{"id":"https://openalex.org/W3100367398","doi":"https://doi.org/10.2174/1381612826666201113095938","title":"The Potential of Hydrogen for Improving Mental Disorders","display_name":"The Potential of Hydrogen for Improving Mental Disorders","publication_year":2020,"publication_date":"2020-11-13","ids":{"openalex":"https://openalex.org/W3100367398","doi":"https://doi.org/10.2174/1381612826666201113095938","mag":"3100367398","pmid":"https://pubmed.ncbi.nlm.nih.gov/33185151"},"language":"en","primary_location":{"id":"doi:10.2174/1381612826666201113095938","doi":"https://doi.org/10.2174/1381612826666201113095938","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1381612826666201113095938","pdf_url":null,"source":{"id":"https://openalex.org/S55674637","display_name":"Current Pharmaceutical Design","issn_l":"1381-6128","issn":["1381-6128","1873-4286"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Pharmaceutical Design","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078310718","display_name":"Yasushi Satoh","orcid":"https://orcid.org/0000-0002-0527-6319","observed_orcids":["https://orcid.org/0000-0002-0527-6319"]},"institutions":[{"id":"https://openalex.org/I53888640","display_name":"National Defense Medical College","ror":"https://ror.org/02e4qbj88","country_code":"JP","type":"education","lineage":["https://openalex.org/I53888640"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yasushi Satoh","raw_affiliation_strings":["Department of Biochemistry, National Defense Medical College, Tokorozawa, Saitama, Japan"],"raw_orcid":"https://orcid.org/0000-0002-0527-6319","affiliations":[{"raw_affiliation_string":"Department of Biochemistry, National Defense Medical College, Tokorozawa, Saitama, Japan","institution_ids":["https://openalex.org/I53888640"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5078310718"],"corresponding_institution_ids":["https://openalex.org/I53888640"],"apc_list":null,"apc_paid":null,"fwci":0.1701,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.22723455,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"27","issue":"5","first_page":"695","last_page":"702"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13775","display_name":"Hydrogen's biological and therapeutic effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13775","display_name":"Hydrogen's biological and therapeutic effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10811","display_name":"Hydrogen Storage and Materials","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12930","display_name":"Biomedical and Chemical Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/molecular-hydrogen","display_name":"molecular hydrogen","score":0.972000002861023},{"id":"https://openalex.org/keywords/hydrogen-therapy","display_name":"hydrogen treatment","score":0.734000027179718},{"id":"https://openalex.org/keywords/mental-disorders","display_name":"mental illness","score":0.9909999966621399},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.9599999785423279},{"id":"https://openalex.org/keywords/anxiety","display_name":"anxiety","score":0.9810000061988831},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9739999771118164},{"id":"https://openalex.org/keywords/inflammatory-stress","display_name":"inflammatory stress","score":0.8379999995231628},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.7170000076293945},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.9150000214576721},{"id":"https://openalex.org/keywords/anti-apoptotic-effects","display_name":"anti-apoptotic effects","score":0.9819999933242798},{"id":"https://openalex.org/keywords/hydroxyl-radical-scavenging","display_name":"hydroxyl radical scavenging","score":0.9110000133514404},{"id":"https://openalex.org/keywords/antidepressant-side-effects","display_name":"antidepressant side effects","score":0.5130000114440918}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4488445222377777},{"id":"https://openalex.org/C512968161","wikidata":"https://www.wikidata.org/wiki/Q556","display_name":"Hydrogen","level":2,"score":0.4473153054714203},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.298797607421875},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.06691113114356995}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001523","descriptor_name":"Mental Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006859","descriptor_name":"Hydrogen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2174/1381612826666201113095938","doi":"https://doi.org/10.2174/1381612826666201113095938","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1381612826666201113095938","pdf_url":null,"source":{"id":"https://openalex.org/S55674637","display_name":"Current Pharmaceutical Design","issn_l":"1381-6128","issn":["1381-6128","1873-4286"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Pharmaceutical Design","raw_type":"journal-article"},{"id":"pmid:33185151","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33185151","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current pharmaceutical design","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2897703719","display_name":"Effects of general anesthetics on the regulatory mechanisms of neuronal development in the critical