction","publication_year":2020,"publication_date":"2020-11-12","ids":{"openalex":"https://openalex.org/W3103100342","doi":"https://doi.org/10.1161/circ.142.suppl_3.16281","mag":"3103100342"},"language":"en","primary_location":{"id":"doi:10.1161/circ.142.suppl_3.16281","doi":"https://doi.org/10.1161/circ.142.suppl_3.16281","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.142.suppl_3.16281","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001238840","display_name":"Haider Aldiwani","orcid":"https://orcid.org/0000-0002-3785-2755","observed_orcids":["https://orcid.org/0000-0002-3785-2755"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Haider Aldiwani","raw_affiliation_strings":["CEDARS SINAI, La Mesa, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CEDARS SINAI, La Mesa, CA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024022330","display_name":"Janet Wei","orcid":"https://orcid.org/0000-0002-1311-618X","observed_orcids":["https://orcid.org/0000-0002-1311-618X"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janet Wei","raw_affiliation_strings":["CEDARS-SINAI MEDICAL CENTER, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CEDARS-SINAI MEDICAL CENTER, Los Angeles, CA","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013846518","display_name":"Panteha Rezaeian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I4210141674","display_name":"Cedars-Sinai Smidt Heart Institute","ror":"https://ror.org/041vn2102","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834","https://openalex.org/I4210141674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Panteha Rezaeian","raw_affiliation_strings":["Cedars-Sinai Heart Institute, Rch Palos Vrd, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Heart Institute, Rch Palos Vrd, CA","institution_ids":["https://openalex.org/I1282927834","https://openalex.org/I4210141674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004524938","display_name":"Alan C. Kwan","orcid":"https://orcid.org/0000-0002-4393-1011","observed_orcids":["https://orcid.org/0000-0002-4393-1011"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan C Kwan","raw_affiliation_strings":["CEDARS SINAI CARDIOLOGY, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CEDARS SINAI CARDIOLOGY, Los Angeles, CA","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010312216","display_name":"Varun K. Pattisapu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Varun Pattisapu","raw_affiliation_strings":["Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Los Angeles, CA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074046007","display_name":"Galen Cook\u2010Wiens","orcid":"https://orcid.org/0000-0003-4088-6240","observed_orcids":["https://orcid.org/0000-0003-4088-6240"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Galen Cook-Wiens","raw_affiliation_strings":["Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Los Angeles, CA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057455260","display_name":"Jenna Maughan","orcid":"https://orcid.org/0000-0002-5983-8436","observed_orcids":["https://orcid.org/0000-0002-5983-8436"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jenna Maughan","raw_affiliation_strings":["Cedars Sinai Med Cntr, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars Sinai Med Cntr, Los Angeles, CA","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030740476","display_name":"CHRISANDRA L. SHUFELT","orcid":"https://orcid.org/0000-0001-6886-9210","observed_orcids":["https://orcid.org/0000-0001-6886-9210"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chrisandra Shufelt","raw_affiliation_strings":["CEDARS-SINAI MEDICAL CENTER, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CEDARS-SINAI MEDICAL CENTER, Los Angeles, CA","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090233967","display_name":"Louise Thomson","orcid":"https://orcid.org/0000-0001-7492-7827","observed_orcids":["https://orcid.org/0000-0001-7492-7827"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"louise e thomson","raw_affiliation_strings":["Cedars Sinai Med Cntr, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars Sinai Med Cntr, Los Angeles, CA","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086264921","display_name":"Balaji