{"id":"https://openalex.org/W3099112004","doi":"https://doi.org/10.1021/bk-2020-1361.ch008","title":"Antiplasmodial Activity of the Extracts and Flavonoids Isolated fromHelichrysum gymnocephalumHumbert (Asteraceae) from Madagascar","display_name":"Antiplasmodial Activity of the Extracts and Flavonoids Isolated fromHelichrysum gymnocephalumHumbert (Asteraceae) from Madagascar","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W3099112004","doi":"https://doi.org/10.1021/bk-2020-1361.ch008","mag":"3099112004"},"language":"en","primary_location":{"id":"doi:10.1021/bk-2020-1361.ch008","doi":"https://doi.org/10.1021/bk-2020-1361.ch008","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bk-2020-1361.ch008","pdf_url":null,"source":{"id":"https://openalex.org/S205053445","display_name":"ACS symposium series","issn_l":"0097-6156","issn":["0097-6156","1947-5918"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Symposium Series","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4243961429","display_name":"African Natural Plant Products, Volume III: Discoveries and Innovations in Chemistry, Bioactivity, and Applications"},"type":"conference-paper","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000552992","display_name":"Rianatiana H. Ranaivoarisoa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121583","display_name":"National Centre for the Application of Pharmaceutical Research","ror":"https://ror.org/02y7h5c73","country_code":"MG","type":"facility","lineage":["https://openalex.org/I4210121583"]}],"countries":["MG"],"is_corresponding":false,"raw_author_name":"Rianatiana H. Ranaivoarisoa","raw_affiliation_strings":["Centre National d\u2019Application de Recherches Pharmaceutiques, rue R. P. Rahajarizafy A. de Padoue, Ambodivoanjo-Ambohijatovo, BP 702, 101 Antananarivo, Madagascar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre National d\u2019Application de Recherches Pharmaceutiques, rue R. P. Rahajarizafy A. de Padoue, Ambodivoanjo-Ambohijatovo, BP 702, 101 Antananarivo, Madagascar","institution_ids":["https://openalex.org/I4210121583"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074708980","display_name":"Sylvia Ralambonirina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121583","display_name":"National Centre for the Application of Pharmaceutical Research","ror":"https://ror.org/02y7h5c73","country_code":"MG","type":"facility","lineage":["https://openalex.org/I4210121583"]}],"countries":["MG"],"is_corresponding":false,"raw_author_name":"Sylvia T. Rasoarivelo Ralambonirina","raw_affiliation_strings":["Centre National d\u2019Application de Recherches Pharmaceutiques, rue R. P. Rahajarizafy A. de Padoue, Ambodivoanjo-Ambohijatovo, BP 702, 101 Antananarivo, Madagascar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre National d\u2019Application de Recherches Pharmaceutiques, rue R. P. Rahajarizafy A. de Padoue, Ambodivoanjo-Ambohijatovo, BP 702, 101 Antananarivo, Madagascar","institution_ids":["https://openalex.org/I4210121583"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086412688","display_name":"Faliarivony Randriamialinoro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121583","display_name":"National Centre for the Application of Pharmaceutical Research","ror":"https://ror.org/02y7h5c73","country_code":"MG","type":"facility","lineage":["https://openalex.org/I4210121583"]}],"countries":["MG"],"is_corresponding":false,"raw_author_name":"Faliarivony Randriamialinoro","raw_affiliation_strings":["Centre National d\u2019Application de Recherches Pharmaceutiques, rue R. P. Rahajarizafy A. de Padoue, Ambodivoanjo-Ambohijatovo, BP 702, 101 Antananarivo, Madagascar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre National d\u2019Application de Recherches Pharmaceutiques, rue R. P. Rahajarizafy A. de Padoue, Ambodivoanjo-Ambohijatovo, BP 702, 101 Antananarivo, Madagascar","institution_ids":["https://openalex.org/I4210121583"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007296053","display_name":"Rivoarison Randrianasolo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137724175","display_name":"University of Antananarivo","ror":"https://ror.org/02w4gwv87","country_code":"MG","type":"education","lineage":["https://openalex.org/I137724175"]}],"countries":["MG"],"is_corresponding":false,"raw_author_name":"Rivoarison Randrianasolo","raw_affiliation_strings":["Parcours Chimie Biologie, Mention Chimie, Domaine Sciences et Technologies, Universit\u00e9 d\u2019Antananarivo, BP 906, 101 Antananarivo, Madagascar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Parcours Chimie Biologie, Mention Chimie, Domaine Sciences et Technologies, Universit\u00e9 d\u2019Antananarivo, BP 906, 101 Antananarivo, Madagascar","institution_ids":["https://openalex.org/I137724175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017998892","display_name":"Michel Ratsimbason","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121583","display_name":"National