{"id":"https://openalex.org/W3102311980","doi":"https://doi.org/10.1183/16000617.0124-2019","title":"Extracellular matrix remodelling in COPD","display_name":"Extracellular matrix remodelling in COPD","publication_year":2020,"publication_date":"2020-11-18","ids":{"openalex":"https://openalex.org/W3102311980","doi":"https://doi.org/10.1183/16000617.0124-2019","mag":"3102311980","pmid":"https://pubmed.ncbi.nlm.nih.gov/33208482","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9488912"},"language":"en","primary_location":{"id":"doi:10.1183/16000617.0124-2019","doi":"https://doi.org/10.1183/16000617.0124-2019","is_oa":true,"landing_page_url":"https://doi.org/10.1183/16000617.0124-2019","pdf_url":"https://err.ersjournals.com/content/errev/29/158/190124.full.pdf","source":{"id":"https://openalex.org/S168221024","display_name":"European Respiratory Review","issn_l":"0905-9180","issn":["0905-9180","1600-0617"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Respiratory Review","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://err.ersjournals.com/content/errev/29/158/190124.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008946625","display_name":"Meropi Karakioulaki","orcid":"https://orcid.org/0000-0002-1067-8582","observed_orcids":["https://orcid.org/0000-0002-1067-8582"]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Meropi Karakioulaki","raw_affiliation_strings":["Clinic of Pulmonary Medicine and Respiratory Cell Research, University Hospital, Basel, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-1067-8582","affiliations":[{"raw_affiliation_string":"Clinic of Pulmonary Medicine and Respiratory Cell Research, University Hospital, Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079421874","display_name":"Eleni Papakonstantinou","orcid":"https://orcid.org/0000-0001-5274-8991","observed_orcids":["https://orcid.org/0000-0001-5274-8991","https://orcid.org/0000-0002-5189-5508"]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]},{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH","GR"],"is_corresponding":false,"raw_author_name":"Eleni Papakonstantinou","raw_affiliation_strings":["Clinic of Pulmonary Medicine and Respiratory Cell Research, University Hospital, Basel, Switzerland","Dept of Pharmacology, Faculty of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinic of Pulmonary Medicine and Respiratory Cell Research, University Hospital, Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]},{"raw_affiliation_string":"Dept of Pharmacology, Faculty of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005195192","display_name":"Daiana Stolz","orcid":"https://orcid.org/0000-0003-0099-882X","observed_orcids":["https://orcid.org/0000-0003-0099-882X"]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Daiana Stolz","raw_affiliation_strings":["Clinic of Pulmonary Medicine and Respiratory Cell Research, University Hospital, Basel, Switzerland daiana.stolz@usb.ch","Clinic of Pulmonary Medicine and Respiratory Cell Research, University Hospital, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinic of Pulmonary Medicine and Respiratory Cell Research, University Hospital, Basel, Switzerland daiana.stolz@usb.ch","institution_ids":["https://openalex.org/I2802542264"]},{"raw_affiliation_string":"Clinic of Pulmonary Medicine and Respiratory Cell Research, University Hospital, Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5005195192"],"corresponding_institution_ids":["https://openalex.org/I2802542264"],"apc_list":null,"apc_paid":null,"fwci":0.7679,"has_fulltext":true,"cited_by_count":90,"citation_normalized_percentile":{"value":0.69679219,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"29","issue":"158","first_page":"190124","last_page":"190124"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/extracellular-matrix-remodeling","display_name":"extracellular matrix remodeling","score":0.8529999852180481},{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.9580000042915344},{"id":"https://openalex.org/keywords/airway-remodeling","display_name":"airway remodeling","score":0.9980000257492065},{"id":"https://openalex.org/keywords/disease-severity","display_name":"disease severity","score":0.6039999723434448},{"id":"https://openalex.org/keywords/acute-exacerbation","display_name":"acute exacerbation","score":0.7770000100135803},{"id":"https://openalex.org/keywords/airway-inflammation","display_name":"airway inflammation","score":0.8040000200271606},{"id":"https://openalex.org/keywords/lung-elasticity","display_name":"lung elasticity","score":0.5220000147819519},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.48500001430511475}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8016293048858643},{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.792413592338562},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.7525554895401001},{"id":"https://openalex.org/C105922876","wikidata":"https://www.wikidata.org/wiki/Q1423981","display_name":"Airway","level":2,"score":0.5280654430389404},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.47740498185157776},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.44587188959121704},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.4455309510231018},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.43741580843925476},{"id":"https://openalex.org/C99322962","wikidata":"https://www.wikidata.org/wiki/Q17165464","display_name":"Vascular