{"id":"https://openalex.org/W3099349338","doi":"https://doi.org/10.1021/acsami.0c17923","title":"Multimode Imaging-Guided Photothermal/Chemodynamic Synergistic Therapy Nanoagent with a Tumor Microenvironment Responded Effect","display_name":"Multimode Imaging-Guided Photothermal/Chemodynamic Synergistic Therapy Nanoagent with a Tumor Microenvironment Responded Effect","publication_year":2020,"publication_date":"2020-11-16","ids":{"openalex":"https://openalex.org/W3099349338","doi":"https://doi.org/10.1021/acsami.0c17923","mag":"3099349338","pmid":"https://pubmed.ncbi.nlm.nih.gov/33196186"},"language":"en","primary_location":{"id":"doi:10.1021/acsami.0c17923","doi":"https://doi.org/10.1021/acsami.0c17923","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsami.0c17923","pdf_url":null,"source":{"id":"https://openalex.org/S164001016","display_name":"ACS Applied Materials & Interfaces","issn_l":"1944-8244","issn":["1944-8244","1944-8252"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Applied Materials & Interfaces","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007100532","display_name":"Yushan Dong","orcid":"https://orcid.org/0009-0002-3105-4450","observed_orcids":["https://orcid.org/0009-0002-3105-4450"]},"institutions":[{"id":"https://openalex.org/I151727225","display_name":"Harbin Engineering University","ror":"https://ror.org/03x80pn82","country_code":"CN","type":"education","lineage":["https://openalex.org/I151727225"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yushan Dong","raw_affiliation_strings":["Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Sciences and Chemical Engineering, Harbin Engineering University, Harbin 150001, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Sciences and Chemical Engineering, Harbin Engineering University, Harbin 150001, P. R. China","institution_ids":["https://openalex.org/I151727225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101549038","display_name":"Shuming Dong","orcid":"https://orcid.org/0009-0003-7350-5050","observed_orcids":["https://orcid.org/0009-0003-7350-5050"]},"institutions":[{"id":"https://openalex.org/I151727225","display_name":"Harbin Engineering University","ror":"https://ror.org/03x80pn82","country_code":"CN","type":"education","lineage":["https://openalex.org/I151727225"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuming Dong","raw_affiliation_strings":["Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Sciences and Chemical Engineering, Harbin Engineering University, Harbin 150001, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Sciences and Chemical Engineering, Harbin Engineering University, Harbin 150001, P. R. China","institution_ids":["https://openalex.org/I151727225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100434577","display_name":"Zhao Wang","orcid":"https://orcid.org/0009-0001-8544-7412","observed_orcids":["https://orcid.org/0009-0001-8544-7412"]},"institutions":[{"id":"https://openalex.org/I151727225","display_name":"Harbin Engineering University","ror":"https://ror.org/03x80pn82","country_code":"CN","type":"education","lineage":["https://openalex.org/I151727225"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhao Wang","raw_affiliation_strings":["Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Sciences and Chemical Engineering, Harbin Engineering University, Harbin 150001, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Sciences and Chemical Engineering, Harbin Engineering University, Harbin 150001, P. R. China","institution_ids":["https://openalex.org/I151727225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059389033","display_name":"Lili Feng","orcid":"https://orcid.org/0000-0001-9459-6594","observed_orcids":["https://orcid.org/0000-0001-9459-6594"]},"institutions":[{"id":"https://openalex.org/I151727225","display_name":"Harbin Engineering University","ror":"https://ror.org/03x80pn82","country_code":"CN","type":"education","lineage":["https://openalex.org/I151727225"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lili Feng","raw_affiliation_strings":["Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Sciences and Chemical Engineering, Harbin