{"id":"https://openalex.org/W3100950996","doi":"https://doi.org/10.1136/jitc-2020-sitc2020.0016","title":"16 Antibody profiling of prostate cancer patients reveals differences in antibody signatures among disease stages and following treatment","display_name":"16 Antibody profiling of prostate cancer patients reveals differences in antibody signatures among disease stages and following treatment","publication_year":2020,"publication_date":"2020-11-01","ids":{"openalex":"https://openalex.org/W3100950996","doi":"https://doi.org/10.1136/jitc-2020-sitc2020.0016","mag":"3100950996"},"language":"en","primary_location":{"id":"doi:10.1136/jitc-2020-sitc2020.0016","doi":"https://doi.org/10.1136/jitc-2020-sitc2020.0016","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2020-sitc2020.0016","pdf_url":null,"source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular and young investigator award abstracts","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1136/jitc-2020-sitc2020.0016","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090284376","display_name":"Hemanth K. Potluri","orcid":"https://orcid.org/0000-0002-3646-4961","observed_orcids":["https://orcid.org/0000-0002-3646-4961"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hemanth Potluri","raw_affiliation_strings":["UW-Madison, Madison, WI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UW-Madison, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015004353","display_name":"Tun Lee Ng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tun Lee Ng","raw_affiliation_strings":["UW-Madison, Madison, WI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UW-Madison, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072759658","display_name":"Michael A. Newton","orcid":"https://orcid.org/0000-0001-9038-878X","observed_orcids":["https://orcid.org/0000-0001-9038-878X","https://orcid.org/0000-0002-8465-7004"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Newton","raw_affiliation_strings":["UW-Madison, Madison, WI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UW-Madison, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101612075","display_name":"Jin Zhang","orcid":"https://orcid.org/0000-0001-6595-9210","observed_orcids":["https://orcid.org/0000-0001-6595-9210"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jin Zhang","raw_affiliation_strings":["Washington University in St. Louis, St. Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University in St. Louis, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028616783","display_name":"Christopher A. Maher","orcid":"https://orcid.org/0000-0002-9035-603X","observed_orcids":["https://orcid.org/0000-0002-9035-603X","https://orcid.org/0009-0005-1728-4614","https://orcid.org/0000-0002-1628-7857"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher Maher","raw_affiliation_strings":["Washington University in St. Louis, St. Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University in St. Louis, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067800417","display_name":"Peter S. Nelson","orcid":"https://orcid.org/0000-0002-5451-5726","observed_orcids":["https://orcid.org/0000-0002-5451-5726"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Nelson","raw_affiliation_strings":["Fred Hutchinson Cancer Research Center, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021686685","display_name":"Douglas G. McNeel","orcid":"https://orcid.org/0000-0003-1471-6723","observed_orcids":["https://orcid.org/0000-0003-1471-6723"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas McNeel","raw_affiliation_strings":["UW-Madison, Madison, WI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UW-Madison, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":{"value":2490,"currency":"USD","value_usd":2490},"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"A8.2","last_page":"A9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.984000027179718},{"id":"https://openalex.org/keywords/autoantibodies","display_name":"autoantibodies","score":0.9860000014305115},{"id":"https://openalex.org/keywords/antibody-profiling","display_name":"antibody profiling","score":0.8420000076293945},{"id":"https://openalex.org/keywords/peptide-microarrays","display_name":"peptide microarrays","score":0.8159999847412109},{"id":"https://openalex.org/keywords/disease-stage","display_name":"disease stage","score":0.7879999876022339},{"id":"https://openalex.org/keywords/castration-resistant-prostate-cancer","display_name":"castration-resistant prostate cancer","score":0.9810000061988831},{"id":"https://openalex.org/keywords/hormone-sensitive-prostate-cancer","display_name":"hormone-sensitive prostate cancer","score":0.8920000195503235},{"id":"https://openalex.org/keywords/androgen-deprivation-therapy","display_name":"androgen deprivation therapy","score":0.921999990940094},{"id":"https://openalex.org/keywords/cancer-vaccines","display_name":"cancer vaccines","score":0.6129999756813049},{"id":"https://openalex.org/keywords/serum-igg","display_name":"serum IgG","score":0.7799999713897705},{"id":"https://openalex.org/keywords/immunomodulatory-therapy","display_name":"immunomodulatory therapy","score":0.6940000057220459}],"concepts":[{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.9028952717781067},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6538287401199341},{"id":"https://openalex.org/C2777899217","wikidata":"https://www.wikidata.org/wiki/Q4759439","display_name":"Androgen deprivation