{"id":"https://openalex.org/W3098422646","doi":"https://doi.org/10.1158/1538-7445.panca20-po-021","title":"Abstract PO-021: Targeting glutamine dependencies in pancreatic cancers","display_name":"Abstract PO-021: Targeting glutamine dependencies in pancreatic cancers","publication_year":2020,"publication_date":"2020-11-13","ids":{"openalex":"https://openalex.org/W3098422646","doi":"https://doi.org/10.1158/1538-7445.panca20-po-021","mag":"3098422646"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.panca20-po-021","doi":"https://doi.org/10.1158/1538-7445.panca20-po-021","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.panca20-po-021","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011348783","display_name":"Alec C. Kimmelman","orcid":"https://orcid.org/0009-0002-9465-8411","observed_orcids":["https://orcid.org/0009-0002-9465-8411"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I4390039310","display_name":"NYU Langone\u2019s Laura and Isaac Perlmutter Cancer Center","ror":"https://ror.org/00sa8g751","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933","https://openalex.org/I4390039310"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alec Kimmelman","raw_affiliation_strings":["Perlmutter Cancer Center, Department of Radiation Oncology, NYU Medical School, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Perlmutter Cancer Center, Department of Radiation Oncology, NYU Medical School, New York, NY, USA","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I4390039310","https://openalex.org/I57206974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066604945","display_name":"Joel Encarnaci\u00f3n-Rosado","orcid":"https://orcid.org/0000-0002-0440-4278","observed_orcids":["https://orcid.org/0000-0002-0440-4278"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I4390039310","display_name":"NYU Langone\u2019s Laura and Isaac Perlmutter Cancer Center","ror":"https://ror.org/00sa8g751","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933","https://openalex.org/I4390039310"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joel Encarnacion-Rosado","raw_affiliation_strings":["Perlmutter Cancer Center, Department of Radiation Oncology, NYU Medical School, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Perlmutter Cancer Center, Department of Radiation Oncology, NYU Medical School, New York, NY, USA","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I4390039310","https://openalex.org/I57206974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"80","issue":"22_Supplement","first_page":"PO","last_page":"021"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.7275000214576721,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.7275000214576721,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.2003999948501587,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.025499999523162842,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/glutamine-metabolism","display_name":"glutamine metabolism","score":0.9509999752044678},{"id":"https://openalex.org/keywords/glutamine-analogs","display_name":"glutamine analogs","score":0.6420000195503235},{"id":"https://openalex.org/keywords/6-diazo-5-oxo-l-norleucine","display_name":"6-diazo-5-oxo-L-norleucine","score":0.9589999914169312},{"id":"https://openalex.org/keywords/glutaminase-inhibition","display_name":"glutaminase inhibition","score":0.7870000004768372},{"id":"https://openalex.org/keywords/cb-839","display_name":"CB-839","score":0.9039999842643738},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.7369999885559082},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.7570000290870667},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.9390000104904175},{"id":"https://openalex.org/keywords/tricarboxylic-acid-cycle","display_name":"TCA cycle","score":0.8180000185966492},{"id":"https://openalex.org/keywords/mitochondrial-respiration","display_name":"mitochondrial respiration","score":0.9909999966621399},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.5680000185966492},{"id":"https://openalex.org/keywords/metabolic-reprogramming","display_name":"metabolic