Engineering University, Harbin 150001, P. R. China"],"raw_orcid":"https://orcid.org/0000-0001-9459-6594","affiliations":[{"raw_affiliation_string":"Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Sciences and Chemical Engineering, Harbin Engineering University, Harbin 150001, P. R. China","institution_ids":["https://openalex.org/I151727225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029548952","display_name":"Qianqian Sun","orcid":"https://orcid.org/0000-0001-9824-705X","observed_orcids":["https://orcid.org/0000-0001-9824-705X"]},"institutions":[{"id":"https://openalex.org/I151727225","display_name":"Harbin Engineering University","ror":"https://ror.org/03x80pn82","country_code":"CN","type":"education","lineage":["https://openalex.org/I151727225"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qianqian Sun","raw_affiliation_strings":["Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Sciences and Chemical Engineering, Harbin Engineering University, Harbin 150001, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Sciences and Chemical Engineering, Harbin Engineering University, Harbin 150001, P. R. China","institution_ids":["https://openalex.org/I151727225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074655512","display_name":"Guanying Chen","orcid":"https://orcid.org/0000-0002-4789-1176","observed_orcids":["https://orcid.org/0000-0002-4789-1176"]},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]},{"id":"https://openalex.org/I890469752","display_name":"Ministry of Industry and Information Technology","ror":"https://ror.org/0385nmy68","country_code":"CN","type":"government","lineage":["https://openalex.org/I890469752"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guanying Chen","raw_affiliation_strings":["MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, School of Chemistry and Chemical Engineering & Key Laboratory of Micro-Systems and Micro-Structures, Ministry of Education, Harbin Institute of Technology, 150001 Harbin, P. R. China"],"raw_orcid":"https://orcid.org/0000-0002-4789-1176","affiliations":[{"raw_affiliation_string":"MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, School of Chemistry and Chemical Engineering & Key Laboratory of Micro-Systems and Micro-Structures, Ministry of Education, Harbin Institute of Technology, 150001 Harbin, P. R. China","institution_ids":["https://openalex.org/I204983213","https://openalex.org/I890469752"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073722575","display_name":"Fei He","orcid":"https://orcid.org/0000-0001-5917-9533","observed_orcids":["https://orcid.org/0000-0001-5917-9533"]},"institutions":[{"id":"https://openalex.org/I151727225","display_name":"Harbin Engineering University","ror":"https://ror.org/03x80pn82","country_code":"CN","type":"education","lineage":["https://openalex.org/I151727225"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Fei He","raw_affiliation_strings":["Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Sciences and Chemical Engineering, Harbin Engineering University, Harbin 150001, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Sciences and Chemical Engineering, Harbin Engineering University, Harbin 150001, P. R. China","institution_ids":["https://openalex.org/I151727225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101584313","display_name":"Shikai Liu","orcid":"https://orcid.org/0000-0001-8838-7948","observed_orcids":["https://orcid.org/0000-0001-8838-7948"]},"institutions":[{"id":"https://openalex.org/I151727225","display_name":"Harbin Engineering University","ror":"https://ror.org/03x80pn82","country_code":"CN","type":"education","lineage":["https://openalex.org/I151727225"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shikai Liu","raw_affiliation_strings":["Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Sciences and Chemical Engineering, Harbin Engineering University, Harbin 150001, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Sciences and Chemical Engineering, Harbin Engineering University, Harbin 150001, P. R. China","institution_ids":["https://openalex.org/I151727225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115602687","display_name":"Wenting