{"id":"https://openalex.org/W3098529305","doi":"https://doi.org/10.1038/s41598-020-77085-z","title":"Intravenous administration of sodium propionate induces antidepressant or prodepressant effect in a dose dependent manner","display_name":"Intravenous administration of sodium propionate induces antidepressant or prodepressant effect in a dose dependent manner","publication_year":2020,"publication_date":"2020-11-16","ids":{"openalex":"https://openalex.org/W3098529305","doi":"https://doi.org/10.1038/s41598-020-77085-z","mag":"3098529305","pmid":"https://pubmed.ncbi.nlm.nih.gov/33199803","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7670463"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-020-77085-z","doi":"https://doi.org/10.1038/s41598-020-77085-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-020-77085-z","pdf_url":"https://www.nature.com/articles/s41598-020-77085-z.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-020-77085-z.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101620165","display_name":"Chunyan Hao","orcid":"https://orcid.org/0000-0003-2885-8503","observed_orcids":["https://orcid.org/0000-0003-2885-8503","https://orcid.org/0009-0004-4944-4507"]},"institutions":[{"id":"https://openalex.org/I46305995","display_name":"Taiyuan University of Science and Technology","ror":"https://ror.org/01wcbdc92","country_code":"CN","type":"education","lineage":["https://openalex.org/I46305995"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunyan Hao","raw_affiliation_strings":["School of Chemical and Biological Engineering, Taiyuan University of Science & Technology, Taiyuan, 030021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemical and Biological Engineering, Taiyuan University of Science & Technology, Taiyuan, 030021, China","institution_ids":["https://openalex.org/I46305995"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091343650","display_name":"Zefeng Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181877577","display_name":"Shanxi University","ror":"https://ror.org/03y3e3s17","country_code":"CN","type":"education","lineage":["https://openalex.org/I181877577"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zefeng Gao","raw_affiliation_strings":["Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institutes of Biomedical Sciences, Shanxi University, No. 92, Wucheng Road, Xiaodian District, TaiyuanShanxi, 030006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institutes of Biomedical Sciences, Shanxi University, No. 92, Wucheng Road, Xiaodian District, TaiyuanShanxi, 030006, China","institution_ids":["https://openalex.org/I181877577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101642830","display_name":"Xianjun Liu","orcid":"https://orcid.org/0000-0002-5790-6503","observed_orcids":["https://orcid.org/0000-0002-5790-6503"]},"institutions":[{"id":"https://openalex.org/I46305995","display_name":"Taiyuan University of Science and Technology","ror":"https://ror.org/01wcbdc92","country_code":"CN","type":"education","lineage":["https://openalex.org/I46305995"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"XianJun Liu","raw_affiliation_strings":["School of Chemical and Biological Engineering, Taiyuan University of Science & Technology, Taiyuan, 030021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemical and Biological Engineering, Taiyuan University of Science & Technology, Taiyuan, 030021, China","institution_ids":["https://openalex.org/I46305995"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069535872","display_name":"Zhijiang Rong","orcid":"https://orcid.org/0000-0003-0605-0669","observed_orcids":["https://orcid.org/0000-0003-0605-0669"]},"institutions":[{"id":"https://openalex.org/I46305995","display_name":"Taiyuan University of Science and Technology","ror":"https://ror.org/01wcbdc92","country_code":"CN","type":"education","lineage":["https://openalex.org/I46305995"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhijiang Rong","raw_affiliation_strings":["School of Chemical and Biological Engineering, Taiyuan University of Science & Technology, Taiyuan, 030021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemical and Biological Engineering, Taiyuan University of Science & Technology, Taiyuan, 