K. Tamarappoo","orcid":"https://orcid.org/0000-0002-8382-4421","observed_orcids":["https://orcid.org/0000-0002-8382-4421"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"balaji tamarappoo","raw_affiliation_strings":["cedars sinai medical center, los angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"cedars sinai medical center, los angeles, CA","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100727282","display_name":"Daniel S. Berman","orcid":"https://orcid.org/0000-0002-3793-9578","observed_orcids":["https://orcid.org/0000-0002-3793-9578"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel Berman","raw_affiliation_strings":["Daniel Berman"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Daniel Berman","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052713249","display_name":"Damini Dey","orcid":"https://orcid.org/0000-0003-2236-6970","observed_orcids":["https://orcid.org/0000-0003-2236-6970"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Damini Dey","raw_affiliation_strings":["8700 Beverly Blvd, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"8700 Beverly Blvd, Los Angeles, CA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083852582","display_name":"C. Noel Bairey Merz","orcid":"https://orcid.org/0000-0002-9933-5155","observed_orcids":["https://orcid.org/0000-0002-9933-5155"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Noel Bairey Merz","raw_affiliation_strings":["CEDARS SINAI, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CEDARS SINAI, Los Angeles, CA","institution_ids":["https://openalex.org/I1282927834"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"142","issue":"Suppl_3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12979","display_name":"Cardiovascular Disease and Adiposity","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12979","display_name":"Cardiovascular Disease and Adiposity","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10372","display_name":"Cardiac Imaging and Diagnostics","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heart-failure-with-preserved-ejection-fraction","display_name":"heart failure with preserved ejection fraction","score":0.972000002861023},{"id":"https://openalex.org/keywords/non-calcified-coronary-plaque","display_name":"non-calcified coronary plaque","score":0.9509999752044678},{"id":"https://openalex.org/keywords/epicardial-adipose-tissue","display_name":"epicardial adipose tissue","score":0.8949999809265137},{"id":"https://openalex.org/keywords/pericoronary-adipose-tissue-attenuation","display_name":"pericoronary adipose tissue attenuation","score":0.9409999847412109},{"id":"https://openalex.org/keywords/coronary-inflammation","display_name":"coronary inflammation","score":0.828000009059906},{"id":"https://openalex.org/keywords/coronary-plaque-burden","display_name":"coronary plaque burden","score":0.5809999704360962},{"id":"https://openalex.org/keywords/coronary-artery-calcium-score","display_name":"coronary artery calcium score","score":0.628000020980835},{"id":"https://openalex.org/keywords/non-obstructive-coronary-artery-disease","display_name":"non-obstructive coronary artery disease","score":0.8460000157356262},{"id":"https://openalex.org/keywords/coronary-ct-angiography","display_name":"coronary CT angiography","score":0.7570000290870667},{"id":"https://openalex.org/keywords/epicardial-fat-volume","display_name":"epicardial fat volume","score":0.7260000109672546},{"id":"https://openalex.org/keywords/age-as-risk-factor","display_name":"age as risk factor","score":0.5019999742507935}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9325602054595947},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.7143331170082092},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6814301609992981},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6749486923217773},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.6392578482627869},{"id":"https://openalex.org/C187954543","wikidata":"https://www.wikidata.org/wiki/Q1501273","display_name":"Hounsfield scale","level":3,"score":0.6355092525482178},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.5457075238227844},{"id":"https://openalex.org/C2909917808","wikidata":"https://www.wikidata.org/wiki/Q5629407","display_name":"Coronary Calcium Score","level":4,"score":0.5003361701965332},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.4335048198699951},{"id":"https://openalex.org/C2994533308","wikidata":"https://www.wikidata.org/wiki/Q5629407","display_name":"Coronary