Li","orcid":"https://orcid.org/0000-0002-1411-0572","observed_orcids":["https://orcid.org/0000-0002-1411-0572"]},"institutions":[{"id":"https://openalex.org/I151727225","display_name":"Harbin Engineering University","ror":"https://ror.org/03x80pn82","country_code":"CN","type":"education","lineage":["https://openalex.org/I151727225"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenting Li","raw_affiliation_strings":["Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Sciences and Chemical Engineering, Harbin Engineering University, Harbin 150001, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Sciences and Chemical Engineering, Harbin Engineering University, Harbin 150001, P. R. China","institution_ids":["https://openalex.org/I151727225"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062571272","display_name":"Piaoping Yang","orcid":"https://orcid.org/0000-0002-9555-1803","observed_orcids":["https://orcid.org/0000-0002-9555-1803"]},"institutions":[{"id":"https://openalex.org/I151727225","display_name":"Harbin Engineering University","ror":"https://ror.org/03x80pn82","country_code":"CN","type":"education","lineage":["https://openalex.org/I151727225"]},{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]},{"id":"https://openalex.org/I890469752","display_name":"Ministry of Industry and Information Technology","ror":"https://ror.org/0385nmy68","country_code":"CN","type":"government","lineage":["https://openalex.org/I890469752"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Piaoping Yang","raw_affiliation_strings":["Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Sciences and Chemical Engineering, Harbin Engineering University, Harbin 150001, P. R. China","MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, School of Chemistry and Chemical Engineering & Key Laboratory of Micro-Systems and Micro-Structures, Ministry of Education, Harbin Institute of Technology, 150001 Harbin, P. R. China"],"raw_orcid":"https://orcid.org/0000-0002-9555-1803","affiliations":[{"raw_affiliation_string":"Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Sciences and Chemical Engineering, Harbin Engineering University, Harbin 150001, P. R. China","institution_ids":["https://openalex.org/I151727225"]},{"raw_affiliation_string":"MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, School of Chemistry and Chemical Engineering & Key Laboratory of Micro-Systems and Micro-Structures, Ministry of Education, Harbin Institute of Technology, 150001 Harbin, P. R. China","institution_ids":["https://openalex.org/I204983213","https://openalex.org/I890469752"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5062571272","https://openalex.org/A5073722575"],"corresponding_institution_ids":["https://openalex.org/I151727225","https://openalex.org/I204983213","https://openalex.org/I890469752"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":3.6616,"has_fulltext":false,"cited_by_count":73,"citation_normalized_percentile":{"value":0.94389142,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"12","issue":"47","first_page":"52479","last_page":"52491"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10097","display_name":"Luminescence Properties of Advanced Materials","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phototheranostics","display_name":"phototheranostics","score":0.8759999871253967},{"id":"https://openalex.org/keywords/nir-ii-fluorescence","display_name":"NIR-II fluorescence","score":0.7839999794960022},{"id":"https://openalex.org/keywords/molybdenum-oxide-nanoparticles","display_name":"molybdenum oxide nanoparticles","score":0.9070000052452087},{"id":"https://openalex.org/keywords/chemodynamic-therapy","display_name":"chemodynamic therapy","score":0.9470000267028809},{"id":"https://openalex.org/keywords/photothermal-therapy","display_name":"photothermal therapy","score":0.9380000233650208},{"id":"https://openalex.org/keywords/synergistic-cancer-therapy","display_name":"synergistic cancer therapy","score":0.6480000019073486},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.7540000081062317},{"id":"https://openalex.org/keywords/hydrogen-peroxide-activation","display_name":"hydrogen