030021, China","institution_ids":["https://openalex.org/I46305995"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001755009","display_name":"Jingjing Jia","orcid":"https://orcid.org/0009-0000-9422-6059","observed_orcids":["https://orcid.org/0009-0000-9422-6059"]},"institutions":[{"id":"https://openalex.org/I181877577","display_name":"Shanxi University","ror":"https://ror.org/03y3e3s17","country_code":"CN","type":"education","lineage":["https://openalex.org/I181877577"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingjing Jia","raw_affiliation_strings":["School of Life Science, Shanxi University, Taiyuan, 030006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Science, Shanxi University, Taiyuan, 030006, China","institution_ids":["https://openalex.org/I181877577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080818738","display_name":"Kaiqi Kang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181877577","display_name":"Shanxi University","ror":"https://ror.org/03y3e3s17","country_code":"CN","type":"education","lineage":["https://openalex.org/I181877577"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kaiqi Kang","raw_affiliation_strings":["School of Life Science, Shanxi University, Taiyuan, 030006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Science, Shanxi University, Taiyuan, 030006, China","institution_ids":["https://openalex.org/I181877577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079952150","display_name":"Weiwei Guo","orcid":"https://orcid.org/0000-0002-2001-7956","observed_orcids":["https://orcid.org/0000-0002-2001-7956"]},"institutions":[{"id":"https://openalex.org/I181877577","display_name":"Shanxi University","ror":"https://ror.org/03y3e3s17","country_code":"CN","type":"education","lineage":["https://openalex.org/I181877577"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weiwei Guo","raw_affiliation_strings":["School of Life Science, Shanxi University, Taiyuan, 030006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Science, Shanxi University, Taiyuan, 030006, China","institution_ids":["https://openalex.org/I181877577"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069107293","display_name":"Jianguo Li","orcid":"https://orcid.org/0000-0002-2251-8308","observed_orcids":["https://orcid.org/0000-0002-2251-8308","https://orcid.org/0009-0002-3500-0855"]},"institutions":[{"id":"https://openalex.org/I181877577","display_name":"Shanxi University","ror":"https://ror.org/03y3e3s17","country_code":"CN","type":"education","lineage":["https://openalex.org/I181877577"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jianguo Li","raw_affiliation_strings":["Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institutes of Biomedical Sciences, Shanxi University, No. 92, Wucheng Road, Xiaodian District, TaiyuanShanxi, 030006, China. lijg@sxu.edu.cn","Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institutes of Biomedical Sciences, Shanxi University, No. 92, Wucheng Road, Xiaodian District, TaiyuanShanxi, 030006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institutes of Biomedical Sciences, Shanxi University, No. 92, Wucheng Road, Xiaodian District, TaiyuanShanxi, 030006, China. lijg@sxu.edu.cn","institution_ids":["https://openalex.org/I181877577"]},{"raw_affiliation_string":"Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institutes of Biomedical Sciences, Shanxi University, No. 92, Wucheng Road, Xiaodian District, TaiyuanShanxi, 030006, China","institution_ids":["https://openalex.org/I181877577"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5069107293"],"corresponding_institution_ids":["https://openalex.org/I181877577"],"apc_list":{"value":1870,"currency":"USD","value_usd":1870},"apc_paid":{"value":1870,"currency":"USD","value_usd":1870},"fwci":2.0436,"has_fulltext":true,"cited_by_count":45,"citation_normalized_percentile":{"value":0.85167996,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"10","issue":"1","first_page":"19917","last_page":"19917"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.7900000214576721,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.7900000214576721,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.1973000019788742,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.007699999958276749,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sodium-propionate","display_name":"sodium