artery calcium","level":3,"score":0.21503138542175293},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.20502984523773193},{"id":"https://openalex.org/C544519230","wikidata":"https://www.wikidata.org/wiki/Q32566","display_name":"Computed tomography","level":2,"score":0.1569708287715912}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.142.suppl_3.16281","doi":"https://doi.org/10.1161/circ.142.suppl_3.16281","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.142.suppl_3.16281","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4409558063","https://openalex.org/W4378953671","https://openalex.org/W4376126024","https://openalex.org/W4403758105","https://openalex.org/W4223470462","https://openalex.org/W2078934621","https://openalex.org/W2069689571","https://openalex.org/W4306319455","https://openalex.org/W7168122847","https://openalex.org/W3141765429"],"abstract_inverted_index":{"Introduction:":[0],"Coronary":[1],"inflammation":[2],"may":[3,257],"be":[4,40],"a":[5,121],"factor":[6],"in":[7,48,65,114,120,236,262],"developing":[8],"heart":[9],"failure":[10],"with":[11,77,84,212,252],"preserved":[12],"ejection":[13],"fraction":[14],"(HFpEF).":[15],"Epicardial":[16],"fat":[17],"volume":[18],"(EFV)":[19],"measured":[20,119],"using":[21,102,109,136],"non-contrast":[22],"computed":[23],"tomography":[24],"(CT)":[25],"and":[26,67,105,139,148,201,208,219,228,247,256],"pericoronary":[27],"adipose":[28],"tissue":[29],"(PCAT)":[30],"attenuation":[31,99,113,188,210,249],"on":[32],"coronary":[33,52,70,85,130,202,214],"CT":[34],"angiography":[35],"(CCTA)":[36],"are":[37,250,270],"considered":[38],"to":[39,152,242,272],"inflammatory":[41],"mediators,":[42],"which":[43],"play":[44,258],"an":[45,60,259],"important":[46,260],"role":[47,261],"the":[49,127,157,213,263],"development":[50],"of":[51,81,88,160,266],"plaque.":[53],"Hypothesis:":[54],"We":[55],"hypothesize":[56],"that":[57],"there":[58],"is":[59],"interrelationship":[61],"between":[62],"these":[63,275],"measures":[64],"HFpEF":[66,78],"no":[68],"obstructive":[69,89],"artery":[71],"disease":[72],"(CAD).":[73],"Methods:":[74],"28":[75],"subjects":[76],"(European":[79],"Society":[80],"Cardiology":[82],"criteria),":[83],"CCTA-documented":[86],"absence":[87],"CAD.":[90],"Non-calcified":[91],"plaque":[92,96,254],"(NCP),":[93],"low-density":[94],"non-calcified":[95,253],"(LDNCP),":[97],"PCAT":[98,112,149,187,209,229,248],"were":[100,240],"quantified":[101,108],"semi-automated":[103],"software":[104],"EFV":[106,182,207,246],"was":[107,118,134],"QFAT":[110],"software.":[111],"Hounsfield":[115],"Units":[116],"(HU)":[117],"standardized":[122],"40":[123],"mm":[124],"segment":[125],"around":[126],"proximal":[128],"right":[129],"artery.":[131],"Statistical":[132],"analysis":[133],"performed":[135],"Spearman":[137],"correlation":[138],"multivariable":[140,225],"regression":[141],"models":[142],"adjusted":[143],"for":[144],"age,":[145],"BMI,":[146],"EFV,":[147],"tested":[150],"relations":[151],"NCP":[153,193,220,237,243],"burden.":[154,244],"Results:":[155],"Overall,":[156],"mean":[158],"age":[159,227],"64.8\u00b112":[161],"years,":[162],"74%":[163],"women,":[164],"BMI":[165],"29.3\u00b14,":[166],"total":[167,192,196],"cholesterol":[168],"162\u00b141mg/dl,":[169],"LDL":[170],"85\u00b129":[171],"mg/dl,":[172,175],"HDL":[173],"55\u00b114":[174],"systolic":[176],"BP":[177,180],"132\u00b122mmHg,":[178],"diastolic":[179],"77\u00b112mmHg,":[181],"139\u00b173":[183],"cm":[184],"3":[185],"and,":[186],"-78\u00b18":[189],"HU.":[190],"Mean":[191],"burden":[194,198,221,238,255],"34\u00b113%,":[195],"LDNCP":[197],"3\u00b11.8":[199],"%,":[200],"calcium":[203],"score":[204],"(CCS)":[205],"414\u00b1920.":[206],"correlated":[211],"risk":[215],"markers":[216],"including":[217],"CCS":[218],"variables":[222],"(Table).":[223],"In":[224],"analysis,":[226],"(\u03b2\u00b1SE=0.43\u00b10.2,":[230],"p=0.04,":[231],"0.64\u00b10.3,":[232],"p=0.03":[233],"per":[234],"1%-change":[235],"respectively)":[239],"related":[241],"Conclusions:":[245],"associated":[251],"pathophysiological":[264],"process":[265],"HFpEF.":[267],"Further":[268],"studies":[269],"needed":[271],"further":[273],"understand":[274],"findings.":[276]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2020-11-23T00:00:00"}