{"id":"https://openalex.org/W3099580960","doi":"https://doi.org/10.4018/978-1-7998-4808-0.ch008","title":"Combinational Therapy Using Chemotherapeutic Agents and Dietary Bioactive Compounds: A Pragmatic Approach to Cancer Treatment","display_name":"Combinational Therapy Using Chemotherapeutic Agents and Dietary Bioactive Compounds: A Pragmatic Approach to Cancer Treatment","publication_year":2020,"publication_date":"2020-11-17","ids":{"openalex":"https://openalex.org/W3099580960","doi":"https://doi.org/10.4018/978-1-7998-4808-0.ch008","mag":"3099580960"},"language":"en","primary_location":{"id":"doi:10.4018/978-1-7998-4808-0.ch008","doi":"https://doi.org/10.4018/978-1-7998-4808-0.ch008","is_oa":false,"landing_page_url":"https://doi.org/10.4018/978-1-7998-4808-0.ch008","pdf_url":null,"source":{"id":"https://openalex.org/S4210196384","display_name":"Advances in medical diagnosis, treatment, and care (AMDTC) book series","issn_l":"2475-6628","issn":["2475-6628","2475-6636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320424","host_organization_name":"IGI Global","host_organization_lineage":["https://openalex.org/P4310320424"],"host_organization_lineage_names":["IGI Global"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Medical Diagnosis, Treatment, and Care","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4213065361","display_name":"Treating Endocrine and Metabolic Disorders With Herbal Medicines"},"type":"book-chapter","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050499971","display_name":"Madhumitha Kedhari Sundaram","orcid":"https://orcid.org/0000-0002-5717-1789","observed_orcids":["https://orcid.org/0000-0002-5717-1789"]},"institutions":[{"id":"https://openalex.org/I164861460","display_name":"Manipal Academy of Higher Education","ror":"https://ror.org/02xzytt36","country_code":"IN","type":"education","lineage":["https://openalex.org/I164861460"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Madhumitha Kedhari Sundaram","raw_affiliation_strings":["Manipal Academy of Higher Education, UAE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Manipal Academy of Higher Education, UAE","institution_ids":["https://openalex.org/I164861460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050596577","display_name":"Shefina Silas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I164861460","display_name":"Manipal Academy of Higher Education","ror":"https://ror.org/02xzytt36","country_code":"IN","type":"education","lineage":["https://openalex.org/I164861460"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shefina Silas","raw_affiliation_strings":["Manipal Academy of Higher Education, UAE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Manipal Academy of Higher Education, UAE","institution_ids":["https://openalex.org/I164861460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024145910","display_name":"Arif Hussain","orcid":"https://orcid.org/0000-0002-0851-4845","observed_orcids":["https://orcid.org/0000-0002-0851-4845"]},"institutions":[{"id":"https://openalex.org/I164861460","display_name":"Manipal Academy of Higher Education","ror":"https://ror.org/02xzytt36","country_code":"IN","type":"education","lineage":["https://openalex.org/I164861460"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Arif Hussain","raw_affiliation_strings":["Manipal Academy of Higher Education, UAE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Manipal Academy of Higher Education, UAE","institution_ids":["https://openalex.org/I164861460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I164861460"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"188","last_page":"214"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.6729000210762024,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.6729000210762024,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.0608999989926815,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.05700000002980232,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.7680000066757202},{"id":"https://openalex.org/keywords/dietary-bioactive-compounds","display_name":"dietary