{"id":"https://openalex.org/W3102433752","doi":"https://doi.org/10.3390/tropicalmed5040169","title":"AAV Vectored Immunoprophylaxis for Filovirus Infections","display_name":"AAV Vectored Immunoprophylaxis for Filovirus Infections","publication_year":2020,"publication_date":"2020-11-09","ids":{"openalex":"https://openalex.org/W3102433752","doi":"https://doi.org/10.3390/tropicalmed5040169","mag":"3102433752","pmid":"https://pubmed.ncbi.nlm.nih.gov/33182447","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7709665"},"language":"en","primary_location":{"id":"doi:10.3390/tropicalmed5040169","doi":"https://doi.org/10.3390/tropicalmed5040169","is_oa":true,"landing_page_url":"https://doi.org/10.3390/tropicalmed5040169","pdf_url":"https://www.mdpi.com/2414-6366/5/4/169/pdf?version=1605000501","source":{"id":"https://openalex.org/S2737916383","display_name":"Tropical Medicine and Infectious Disease","issn_l":"2414-6366","issn":["2414-6366"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tropical Medicine and Infectious Disease","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2414-6366/5/4/169/pdf?version=1605000501","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083693694","display_name":"Amira D. Rghei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4391768212","display_name":"Ontario Veterinary College","ror":"https://ror.org/04frvgs13","country_code":"CA","type":"education","lineage":["https://openalex.org/I4391768212","https://openalex.org/I79817857"]},{"id":"https://openalex.org/I79817857","display_name":"University of Guelph","ror":"https://ror.org/01r7awg59","country_code":"CA","type":"education","lineage":["https://openalex.org/I79817857"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Amira D. Rghei","raw_affiliation_strings":["Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada","institution_ids":["https://openalex.org/I4391768212","https://openalex.org/I79817857"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015009070","display_name":"Laura P. van Lieshout","orcid":"https://orcid.org/0000-0001-7977-3978","observed_orcids":["https://orcid.org/0000-0001-7977-3978"]},"institutions":[{"id":"https://openalex.org/I4391768212","display_name":"Ontario Veterinary College","ror":"https://ror.org/04frvgs13","country_code":"CA","type":"education","lineage":["https://openalex.org/I4391768212","https://openalex.org/I79817857"]},{"id":"https://openalex.org/I79817857","display_name":"University of Guelph","ror":"https://ror.org/01r7awg59","country_code":"CA","type":"education","lineage":["https://openalex.org/I79817857"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Laura P. van Lieshout","raw_affiliation_strings":["Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada","institution_ids":["https://openalex.org/I4391768212","https://openalex.org/I79817857"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088839126","display_name":"Lisa A. Santry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4391768212","display_name":"Ontario Veterinary College","ror":"https://ror.org/04frvgs13","country_code":"CA","type":"education","lineage":["https://openalex.org/I4391768212","https://openalex.org/I79817857"]},{"id":"https://openalex.org/I79817857","display_name":"University of Guelph","ror":"https://ror.org/01r7awg59","country_code":"CA","type":"education","lineage":["https://openalex.org/I79817857"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Lisa A. Santry","raw_affiliation_strings":["Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada","institution_ids":["https://openalex.org/I4391768212","https://openalex.org/I79817857"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050599414","display_name":"Matthew M. Guilleman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4391768212","display_name":"Ontario Veterinary College","ror":"https://ror.org/04frvgs13","country_code":"CA","type":"education","lineage":["https://openalex.org/I4391768212","https://openalex.org/I79817857"]},{"id":"https://openalex.org/I79817857","display_name":"University of Guelph","ror":"https://ror.org/01r7awg59","country_code":"CA","type":"education","lineage":["https://openalex.org/I79817857"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Matthew M. Guilleman","raw_affiliation_strings":["Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada","institution_ids":["https://openalex.org/I4391768212","https://openalex.org/I79817857"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001279470","display_name":"Sylvia P. Thomas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4391768212","display_name":"Ontario Veterinary College","ror":"https://ror.org/04frvgs13","country_code":"CA","type":"education","lineage":["https://openalex.org/I4391768212","https://openalex.org/I79817857"]},{"id":"https://openalex.org/I79817857","display_name":"University