{"id":"https://openalex.org/W309973110","doi":"https://doi.org/10.1023/a:1013133224044","title":"Differences of vascular endothelial growth factor (VEGF) expression between liver and abdominal metastases from colon cancer. Implications for the treatment with VEGF inhibitors","display_name":"Differences of vascular endothelial growth factor (VEGF) expression between liver and abdominal metastases from colon cancer. Implications for the treatment with VEGF inhibitors","publication_year":2000,"publication_date":"2000-12-01","ids":{"openalex":"https://openalex.org/W309973110","doi":"https://doi.org/10.1023/a:1013133224044","mag":"309973110","pmid":"https://pubmed.ncbi.nlm.nih.gov/11827068"},"language":"en","primary_location":{"id":"doi:10.1023/a:1013133224044","doi":"https://doi.org/10.1023/a:1013133224044","is_oa":false,"landing_page_url":"https://doi.org/10.1023/a:1013133224044","pdf_url":null,"source":{"id":"https://openalex.org/S100674681","display_name":"Clinical & Experimental Metastasis","issn_l":"0262-0898","issn":["0262-0898","1573-7276"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical & Experimental Metastasis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042028913","display_name":"Stefano Cascinu","orcid":"https://orcid.org/0000-0003-2215-0731","observed_orcids":["https://orcid.org/0000-0003-2215-0731"]},"institutions":[{"id":"https://openalex.org/I4210135416","display_name":"Ospedale di Parma","ror":"https://ror.org/03jg24239","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210135416"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Stefano Cascinu","raw_affiliation_strings":["Department of Medical Oncology, Azienda Ospedaliera di Parma, Italy. cascinu@yahoo.com","Department of Medical Oncology, Azienda Ospedaliera di Parma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Azienda Ospedaliera di Parma, Italy. cascinu@yahoo.com","institution_ids":["https://openalex.org/I4210135416"]},{"raw_affiliation_string":"Department of Medical Oncology, Azienda Ospedaliera di Parma, Italy","institution_ids":["https://openalex.org/I4210135416"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018141422","display_name":"Francesco Graziano","orcid":"https://orcid.org/0000-0002-4896-1842","observed_orcids":["https://orcid.org/0000-0002-4896-1842","https://orcid.org/0009-0003-5750-0559"]},"institutions":[{"id":"https://openalex.org/I190397597","display_name":"University of Urbino","ror":"https://ror.org/04q4kt073","country_code":"IT","type":"education","lineage":["https://openalex.org/I190397597"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Graziano","raw_affiliation_strings":["Medical Oncology Unit, Hospital of Urbino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology Unit, Hospital of Urbino, Italy","institution_ids":["https://openalex.org/I190397597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038347927","display_name":"Vincenzo Catalano","orcid":"https://orcid.org/0000-0002-8380-7736","observed_orcids":["https://orcid.org/0000-0002-8380-7736"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vincenzo Catalano","raw_affiliation_strings":["Department of Medical Oncology, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011248636","display_name":"Maria Pia Staccioli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098685","display_name":"San Salvatore Hospital","ror":"https://ror.org/0112t7451","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210098685"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria Pia Staccioli","raw_affiliation_strings":["Department of Pathology, Azienda Ospedaliera Ospedale S. Salvatore, Pesaro"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Azienda Ospedaliera Ospedale S. Salvatore, Pesaro","institution_ids":["https://openalex.org/I4210098685"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061179981","display_name":"Sandro Barni","orcid":"https://orcid.org/0000-0002-7633-0378","observed_orcids":["https://orcid.org/0000-0002-7633-0378"]},"institutions":[{"id":"https://openalex.org/I4210161395","display_name":"Azienda Ospedaliera Treviglio","ror":"https://ror.org/05rv6z116","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210161395"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sandro Barni","raw_affiliation_strings":["Department of Medical Oncology, Azienda Ospedaliera di Treviglio (BG), Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Azienda Ospedaliera di Treviglio (BG), Italy","institution_ids":["https://openalex.org/I4210161395"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073829389","display_name":"Paolo Giordani","orcid":"https://orcid.org/0000-0003-0087-7315","observed_orcids":["https://orcid.org/0000-0003-0087-7315"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paolo Giordani","raw_affiliation_strings":["Department of Medical Oncology, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109264723","display_name":"Maria Cristina Rossi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria Cristina Rossi","raw_affiliation_strings":["Department of Medical Oncology, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111873146","display_name":"Anna Maria Baldelli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anna Maria Baldelli","raw_affiliation_strings":["Department of Medical Oncology, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025410112","display_name":"Pietro Muretto","orcid":"https://orcid.org/0000-0001-8363-0945","observed_orcids":["https://orcid.org/0000-0001-8363-0945"]},"institutions":[{"id":"https://openalex.org/I4210098685","display_name":"San Salvatore Hospital","ror":"https://ror.org/0112t7451","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210098685"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Pietro Muretto","raw_affiliation_strings":["Department of Pathology, Azienda Ospedaliera Ospedale S. Salvatore, Pesaro"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Azienda Ospedaliera Ospedale S. Salvatore, Pesaro","institution_ids":["https://openalex.org/I4210098685"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101631999","display_name":"Andrea Valenti","orcid":"https://orcid.org/0009-0001-1303-3595","observed_orcids":["https://orcid.org/0009-0001-1303-3595"]},"institutions":[{"id":"https://openalex.org/I112862951","display_name":"University