{"id":"https://openalex.org/W3102869048","doi":"https://doi.org/10.3389/fneur.2020.594289","title":"Selective Brain Hypothermia in Acute Ischemic Stroke: Reperfusion Without Reperfusion Injury","display_name":"Selective Brain Hypothermia in Acute Ischemic Stroke: Reperfusion Without Reperfusion Injury","publication_year":2020,"publication_date":"2020-11-13","ids":{"openalex":"https://openalex.org/W3102869048","doi":"https://doi.org/10.3389/fneur.2020.594289","mag":"3102869048","pmid":"https://pubmed.ncbi.nlm.nih.gov/33281733","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7691595"},"language":"en","primary_location":{"id":"doi:10.3389/fneur.2020.594289","doi":"https://doi.org/10.3389/fneur.2020.594289","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fneur.2020.594289","pdf_url":"https://www.frontiersin.org/articles/10.3389/fneur.2020.594289/pdf","source":{"id":"https://openalex.org/S96975567","display_name":"Frontiers in Neurology","issn_l":"1664-2295","issn":["1664-2295"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fneur.2020.594289/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048322657","display_name":"Jae Hyung Choi","orcid":"https://orcid.org/0000-0003-1173-2787","observed_orcids":["https://orcid.org/0000-0003-1173-2787"]},"institutions":[{"id":"https://openalex.org/I4210157890","display_name":"Neurological Surgery","ror":"https://ror.org/04r0gp612","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210157890"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jae H. Choi","raw_affiliation_strings":["Hybernia Medical, LLC, New Rochelle, NY, United States","Neurovascular Center, Neurological Surgery, P.C., Lake Success, NY, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hybernia Medical, LLC, New Rochelle, NY, United States","institution_ids":[]},{"raw_affiliation_string":"Neurovascular Center, Neurological Surgery, P.C., Lake Success, NY, United States","institution_ids":["https://openalex.org/I4210157890"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010931202","display_name":"Sven Poli","orcid":"https://orcid.org/0000-0002-0286-8781","observed_orcids":["https://orcid.org/0000-0002-0286-8781"]},"institutions":[{"id":"https://openalex.org/I4210141865","display_name":"Hertie Institute for Clinical Brain Research","ror":"https://ror.org/04zzwzx41","country_code":"DE","type":"other","lineage":["https://openalex.org/I4210094118","https://openalex.org/I4210141865","https://openalex.org/I8087733"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sven Poli","raw_affiliation_strings":["Department of Neurology & Stroke, Hertie-Institute for Clinical Brain Research, Eberhard-Karls University of T\u00fcbingen, T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology & Stroke, Hertie-Institute for Clinical Brain Research, Eberhard-Karls University of T\u00fcbingen, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I4210141865","https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100705949","display_name":"Michael Chen","orcid":"https://orcid.org/0000-0003-2412-8167","observed_orcids":["https://orcid.org/0000-0003-2412-8167","https://orcid.org/0009-0000-3353-1770"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Chen","raw_affiliation_strings":["Stroke Center, Department of Neurosurgery, Rush University Medical Center, Chicago, IL, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stroke Center, Department of Neurosurgery, Rush University Medical Center, Chicago, IL, United States","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060595935","display_name":"Thanh Ngoc Nguyen","orcid":"https://orcid.org/0000-0002-2810-1685","observed_orcids":["https://orcid.org/0000-0002-2810-1685","https://orcid.org/0000-0002-5919-6170","https://orcid.org/0000-0003-1448-8791"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thanh N. Nguyen","raw_affiliation_strings":["Interventional Neurology/Neuroradiology, Boston University School of Medicine, Boston, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interventional Neurology/Neuroradiology, Boston University School of Medicine, Boston, MA, United States","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075359983","display_name":"Jeffrey L. Saver","orcid":"https://orcid.org/0000-0001-9141-2251","observed_orcids":["https://orcid.org/0000-0001-9141-2251"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey L. Saver","raw_affiliation_strings":["Comprehensive Stroke Center and Department of Neurology, University of California, Los Angeles (UCLA), Los Angeles, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comprehensive Stroke Center and Department of Neurology, University of California, Los Angeles (UCLA), Los Angeles, CA, United States","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089032910","display_name":"Charles Christian Matouk","orcid":"https://orcid.org/0000-0003-3234-9541","observed_orcids":["https://orcid.org/0000-0003-3234-9541"]},"institutions":[{"id":"https://openalex.org/I1323778983","display_name":"Yale New Haven Hospital","ror":"https://ror.org/05tszed37","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1323778983","https://openalex.org/I4210117499"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles Matouk","raw_affiliation_strings":["Neurovascular Surgery, Department of Neurosurgery, Yale University-New Haven Hospital, New Haven, CT, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurovascular Surgery, Department of Neurosurgery, Yale University-New Haven Hospital, New Haven, CT, United States","institution_ids":["https://openalex.org/I1323778983","https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026699335","display_name":"John Pile\u2010Spellman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157890","display_name":"Neurological Surgery","ror":"https://ror.org/04r0gp612","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210157890"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Pile-Spellman","raw_affiliation_strings":["Hybernia Medical, LLC, New Rochelle, NY, United States","Neurovascular Center, Neurological Surgery, P.C., Lake Success, NY, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hybernia Medical, LLC, New Rochelle, NY, United States","institution_ids":[]},{"raw_affiliation_string":"Neurovascular Center, Neurological Surgery, P.C., Lake Success, NY, United States","institution_ids":["https://openalex.org/I4210157890"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5048322657"],"corresponding_institution_ids":["https://openalex.org/I4210157890"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":1.1112,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.80031471,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"11","issue":null,"first_page":"594289","last_page":"594289"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11861","display_name":"Thermal Regulation in Medicine","score":0.6865000128746033,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11861","display_name":"Thermal Regulation in Medicine","score":0.6865000128746033,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.30709999799728394,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10420","display_name":"Intracranial Aneurysms: Treatment and Complications","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-ischemic-stroke","display_name":"acute ischemic stroke","score":0.925000011920929},{"id":"https://openalex.org/keywords/ischemia-reperfusion-injury","display_name":"ischemia-reperfusion injury","score":0.9509999752044678},{"id":"https://openalex.org/keywords/mechanical-thrombectomy","display_name":"mechanical thrombectomy","score":0.9710000157356262},{"id":"https://openalex.org/keywords/large-vessel-occlusion","display_name":"large vessel occlusion","score":0.8159999847412109},{"id":"https://openalex.org/keywords/thrombolysis","display_name":"thrombolysis","score":0.6639999747276306},{"id":"https://openalex.org/keywords/infarct-progression","display_name":"infarct progression","score":0.7820000052452087},{"id":"https://openalex.org/keywords/intracranial-hemorrhage","display_name":"intracranial hemorrhage","score":0.9729999899864197},{"id":"https://openalex.org/keywords/recanalization","display_name":"recanalization","score":0.6019999980926514}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8918061256408691},{"id":"https://openalex.org/C2777390192","wikidata":"https://www.wikidata.org/wiki/Q1036696","display_name":"Hypothermia","level":2,"score":0.8214236497879028},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.5628223419189453},{"id":"https://openalex.org/C2780114680","wikidata":"https://www.wikidata.org/wiki/Q1413991","display_name":"Reperfusion