period","funder_award_id":"15H04970","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":92,"referenced_works":["https://openalex.org/W135125622","https://openalex.org/W325313113","https://openalex.org/W1529163965","https://openalex.org/W1556444059","https://openalex.org/W1725820881","https://openalex.org/W1848144340","https://openalex.org/W1967105793","https://openalex.org/W1971096486","https://openalex.org/W1979084421","https://openalex.org/W1979603195","https://openalex.org/W1986211748","https://openalex.org/W1994756087","https://openalex.org/W1995006301","https://openalex.org/W1996311925","https://openalex.org/W1996673522","https://openalex.org/W1998878650","https://openalex.org/W2000276125","https://openalex.org/W2003845176","https://openalex.org/W2008971294","https://openalex.org/W2009672399","https://openalex.org/W2009814577","https://openalex.org/W2014780789","https://openalex.org/W2015427111","https://openalex.org/W2018821577","https://openalex.org/W2023453911","https://openalex.org/W2032502039","https://openalex.org/W2036450246","https://openalex.org/W2038497526","https://openalex.org/W2039713589","https://openalex.org/W2049361817","https://openalex.org/W2057017838","https://openalex.org/W2060657502","https://openalex.org/W2064965507","https://openalex.org/W2068710494","https://openalex.org/W2079657721","https://openalex.org/W2082245790","https://openalex.org/W2084480427","https://openalex.org/W2086379739","https://openalex.org/W2097694851","https://openalex.org/W2098970247","https://openalex.org/W2104969272","https://openalex.org/W2108187295","https://openalex.org/W2109179624","https://openalex.org/W2112951169","https://openalex.org/W2116541339","https://openalex.org/W2118377980","https://openalex.org/W2118625591","https://openalex.org/W2121075670","https://openalex.org/W2125278063","https://openalex.org/W2129579709","https://openalex.org/W2133538175","https://openalex.org/W2134549690","https://openalex.org/W2136223152","https://openalex.org/W2138812470","https://openalex.org/W2141656798","https://openalex.org/W2143123443","https://openalex.org/W2144097932","https://openalex.org/W2147119341","https://openalex.org/W2147242210","https://openalex.org/W2156150528","https://openalex.org/W2157611444","https://openalex.org/W2163335252","https://openalex.org/W2167938116","https://openalex.org/W2167941678","https://openalex.org/W2169657429","https://openalex.org/W2171668194","https://openalex.org/W2174461387","https://openalex.org/W2251567434","https://openalex.org/W2290887543","https://openalex.org/W2307324788","https://openalex.org/W2331945768","https://openalex.org/W2332193566","https://openalex.org/W2399060753","https://openalex.org/W2519453916","https://openalex.org/W2580478036","https://openalex.org/W2601121693","https://openalex.org/W2601675615","https://openalex.org/W2742103013","https://openalex.org/W2743262317","https://openalex.org/W2743330831","https://openalex.org/W2747166022","https://openalex.org/W2753668863","https://openalex.org/W2770902446","https://openalex.org/W2782950904","https://openalex.org/W2794630067","https://openalex.org/W2883222829","https://openalex.org/W2885848383","https://openalex.org/W2905808540","https://openalex.org/W2912436883","https://openalex.org/W2970686316","https://openalex.org/W3191956221","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2410719073","https://openalex.org/W3092951235","https://openalex.org/W2530363383","https://openalex.org/W2401015570","https://openalex.org/W2109179624","https://openalex.org/W7101161585","https://openalex.org/W2759847566","https://openalex.org/W4233640477","https://openalex.org/W4307369998","https://openalex.org/W2135082935"],"abstract_inverted_index":{"In":[0],"2007,":[1],"Ohsawa":[2],"and":[3,49,77,88,111,118,124,164,180,202,218],"colleagues":[4],"reported":[5],"that":[6,40,72,90,155,220],"molecular":[7],"hydrogen":[8],"(H2)":[9],"gas":[10],"significantly":[11],"reduced":[12],"the":[13,57,92,178,188,192,197,209,213],"infarct":[14],"volume":[15],"size":[16],"in":[17,56,62,96,191],"a":[18,128,144,174],"rat":[19],"model":[20],"of":[21,60,68,116,131,146,182,194,199,212,216],"cerebral":[22],"infarction,":[23],"which":[24,52],"was,":[25],"at":[26],"least,":[27],"partially":[28],"due":[29],"to":[30,94,105,140,225],"scavenging":[31],"hydroxyl":[32],"radicals.":[33],"Since":[34],"then,":[35],"multiple":[36],"studies":[37,69],"have":[38,121],"shown":[39,154],"H2":[41,61,73,168,195,217,221],"has":[42,53,70,153,169],"not":[43],"only":[44],"anti-oxidative":[45],"but":[46],"also":[47,207],"anti-inflammatory":[48],"anti-apoptotic":[50],"properties,":[51],"ignited":[54],"interest":[55],"clinical":[58],"use":[59,193],"diverse":[63],"diseases.":[64,205],"A":[65],"growing":[66],"body":[67],"indicated":[71],"affects":[74],"both":[75],"mental":[76,107,135,183,200,229],"physical":[78],"conditions.":[79],"Mental":[80],"disorders":[81,136,157,201],"are":[82,125,137,158],"characterized":[83],"by":[84,127,143],"disordered":[85],"mood,":[86],"thoughts,":[87],"behaviors":[89],"affect":[91],"ability":[93],"function":[95],"daily":[97],"life.":[98],"However,":[99],"there":[100],"is":[101],"no":[102],"sure":[103],"way":[104],"prevent":[106],"disorders.":[108,184,230],"Although":[109],"antidepressant":[110],"antianxiety":[112],"drugs":[113],"relieve":[114],"symptoms":[115],"depression":[117],"anxiety,":[119],"they":[120],"efficacy":[122],"limitations":[123],"accompanied":[126],"wide":[129],"range":[130],"side":[132],"effects.":[133],"While":[134],"generally":[138],"thought":[139],"be":[141],"caused":[142],"variety":[145],"genetic":[147],"and/or":[148],"environmental":[149],"factors,":[150],"recent":[151,189],"progress":[152,190],"these":[156],"strongly":[159],"associated":[160],"with":[161],"increased":[162],"oxidative":[163],"inflammatory":[165],"stress.":[166],"Thus,":[167],"received":[170],"much":[171],"attention":[172],"as":[173],"novel":[175],"therapy":[176],"for":[177,196],"prevention":[179],"treatment":[181,198],"This":[185],"review":[186],"summarizes":[187],"other":[203],"related":[204],"We":[206],"discuss":[208],"potential":[210],"mechanisms":[211],"biomedical":[214],"effects":[215],"conclude":[219],"could":[222],"offer":[223],"relief":[224],"people":[226],"suffering":[227],"from":[228]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-11-23T00:00:00"}