therapy","level":4,"score":0.6017473936080933},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5874192118644714},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5678815841674805},{"id":"https://openalex.org/C2779256933","wikidata":"https://www.wikidata.org/wiki/Q58929","display_name":"Castration","level":3,"score":0.518356204032898},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.48172715306282043},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4746161997318268},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.450822114944458},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4478517472743988},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2658330202102661},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.12644165754318237}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1136/jitc-2020-sitc2020.0016","doi":"https://doi.org/10.1136/jitc-2020-sitc2020.0016","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2020-sitc2020.0016","pdf_url":null,"source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular and young investigator award abstracts","raw_type":"proceedings-article"},{"id":"pmh:oai:doaj.org/article:795075d36a0c4b0cb9d4db126b9a8f39","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/795075d36a0c4b0cb9d4db126b9a8f39","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1136/jitc-2020-sitc2020.0016","doi":"https://doi.org/10.1136/jitc-2020-sitc2020.0016","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2020-sitc2020.0016","pdf_url":null,"source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular and young investigator award abstracts","raw_type":"proceedings-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3111700740","https://openalex.org/W2027471155","https://openalex.org/W7100509894","https://openalex.org/W3088801732","https://openalex.org/W4376224608","https://openalex.org/W2298185627","https://openalex.org/W3022987203","https://openalex.org/W7100839309","https://openalex.org/W2123605040","https://openalex.org/W2079018834"],"abstract_inverted_index":{"Background":[0],"Previous":[1],"studies":[2],"of":[3,27,38,43,61,65,98,165,175,187,194,248,258,268,282,300,339,349,364],"prostate":[4,28,67,80,103,107,112],"cancer":[5,81,108,113],"autoantibodies":[6],"have":[7,16,275],"largely":[8],"focused":[9],"on":[10],"diagnostic":[11],"applications.":[12],"So":[13],"far,":[14],"there":[15],"been":[17,276],"no":[18],"reports":[19],"attempting":[20],"to":[21,86,142,146,227,242,272,278,310],"more":[22,216,243],"comprehensively":[23],"profile":[24],"the":[25,36,41,57,62,88,144,172,185,200,246,256,265,280,298,347],"landscape":[26],"cancer-associated":[29,68],"antibodies.":[30],"Specifically,":[31],"it":[32],"is":[33],"unknown":[34],"whether":[35,148],"quantity":[37],"antibodies":[39,271],"or":[40,50,135],"types":[42],"proteins":[44,189,217,244,283],"recognized":[45,188,215,284],"change":[46,291],"with":[47,94,128,181,191,206,212,219,255,292],"disease":[48,118,182,214,293],"progression":[49],"treatment.":[51],"Methods":[52],"A":[53],"peptide":[54,159],"microarray":[55],"spanning":[56],"amino":[58],"acid":[59,221],"sequences":[60],"gene":[63,224],"products":[64,366],"1611":[66],"genes":[69],"was":[70,203],"synthesized.":[71],"Serum":[72],"samples":[73,91,122,342],"from":[74,123],"healthy":[75],"male":[76],"volunteers":[77],"(n=15)":[78],"and":[79,115,208,223,287,307,323,337,345],"patients":[82,93,205,238,286,357],"(n=85)":[83],"were":[84,139,343],"used":[85,141],"probe":[87,143],"array.":[89],"These":[90],"included":[92],"various":[95],"clinical":[96,192],"stages":[97],"disease:":[99],"newly":[100],"diagnosed":[101],"localized":[102],"cancer,":[104],"castration-sensitive":[105,207],"non-metastatic":[106,111],"(nmCSPC),":[109],"castration-resistant":[110,116,209,213],"(nmCRPC),":[114],"metastatic":[117],"(mCRPC).":[119],"Serial":[120],"sera":[121],"individuals":[124],"who":[125],"received":[126],"treatment":[127,249],"either":[129],"standard":[130],"androgen":[131],"deprivation":[132],"therapy":[133],"(ADT)":[134],"an":[136],"anti-tumor":[137],"vaccine":[138],"also":[140],"array,":[145],"determine":[147,288],"we":[149],"could":[150],"detect":[151],"treatment-related":[152],"changes.":[153],"Results":[154],"We":[155,169,274],"demonstrated":[156],"that":[157,171,199,236,334],"this":[158,301],"array":[160],"yielded":[161],"highly":[162],"reproducible":[163],"measurements":[164],"serum":[166],"IgG":[167],"levels.":[168],"found":[170],"overall":[173],"number":[174],"antibody":[176],"responses":[177,241,309],"did":[178,251],"not":[179],"increase":[180],"burden.":[183,294],"However,":[184],"composition":[186],"shifted":[190],"stage":[193],"disease.":[195,210],"Our":[196,232,295],"analysis":[197],"revealed":[198],"largest":[201,266],"difference":[202],"between":[204],"Patients":[211],"associated":[218,270],"nucleic":[220],"binding":[222],"regulation":[225],"compared":[226],"men":[228],"in":[229],"other":[230],"groups.":[231],"longitudinal":[233],"data":[234],"showed":[235],"vaccine-treated":[237],"developed":[239],"increased":[240],"over":[245],"course":[247],"than":[250],"ADT-treated":[252],"patients,":[253],"consistent":[254],"development":[257],"antigen":[259,305],"spread.":[260],"Conclusions":[261],"This":[262],"study":[263],"represents":[264],"survey":[267],"prostate-cancer":[269],"date.":[273],"able":[277],"characterize":[279],"classes":[281],"by":[285],"how":[289],"they":[290],"findings":[296],"demonstrate":[297],"potential":[299],"platform":[302],"for":[303,321,362,367],"measuring":[304],"spread":[306],"studying":[308],"immunomodulatory":[311],"therapies.":[312],"Acknowledgements":[313],"UW-Madison":[314],"Medical":[315],"Scientist":[316],"Training":[317],"Program:":[318,328],"GM008692UW-Madison":[319],"Institute":[320],"Clinical":[322],"Translational":[324],"Research":[325],"Predoctoral":[326],"TL1":[327],"TR002375":[329],"Ethics":[330],"Approval":[331],"Study":[332],"protocols":[333],"permitted":[335],"collection":[336],"use":[338,363],"human":[340],"blood":[341,365],"reviewed":[344],"approved":[346],"University":[348],"Wisconsin":[350],"Human":[351],"Subjects\u2019":[352],"Review":[353],"Board":[354],"(IRB).":[355],"All":[356],"gave":[358],"written":[359],"informed":[360],"consent":[361],"research.":[368]},"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2020-11-23T00:00:00"}