reprogramming","score":0.6570000052452087},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.640999972820282}],"concepts":[{"id":"https://openalex.org/C2778160063","wikidata":"https://www.wikidata.org/wiki/Q1532402","display_name":"Glutaminolysis","level":4,"score":0.850374162197113},{"id":"https://openalex.org/C2779349466","wikidata":"https://www.wikidata.org/wiki/Q181619","display_name":"Glutamine","level":3,"score":0.8473076224327087},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5929895639419556},{"id":"https://openalex.org/C109549099","wikidata":"https://www.wikidata.org/wiki/Q24773687","display_name":"Glutaminase","level":4,"score":0.5412326455116272},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.49270346760749817},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.488860547542572},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4824810326099396},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.4423958361148834},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3453952670097351},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3228966295719147},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3084402084350586},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.11348190903663635},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.08459287881851196},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0736091136932373}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.panca20-po-021","doi":"https://doi.org/10.1158/1538-7445.panca20-po-021","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.panca20-po-021","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9789000153541565}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4390915377","https://openalex.org/W4387451329","https://openalex.org/W2741653872","https://openalex.org/W4387451269","https://openalex.org/W4412137529","https://openalex.org/W3030858653","https://openalex.org/W4403057632","https://openalex.org/W4238998985","https://openalex.org/W4406777642","https://openalex.org/W3168097011"],"abstract_inverted_index":{"Abstract":[0],"Pancreatic":[1,255],"ductal":[2],"adenocarcinoma":[3],"(PDAC)":[4],"is":[5,77],"a":[6,11,22,48,103,123,145,158,167,176,186],"highly":[7],"aggressive":[8],"disease":[9],"with":[10],"5-year":[12],"survival":[13],"rate":[14],"of":[15,32,57,69,114,134,160,192,204,219,225,248],"less":[16],"than":[17],"10%.":[18],"PDAC":[19,87,137,161,230],"cells":[20,88],"activate":[21],"non-canonical":[23],"glutamine":[24,44,70,104,211,240],"metabolic":[25,116],"pathway":[26],"essential":[27],"to":[28,144,210],"increase":[29],"the":[30,54,66,73,115,132,173,189,202,205,208,217,249],"level":[31],"NADPH,":[33],"an":[34,228],"important":[35],"metabolite":[36],"for":[37,79,127],"redox":[38],"balance,":[39],"promoting":[40],"tumor":[41,180],"growth.":[42,181],"Targeting":[43,239],"metabolism":[45,92,138],"using":[46,102,166,227],"CB-839,":[47],"small":[49],"molecule":[50],"that":[51,86,101,118],"targets":[52],"glutaminase,":[53],"first":[55],"step":[56],"glutaminolysis":[58],"failed":[59],"in":[60,136,148,157,172,179,188,207,242],"PDAC.":[61,128],"CB839":[62],"treatment":[63,142],"only":[64],"blocks":[65],"carbon":[67],"utilization":[68],"and":[71,93,139,153,194,222],"not":[72],"nitrogen":[74],"portion":[75],"which":[76,110,196],"critical":[78],"anabolic":[80],"processes.":[81],"We":[82,99],"have":[83],"previously":[84],"shown":[85],"can":[89],"rewire":[90],"their":[91],"overcome":[94],"GLS":[95],"inhibition":[96],"within":[97],"days.":[98],"hypothesize":[100],"analog,":[105],"such":[106],"as":[107],"6-Diazo-5-oxo-L-norleucine":[108],"(DON),":[109],"broadly":[111],"inhibits":[112],"all":[113],"reactions":[117],"require":[119],"glutamine,":[120],"will":[121],"provide":[122],"new":[124],"therapeutic":[125],"avenue":[126],"Here,":[129],"we":[130,214],"investigate":[131],"role":[133,203,218],"DON":[135,141],"progression.":[140],"leads":[143],"profound":[146],"decrease":[147,178,187],"proliferation,":[149],"TCA":[150],"cycle":[151],"metabolites,":[152],"mitochondrial":[154],"basal":[155],"respiration":[156],"panel":[159],"cells.":[162],"In":[163],"vivo":[164],"studies":[165,184],"syngeneic,":[168],"orthotopically":[169],"transplantation":[170],"model":[171],"pancreas":[174],"demonstrated":[175,185],"significant":[177],"Bulk":[182],"RNA-seq":[183],"transcriptional":[190],"signature":[191],"ECM":[193],"hypoxia,":[195],"was":[197],"confirm":[198],"by":[199],"histology,":[200],"suggesting":[201],"TME":[206],"response":[209],"blockage.":[212],"Currently,":[213],"are":[215],"testing":[216],"this":[220],"drug":[221],"potential":[223],"mechanisms":[224],"resistance":[226],"autochthonous":[229],"mouse":[231],"model.":[232],"Citation":[233],"Format:":[234],"Alec":[235],"Kimmelman,":[236],"Joel":[237],"Encarnacion-Rosado.":[238],"dependencies":[241],"pancreatic":[243],"cancers":[244],"[abstract].":[245],"In:":[246],"Proceedings":[247],"AACR":[250],"Virtual":[251],"Special":[252],"Conference":[253],"on":[254],"Cancer;":[256],"2020":[257],"Sep":[258],"29-30.":[259],"Philadelphia":[260],"(PA):":[261],"AACR;":[262],"Cancer":[263],"Res":[264],"2020;80(22":[265],"Suppl):Abstract":[266],"nr":[267],"PO-021.":[268]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2020-11-23T00:00:00"}