bioactive compounds","score":0.777999997138977},{"id":"https://openalex.org/keywords/phytochemicals","display_name":"phytochemicals","score":0.949999988079071},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.7839999794960022},{"id":"https://openalex.org/keywords/chemoprevention","display_name":"chemoprevention","score":0.7820000052452087},{"id":"https://openalex.org/keywords/sulforaphane","display_name":"sulforaphane","score":0.8930000066757202},{"id":"https://openalex.org/keywords/epigallocatechin-gallate","display_name":"epigallocatechin gallate","score":0.9229999780654907},{"id":"https://openalex.org/keywords/curcumin","display_name":"curcumin","score":1.0},{"id":"https://openalex.org/keywords/genistein","display_name":"genistein","score":1.0},{"id":"https://openalex.org/keywords/resveratrol","display_name":"resveratrol","score":1.0},{"id":"https://openalex.org/keywords/eugenol","display_name":"eugenol","score":1.0},{"id":"https://openalex.org/keywords/chemotherapy-side-effects","display_name":"chemotherapy side effects","score":0.6909999847412109},{"id":"https://openalex.org/keywords/cancer-risk-reduction","display_name":"cancer risk reduction","score":0.6330000162124634}],"concepts":[{"id":"https://openalex.org/C2778250585","wikidata":"https://www.wikidata.org/wiki/Q312266","display_name":"Curcumin","level":2,"score":0.8044716119766235},{"id":"https://openalex.org/C2780841255","wikidata":"https://www.wikidata.org/wiki/Q424489","display_name":"Sulforaphane","level":2,"score":0.7788370847702026},{"id":"https://openalex.org/C2776816829","wikidata":"https://www.wikidata.org/wiki/Q407329","display_name":"Resveratrol","level":2,"score":0.6044217348098755},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5864890813827515},{"id":"https://openalex.org/C2778298627","wikidata":"https://www.wikidata.org/wiki/Q415957","display_name":"Genistein","level":2,"score":0.5030011534690857},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3751487731933594},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36619144678115845},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.1928553581237793},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10266339778900146}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4018/978-1-7998-4808-0.ch008","doi":"https://doi.org/10.4018/978-1-7998-4808-0.ch008","is_oa":false,"landing_page_url":"https://doi.org/10.4018/978-1-7998-4808-0.ch008","pdf_url":null,"source":{"id":"https://openalex.org/S4210196384","display_name":"Advances in medical diagnosis, treatment, and care (AMDTC) book series","issn_l":"2475-6628","issn":["2475-6628","2475-6636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320424","host_organization_name":"IGI Global","host_organization_lineage":["https://openalex.org/P4310320424"],"host_organization_lineage_names":["IGI Global"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Medical Diagnosis, Treatment, and Care","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":88,"referenced_works":["https://openalex.org/W1193490603","https://openalex.org/W1567103617","https://openalex.org/W1596357896","https://openalex.org/W1602155627","https://openalex.org/W1627803359","https://openalex.org/W1802523704","https://openalex.org/W1880916116","https://openalex.org/W1902923868","https://openalex.org/W1945957309","https://openalex.org/W1962837728","https://openalex.org/W1966059799","https://openalex.org/W1968791085","https://openalex.org/W1969275173","https://openalex.org/W1976859333","https://openalex.org/W1977989411","https://openalex.org/W1978495572","https://openalex.org/W1978763455","https://openalex.org/W1986338068","https://openalex.org/W1995059832","https://openalex.org/W2000283853","https://openalex.org/W2005233860","https://openalex.org/W2010646521","https://openalex.org/W2017945551","https://openalex.org/W2024626460","https://openalex.org/W2027653913","https://openalex.org/W2028907915","https://openalex.org/W2030345262","https://openalex.org/W2038615086","https://