injury","level":3,"score":0.533584713935852},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.5309177041053772},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.49225226044654846},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4649715721607208},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4193095862865448},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fneur.2020.594289","doi":"https://doi.org/10.3389/fneur.2020.594289","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fneur.2020.594289","pdf_url":"https://www.frontiersin.org/articles/10.3389/fneur.2020.594289/pdf","source":{"id":"https://openalex.org/S96975567","display_name":"Frontiers in Neurology","issn_l":"1664-2295","issn":["1664-2295"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neurology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7691595","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7691595","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Neurol","raw_type":"Text"},{"id":"pmid:33281733","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33281733","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in neurology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:75c8ecf26db64ef38ac1b83b3eaad556","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/75c8ecf26db64ef38ac1b83b3eaad556","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Neurology, Vol 11 (2020)","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt4cb5b8pr","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/4cb5b8pr","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Neurology, vol 11","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fneur.2020.594289","doi":"https://doi.org/10.3389/fneur.2020.594289","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fneur.2020.594289","pdf_url":"https://www.frontiersin.org/articles/10.3389/fneur.2020.594289/pdf","source":{"id":"https://openalex.org/S96975567","display_name":"Frontiers in Neurology","issn_l":"1664-2295","issn":["1664-2295"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neurology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3102869048.pdf","grobid_xml":"https://content.openalex.org/works/W3102869048.grobid-xml"},"referenced_works_count":86,"referenced_works":["https://openalex.org/W595264456","https://openalex.org/W1551533003","https://openalex.org/W1581567111","https://openalex.org/W1816181927","https://openalex.org/W1940071153","https://openalex.org/W1970188265","https://openalex.org/W1971560806","https://openalex.org/W1976214343","https://openalex.org/W1983112915","https://openalex.org/W1984715375","https://openalex.org/W1998557118","https://openalex.org/W1998796974","https://openalex.org/W2001049742","https://openalex.org/W2002526073","https://openalex.org/W2003188614","https://openalex.org/W2005726985","https://openalex.org/W2009391702","https://openalex.org/W2014025142","https://openalex.org/W2029185988","https://openalex.org/W2035750459","https://openalex.org/W2036717560","https://openalex.org/W2037399775","https://openalex.org/W2039139161","https://openalex.org/W2039262033","https://openalex.org/W2044636914","https://openalex.org/W2044750485","https://openalex.org/W2045445343","https://openalex.org/W2058656097","https://openalex.org/W2062642814","https://openalex.org/W2063504330","https://openalex.org/W2064634626","https://openalex.org/W2068462361","https://openalex.org/W2076856953","https://openalex.org/W2087841807","https://openalex.org/W2092231656","https://openalex.org/W2096316234","https://openalex.org/W2096523744","https://openalex.org/W2101736298","https://openalex.org/W2119542322","https://openalex.org/W2120003285","https://openalex.org/W2125246565","https://openalex.org/W2129736635","https://openalex.org/W2132689928","https://openalex.org/W2136542400","https://openalex.org/W2139621750","https://openalex.org/W2143237216","https://openalex.org/W2144025192","https://openalex.org/W2146047031","https://openalex.org/W2151475645","https://openalex.org/W2151892297","https://openalex.org/W2156058797","https://openalex.org/W2157368934","https://openalex.org/W2157721702","https://openalex.org/W2164127547","https://openalex.org/W2169852210","https://openalex.org/W2171058244","https://openalex.org/W2215162993","https://openalex.org/W2336925175","https://openalex.org/W2341337627","https://openalex.org/W2401831246","https://openalex.org/W2442033361","https://openalex.org/W2444413684","https://openalex.org/W2469502808","https://openalex.org/W2475487380","https://openalex.org/W2518892410","https://openalex.org/W2526978419","https://openalex.org/W2544578848","https://openalex.org/W2550224805","https://openalex.org/W2554682506","https://openalex.org/W2767776410","https://openalex.org/W2787867590","https://openalex.org/W2884469766","https://openalex.org/W2896947232","https://openalex.org/W2900887814","https://openalex.org/W2937750147","https://openalex.org/W2955286986","https://openalex.org/W2964635904","https://openalex.org/W2979222658","https://openalex.org/W2982841701","https://openalex.org/W2996061133","https://openalex.org/W2998601828","https://openalex.org/W3007594181","https://openalex.org/W3025783441","https://openalex.org/W3033068490","https://openalex.org/W4296463886","https://openalex.org/W6687142204"],"related_works":["https://openalex.org/W2801250610","https://openalex.org/W2996061133","https://openalex.org/W2401831246","https://openalex.org/W4308961890","https://openalex.org/W158312794","https://openalex.org/W2954191868","https://openalex.org/W2996795936","https://openalex.org/W1975456586","https://openalex.org/W2896458820","https://openalex.org/W2896335021"],"abstract_inverted_index":{"In":[0,88,135,229],"acute":[1],"ischemic":[2,26,117,129,183],"stroke,":[3],"early":[4],"recanalization":[5],"of":[6,44,58,92,105,128,142,182,193,206,238],"the":[7,25,84,90,122,179,210,235],"occluded":[8],"artery":[9],"is":[10,30,102,112,188,203],"crucial":[11],"for":[12],"best":[13],"outcome":[14,94],"to":[15,24,50,83,131,173,208],"be":[16,148],"achieved.":[17],"Recanalization":[18],"aims":[19],"at":[20,95],"restoring":[21],"blood":[22],"flow":[23],"tissue":[27,130,213],"(reperfusion)":[28],"and":[29,53,63,125,165,197,215],"achieved":[31],"with":[32,56,69,98,217,225],"pharmacological":[33],"thrombolytic":[34],"drugs,":[35],"endovascular":[36,46,204,241],"thrombectomy":[37],"(EVT)":[38],"devices,":[39],"or":[40],"both.":[41],"The":[42],"introduction":[43],"modern":[45],"devices":[47],"has":[48,170],"led":[49],"tremendous":[51],"anatomical":[52],"clinical":[54,65,86,198],"success":[55],"rates":[57],"substantial":[59],"reperfusion":[60,80,154,157],"exceeding":[61],"80%":[62],"proven":[64],"benefit":[66],"in":[67],"patients":[68],"anterior":[70],"circulation":[71],"large":[72],"vessel":[73],"occlusions":[74],"(LVOs).":[75],"However,":[76],"not":[77,120,223],"every":[78],"successful":[79],"procedure":[81],"leads":[82],"desired":[85],"outcome.":[87,167],"fact,":[89,136],"rate":[91],"non-disabled":[93],"3":[96],"months":[97],"current":[99],"EVT":[100],"treatment":[101],"~1":[103],"out":[104],"4.":[106],"A":[107,200],"constraint":[108],"upon":[109],"better":[110],"outcomes":[111],"that":[113,145],"reperfusion,":[114],"though":[115],"resolving":[116],"stress,":[118],"may":[119,159],"restore":[121],"anatomic":[123],"structures":[124],"metabolic":[126],"functions":[127],"their":[132],"baseline":[133],"states.":[134],"ischemia":[137],"triggers":[138],"a":[139,175],"complex":[140],"cascade":[141],"destructive":[143],"mechanisms":[144],"can":[146],"sometimes":[147],"exacerbated":[149],"rather":[150],"than":[151],"alleviated":[152],"by":[153,190],"therapy.":[155],"Such":[156],"injury":[158],"cause":[160],"infarct":[161],"progression,":[162],"intracranial":[163],"hemorrhage,":[164],"unfavorable":[166],"Therapeutic":[168],"hypothermia":[169,187,207,227,243],"been":[171],"shown":[172],"have":[174],"favorable":[176],"impact":[177],"on":[178],"molecular":[180],"elaboration":[181],"injury,":[184],"but":[185],"systemic":[186,226],"limited":[189],"slow":[191],"speed":[192],"attaining":[194],"target":[195],"temperatures":[196],"complications.":[199],"novel":[201],"approach":[202],"delivery":[205],"cool":[209],"affected":[211],"brain":[212,242],"selectively":[214],"rapidly":[216],"tight":[218],"local":[219],"temperature":[220],"control,":[221],"features":[222],"available":[224],"devices.":[228],"this":[230],"perspective":[231],"article,":[232],"we":[233],"discuss":[234],"possible":[236],"benefits":[237],"adjunctive":[239],"selective":[240],"during":[244],"interventional":[245],"stroke":[246],"treatment.":[247]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2020-11-23T00:00:00"}