peroxide activation","score":0.6610000133514404},{"id":"https://openalex.org/keywords/singlet-oxygen-generation","display_name":"singlet oxygen generation","score":0.8040000200271606},{"id":"https://openalex.org/keywords/glutathione-depletion","display_name":"glutathione depletion","score":0.9390000104904175},{"id":"https://openalex.org/keywords/tumor-hypoxia","display_name":"tumor hypoxia","score":0.6949999928474426},{"id":"https://openalex.org/keywords/multimodal-imaging","display_name":"multimodal imaging","score":0.7699999809265137},{"id":"https://openalex.org/keywords/dendritic-mesoporous-silica","display_name":"dendritic mesoporous silica","score":0.7900000214576721},{"id":"https://openalex.org/keywords/pegylation","display_name":"PEGylation","score":0.5109999775886536}],"concepts":[{"id":"https://openalex.org/C182606246","wikidata":"https://www.wikidata.org/wiki/Q7187926","display_name":"Photothermal therapy","level":2,"score":0.7775303721427917},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.774890661239624},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.6182255148887634},{"id":"https://openalex.org/C2781323092","wikidata":"https://www.wikidata.org/wiki/Q1428072","display_name":"Photodynamic therapy","level":2,"score":0.44987383484840393},{"id":"https://openalex.org/C101645829","wikidata":"https://www.wikidata.org/wiki/Q1781857","display_name":"Multi-mode optical fiber","level":3,"score":0.41520053148269653},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.38197821378707886},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3732919991016388},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3725986182689667},{"id":"https://openalex.org/C49040817","wikidata":"https://www.wikidata.org/wiki/Q193091","display_name":"Optoelectronics","level":1,"score":0.3204706311225891},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.2616967260837555},{"id":"https://openalex.org/C194232370","wikidata":"https://www.wikidata.org/wiki/Q162","display_name":"Optical fiber","level":2,"score":0.19966450333595276},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.19619932770729065},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16744539141654968},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10829716920852661},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.09123057126998901},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000082703","descriptor_name":"Photothermal Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008982","descriptor_name":"Molybdenum","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D010087","descriptor_name":"Oxides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010778","descriptor_name":"Photochemotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012822","descriptor_name":"Silicon Dioxide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016062","descriptor_name":"Porosity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D026082","descriptor_name":"Singlet Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D026082","descriptor_name":"Singlet Oxygen","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D064847","descriptor_name":"Multimodal Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acsami.0c17923","doi":"https://doi.org/10.1021/acsami.0c17923","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsami.0c17923","pdf_url":null,"source":{"id":"https://openalex.org/S164001016","display_name":"ACS Applied Materials & Interfaces","issn_l":"1944-8244","issn":["1944-8244","1944-8252"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Applied Materials & Interfaces","raw_type":"journal-article"},{"id":"pmid:33196186","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33196186","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS applied materials & interfaces","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1828845383","display_name":null,"funder_award_id":"3072020CF1002","funder_id":"https://openalex.org/F4320321106","funder_display_name":"Ministry of Education of the People's Republic of