Centre for the Application of Pharmaceutical Research","ror":"https://ror.org/02y7h5c73","country_code":"MG","type":"facility","lineage":["https://openalex.org/I4210121583"]}],"countries":["MG"],"is_corresponding":false,"raw_author_name":"Michel Ratsimbason","raw_affiliation_strings":["Centre National d\u2019Application de Recherches Pharmaceutiques, rue R. P. Rahajarizafy A. de Padoue, Ambodivoanjo-Ambohijatovo, BP 702, 101 Antananarivo, Madagascar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre National d\u2019Application de Recherches Pharmaceutiques, rue R. P. Rahajarizafy A. de Padoue, Ambodivoanjo-Ambohijatovo, BP 702, 101 Antananarivo, Madagascar","institution_ids":["https://openalex.org/I4210121583"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112583304","display_name":"Lalasoa Ranaivoarison Ranarivelo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121583","display_name":"National Centre for the Application of Pharmaceutical Research","ror":"https://ror.org/02y7h5c73","country_code":"MG","type":"facility","lineage":["https://openalex.org/I4210121583"]}],"countries":["MG"],"is_corresponding":true,"raw_author_name":"Lalasoa R. Ranarivelo","raw_affiliation_strings":["Centre National d\u2019Application de Recherches Pharmaceutiques, rue R. P. Rahajarizafy A. de Padoue, Ambodivoanjo-Ambohijatovo, BP 702, 101 Antananarivo, Madagascar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre National d\u2019Application de Recherches Pharmaceutiques, rue R. P. Rahajarizafy A. de Padoue, Ambodivoanjo-Ambohijatovo, BP 702, 101 Antananarivo, Madagascar","institution_ids":["https://openalex.org/I4210121583"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5112583304"],"corresponding_institution_ids":["https://openalex.org/I4210121583"],"apc_list":null,"apc_paid":null,"fwci":0.5611,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.6971831,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":"171","last_page":"178"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12685","display_name":"Phytochemical compounds biological activities","score":0.9496999979019165,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12685","display_name":"Phytochemical compounds biological activities","score":0.9496999979019165,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.026000000536441803,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11547","display_name":"Sesquiterpenes and Asteraceae Studies","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antiplasmodial-activity","display_name":"antiplasmodial activity","score":0.9919999837875366},{"id":"https://openalex.org/keywords/plasmodium-falciparum","display_name":"Plasmodium falciparum","score":0.9950000047683716},{"id":"https://openalex.org/keywords/chloroquine-resistant-strain","display_name":"chloroquine-resistant strain","score":0.800000011920929},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.8519999980926514},{"id":"https://openalex.org/keywords/pinocembrin","display_name":"pinocembrin","score":0.9919999837875366},{"id":"https://openalex.org/keywords/plant-extracts","display_name":"plant extracts","score":0.703000009059906},{"id":"https://openalex.org/keywords/ethnomedicine","display_name":"ethnomedicine","score":0.890999972820282},{"id":"https://openalex.org/keywords/madagascar","display_name":"Madagascar","score":0.3370000123977661}],"concepts":[{"id":"https://openalex.org/C2780400988","wikidata":"https://www.wikidata.org/wiki/Q421748","display_name":"Dichloromethane","level":3,"score":0.8090305328369141},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.61577308177948},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.6112316846847534},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.59309983253479},{"id":"https://openalex.org/C2779878721","wikidata":"https://www.wikidata.org/wiki/Q25400","display_name":"Asteraceae","level":2,"score":0.5685942769050598},{"id":"https://openalex.org/C2780161600","wikidata":"https://www.wikidata.org/wiki/Q153","display_name":"Ethanol","level":2,"score":0.5649178624153137},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.5240780711174011},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.5147190690040588},{"id":"https://openalex.org/C2780471494","wikidata":"https://www.wikidata.org/wiki/Q146505","display_name":"Solvent","level":2,"score":0.480258971452713},{"id":"https://openalex.org/C149629883","wikidata":"https://www.wikidata.org/wiki/Q660926","display_name":"Fraction (chemistry)","level":2,"score":0.4740203022956848},{"id":"https://openalex.org/C2777077568","wikidata":"https://www.wikidata.org/wiki/Q150440","display_name":"Hexane","level":2,"score":0.43362611532211304},{"id":"https://openalex.org/C2779858419","wikidata":"https://www.wikidata.org/wiki/Q407153","display_name":"Ethyl