of Guelph","ror":"https://ror.org/01r7awg59","country_code":"CA","type":"education","lineage":["https://openalex.org/I79817857"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Sylvia P. Thomas","raw_affiliation_strings":["Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada","institution_ids":["https://openalex.org/I4391768212","https://openalex.org/I79817857"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001722770","display_name":"Leonardo Susta","orcid":"https://orcid.org/0000-0002-4578-6145","observed_orcids":["https://orcid.org/0000-0002-4578-6145"]},"institutions":[{"id":"https://openalex.org/I4391768212","display_name":"Ontario Veterinary College","ror":"https://ror.org/04frvgs13","country_code":"CA","type":"education","lineage":["https://openalex.org/I4391768212","https://openalex.org/I79817857"]},{"id":"https://openalex.org/I79817857","display_name":"University of Guelph","ror":"https://ror.org/01r7awg59","country_code":"CA","type":"education","lineage":["https://openalex.org/I79817857"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Leonardo Susta","raw_affiliation_strings":["Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada"],"raw_orcid":"https://orcid.org/0000-0002-4578-6145","affiliations":[{"raw_affiliation_string":"Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada","institution_ids":["https://openalex.org/I4391768212","https://openalex.org/I79817857"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026441514","display_name":"Khalil Karimi","orcid":"https://orcid.org/0000-0002-7245-5851","observed_orcids":["https://orcid.org/0000-0002-7245-5851"]},"institutions":[{"id":"https://openalex.org/I4391768212","display_name":"Ontario Veterinary College","ror":"https://ror.org/04frvgs13","country_code":"CA","type":"education","lineage":["https://openalex.org/I4391768212","https://openalex.org/I79817857"]},{"id":"https://openalex.org/I79817857","display_name":"University of Guelph","ror":"https://ror.org/01r7awg59","country_code":"CA","type":"education","lineage":["https://openalex.org/I79817857"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Khalil Karimi","raw_affiliation_strings":["Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada"],"raw_orcid":"https://orcid.org/0000-0002-7245-5851","affiliations":[{"raw_affiliation_string":"Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada","institution_ids":["https://openalex.org/I4391768212","https://openalex.org/I79817857"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046228493","display_name":"Byram W. Bridle","orcid":"https://orcid.org/0000-0002-8335-1118","observed_orcids":["https://orcid.org/0000-0002-8335-1118"]},"institutions":[{"id":"https://openalex.org/I4391768212","display_name":"Ontario Veterinary College","ror":"https://ror.org/04frvgs13","country_code":"CA","type":"education","lineage":["https://openalex.org/I4391768212","https://openalex.org/I79817857"]},{"id":"https://openalex.org/I79817857","display_name":"University of Guelph","ror":"https://ror.org/01r7awg59","country_code":"CA","type":"education","lineage":["https://openalex.org/I79817857"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Byram W. Bridle","raw_affiliation_strings":["Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada"],"raw_orcid":"https://orcid.org/0000-0002-8335-1118","affiliations":[{"raw_affiliation_string":"Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada","institution_ids":["https://openalex.org/I4391768212","https://openalex.org/I79817857"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056457864","display_name":"Sarah K. Wootton","orcid":"https://orcid.org/0000-0002-5985-2406","observed_orcids":["https://orcid.org/0000-0002-5985-2406"]},"institutions":[{"id":"https://openalex.org/I4391768212","display_name":"Ontario Veterinary College","ror":"https://ror.org/04frvgs13","country_code":"CA","type":"education","lineage":["https://openalex.org/I4391768212","https://openalex.org/I79817857"]},{"id":"https://openalex.org/I79817857","display_name":"University of Guelph","ror":"https://ror.org/01r7awg59","country_code":"CA","type":"education","lineage":["https://openalex.org/I79817857"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Sarah K. Wootton","raw_affiliation_strings":["Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada"],"raw_orcid":"https://orcid.org/0000-0002-5985-2406","affiliations":[{"raw_affiliation_string":"Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada","institution_ids":["https://openalex.org/I4391768212","https://openalex.org/I79817857"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5056457864"],"corresponding_institution_ids":["https://openalex.org/I4391768212","https://openalex.org/I79817857"],"apc_list":{"value":1000,"currency":"CHF","value_usd":1056},"apc_paid":{"value":1000,"currency":"CHF","value_usd":1056},"fwci":0.1341,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.28148357,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"5","issue":"4","first_page":"169","last_page":"169"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11581","display_name":"Viral