openalex.org/W2045605237","https://openalex.org/W2047503765","https://openalex.org/W2048256263","https://openalex.org/W2049795547","https://openalex.org/W2060024169","https://openalex.org/W2061153713","https://openalex.org/W2066441945","https://openalex.org/W2067915666","https://openalex.org/W2075938797","https://openalex.org/W2077945404","https://openalex.org/W2082007907","https://openalex.org/W2089812305","https://openalex.org/W2090000401","https://openalex.org/W2095569714","https://openalex.org/W2104883825","https://openalex.org/W2105999198","https://openalex.org/W2112584685","https://openalex.org/W2115479019","https://openalex.org/W2119573310","https://openalex.org/W2127992833","https://openalex.org/W2135871242","https://openalex.org/W2136604882","https://openalex.org/W2138784722","https://openalex.org/W2139635418","https://openalex.org/W2142661454","https://openalex.org/W2148693352","https://openalex.org/W2156003203","https://openalex.org/W2157652647","https://openalex.org/W2159620123","https://openalex.org/W2161666819","https://openalex.org/W2162621586","https://openalex.org/W2165212776","https://openalex.org/W2176790612","https://openalex.org/W2178563668","https://openalex.org/W2230931058","https://openalex.org/W2287907138","https://openalex.org/W2288654343","https://openalex.org/W2289457440","https://openalex.org/W2325171188","https://openalex.org/W2325892404","https://openalex.org/W2339421370","https://openalex.org/W2359150653","https://openalex.org/W2382179855","https://openalex.org/W2428657211","https://openalex.org/W2462715093","https://openalex.org/W2475168395","https://openalex.org/W2503631443","https://openalex.org/W2510704354","https://openalex.org/W2524228506","https://openalex.org/W2585029300","https://openalex.org/W2603320479","https://openalex.org/W2610189207","https://openalex.org/W2620727335","https://openalex.org/W2745004068","https://openalex.org/W2753000927","https://openalex.org/W2759051904","https://openalex.org/W2766094141","https://openalex.org/W2796954545","https://openalex.org/W4234280947","https://openalex.org/W4234499877"],"related_works":["https://openalex.org/W2151698186","https://openalex.org/W2090133492","https://openalex.org/W2110122357","https://openalex.org/W2061795006","https://openalex.org/W7020781706","https://openalex.org/W1968853682","https://openalex.org/W7160867229","https://openalex.org/W2269973970","https://openalex.org/W1994508517","https://openalex.org/W2950956007"],"abstract_inverted_index":{"Diet-derived":[0],"phytochemicals":[1],"find":[2],"prominent":[3],"use":[4],"in":[5,71,110],"traditional":[6],"medicine":[7],"and":[8,27,41,50,68,76,116],"have":[9,33,99],"been":[10],"credited":[11],"with":[12,112,117],"lowering":[13],"cancer":[14,72],"risk":[15],"significantly.":[16],"Dietary":[17],"agents":[18,44,115],"demonstrate":[19],"anticancer":[20],"activity":[21],"by":[22],"modulating":[23],"various":[24],"molecular":[25],"targets":[26],"cell":[28],"signaling":[29],"pathways.":[30],"Several":[31],"studies":[32,97],"focused":[34],"on":[35],"combinations":[36,82],"of":[37,55,79,91],"dietary":[38,101],"bioactive":[39,102],"compounds":[40,103],"conventional":[42,56,113],"chemotherapeutic":[43,69],"to":[45,86],"augment":[46],"their":[47],"therapeutic":[48],"response":[49,61],"mitigate":[51],"the":[52,80,89],"side":[53],"effects":[54],"chemotherapy.":[57],"The":[58],"observed":[59],"synergistic":[60],"heralds":[62],"promise":[63],"for":[64],"successful":[65],"future":[66],"chemopreventive":[67,114],"strategies":[70],"management.":[73],"Animal":[74],"models":[75],"pre-clinical":[77],"trials":[78],"effective":[81],"must":[83],"be":[84],"undertaken":[85],"clearly":[87],"understand":[88],"mechanism":[90],"action.":[92],"This":[93],"chapter":[94],"catalogues":[95],"recent":[96],"that":[98],"used":[100],"(sulforaphane,":[104],"EGCG,":[105],"curcumin,":[106],"genistein,":[107],"resveratrol,":[108],"eugenol)":[109],"combination":[111],"other":[118],"phytochemicals.":[119]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2020-11-23T00:00:00"}