China"},{"id":"https://openalex.org/G3720063425","display_name":null,"funder_award_id":"YQ2019E014","funder_id":"https://openalex.org/F4320323085","funder_display_name":"Natural Science Foundation of Heilongjiang Province"},{"id":"https://openalex.org/G4373950293","display_name":null,"funder_award_id":"51972076","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4840436077","display_name":null,"funder_award_id":"RERU2020002","funder_id":"https://openalex.org/F4320335617","funder_display_name":"State Key Laboratory of Rare Earth Resources Utilization"},{"id":"https://openalex.org/G7288745666","display_name":"\u8fd1\u7ea2\u5916\u5149\u8bf1\u5bfc\u6c27\u8865\u507f\u5149\u5b66\u8bca\u7597\u4f53\u7cfb\u7684\u6784\u5efa\u53ca\u6027\u80fd\u7814\u7a76","funder_award_id":"51972075","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7877581150","display_name":"\u5149\u654f\u7eb3\u7c73\u590d\u5408\u6750\u6599\u7684\u5236\u5907\u53ca\u5728\u7f3a\u6c27\u5fae\u73af\u5883\u4e2d\u80bf\u7624\u5149\u52a8\u529b\u6cbb\u7597\u7814\u7a76","funder_award_id":"51772059","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321106","display_name":"Ministry of Education of the People's Republic of China","ror":"https://ror.org/01mv9t934"},{"id":"https://openalex.org/F4320323085","display_name":"Natural Science Foundation of Heilongjiang Province","ror":null},{"id":"https://openalex.org/F4320335617","display_name":"State Key Laboratory of Rare Earth Resources Utilization","ror":"https://ror.org/03en4sq15"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":66,"referenced_works":["https://openalex.org/W1977871291","https://openalex.org/W1999313400","https://openalex.org/W2013765163","https://openalex.org/W2022074169","https://openalex.org/W2034717709","https://openalex.org/W2040532000","https://openalex.org/W2043303702","https://openalex.org/W2060238699","https://openalex.org/W2077863889","https://openalex.org/W2093026312","https://openalex.org/W2100892270","https://openalex.org/W2156036794","https://openalex.org/W2156439911","https://openalex.org/W2159478010","https://openalex.org/W2236332245","https://openalex.org/W2319295441","https://openalex.org/W2320589001","https://openalex.org/W2374355134","https://openalex.org/W2413193118","https://openalex.org/W2554773181","https://openalex.org/W2563570451","https://openalex.org/W2566963658","https://openalex.org/W2569658671","https://openalex.org/W2583207915","https://openalex.org/W2593226598","https://openalex.org/W2602000459","https://openalex.org/W2605407725","https://openalex.org/W2606079573","https://openalex.org/W2612371420","https://openalex.org/W2738223703","https://openalex.org/W2766554468","https://openalex.org/W2767090914","https://openalex.org/W2775564383","https://openalex.org/W2802831093","https://openalex.org/W2804516406","https://openalex.org/W2809595609","https://openalex.org/W2883358359","https://openalex.org/W2883440571","https://openalex.org/W2888625569","https://openalex.org/W2890725242","https://openalex.org/W2899114650","https://openalex.org/W2902416943","https://openalex.org/W2903659409","https://openalex.org/W2905504906","https://openalex.org/W2907278948","https://openalex.org/W2908266099","https://openalex.org/W2912665154","https://openalex.org/W2912904788","https://openalex.org/W2920341565","https://openalex.org/W2922743362","https://openalex.org/W2941561244","https://openalex.org/W2943087581","https://openalex.org/W2943288317","https://openalex.org/W2946538408","https://openalex.org/W2947512353","https://openalex.org/W2948231961","https://openalex.org/W2956004678","https://openalex.org/W2966091466","https://openalex.org/W2969296993","https://openalex.org/W2974996748","https://openalex.org/W2979380254","https://openalex.org/W2981437046","https://openalex.org/W2985055119","https://openalex.org/W2997485145","https://openalex.org/W2998560245","https://openalex.org/W3084621691"],"related_works":["https://openalex.org/W3193744689","https://openalex.org/W3015286990","https://openalex.org/W2979380254","https://openalex.org/W2936090102","https://openalex.org/W3047971458","https://openalex.org/W3215517021","https://openalex.org/W4309488448","https://openalex.org/W3183192055","https://openalex.org/W2946538408","https://openalex.org/W4416410363"],"abstract_inverted_index":{"The":[0],"development":[1],"of":[2,29,81,112,167,178,189,198,205,230,276],"near-infrared":[3],"(NIR)":[4],"laser":[5,18,298],"triggered":[6],"phototheranostics":[7],"for":[8],"multimodal":[9,306],"imaging-guided":[10,307],"combination":[11],"therapy":[12],"is":[13],"highly":[14],"desirable.":[15],"However,":[16],"multiple":[17],"sources,":[19],"as":[20,22,268],"well":[21],"inadequate":[23],"therapeutic":[24],"efficacy,":[25],"impede":[26],"the":[27,63,79,131,140,145,150,157,164,171,187,202,209,245,303,315],"application":[28],"phototheranostics.":[30,322],"Here,":[31],"we":[32],"develop":[33],"an":[34,74,87,181,234,289],"all-in-one":[35],"theranostic":[36],"nanoagent":[37],"PEGylated":[38],"DCNP@DMSN-MoO":[39],"x":[40,70,115,214],"NPs":[41,116,215],"(DCDMs)":[42],"with":[43,55],"a":[44,227,269],"flower-like":[45],"structure":[46],"fabricated":[47],"by":[48,86,121],"coating":[49],"uniformly":[50],"sized":[51],"down-conversion":[52],"nanoparticles":[53,68],"(DCNPs)":[54],"dendritic":[56],"mesoporous":[57],"silica":[58],"(DMSN)":[59],"and":[60,97,106,249,261,282],"then":[61],"loading":[62],"ultrasmall":[64],"oxygen-deficient":[65],"molybdenum":[66,199],"oxide":[67],"(MoO":[69],"NPs)":[71],"inside":[72],"through":[73,156],"electrostatic":[75],"interaction.":[76],"Owing":[77],"to":[78,317],"doping":[80],"Nd":[82],"ions,":[83],"when":[84],"excited":[85],"808":[88,182],"nm":[89,183],"laser,":[90],"DCNPs":[91,266],"emit":[92],"bright":[93],"NIR-II":[94,304],"emissions":[95],"(1060":[96],"1300":[98],"nm),":[99],"which":[100],"have":[101],"characteristic":[102],"high":[103,203],"spatial":[104],"resolution":[105],"deep":[107],"tissue":[108],"penetration.":[109],"In":[110,143],"terms":[111],"treatment,":[113],"MoO":[114,213],"could":[117,153,216],"be":[118,154],"specifically":[119],"activated":[120],"excessive":[122,146],"hydrogen":[123],"peroxide":[124],"(H":[125],"2":[126,128,138,192,223,225,232],"O":[127,137,191,224,231],")":[129],"in":[130,149,233,241,280,283],"tumor":[132,151,168,220,236,242,277],"microenvironment,":[133,237],"thus":[134,161,238],"generating":[135],"1":[136,190,251],"via":[139],"Russell":[141],"mechanism.":[142],"addition,":[144],"glutathione":[147],"(GSH)":[148],"cells":[152],"depleted":[155],"Mo-mediated":[158],"redox":[159,196],"reaction,":[160],"effectively":[162],"decreasing":[163],"antioxidant":[165],"capacity":[166],"cells.":[169],"Importantly,":[170],"excellent":[172],"photothermal":[173],"properties":[174],"(photothermal":[175],"conversion":[176],"efficiency":[177],"51.5%":[179],"under":[180,296],"laser)":[184],"synergistically":[185],"accelerate":[186],"generation":[188],".":[193],"This":[194],"cyclic":[195],"reaction":[197],"indeed":[200],"ensured":[201],"efficacy":[204],"tumor-specific":[206],"therapy,":[207],"leaving":[208],"normal":[210],"tissues":[211],"unharmed.":[212],"also":[217],"efficiently":[218],"catalyze":[219],"endogenous":[221],"H":[222],"into":[226],"considerable":[228],"amount":[229],"acidic":[235],"relieving":[239],"hypoxia":[240],"tissues.":[243],"Moreover,":[244],"computed":[246],"tomography":[247],"(CT)":[248],"T":[250],"-weighted":[252],"magnetic":[253],"resonance":[254],"imaging":[255,271],"(MRI)":[256],"effect":[257],"from":[258,302],"Gd":[259],"3+":[260,263],"Y":[262],"ions":[264],"make":[265],"act":[267],"hybrid":[270],"agent,":[272],"allowing":[273],"comprehensive":[274],"analysis":[275],"lesions.":[278],"Both":[279],"vitro":[281],"vivo":[284],"experiments":[285],"validate":[286],"that":[287],"such":[288],"\u201call-in-one\u201d":[290],"nanoplatform":[291],"possesses":[292],"desirable":[293],"anticancer":[294],"abilities":[295],"single":[297],"source":[299],"irradiation,":[300],"benefiting":[301],"fluorescence/CT/MR":[305],"photothermal/chemodynamic":[308],"synergistic":[309],"therapy.":[310],"Overall,":[311],"our":[312],"strategy":[313],"paves":[314],"way":[316],"explore":[318],"other":[319],"noninvasive":[320],"cancer":[321]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":17},{"year":2022,"cited_by_count":25},{"year":2021,"cited_by_count":10}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-11-23T00:00:00"}