Infections and Outbreaks Research","score":0.9253000020980835,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11581","display_name":"Viral Infections and Outbreaks Research","score":0.9253000020980835,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.045099999755620956,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12047","display_name":"Viral Infections and Vectors","score":0.0066999997943639755,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/filovirus-infection","display_name":"filovirus infection","score":0.890999972820282},{"id":"https://openalex.org/keywords/adeno-associated-virus-vectors","display_name":"adeno-associated virus vectors","score":0.8080000281333923},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.9110000133514404},{"id":"https://openalex.org/keywords/ebola-virus","display_name":"Ebola virus","score":0.656000018119812},{"id":"https://openalex.org/keywords/zaire-ebolavirus","display_name":"Zaire ebolavirus","score":0.9100000262260437},{"id":"https://openalex.org/keywords/hemorrhagic-fever","display_name":"hemorrhagic fever","score":0.8090000152587891},{"id":"https://openalex.org/keywords/passive-antibody-therapy","display_name":"passive antibody therapy","score":0.5789999961853027},{"id":"https://openalex.org/keywords/long-term-immunity","display_name":"long-term immunity","score":0.5600000023841858},{"id":"https://openalex.org/keywords/filovirus-vaccines","display_name":"filovirus vaccines","score":0.6069999933242798}],"concepts":[{"id":"https://openalex.org/C2777469322","wikidata":"https://www.wikidata.org/wiki/Q8064876","display_name":"Ebola virus","level":3,"score":0.7994697093963623},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7114888429641724},{"id":"https://openalex.org/C2909623084","wikidata":"https://www.wikidata.org/wiki/Q5331908","display_name":"Ebolavirus","level":4,"score":0.6966359615325928},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5267797708511353},{"id":"https://openalex.org/C116675565","wikidata":"https://www.wikidata.org/wiki/Q3241045","display_name":"Outbreak","level":2,"score":0.5086163282394409},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.5077246427536011},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.37070339918136597},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3278689682483673},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.25467944145202637}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/tropicalmed5040169","doi":"https://doi.org/10.3390/tropicalmed5040169","is_oa":true,"landing_page_url":"https://doi.org/10.3390/tropicalmed5040169","pdf_url":"https://www.mdpi.com/2414-6366/5/4/169/pdf?version=1605000501","source":{"id":"https://openalex.org/S2737916383","display_name":"Tropical Medicine and Infectious Disease","issn_l":"2414-6366","issn":["2414-6366"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tropical Medicine and Infectious Disease","raw_type":"journal-article"},{"id":"pmid:33182447","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33182447","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tropical medicine and infectious disease","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7709665","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7709665/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trop Med Infect Dis","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:46be403b99ab488583d634e852cda2bd","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/46be403b99ab488583d634e852cda2bd","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Tropical Medicine and Infectious Disease, Vol 5, Iss 4, p 169 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/tropicalmed5040169","doi":"https://doi.org/10.3390/tropicalmed5040169","is_oa":true,"landing_page_url":"https://doi.org/10.3390/tropicalmed5040169","pdf_url":"https://www.mdpi.com/2414-6366/5/4/169/pdf?version=1605000501","source":{"id":"https://openalex.org/S2737916383","display_name":"Tropical Medicine and Infectious Disease","issn_l":"2414-6366","issn":["2414-6366"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tropical Medicine and Infectious Disease","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3524470072","display_name":"Pathogenesis of ovine