of Messina","ror":"https://ror.org/05ctdxz19","country_code":"IT","type":"education","lineage":["https://openalex.org/I112862951"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Andrea Valenti","raw_affiliation_strings":["Department of General Pathology, University of Messina, Messina, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Pathology, University of Messina, Messina, Italy","institution_ids":["https://openalex.org/I112862951"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067058355","display_name":"Giuseppina Catalano","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Giuseppina Catalano","raw_affiliation_strings":["Department of Medical Oncology, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Italy","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5090,"currency":"USD","value_usd":5090},"apc_paid":null,"fwci":0.2986,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.47005845,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"18","issue":"8","first_page":"651","last_page":"655"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.996999979019165},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.796999990940094},{"id":"https://openalex.org/keywords/liver-metastases","display_name":"liver metastasis","score":0.9459999799728394},{"id":"https://openalex.org/keywords/abdominal-metastases","display_name":"abdominal metastasis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/vegf-expression","display_name":"VEGF expression","score":0.8349999785423279},{"id":"https://openalex.org/keywords/anti-vegf-therapy","display_name":"anti-VEGF therapy","score":0.8270000219345093},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.8090000152587891},{"id":"https://openalex.org/keywords/immunohistochemistry","display_name":"immunohistochemistry","score":0.675000011920929}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8299624919891357},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.7887400388717651},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7433328628540039},{"id":"https://openalex.org/C2780140570","wikidata":"https://www.wikidata.org/wiki/Q3545481","display_name":"Surgical oncology","level":2,"score":0.6267682313919067},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.5917555093765259},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5437650680541992},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.504574179649353},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.48929378390312195},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.4885040521621704},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4722660779953003},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4581758677959442},{"id":"https://openalex.org/C41260117","wikidata":"https://www.wikidata.org/wiki/Q668064","display_name":"Hepatology","level":2,"score":0.4124448895454407},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.32470637559890747},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.26389995217323303}],"mesh":[{"descriptor_ui":"D000008","descriptor_name":"Abdominal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000008","descriptor_name":"Abdominal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000008","descriptor_name":"Abdominal Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D008222","descriptor_name":"Lymphokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016228","descriptor_name":"Endothelial Growth Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D042442","descriptor_name":"Vascular Endothelial Growth Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1023/a:1013133224044","doi":"https://doi.org/10.1023/a:1013133224044","is_oa":false,"landing_page_url":"https://doi.org/10.1023/a:1013133224044","pdf_url":null,"source":{"id":"https://openalex.org/S100674681","display_name":"Clinical & Experimental Metastasis","issn_l":"0262-0898","issn":["0262-0898","1573-7276"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical & Experimental Metastasis","raw_type":"journal-article"},{"id":"pmid:11827068","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11827068","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical & experimental metastasis","raw_type":"Journal Article"},{"id":"pmh:oai:iris.univpm.it:11566/71576","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11566/71576","pdf_url":null,"source":{"id":"https://openalex.org/S4306402571","display_name":"Universit\u00e0 Politecnica delle Marche (Universit\u00e0 Politecnica delle Marche)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122534668","host_organization_name":"Marche Polytechnic University","host_organization_lineage":["https://openalex.org/I122534668"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W149403254","https://openalex.org/W1499520412","https://openalex.org/W1532019756","https://openalex.org/W1586129343","https://openalex.org/W1678310528","https://openalex.org/W1903437307","https://openalex.org/W1923484756","https://openalex.org/W1967007810","https://openalex.org/W1967694023","https://openalex.org/W1968954623","https://openalex.org/W1969026343","https://openalex.org/W1969328947","https://openalex.org/W1980969801","https://openalex.org/W1985531513","https://openalex.org/W2013806881","https://openalex.org/W2028195344","https://openalex.org/W2037543174","https://openalex.org/W2049852228","https://openalex.org/W2054119278","https://openalex.org/W2064739543","https://openalex.org/W2068155691","https://openalex.org/W2086101934","https://openalex.org/W2088377055","https://openalex.org/W2093688917","https://openalex.org/W2101914663","https://openalex.org/W2122240723","https://openalex.org/W2142383042","https://openalex.org/W2150908379","https://openalex.org/W2167901553","https://openalex.org/W2264426661","https://openalex.org/W2300081330"],"related_works":["https://openalex.org/W2210820222","https://openalex.org/W2375757340","https://openalex.org/W2332771722","https://openalex.org/W2000450466","https://openalex.org/W1586129343","https://openalex.org/W2006067741","https://openalex.org/W2370915274","https://openalex.org/W2003232455","https://openalex.org/W2049972026","https://openalex.org/W2387665645"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}