remodelling in the embryo","level":2,"score":0.4105612635612488},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3154712915420532},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.30059319734573364},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18378308415412903},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09415996074676514},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.08002263307571411}],"mesh":[{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D056151","descriptor_name":"Airway Remodeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1183/16000617.0124-2019","doi":"https://doi.org/10.1183/16000617.0124-2019","is_oa":true,"landing_page_url":"https://doi.org/10.1183/16000617.0124-2019","pdf_url":"https://err.ersjournals.com/content/errev/29/158/190124.full.pdf","source":{"id":"https://openalex.org/S168221024","display_name":"European Respiratory Review","issn_l":"0905-9180","issn":["0905-9180","1600-0617"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Respiratory Review","raw_type":"journal-article"},{"id":"pmid:33208482","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33208482","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European respiratory review : an official journal of the European Respiratory Society","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9488912","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9488912/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eur Respir Rev","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:2b3f7f94dd344f8ea545ba1de04aa905","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/2b3f7f94dd344f8ea545ba1de04aa905","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"European Respiratory Review, Vol 29, Iss 158 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1183/16000617.0124-2019","doi":"https://doi.org/10.1183/16000617.0124-2019","is_oa":true,"landing_page_url":"https://doi.org/10.1183/16000617.0124-2019","pdf_url":"https://err.ersjournals.com/content/errev/29/158/190124.full.pdf","source":{"id":"https://openalex.org/S168221024","display_name":"European Respiratory Review","issn_l":"0905-9180","issn":["0905-9180","1600-0617"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Respiratory Review","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3102311980.pdf","grobid_xml":"https://content.openalex.org/works/W3102311980.grobid-xml"},"referenced_works_count":138,"referenced_works":["https://openalex.org/W90346617","https://openalex.org/W612221030","https://openalex.org/W774234807","https://openalex.org/W933858873","https://openalex.org/W1503363172","https://openalex.org/W1504461065","https://openalex.org/W1511154697","https://openalex.org/W1619279056","https://openalex.org/W1787865208","https://openalex.org/W1834182183","https://openalex.org/W1850182854","https://openalex.org/W1964179595","https://openalex.org/W1970148422","https://openalex.org/W1971485286","https://openalex.org/W1972644034","https://openalex.org/W1973463627","https://openalex.org/W1976323116","https://openalex.org/W1977628719","https://openalex.org/W1979339922","https://openalex.org/W1982605143","https://openalex.org/W1985962986","https://openalex.org/W1987413312","https://openalex.org/W1989412685","https://openalex.org/W1993242384","https://openalex.org/W1993255671","https://openalex.org/W1993557008","https://openalex.org/W2000460436","https://openalex.org/W2002413678","https://openalex.org/W2003380614","https://openalex.org/W2008562767","https://openalex.org/W2008831005","https://openalex.org/W2009343792","https://openalex.org/W2011018453","https://openalex.org/W2015002898","https://openalex.org/W2016291234","https://openalex.org/W2018120978","https://openalex.org/W2018599317","https://openalex.org/W2020075193","https://openalex.org/W2021423422","https://openalex.org/W2024441304","https://openalex.org/W2026019427","https://openalex.org/W2027519306","https://openalex.org/W2028101194","https://openalex.org/W2030295847","https://openalex.org/W2030993607","https://openalex.org/W2035719576","https://openalex.org/W2038798818","https://openalex.org/W2040551725","https://openalex.org/W2041180426","https://openalex.org/W2042742363","https://openalex.org/W2045295282","https://openalex.org/W2045952552","https://openalex.org/W2046246972","https://openalex.org/W2046405683","https://openalex.org/W2049140829","https://openalex.org/W2053497293","https://openalex.org/W2053802748","https://openalex.org/W2055331835","https://openalex.org/W2056875960","https://openalex.org/W2056888987","https://openalex.org/W2056978648","https://openalex.org/W2057796977","https://openalex.org/W2061681043","https://openalex.org/W2062461864","https://openalex.org/W2066265400","https://openalex.org/W2069533740","https://openalex.org/W2071167287","https://openalex.org/W2071266145","https://openalex.