betaretroviruses","funder_award_id":"rgpin-2018-04737","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"},{"id":"https://openalex.org/G7183145014","display_name":null,"funder_award_id":"04737","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"},{"id":"https://openalex.org/G814497173","display_name":null,"funder_award_id":"RGPIN 2018","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"}],"funders":[{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3102433752.pdf","grobid_xml":"https://content.openalex.org/works/W3102433752.grobid-xml"},"referenced_works_count":178,"referenced_works":["https://openalex.org/W110869217","https://openalex.org/W168143921","https://openalex.org/W170813910","https://openalex.org/W200639421","https://openalex.org/W585575935","https://openalex.org/W807802234","https://openalex.org/W1062587256","https://openalex.org/W1084428056","https://openalex.org/W1603558825","https://openalex.org/W1774632695","https://openalex.org/W1850664963","https://openalex.org/W1862569453","https://openalex.org/W1908675203","https://openalex.org/W1964628542","https://openalex.org/W1965205681","https://openalex.org/W1966244491","https://openalex.org/W1968450421","https://openalex.org/W1971883527","https://openalex.org/W1973539590","https://openalex.org/W1978519692","https://openalex.org/W1979049945","https://openalex.org/W1979071280","https://openalex.org/W1982754464","https://openalex.org/W1989676021","https://openalex.org/W1998572628","https://openalex.org/W1999760686","https://openalex.org/W2002206719","https://openalex.org/W2006144333","https://openalex.org/W2007854533","https://openalex.org/W2012052755","https://openalex.org/W2012104351","https://openalex.org/W2015399727","https://openalex.org/W2015535237","https://openalex.org/W2016364569","https://openalex.org/W2022639203","https://openalex.org/W2023388704","https://openalex.org/W2027049071","https://openalex.org/W2028450449","https://openalex.org/W2028463307","https://openalex.org/W2029135056","https://openalex.org/W2032755224","https://openalex.org/W2033630555","https://openalex.org/W2036943232","https://openalex.org/W2040505385","https://openalex.org/W2042147187","https://openalex.org/W2042411936","https://openalex.org/W2042995802","https://openalex.org/W2043149070","https://openalex.org/W2044050006","https://openalex.org/W2044585968","https://openalex.org/W2045673606","https://openalex.org/W2047950484","https://openalex.org/W2050796131","https://openalex.org/W2051519190","https://openalex.org/W2055995773","https://openalex.org/W2056144642","https://openalex.org/W2057134222","https://openalex.org/W2060938552","https://openalex.org/W2061656901","https://openalex.org/W2070086938","https://openalex.org/W2072075382","https://openalex.org/W2072123447","https://openalex.org/W2075032293","https://openalex.org/W2077674909","https://openalex.org/W2081315886","https://openalex.org/W2082882388","https://openalex.org/W2083726777","https://openalex.org/W2084723039","https://openalex.org/W2087482145","https://openalex.org/W2092747941","https://openalex.org/W2094993149","https://openalex.org/W2095942414","https://openalex.org/W2100260641","https://openalex.org/W2103523781","https://openalex.org/W2103992594","https://openalex.org/W2106522948","https://openalex.org/W2107792909","https://openalex.org/W2108398364","https://openalex.org/W2109368056","https://openalex.org/W2114741749","https://openalex.org/W2115048752","https://openalex.org/W2115596188","https://openalex.org/W2116029690","https://openalex.org/W2117671399","https://openalex.org/W2120990334","https://openalex.org/W2123811618","https://openalex.org/W2128406623","https://openalex.org/W2130063921","https://openalex.org/W2133294119","https://openalex.org/W2133900940","https://openalex.org/W2133984373","https://openalex.org/W2134066463","https://openalex.org/W2137005738","https://openalex.org/W2137574173","https://openalex.org/W2141122594","https://openalex.org/W2142957009","https://openalex.org/W2143036112","https://openalex.org/W2145365087","https://openalex.org/W2147572243","https://openalex.org/W2147810684","https://openalex.org/W2147908459","https://openalex.org/W2148043455","https://openalex.org/W2150447973","https://openalex.org/W2152041346","https://openalex.org/W2152939400","https://openalex.org/W2155767550","https://openalex.org/W2155802193","https://openalex.org/W2155970168","https://openalex.org/W2162554556","https://openalex.org/W2163760194","https://openalex.org/W2163858364","https://openalex.org/W2168444132","https://openalex.org/W2173672434","https://openalex.org/W2174465486","https://openalex.org/W2264232485","https://openalex.org/W2266881505","https://openalex.org/W2276335432","https://openalex.org/W2288202420","https://openalex.org/W2308602445","https://openalex.org/W2320443657","https://openalex.org/W2346830803","https://openalex.org/W2399805065","https://openalex.org/W2414145494","https://openalex.org/W2460825604","https://openalex.org/W2471204385","https://openalex.org/W2474704550","https://openalex.org/W2490963809","https://openalex.org/W2502757227","https://openalex.org/W2504151231","https://openalex.org/W2544612685","https://openalex.org/W2549534747","https://openalex.org/W2560056337","https://openalex.org/W2564361602","https://openalex.org/W2591048608","https://openalex.org/W2604139512","https://openalex.org/W2607397084","https://openalex.org/W2609060004","https://openalex.org/W2616753020","https://openalex.org/W2616831184","https://openalex.org/W2617246817","https://openalex.org/W2736065260","https://openalex.org/W2747415234","https://openalex.org/W2765253110","https://openalex.org/W2769666271","https://openalex.org/W2773565340","https://openalex.org/W2788330253","https://openalex.org/W2788950211","https://openalex.org/W2789458710","https://openalex.org/W2792845868","https://openalex.org/W2797362195","https://openalex.org/W2802746041","https://openalex.org/W2806465206","https://openalex.org/W2809855642","https://openalex.org/W2883655927","https://openalex.org/W2888770709","https://openalex.org/W2894600652","https://openalex.org/W2902818658","https://openalex.org/W2906490481","https://openalex.org/W2909414856","https://openalex.org/W2909940174","https://openalex.org/W2910219677","https://openalex.org/W2912112623","https://openalex.org/W2920220762","https://openalex.org/W2920817121","https://openalex.org/W2930343122","https://openalex.org/W2935889084","https://openalex.org/W2935998528","https://openalex.org/W2953306601","https://openalex.org/W2955897565","https://openalex.org/W2982642142","https://openalex.org/W2999958881","https://openalex.org/W3011360311","https://openalex.org/W3087030402","https://openalex.org/W3123411076","https://openalex.org/W4235232179","https://openalex.org/W4235292492","https://openalex.org/W6608162391","https://openalex.org/W6657062945"],"related_works":["https://openalex.org/W4293685785","https://openalex.org/W7099857674","https://openalex.org/W977762980","https://openalex.org/W2910219677","https://openalex.org/W2909924249","https://openalex.org/W2119095733","https://openalex.org/W2048186359","https://openalex.org/W2419074924","https://openalex.org/W3097293958","https://openalex.org/W2769289510"],"abstract_inverted_index":{"Filoviruses":[0],"are":[1,182],"among":[2],"the":[3,33,48,150,162],"deadliest":[4],"infectious":[5],"agents":[6],"known":[7],"to":[8,16,53,110,128,153,175],"man,":[9],"causing":[10],"severe":[11],"hemorrhagic":[12],"fever,":[13],"with":[14],"up":[15],"90%":[17],"fatality":[18],"rates.":[19],"The":[20],"2014":[21],"Ebola":[22],"outbreak":[23],"in":[24,28,136],"West":[25],"Africa":[26],"resulted":[27],"over":[29],"28,000":[30],"infections,":[31],"demonstrating":[32],"large-scale":[34],"human":[35],"health":[36],"and":[37,55,72,82,146,169],"economic":[38],"impact":[39],"generated":[40],"by":[41],"filoviruses.":[42,97],"Zaire":[43],"ebolavirus":[44],"is":[45,58,105,117],"responsible":[46],"for":[47,95],"greatest":[49],"number":[50],"of":[51,80,91,132,142,149,164],"deaths":[52],"date":[54],"consequently":[56],"there":[57],"now":[59],"an":[60,123],"approved":[61],"vaccine,":[62],"Ervebo,":[63],"while":[64],"other":[65,96],"filovirus":[66,165],"species":[67],"have":[68],"similar":[69],"epidemic":[70],"potential":[71],"remain":[73],"without":[74],"effective":[75],"vaccines.":[76],"Recent":[77],"clinical":[78],"success":[79],"REGN-EB3":[81],"mAb-114":[83],"monoclonal":[84],"antibody":[85],"(mAb)-based":[86],"therapies":[87,104],"supports":[88],"further":[89],"investigation":[90],"this":[92,158],"treatment":[93],"approach":[94,139],"While":[98],"efficacious,":[99],"protection":[100],"from":[101],"passive":[102],"mAb":[103,144],"short-lived,":[106],"requiring":[107],"repeat":[108],"dosing":[109],"maintain":[111],"therapeutic":[112],"concentrations.":[113],"An":[114],"alternative":[115],"strategy":[116],"vectored":[118],"immunoprophylaxis":[119],"(VIP),":[120],"which":[121],"utilizes":[122],"adeno-associated":[124],"virus":[125],"(AAV)":[126],"vector":[127],"generate":[129],"sustained":[130],"expression":[131],"selected":[133],"mAbs":[134],"directly":[135],"vivo.":[137],"This":[138],"takes":[140],"advantage":[141],"validated":[143],"development":[145],"enables":[147],"vectorization":[148],"top":[151],"candidates":[152],"provide":[154],"long-term":[155],"immunity.":[156],"In":[157],"review,":[159],"we":[160],"summarize":[161],"history":[163],"outbreaks,":[166],"mAb-based":[167],"therapeutics,":[168],"highlight":[170],"promising":[171],"AAV":[172],"vectorized":[173],"approaches":[174],"providing":[176],"immunity":[177],"against":[178],"filoviruses":[179],"where":[180],"vaccines":[181],"not":[183],"yet":[184],"available.":[185]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-11-23T00:00:00"}