propionate","score":0.9929999709129333},{"id":"https://openalex.org/keywords/antidepressant-effects","display_name":"antidepressant effects","score":0.6769999861717224},{"id":"https://openalex.org/keywords/dose-dependent-effects","display_name":"dose-dependent effects","score":0.8840000033378601},{"id":"https://openalex.org/keywords/chronic-unpredictable-mild-stress","display_name":"chronic unpredictable mild stress","score":0.9150000214576721},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.6579999923706055},{"id":"https://openalex.org/keywords/kynurenine-pathway","display_name":"kynurenine pathway","score":0.8320000171661377},{"id":"https://openalex.org/keywords/food-additive-toxicity","display_name":"food additive toxicity","score":0.6100000143051147},{"id":"https://openalex.org/keywords/autism-like-symptoms","display_name":"autism-like symptoms","score":0.7070000171661377},{"id":"https://openalex.org/keywords/reward-seeking-behavior","display_name":"reward-seeking behavior","score":0.6209999918937683}],"concepts":[{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.7459902763366699},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6363257169723511},{"id":"https://openalex.org/C2780014933","wikidata":"https://www.wikidata.org/wiki/Q422956","display_name":"Propionate","level":2,"score":0.5107555389404297},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5017917156219482},{"id":"https://openalex.org/C2911225412","wikidata":"https://www.wikidata.org/wiki/Q422956","display_name":"Propionates","level":2,"score":0.4979536533355713},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.48525500297546387},{"id":"https://openalex.org/C2780765947","wikidata":"https://www.wikidata.org/wiki/Q12033531","display_name":"Administration (probate law)","level":2,"score":0.47030848264694214},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36118805408477783},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2555190324783325},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10684025287628174},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011422","descriptor_name":"Propionates","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D011422","descriptor_name":"Propionates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061605","descriptor_name":"Administration, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/s41598-020-77085-z","doi":"https://doi.org/10.1038/s41598-020-77085-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-020-77085-z","pdf_url":"https://www.nature.com/articles/s41598-020-77085-z.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7670463","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7670463","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:33199803","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33199803","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/s41598-020-77085-z","doi":"https://doi.org/10.1038/s41598-020-77085-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-020-77085-z","pdf_url":"https://www.nature.com/articles/s41598-020-77085-z.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322536","display_name":"Shanxi University","ror":"https://ror.org/03y3e3s17"},{"id":"https://openalex.org/F4320329860","display_name":"National Science and Technology Major Project","ror":null},{"id":"https://openalex.org/F4320336360","display_name":"Scientific Instrument Center, SXU","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3098529305.pdf","grobid_xml":"https://content.openalex.org/works/W3098529305.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1531606462","https://openalex.org/W1546207985","https://openalex.org/W1869544959","https://openalex.org/W1941293036","https://openalex.org/W1963736896","https://openalex.org/W1968077576","https://openalex.org/W1998060132","https://openalex.org/W2013598219","https://openalex.org/W2014444288","https://openalex.org/W2022673879","https://openalex.org/W2052317258","https://openalex.org/W2052830386","https://openalex.org/W2064284817","https://openalex.org/W2093759195","https://openalex.org/W2152037884","https://openalex.org/W2158030963","https://openalex.org/W2196681167","https://openalex.org/W2229859804","https://openalex.org/W2300911794","https://openalex.org/W2337092408","https://openalex.org/W2338113655","https://openalex.org/W2429960568","https://openalex.org/W2480241421","https://openalex.org/W2519531315","https://openalex.org/W2532458527","https://openalex.org/W2563827379","https://openalex.org/W2590245531","https://openalex.org/W2617474448","https://openalex.org/W2626828975","https://openalex.org/W2752259647","https://openalex.org/W2787646573","https://openalex.org/W2788337440","https://openalex.org/W2789500132","https://openalex.org/W2803703235","https://openalex.org/W2883883307","https://openalex.org/W2888189358","https://openalex.org/W2891370960","https://openalex.org/W2891851874","https://openalex.org/W2903821735","https://openalex.org/W2911700361","https://openalex.org/W3027696415","https://openalex.org/W3031057806","https://openalex.org/W4253145015"],"related_works":["https://openalex.org/W2891370960","https://openalex.org/W2423084265","https://openalex.org/W7135100501","https://openalex.org/W178942794","https://openalex.org/W2015838764","https://openalex.org/W4402664589","https://openalex.org/W2078662465","https://openalex.org/W2111200148","https://openalex.org/W2588585556","https://openalex.org/W2916739734"],"abstract_inverted_index":{"Propionate":[0],"has":[1],"been":[2],"reported":[3],"to":[4,30,35,52,81,84,242],"exert":[5],"antidepressant":[6,107],"effects,":[7],"but":[8],"high-dose":[9,61,120,162,196],"propionate":[10,28,62,72,75,101,121,163,197,228,237],"may":[11,47],"induce":[12],"autism-like":[13],"symptoms":[14],"in":[15,140,201,212],"experimental":[16],"animals":[17],"through":[18,109],"induction":[19],"of":[20,22,27,60,71,94,130,132,138,148,172,180,214,219,227,236],"dysbiosis":[21],"neurotransmitters.":[23],"The":[24,54,192,217],"bi-directional":[25],"effects":[26,70,128,167,226],"seem":[29],"be":[31,49],"dose-dependent.":[32],"However,":[33],"due":[34],"the":[36,69,141,202,208,223],"pathological":[37],"discrepancies":[38],"between":[39],"depression":[40,64,230],"and":[41,56,115,176,178,190,231],"autism,":[42],"conclusions":[43],"drawn":[44],"from":[45],"autism":[46],"not":[48],"simply":[50],"transferable":[51],"depression.":[53],"effect":[55,108],"underlying":[57],"action":[58],"mechanisms":[59],"on":[63,73,168,229],"remains":[65],"undetermined.":[66],"To":[67],"investigate":[68],"depression,":[74],"dose":[76],"gradients":[77],"were":[78,205],"intravenously":[79],"administrated":[80],"rats":[82],"exposed":[83],"chronic":[85],"unpredictable":[86],"mild":[87],"stress":[88],"(CUMS)":[89],"for":[90],"1":[91],"week.":[92],"Results":[93],"these":[95],"behavioral":[96],"tests":[97],"demonstrate":[98,222],"that":[99,144],"low-dose":[100,133,159],"(2":[102],"mg/kg":[103,123],"body":[104,124],"weight/day)":[105,125],"induces":[106,126,146],"bodyweight":[110],"recovery,":[111],"elevated":[112],"reward-seeking":[113],"behaviors,":[114,118],"reduced":[116],"depression-like":[117],"while":[119,161],"(200":[122],"prodepressant":[127],"opposite":[129],"those":[131],"propionate.":[134],"A":[135],"comprehensive":[136],"profiling":[137],"neurotransmitters":[139,193],"hippocampus":[142],"demonstrated":[143],"CUMS":[145],"reduction":[147,171],"NE":[149],"(Norepinephrine),":[150],"DA":[151],"(Dopamine).":[152],"GABA":[153],"(\u03b3-aminobutyric":[154],"acid)":[155],"was":[156],"recovered":[157],"by":[158,195,207],"propionate,":[160],"exerted":[164],"more":[165],"complicated":[166],"neurotransmitters,":[169],"including":[170],"NE,":[173],"DA,":[174],"5-Hydroxytryptamine":[175],"Tryptophan,":[177],"increase":[179],"GABA,":[181],"Kynurenine,":[182],"Homovanillic":[183],"acid,":[184,186,189],"3-hydroxyanthranilic":[185],"3-hydroxykynurenine,":[187],"3,4-dihydroxyphenylacetic":[188],"3-methoxytyramine.":[191],"disturbed":[194],"suggest":[198,232],"metabolic":[199],"disorders":[200],"hippocampus,":[203],"which":[204],"confirmed":[206],"clear":[209],"group":[210],"separation":[211],"PCA":[213],"metabolomic":[215],"profiling.":[216],"results":[218],"this":[220],"study":[221],"double-edged":[224],"dose-dependent":[225],"potential":[233],"cumulative":[234],"toxicity":[235],"as":[238],"a":[239],"food":[240],"additive":[241],"mood":[243],"disorders.":[244]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-11-23T00:00:00"}