org/W2073813597","https://openalex.org/W2075545603","https://openalex.org/W2075570293","https://openalex.org/W2076913518","https://openalex.org/W2079826210","https://openalex.org/W2082093930","https://openalex.org/W2084862813","https://openalex.org/W2085115658","https://openalex.org/W2086707178","https://openalex.org/W2089695818","https://openalex.org/W2089723196","https://openalex.org/W2094242637","https://openalex.org/W2104564301","https://openalex.org/W2107291281","https://openalex.org/W2108579114","https://openalex.org/W2116397695","https://openalex.org/W2119946727","https://openalex.org/W2121676520","https://openalex.org/W2122590281","https://openalex.org/W2122910171","https://openalex.org/W2127823826","https://openalex.org/W2131495509","https://openalex.org/W2133863770","https://openalex.org/W2134706315","https://openalex.org/W2135677683","https://openalex.org/W2136037247","https://openalex.org/W2144058774","https://openalex.org/W2144428447","https://openalex.org/W2146275594","https://openalex.org/W2149849734","https://openalex.org/W2151551276","https://openalex.org/W2155122139","https://openalex.org/W2157022248","https://openalex.org/W2158075034","https://openalex.org/W2159488456","https://openalex.org/W2161091841","https://openalex.org/W2166063586","https://openalex.org/W2166792528","https://openalex.org/W2167704983","https://openalex.org/W2168912691","https://openalex.org/W2169496277","https://openalex.org/W2171165694","https://openalex.org/W2264924852","https://openalex.org/W2276227966","https://openalex.org/W2295444255","https://openalex.org/W2298105916","https://openalex.org/W2326926092","https://openalex.org/W2412850688","https://openalex.org/W2417831017","https://openalex.org/W2476542314","https://openalex.org/W2511864568","https://openalex.org/W2518126672","https://openalex.org/W2522881241","https://openalex.org/W2529121786","https://openalex.org/W2558038905","https://openalex.org/W2565849713","https://openalex.org/W2619752415","https://openalex.org/W2734318655","https://openalex.org/W2754736641","https://openalex.org/W2765610915","https://openalex.org/W2776070428","https://openalex.org/W2778203991","https://openalex.org/W2781539022","https://openalex.org/W2783197989","https://openalex.org/W2783317651","https://openalex.org/W2784146930","https://openalex.org/W2810183781","https://openalex.org/W2912767016","https://openalex.org/W2927018258","https://openalex.org/W2938986511"],"related_works":["https://openalex.org/W2810402969","https://openalex.org/W2575124789","https://openalex.org/W7167019057","https://openalex.org/W2948938392","https://openalex.org/W2522881241","https://openalex.org/W4387979170","https://openalex.org/W4400010840","https://openalex.org/W4312419705","https://openalex.org/W2734318655","https://openalex.org/W2159488456"],"abstract_inverted_index":{"The":[0],"extracellular":[1],"matrix":[2],"(ECM)":[3],"of":[4,25,41,57,81,86,95,101,112,129,161],"the":[5,23,34,39,79,82,109,113,157,162,165],"lung":[6,12],"plays":[7],"several":[8],"important":[9],"roles":[10],"in":[11,71,78,138,154,164],"function,":[13],"as":[14,52,145],"it":[15],"offers":[16],"a":[17,53,60],"low":[18],"resistant":[19],"pathway":[20],"that":[21,32,69,126],"allows":[22],"exchange":[24],"gases,":[26],"provides":[27],"compressive":[28],"strength":[29],"and":[30,46,50,90,120,142,152,177],"elasticity":[31],"supports":[33],"fragile":[35],"alveolar-capillary":[36],"intersection,":[37],"controls":[38],"binding":[40],"cells":[42],"with":[43,135,140],"growth":[44],"factors":[45],"cell":[47],"surface":[48],"receptors":[49],"acts":[51],"buffer":[54],"against":[55],"retention":[56],"water.COPD":[58],"is":[59,103],"chronic":[61],"inflammatory":[62],"respiratory":[63],"condition,":[64],"characterised":[65],"by":[66],"various":[67],"conditions":[68],"result":[70],"progressive":[72],"airflow":[73],"limitation.":[74],"At":[75],"any":[76],"stage":[77],"course":[80],"disease,":[83],"acute":[84],"exacerbations":[85],"COPD":[87,102,141],"may":[88,143],"occur":[89],"lead":[91],"to":[92,108,148,170],"accelerated":[93],"deterioration":[94],"pulmonary":[96],"function.":[97],"A":[98],"key":[99],"factor":[100],"airway":[104,116,150],"remodelling,":[105],"which":[106],"refers":[107],"serious":[110],"alterations":[111],"ECM":[114,130,163],"affecting":[115],"wall":[117],"thickness,":[118],"resistance":[119],"elasticity.":[121],"Various":[122],"studies":[123],"have":[124],"shown":[125],"serum":[127],"biomarkers":[128,173],"turnover":[131],"are":[132],"significantly":[133],"associated":[134],"disease":[136,175],"severity":[137],"patients":[139],"serve":[144],"potential":[146],"targets":[147],"control":[149],"inflammation":[151],"remodelling":[153],"COPD.":[155],"Unravelling":[156],"complete":[158],"molecular":[159],"composition":[160],"diseased":[166],"lungs":[167],"will":[168],"help":[169],"identify":[171],"novel":[172],"for":[174],"progression":[176],"therapy.":[178]},"counts_by_year":[{"year":2026,"cited_by_count":29},{"year":2025,"cited_by_count":21},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":7}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2020-11-23T00:00:00"}