acetate","level":2,"score":0.4320310950279236},{"id":"https://openalex.org/C2779054382","wikidata":"https://www.wikidata.org/wiki/Q72185287","display_name":"Flavonoid","level":3,"score":0.41476064920425415},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2858543395996094},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25495362281799316},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.2146681249141693},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.17740857601165771},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16768410801887512},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14710411429405212},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.06285029649734497},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.0},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/bk-2020-1361.ch008","doi":"https://doi.org/10.1021/bk-2020-1361.ch008","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bk-2020-1361.ch008","pdf_url":null,"source":{"id":"https://openalex.org/S205053445","display_name":"ACS symposium series","issn_l":"0097-6156","issn":["0097-6156","1947-5918"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Symposium Series","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W5088213","https://openalex.org/W323695587","https://openalex.org/W1524145479","https://openalex.org/W1543236900","https://openalex.org/W1648586995","https://openalex.org/W1841777696","https://openalex.org/W1922647407","https://openalex.org/W1970810952","https://openalex.org/W1973512039","https://openalex.org/W1981959045","https://openalex.org/W1984658969","https://openalex.org/W2006371350","https://openalex.org/W2040220282","https://openalex.org/W2055153842","https://openalex.org/W2089045264","https://openalex.org/W2091386938","https://openalex.org/W2098153147","https://openalex.org/W2103303796","https://openalex.org/W2114971505","https://openalex.org/W2133648606","https://openalex.org/W2157525511","https://openalex.org/W2315456261","https://openalex.org/W2341722039","https://openalex.org/W2463719897","https://openalex.org/W2604783640","https://openalex.org/W2605848440","https://openalex.org/W2619241086","https://openalex.org/W2759519500","https://openalex.org/W2782969246","https://openalex.org/W2783155370","https://openalex.org/W2789824369","https://openalex.org/W2802951524","https://openalex.org/W2885005744","https://openalex.org/W2887079659","https://openalex.org/W2890543013","https://openalex.org/W2892369450","https://openalex.org/W2896187181","https://openalex.org/W2944146722","https://openalex.org/W2956389443","https://openalex.org/W2992626227"],"related_works":["https://openalex.org/W7098689024","https://openalex.org/W2993392318","https://openalex.org/W3176603038","https://openalex.org/W1994781602","https://openalex.org/W2303735282","https://openalex.org/W3004772731","https://openalex.org/W2342623291","https://openalex.org/W2189505713","https://openalex.org/W1988611461","https://openalex.org/W2010912653"],"abstract_inverted_index":{"Helichrysum":[0],"gymnocephalum":[1],"is":[2,18],"a":[3],"popular":[4],"plant":[5,78],"in":[6,13,29],"traditional":[7],"Malagasy":[8],"medicine":[9],"with":[10,80,97,158,161],"several":[11],"uses":[12],"ethnomedicine.":[14],"As":[15],"febrifuge":[16],"use":[17],"most":[19,144],"common,":[20],"this":[21],"study":[22],"seeks":[23],"to":[24,56,67,120],"evaluate":[25],"the":[26,37,40,44,50,57,77,81,90,111,143],"antiplasmodial":[27,159],"activity":[28,32,160],"vitro.":[30],"This":[31],"was":[33],"assessed":[34],"by":[35,43],"measuring":[36],"inhibition":[38],"of":[39,60,72,76,165],"fluorescence":[41],"emitted":[42],"complex":[45],"formed":[46],"between":[47],"dsDNA":[48],"and":[49,74,99,110,133,154,174],"fluorophore":[51],"SYBR":[52],"Green":[53],"I,":[54],"added":[55],"culture":[58],"medium":[59],"Plasmodium":[61],"falciparum":[62,83],"FCM29":[63],"(a":[64],"resistant":[65],"strain":[66],"chloroquine)":[68],"after":[69,94],"72":[70],"h":[71],"incubation":[73],"contact":[75],"extract":[79,93],"P.":[82],"culture.":[84],"Three":[85],"fractions":[86],"were":[87],"obtained":[88],"from":[89,142],"ethanol":[91,103],"crude":[92,104],"liquid\u2013liquid":[95],"partitioning":[96],"hexane":[98,106],"then":[100],"dichloromethane.":[101],"The":[102,139],"extract,":[105],"fraction,":[107,109],"dichloromethane":[108,146],"last":[112],"aqueous":[113],"fraction":[114,147],"have":[115],"an":[116,162],"IC":[117,163],"50":[118,164],"equal":[119],"39.64":[121],"\u00b1":[122,126,130,135,167,171,176],"0.58":[123],"\u00b5g/mL,":[124,128,132,137],"38.35":[125],"1.75":[127],"8.81":[129],"0.51":[131],"46.24":[134],"7.42":[136],"respectively.":[138,179],"isolated":[140],"compounds":[141],"active":[145],"are":[148],"flavonoids":[149],"(Pinocembrin,":[150],"3-":[151],"O":[152],"-Acetylpinobanksin":[153],"5,7-Dihydroxyisoflavone),":[155],"all":[156],"endowed":[157],"96.72":[166],"1.93":[168],"\u00b5M,":[169,173,178],"15.62":[170],"1.35":[172],"74.80":[175],"0.06":[177]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2020-11-23T00:00:00"}
